Full Text Journal Articles by
Author Vasantha H S Kumar

Advertisement

Find full text journal articles








Caffeine and Clinical Outcomes in Premature Neonates.

Vasantha H S Kumar, Steven E Lipshultz,

Caffeine is the most widely used drug by both adults and children worldwide due to its ability to promote alertness and elevate moods. It is effective in the management of apnea of prematurity in premature infants. Caffeine for apnea of prematurity reduces the incidence of bronchopulmonary dysplasia in very-low-birth-weight infants ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2019, 6(11):]

Cited: 0 times

View full text PDF listing >>



Glucose Levels during the First 24 Hours following Perinatal Hypoxia.

Mahdi Alsaleem, Lida I Zeinali, Bobby Mathew, Vasantha H S Kumar,

OBJECTIVE: Hypoglycemia is a significant risk factor for perinatal brain injury and adverse outcomes, particularly in infants requiring resuscitation following hypoxic ischemic (HI) insult. We aimed to study blood glucose (BG) levels in physiologically stressed infants in the presence or absence of epinephrine (Epi) administration at resuscitation in the first 24 hours ... Read more >>

Am J Perinatol (American journal of perinatology)
[2019, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Caffeine is associated with improved alveolarization and angiogenesis in male mice following hyperoxia induced lung injury.

Vikramaditya Dumpa, Lori Nielsen, Huamei Wang, Vasantha H S Kumar,

BACKGROUND:Caffeine therapy for apnea of prematurity reduces the incidence of bronchopulmonary dysplasia (BPD) in premature neonates. Several mechanisms, including improvement in pulmonary mechanics underly beneficial effects of caffeine in BPD. As vascular development promotes alveologenesis, we hypothesized that caffeine might enhance angiogenesis in the lung, promoting lung growth, thereby attenuating ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2019, 19(1):138]

Cited: 1 time

View full text PDF listing >>



Subcutaneous fat necrosis, a rare but serious side effect of hypoxic-ischemic encephalopathy and whole-body hypothermia.

Mahdi Alsaleem, Lina Saadeh, Valerie Elberson, Vasantha H S Kumar,

Objective To describe the clinical characteristics and risk factors in infants with subcutaneous fat necrosis (SFN) following therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE). Methods A case-control study was performed by a retrospective chart review of infants with moderate or severe HIE admitted to a level IV regional perinatal center and ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2019, 47(9):986-990]

Cited: 0 times

View full text PDF listing >>



Clinical and Red Blood Cell Indices of Acute and Chronic Fetomaternal Hemorrhage.

Vasantha H S Kumar, Kruthika V Kumar, Bobby Mathew,

Clin Pediatr (Phila) (Clinical pediatrics)
[2019, 58(11-12):1330-1333]

Cited: 0 times

View full text PDF listing >>



Continued Enteral Feeding Is Beneficial in Hypoglycemic Infants Admitted to Intensive Care for Parenteral Dextrose Therapy.

Mahdi Alsaleem, Lina Saadeh, Vasantha H S Kumar, Gregory E Wilding, Lorin Miller, Bobby Mathew,

There is variability in practice among care providers on feeding infants admitted with neonatal hypoglycemia (NH) for parenteral dextrose. We compared clinical outcomes in infants who were fed (NH-Fed) and hypoglycemic infants who were kept nothing per os (NPO) (NH-NPO) at the time of initiation of intravenous (IV) dextrose. We ... Read more >>

Glob Pediatr Health (Global pediatric health)
[2019, 6:2333794X19857415]

Cited: 0 times

View full text PDF listing >>



Current and Emerging Therapies in the Management of Hypoxic Ischemic Encephalopathy in Neonates.

Jayasree Nair, Vasantha H S Kumar,

Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard of care for infants with moderate to severe HIE, but has not definitively changed outcomes in severe HIE. In this review, we discuss newer promising markers ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2018, 5(7):]

Cited: 4 times

View full text PDF listing >>



Response to pulmonary vasodilators in infants with congenital diaphragmatic hernia.

