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Author Vanessa De Castro

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Characterization of Primary Direct Acting Antiviral Drugs (DAA) Resistance Mutations in NS5A/NS5B Regions of Hepatitis C Virus with Genotype 1a and 1b from Patients with Chronic Hepatitis

Ana Paula de Torres Santos, Vanessa Cristina Martins Silva, Maria Cássia Mendes-Corrêa, Marcilio Figueiredo Lemos, Fernanda de Mello Malta, Rúbia Anita Ferraz Santana, Gregório Tadeu Fernando Dastoli, Vanessa Fusco Duarte de Castro, João Renato Rebello Pinho, Regina Célia Moreira,

Hepatitis C virus (HCV) infection is a public health problem with an estimated 71 million infected people worldwide. The high level of HCV replication and its lack of post - transcriptional correction mechanisms result in the rapid emergence of viral variants, difficulty in determining polymorphisms, and variants that contain substitutions ... Read more >>

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Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response Against Schistosoma mansoni Infection in Humans.

Guilherme Silva Miranda, Samira Diniz Resende, Diogo Tavares Cardoso, Genil Mororó Araújo Camelo, Jeferson Kelvin Alves Oliveira Silva, Vanessa Normandio de Castro, Stefan Michael Geiger, Mariângela Carneiro, Deborah Negrão-Corrêa,

Schistosomiasis and Leishmaniasis are chronic parasitic diseases with high prevalence in some tropical regions and, due to their wide distribution, a risk of co-infections is present in some areas. Nevertheless, the impact of this interaction on human populations is still poorly understood. Thus, the current study evaluated the effect of ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:630934]

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Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus).

Vanessa De Castro, Pascal Girard,

Episodic memory decline is an early marker of cognitive aging in human. Although controversial in animals and called "episodic-like memory", several models have been successfully developed, however they rarely focused on ageing. While marmoset is an emerging primate model in aging science, episodic-like memory has never been tested in this ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):9138]

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Symmetry processing in the macaque visual cortex

Pauline Audurier, Yseult Héjja-Brichard, Vanessa De Castro, Peter Kohler, Anthony Norcia, Jean-Baptiste Durand, Benoit Cottereau,

Symmetry is a highly salient feature of the natural world that is perceived by many species of the animal kingdom and that impacts a large array of behaviours such as partner selection or food choice. In humans, the cerebral areas processing symmetry are now well identified from neuroimaging measurements. However, ... Read more >>

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Prevalence and Pattern of Resistance in NS5A/NS5B in Hepatitis C Chronic Patients Genotype 3 Examined at a Public Health Laboratory in the State of São Paulo, Brazil.

Ana Paula de Torres Santos, Vanessa Cristina Martins Silva, Maria Cássia Mendes-Corrêa, Marcilio Figueiredo Lemos, Fernanda de Mello Malta, Rúbia Anita Ferraz Santana, Gregório Tadeu Fernando Dastoli, Vanessa Fusco Duarte de Castro, João Renato Rebello Pinho, Regina Célia Moreira,

<h4>Purpose</h4>Globally, it is estimated that 71 million people are chronically infected with hepatitis C, and 10-20% of these will develop cirrhosis and hepatocellular carcinoma. The development of new direct-acting antiviral (DAA) drugs has contributed to sustained virological response (SVR), eliminating the infection and achieving cure of chronic hepatitis C. However, ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2021, 14:723-730]

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Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.

Juan Jose Fernandez-Valenzuela, Raquel Sanchez-Varo, Clara Muñoz-Castro, Vanessa De Castro, Elisabeth Sanchez-Mejias, Victoria Navarro, Sebastian Jimenez, Cristina Nuñez-Diaz, Angela Gomez-Arboledas, Ines Moreno-Gonzalez, Marisa Vizuete, Jose Carlos Davila, Javier Vitorica, Antonia Gutierrez,

In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation of hyperphosphorylated tau leading to neurofibrillary pathology. AD brains also accumulate amyloid-beta (Aβ) deposits. However, the effect of microtubule stabilizing agents on Aβ pathology has ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14776]

Cited: 2 times

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Identification of priority areas for surveillance of cutaneous leishmaniasis using spatial analysis approaches in Southeastern Brazil.

Diogo Tavares Cardoso, Dayane Costa de Souza, Vanessa Normandio de Castro, Stefan Michael Geiger, David Soeiro Barbosa,

<h4>Background</h4>Cutaneous leishmaniasis (CL) is an important public health problem in Brazil and in several tropical regions of the world. In the Americas, Brazil is the country with the highest number of registered cases. In Brazil, the state of Minas Gerais has the highest number of cases in the southeastern region. ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2019, 19(1):318]

Cited: 6 times

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Prevalence of naturally occurring amino acid substitutions associated with resistance to hepatitis C virus NS3/NS4A protease inhibitors in São Paulo state.

