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Author Vandana Jain

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Gut Microbiome: A Potential Modifiable Risk Factor in Biliary Atresia.

Vandana Jain, Emma C Alexander, Charlotte Burford, Anita Verma, Anil Dhawan,

<h4>Abstract</h4>Biliary atresia (BA) is a fibro-obliterative condition of the biliary tree, presenting in infancy. The bilioenteric conduit formed at Kasai portoenterostomy (KPE), achieves restoration of bile flow in approximately 60% of infants. Even if the operation is successful, cirrhosis and its associated complications are, however, common. BA remains the leading ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2021, 72(2):184-193]

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Andrographolide: A Review of Analytical Methods.

Rashmi Patil, Vandana Jain,

Bicyclic diterpenoid lactone andrographolide is regarded as a "natural antibiotic" as it is known to exhibit a range of bioactivities including anti-inflammatory, antibacterial, antipyretic, antineoplastic, cardioprotective, hepatoprotective and hypoglycaemic, and is present in Andrographis paniculata. The aim of this article is to review the information on analytical methods for andrographolide ... Read more >>

J Chromatogr Sci (Journal of chromatographic science)
[2021, 59(2):191-203]

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Catch-up and Catch-down Growth in Term Healthy Indian Infants From Birth to 2 Years: A Prospective Cohort Study.

Vandana Jain, Brijesh Kumar, Sapna Khatak,

<h4>Background</h4>Catch-up in the first two years of life may help in reducing the growth deficit.<h4>Objectives</h4>To study growth pattern of term infants from birth to 2 years, focusing on catch-up and catch-down growth (increase or decrease in Z-score >0.67) in weight and length.<h4>Study design</h4>Prospective birth cohort.<h4>Participants</h4>262 healthy term infants with birthweight ... Read more >>

Indian Pediatr (Indian pediatrics)
[2021, :]

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Marathi translation, linguistic validation, and cross-cultural adaptation of speech handicap index and voice handicap index in patients of head and neck squamous cell cancer.

Chaitali M Waghmare, Vasundhara Aggarwal, Anup L Kharde, Vandana S Jain, Pradeep Kumar Thakur,

<h4>Background</h4>Patient reported treatment outcomes is a better way to measure the quality of life (QOL). This study was undertaken to translate the speech handicap index (SHI) and voice handicap index (VHI) in Marathi language and its linguistic validation and cross-cultural adaptation in patients of head and neck squamous cell cancer ... Read more >>

Indian J Cancer (Indian journal of cancer)
[2021, :]

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December consultation #3.

Vandana Jain,

J Cataract Refract Surg (Journal of cataract and refractive surgery)
[2020, 46(12):1686-1687]

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Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes.

Pamela Bowman, Frances Mathews, Fabrizio Barbetti, Maggie H Shepherd, Janine Sanchez, Barbara Piccini, Jacques Beltrand, Lisa R Letourneau-Freiberg, Michel Polak, Siri Atma W Greeley, Eamon Rawlins, Tarig Babiker, Nicholas J Thomas, Elisa De Franco, Sian Ellard, Sarah E Flanagan, Andrew T Hattersley, ,

<h4>Objective</h4><i>ABCC8</i> mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with <i>ABCC8-</i>PNDM require lower sulfonylurea doses and have milder neurological features than those with <i>KCNJ11-</i>PNDM. However, these ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(1):35-42]

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Frequency spectrum of rare and clinically relevant markers in multiethnic Indian populations (ClinIndb): A resource for genomic medicine in India.

Ankita Narang, Bharathram Uppilli, Asokachandran Vivekanand, Salwa Naushin, Arti Yadav, Khushboo Singhal, Uzma Shamim, Pooja Sharma, Sana Zahra, Aradhana Mathur, Malika Seth, Shaista Parveen, Archana Vats, Sara Hillman, Padma Dolma, Binuja Varma, Vandana Jain, , Bhavana Prasher, Shantanu Sengupta, Mitali Mukerji, Mohammed Faruq,

There have been concerted efforts toward cataloging rare and deleterious variants in different world populations using high-throughput genotyping and sequencing-based methods. The Indian population is underrepresented or its information with respect to clinically relevant variants is sparse in public data sets. The aim of this study was to estimate the burden ... Read more >>

Hum Mutat (Human mutation)
[2020, 41(11):1833-1847]

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Topical timolol for the treatment of conjunctival pyogenic granulomas: Outcomes and effect on intraocular pressure.