Vasantha H S Kumar, Rita Dadiz, Jamie Koumoundouros, Stephanie Guilford, Satyan Lakshminrusimha,

BACKGROUND:Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia, cardiac dysfunction and pulmonary hypertension. Inhaled nitric oxide (iNO) and milrinone are commonly used pulmonary vasodilators in CDH. We studied the hemodynamic effects of iNO and milrinone in infants with CDH. METHODS:A retrospective chart review was performed of all CDH infants ... Read more >>

Pediatr. Surg. Int. (Pediatric surgery international)
[2018, 34(7):735-742]

Cited: 1 time

View full text PDF listing >>



Liver Failure and Conjugated Hyperbilirubinemia in a Preterm Neonate: Role of Early IVIG and Exchange Transfusion.

Jayasree Nair, Vasantha H S Kumar,

Neonatal liver failure (NLF) is a rare diagnosis but carries with it significant risks of mortality and morbidity. Common etiologies for NLF include metabolic causes, gestational alloimmune liver disease (GALD or neonatal hemochromatosis), and viral infections. We report a case of liver failure in a premature infant with abnormal iron ... Read more >>

AJP Rep (AJP reports)
[2018, 8(2):e95-e98]

Cited: 0 times

View full text PDF listing >>



Long-Term Effects of Neonatal Hyperoxia in Adult Mice.

Vasantha H S Kumar, Huamei Wang, Sergei Kishkurno, Babu S Paturi, Lori Nielsen, Rita M Ryan,

The outcomes of premature infants have improved greatly; however, the health risks in adulthood are still relatively unclear. Bronchopulmonary dysplasia (BPD) in premature infants is a major risk factor for alteration in lung function and predisposition to respiratory morbidity, and is associated with hyperoxia. The study explores the effect of ... Read more >>

Anat Rec (Hoboken) (Anatomical record (Hoboken, N.J. : 2007))
[2018, 301(4):717-726]

Cited: 4 times

View full text PDF listing >>



Adaptive immune responses are altered in adult mice following neonatal hyperoxia.

Vasantha H S Kumar, Huamei Wang, Lori Nielsen,

Premature infants with bronchopulmonary dysplasia (BPD), are at risk for frequent respiratory infections and reduced pulmonary function. We studied whether neonatal hyperoxia disrupts adaptive immune responses in adult mice, contributing to higher respiratory-related morbidities seen in these infants. Newborn mice litters were randomized at 3 days to 85% O2 or room ... Read more >>

Physiol Rep (Physiological reports)
[2018, 6(2):]

Cited: 1 time

View full text PDF listing >>



Nfib hemizygous mice are protected from hyperoxic lung injury and death.

Vasantha H S Kumar, Joseph Chaker El Khoury, Richard Gronostajski, Huamei Wang, Lori Nielsen, Rita M Ryan,

Nuclear Factor I (Nfi) genes encode transcription factors essential for the development of organ systems including the lung. Nfib null mice die at birth with immature lungs. Nfib hemizygous mice have reduced lung maturation with decreased survival. We therefore hypothesized that these mice would be more sensitive to lung injury ... Read more >>

Physiol Rep (Physiological reports)
[2017, 5(16):]

Cited: 2 times

View full text PDF listing >>



Natriuretic peptide C receptor in the developing sheep lung: role in perinatal transition.

Bobby Mathew, Christopher A D'Angelis, Satyan Lakshminrusimha, Peter A Nickerson, June J Sokolowski, Vasantha H S Kumar, Huamei Wang, Karen A Wynn, Bruce A Holm, Rita M Ryan,

Background: At birth, the release of surfactant from alveolar type II cells (ATIIs) is stimulated by increased activity of the beta-adrenergic/adenylyl cyclase/cyclic 3'-5' adenosine monophosphate-signaling cascade. Atrial natriuretic peptide (ANP) stimulates surfactant secretion through natriuretic peptide receptor A (NPR-A). ANP inhibits adenylyl cyclase activity through its binding to NPR-C. We ... Read more >>

Pediatr. Res. (Pediatric research)
[2017, 82(2):349-355]

Cited: 0 times

View full text PDF listing >>



Diagnostic Approach to Pulmonary Hypertension in Premature Neonates.