Regina Célia Moreira, Ana Paula de Torres Santos, Gaspar Lisboa-Neto, Maria Cássia Jacintho Mendes-Corrêa, Marcilio Figueiredo Lemos, Fernanda Mello Malta, Rúbia Anita Ferraz Santana, Gregório Tadeu Fernando Dastoli, Vanessa Fusco Duarte de Castro, João Renato Rebello Pinho,

Hepatitis C (HCV)-infected patients are treated with direct-acting antiviral agents (DAAs) in highly effective, well-tolerated, all-oral regimens. However, naturally occurring resistance-associated amino acid substitutions (RASs) may be selected during treatment. This study aimed to screen naturally occurring RASs NS3/NS4A inhibitors (PIs). Samples were obtained from DAA naïve patients, living in ... Read more >>

Arch Virol (Archives of virology)
[2018, 163(10):2757-2764]

Cited: 1 time

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Prevalence of resistance-associated substitutions to direct-acting antiviral agents in hemodialysis and renal transplant patients infected with hepatitis C virus.

Rita Chelly Felix Tavares, Ana Cristina de Castro Amaral Feldner, João Renato Rebello Pinho, Fernanda de Mello Malta, Roberto José Carvalho-Filho, Rúbia Anita Ferraz Santana, Vanessa Fusco Duarte de Castro, Gregório Tadeu Fernando Dastoli, Juliana Custódio Lima, Maria Lucia Cardoso Gomes Ferraz,

<h4>Background</h4>Direct-acting antiviral agents (DAAs) permit the use of interferon (IFN)-free regimens to treat hepatitis C (HCV) in patients with chronic kidney disease (CKD) on hemo-dialysis (HD) or renal transplant (RTx) recipients, with excellent response rates and safety. However, the occurrence of basal or therapy-induced resistance-associated substitutions (RASs) to DAAs can ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2018, 11:1993-2000]

Cited: 3 times

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Prevalence of naturally occurring protease inhibitor resistance-associated variants in hemodialysis and renal transplant patients with hepatitis C virus infection.

Rita C F Tavares, Ana C C A Feldner, João R R Pinho, Silvia N O Uehara, Christini T Emori, Roberto J Carvalho-Filho, Ivonete S S Silva, Rúbia A F Santana, Vanessa F D de Castro, Gregório T F Castoli, Charliana U Cristovão, Maria L C G Ferraz,

Background NS3 protease inhibitors (PIs) were the first direct antiviral agents used for the treatment of hepatitis C virus. The combination of second-wave PIs with other direct antiviral agents enabled the use of interferon-free regimens for chronic kidney disease patients on dialysis and renal transplant (RTx) recipients, populations in which ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2017, 29(7):754-758]

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Natural occurrence of NS5B inhibitor resistance-associated variants in Brazilian patients infected with HCV or HCV and HIV.

Caroline Furtado Noble, Fernanda Malta, Gaspar Lisboa-Neto, Michele Soares Gomes-Gouvêa, Andrea Gurgel Batista Leite, Vanessa Fusco Duarte de Castro, Rubia Anita Ferraz Santana, Flair José Carrilho, Maria Cássia Mendes-Correa, João Renato Rebello Pinho,

Resistance-associated variants (RAVs) represent a challenge to the success of new HCV therapies. The aim of this study was to describe the prevalence of naturally occurring NS5B RAVs in Brazilian direct acting antivirals (DAA)-naïve patients infected with HCV genotype 1, or co-infected with HIV. Patient enrollment and sample collection were ... Read more >>

Arch Virol (Archives of virology)
[2017, 162(1):165-169]

Cited: 5 times

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Children using Day Nurseries' Facilities can be Associated with more Risk to Nonnutritive Sucking Habits.

Fabiana Bt Alves, Denise S Wambier, Jenny Ha Alvarez, José Cf da Rocha, Thais R Kummer, Vanessa C de Castro, Howard Cabral, Vitoldo A Kozlowski,

<h4>Introduction</h4>This study evaluated the expression of nonnutritive sucking habits and the presence of malocclusion in children using day nurseries' facilities.<h4>Materials and methods</h4>The 195 children (7-40 months) attending 18 public day nurseries were evaluated clinically in Ponta Grossa, Brazil. Statistical package software was used for descriptive, univariate, bivariate, and multiple logistic ... Read more >>

J Contemp Dent Pract (The journal of contemporary dental practice)
[2016, 17(9):721-727]

Cited: 0 times

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Interferon lambda and hepatitis C virus core protein polymorphisms associated with liver cancer.