Akshay Gopinathan Nair, Ronnie Jacob George, Sundaram Natarajan, Vandana Jain,

<h4>Purpose</h4>To report the clinical outcomes of 0.5% timolol maleate eye drops for the treatment of conjunctival pyogenic granuloma (PG) and its effect on intraocular pressure (IOP).<h4>Methods</h4>In this retrospective study, consecutive patients with conjunctival pyogenic granuloma between January 2019 and September 2019 were prescribed 0.5% timolol maleate eye drops twice a ... Read more >>

Indian J Ophthalmol (Indian journal of ophthalmology)
[2020, 68(10):2170-2174]

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Squamous cell carcinoma of the lacrimal punctum: A rare presentation.

Akshay Gopinathan Nair, Indumati Gopinathan, Vandana Jain,

Indian J Ophthalmol (Indian journal of ophthalmology)
[2020, 68(10):2245-2247]

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Intestinal mucormycosis complicated by iliac artery aneurysm and ureteric rupture in a child with new-onset type 1 diabetes mellitus.

Ganesh Jevalikar, Rajni Sharma, Veena Raghunathan, Meera Luthra, Maninder S Dhaliwal, Vandana Jain, Ambrish Mithal,

J Paediatr Child Health (Journal of paediatrics and child health)
[2020, :]

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Electrowetting-on-Dielectric System for COVID-19 Testing

Vandana Jain, K. Muralidhar,

The ongoing viral outbreak labeled COVID-19 is spreading rapidly across states and is posing a great threat to public health. Rapid identification of the virus in the population plays a crucial role in isolating the individual and breaking the transmission chain, apart from initiating an appropriate treatment procedure. Here, we ... Read more >>

(Transactions of the Indian National Academy of Engineering)
[2020, :1-4]

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Utility of MR proton density fat fraction and its correlation with ultrasonography and biochemical markers in nonalcoholic fatty liver disease in overweight adolescents.

Arjunlokesh Netaji, Vandana Jain, Arun Kumar Gupta, Udit Kumar, Manisha Jana,

Background Clinical or biochemical markers that have good correlation with magnetic resonance proton density fat fraction (MR PDFF) can be used as simple tools for the screening for nonalcoholic fatty liver disease (NAFLD) and in determining the degree of fatty infiltration of the liver. The objective of this study was ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(4):473-479]

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Clinical application of hepatocyte transplantation: current status, applicability, limitations, and future outlook.

Minh Phuong Nguyen, Vandana Jain, Valeria Iansante, Ragai R Mitry, Celine Filippi, Anil Dhawan,

<b>Introduction</b>: Hepatocyte transplantation (HT) is a promising alternative to liver transplantation for the treatment of liver-based metabolic diseases and acute liver failure (ALF). However, shortage of good-quality liver tissues, early cell loss post-infusion, reduced cell engraftment and function restricts clinical application.<b>Areas covered</b>: A comprehensive literature search was performed to cover ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2020, 14(3):185-196]

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Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature.

Anil Kumar, Vandana Jain, Madhumita Roy Chowdhury, Manoj Kumar, Punit Kaur, Madhulika Kabra,

Background Our objective was to estimate the prevalence of pathogenic/likely pathogenic variants in the SHOX, GHR, and IGFALS genes among Indian children with idiopathic short stature (ISS), and assess the genotype-phenotype correlation. Methods We recruited 61 children with short stature, who were born appropriate for gestational age, had no obvious ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(1):79-88]

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Management of Infants with Congenital Adrenal Hyperplasia.

Aashima Dabas, Pallavi Vats, Rajni Sharma, Preeti Singh, Anju Seth, Vandana Jain, Prerna Batra, Neerja Gupta, Ravindra Kumar, Madhulika Kabra, Seema Kapoor, Sangeeta Yadav,

Treatment of congenital adrenal hyperplasia (CAH) requires lifelong replacement of glucocorticoids with regular follow up to manage associated morbidities. The current review focuses on follow-up and management of infants diagnosed with classical CAH pertinent to Indian context. Early initiation of oral hydrocortisone in divided doses is recommended after diagnosis in ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, 57(2):159-164]

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Newborn Screening and Diagnosis of Infants with Congenital Adrenal Hyperplasia.

Pallavi Vats, Aashima Dabas, Vandana Jain, Anju Seth, Sangeeta Yadav, Madhulika Kabra, Neerja Gupta, Preeti Singh, Rajni Sharma, Ravindra Kumar, Sunil K Polipalli, Prerna Batra, B K Thelma, Seema Kapoor,

Congenital adrenal hyperplasia (CAH) is an autosomal recessive endocrine disorder which can manifest after birth with ambiguous genitalia and salt-wasting crisis. However, genital ambiguity is not seen in male babies and may be mild in female babies, leading to a missed diagnosis of classical CAH at birth. In this review, ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, 57(1):49-55]

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Life-threatening Hypercalcemia as the First Manifestation of Acute Lymphoblastic Leukemia.