Vasantha H S Kumar,

Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease in premature infants following respiratory distress at birth. With increasing survival of extremely low birth weight infants, alveolar simplification is the defining lung characteristic of infants with BPD, and along with pulmonary hypertension, increasingly contributes to both respiratory morbidity and ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2017, 4(9):]

Cited: 1 time

View full text PDF listing >>



Commentaries on Viewpoint: Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing.

M Olaithe, P R Eastwood, R S Bucks, Naomi L Deacon, Atul Malhotra, Vasantha H S Kumar, Li Zuo, Chia-Chen Chuang, Helena Schotland,

J. Appl. Physiol. (Journal of applied physiology (Bethesda, Md. : 1985))
[2016, 120(12):1487-1488]

Cited: 1 time

View full text PDF listing >>



Commentaries on Viewpoint: Time for a new metric for hypoxic dose?

Grégoire P Millet, Franck Brocherie, Olivier Girard, Jon Peter Wehrlin, Severin Troesch, Anna Hauser, Thomas Steiner, Juha E Peltonen, Heikki K Rusko, Keren Constantini, Timothy J Fulton, Daniel G Hursh, Tyler J Noble, Hunter L R Paris, Chad C Wiggins, Robert F Chapman, Benjamin D Levine, Vasantha H S Kumar, Walter F J Schmidt,

J. Appl. Physiol. (Journal of applied physiology (Bethesda, Md. : 1985))
[2016, 121(1):356-358]

Cited: 7 times

View full text PDF listing >>



Early Use of Inhaled Nitric Oxide in Preterm Infants: Is there a Rationale for Selective Approach?

Praveen Chandrasekharan, Rafal Kozielski, Vasantha H S Kumar, Munmun Rawat, Veena Manja, Changxing Ma, Satyan Lakshminrusimha,

Background Inhaled nitric oxide (iNO) is being increasingly used in preterm infants < 34 weeks with hypoxemic respiratory failure (HRF) and/or pulmonary hypertension (PH). Objective To evaluate the risk factors, survival characteristics, and lung histopathology in preterm infants with PH/HRF. Methods Retrospective chart review was conducted to determine characteristics of 93 preterm infants treated with ... Read more >>

Am J Perinatol (American journal of perinatology)
[2017, 34(5):428-440]

Cited: 7 times

View full text PDF listing >>



Neonatal hyperoxia increases airway reactivity and inflammation in adult mice.

Vasantha H S Kumar, Satyan Lakshminrusimha, Sergei Kishkurno, Babu S Paturi, Sylvia F Gugino, Lori Nielsen, Huamei Wang, Rita M Ryan,

Supplemental O2 to treat bronchopulmonary dysplasia (BPD) in premature infants, is a major risk factor producing alteration in lung function, airway reactivity, and predisposition to respiratory infections. This study explores inflammatory and airway responses following neonatal hyperoxia in adult mice.Newborn mouse litters were randomized to 85% O2 or room air ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2016, 51(11):1131-1141]

Cited: 12 times

View full text PDF listing >>



Inguinal hernia in preterm infants (< or = 32-week gestation).

Vasantha H S Kumar, Jonathan Clive, Ted S Rosenkrantz, Michael D Bourque, Naveed Hussain,

The current incidence of inguinal hernia (IH) in premature infants is not well-established. It is also unclear whether common co-morbidities in this population, i.e., chronic lung disease (CLD) or nutritional status or both contribute to the development of IH. The purpose of this study was to establish the epidemiologic profile ... Read more >>

Pediatr. Surg. Int. (Pediatric surgery international)
[2002, 18(2-3):147-152]

Cited: 16 times

View full text PDF listing >>





Advertisement

Disclaimer
0.9301 s