João Paulo Moreira, Fernanda de Mello Malta, Márcio Augusto Diniz, Luciana Kikuchi, Aline Lopes Chagas, Livia de Souza Botelho Lima, Michele Soares Gomes-Gouvêa, Vanessa Fusco Duarte de Castro, Rubia Anita Ferraz Santana, Nairo Massakazu Sumita, Denise Cerqueira Paranagua Vezozzo, Flair José Carrilho, João Renato Rebello Pinho,

<h4>Background</h4>Hepatitis C virus (HCV) infection is often persistent and gradually advances from chronic hepatitis to liver cirrhosis and hepatocellular carcinoma (HCC). Worldwide, hepatocellular carcinoma is the fifth most common neoplasm.<h4>Method of study</h4>the Interferon lambda (IFNL) polymorphisms genotypes (rs8099917, rs12979860 and rs12980275) and the presence of mutations in HCV core protein ... Read more >>

Virology (Virology)
[2016, 493:136-141]

Cited: 6 times

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Enzymatic production of bioactive docosahexaenoic acid phenolic ester.

Mohamed H Roby, Ahmad Allouche, Layal Dahdou, Vanessa C De Castro, Paulo H Alves da Silva, Brenda N Targino, Marion Huguet, Cédric Paris, Françoise Chrétien, Rosa-Maria Guéant, Stéphane Desobry, Thierry Oster, Catherine Humeau,

Docosahexaenoic acid (DHA) is increasingly considered for its health benefits. However, its use as functional food ingredient is still limited by its instability. In this work, we developed an efficient and solvent-free bioprocess for the synthesis of a phenolic ester of DHA. A fed-batch process catalyzed by Candida antarctica lipase ... Read more >>

Food Chem (Food chemistry)
[2015, 171:397-404]

Cited: 3 times

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Oxidative stability of DHA phenolic ester.

Mohamed H H Roby, Vanessa C De Castro, Brenda N Targino, Paulo H Alves Da Silva, Cécile Mangavel, Françoise Chretien, Catherine Humeau, Stephane Desobry,

Docosahexaenoic acid vanillyl ester (DHA-VE) was synthesized from docosahexaenoic acid ethyl ester (DHA-EE) and vanillyl alcohol by a solvent-free alcoholysis process catalysed by Candida antarctica lipase B. Oxidative stability of pure DHA-VE and the crude reaction medium consisting of 45% DHA-VE and 55% DHA-EE were compared with that of DHA-EE ... Read more >>

Food Chem (Food chemistry)
[2015, 169:41-48]

Cited: 2 times

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In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.

Laura Trujillo-Estrada, Sebastian Jimenez, Vanessa De Castro, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Victoria Navarro, Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

<h4>Background</h4>Alzheimer's disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, neuronal loss and the deterioration of cognitive capabilities of patients. However, no effective disease-modifying treatment has been yet developed. In this work we have evaluated whether chronic lithium ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2013, 1:73]

Cited: 12 times

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Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.

Raquel Sanchez-Varo, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Vanessa De Castro, Sebastian Jimenez, Diego Ruano, Marisa Vizuete, Jose Carlos Davila, Jose Manuel Garcia-Verdugo, Antonio Jesus Jimenez, Javier Vitorica, Antonia Gutierrez,

Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer's disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus of young (4- to 6-month-old) PS1(M146L)/APP(751SL) mice model, as the initial degenerative process underlying functional disturbance prior to neuronal loss. Neuritic ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2012, 123(1):53-70]

Cited: 95 times

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Effects of (RS)-3,4-DCPG, a mixed AMPA antagonist/mGluR8 agonist, on aggressive behavior in mice.

José Francisco Navarro, Vanessa de Castro, Mercedes Martín-López,

<h4>Introduction</h4>Ionotropic and metabotropic (mGlu) receptors of glutamate have been suggested to be involved in the modulation of aggression. Thus, recent studies found reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice. Likewise, mGlu1 and 5 receptors have also been implicated in aggression regulation. (RS)-3,4-DCPG is a mixed antagonist of AMPA ... Read more >>

Rev Psiquiatr Salud Ment (Revista de psiquiatria y salud mental)
[2009, 2(3):133-137]

Cited: 1 time

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Behavioural profile of selective ligands for mGlu7 and mGlu8 glutamate receptors in agonistic encounters between mice.

José Francisco Navarro, Vanessa de Castro, Mercedes Martín-López,

Evidence is accumulating for a role of glutamate transmission in aggression modulation. Recent studies indicate that glutamate metabotropic receptors (mGlu1 and mGlu5) are involved in the regulation of aggressive behaviour. However, to date, the possible role of mGlu7 and mGlu8 receptors has not been explored. In this work, we analyze ... Read more >>

Psicothema (Psicothema)
[2009, 21(3):475-479]

Cited: 7 times

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JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice.

José Francisco Navarro, Vanessa De Castro, Mercedes Martín-López,

mGlu1 receptors are present in brain regions involved in aggression modulation. This study examines the effects of 3-4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(cis-4-methoxycyclohexyl)-methanone (JNJ16259685; 0.125, 0.25, 0.5, 1, 2, 4 and 8 mg/kg, i.p), a selective antagonist of the mGlu1 receptors, on agonistic interactions between male mice. Individually housed mice were exposed to anosmic "standard ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2008, 586(1-3):217-220]

Cited: 12 times

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