Kakali Roy, Rajni Sharma, Manisha Jana, Vandana Jain,

Hypercalcemia of malignancy, usually reported in adults in advanced stages, is rare in children. A 4-year-old boy presented with intermittent episodes of severe hypercalcemia, which improved with intravenous hydration therapy, furosemide and bisphosphonates as the initial manifestation of occult acute lymphoblastic leukemia. Pediatricians should rule out hematological malignancy in patients ... Read more >>

Indian Pediatr (Indian pediatrics)
[2019, 56(11):972-974]

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Genomics of rare genetic diseases-experiences from India.

, Sridhar Sivasubbu, Vinod Scaria,

Home to a culturally heterogeneous population, India is also a melting pot of genetic diversity. The population architecture characterized by multiple endogamous groups with specific marriage patterns, including the widely prevalent practice of consanguinity, not only makes the Indian population distinct from rest of the world but also provides a ... Read more >>

Hum Genomics (Human genomics)
[2019, 14(1):52]

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Genetic polymorphisms associated with obesity and non-alcoholic fatty liver disease in Asian Indian adolescents.

Vandana Jain, Anil Kumar, Nayeem Ahmad, Manisha Jana, Mani Kalaivani, Brijesh Kumar, Shivaram Shastri, Oshima Jain, Madhulika Kabra,

Background The objective of this study was to investigate the association of polymorphisms in four genes, tumor necrosis factor-α (TNFA), patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin (ADIPOQ) and apolipoprotein C3 (APOC3), with obesity and non-alcoholic fatty liver disease (NAFLD) in Asian Indian adolescents. Methods In this case-control study, 218 ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2019, 32(7):749-758]

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Congenital Hyperinsulinemic Hypoglycemia and Hyperammonemia due to Pathogenic Variants in GLUD1.

Kakali Roy, Amit Kumar Satapathy, Jayne A L Houhton, Sarah E Flanagan, Venkatesan Radha, Viswanathan Mohan, Rajni Sharma, Vandana Jain,

Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous disorder, characterized by dysregulated insulin secretion. Pathogenic variants in at least twelve different genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A, HNF1A, UCP2, TRMT10A HK1, and PGM1) are known to cause CHI. Pathogenic variants in the GLUD1 gene, which encodes the ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2019, 86(11):1051-1053]

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Young People With Biliary Atresia Requiring Liver Transplantation: A Distinct Population Requiring Specialist Care.

Marianne Samyn, Mark Davenport, Vandana Jain, Nedim Hadzic, Deepak Joshi, Michael Heneghan, Anil Dhawan, Nigel Heaton,

<h4>Background</h4>Young people (YP) born with biliary atresia (BA) are an emerging population for adult hepatologists with 40% to 45% of children entering adolescence with their native liver intact. For those requiring liver transplantation (LT) during adolescence, disparity on the waiting list and post-LT outcome for young adults compared with younger ... Read more >>

Transplantation (Transplantation)
[2019, 103(4):e99-e107]

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Prognostic markers at adolescence in patients requiring liver transplantation for biliary atresia in adulthood.

Vandana Jain, Charlotte Burford, Emma C Alexander, Harry Sutton, Anil Dhawan, Deepak Joshi, Mark Davenport, Nigel Heaton, Nedim Hadzic, Marianne Samyn,

<h4>Background & aims</h4>In patients with biliary atresia (BA), the rate of native liver survival (NLS) to adulthood has been reported as 14-44% worldwide. Complications related to portal hypertension (PHT) and cholangitis are common in adulthood. For those requiring liver transplantation (LT), the timing can be challenging. The aim of this ... Read more >>

J Hepatol (Journal of hepatology)
[2019, 71(1):71-77]

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An Optimal Capillary Screen Cut-off of Thyroid Stimulating Hormone for Diagnosing Congenital Hypothyroidism: Data from a Pilot Newborn Screening Program in Delhi.

Prashant Verma, Seema Kapoor, Mani Kalaivani, Pallavi Vats, Sangeeta Yadav, Vandana Jain, B K Thelma, ,

<h4>Objective</h4>To determine an appropriate cut-off of capillary Thyroid stimulating hormone (TSH) for congenital hypothyroidism.<h4>Study design</h4>Cross-sectional.<h4>Participants</h4>174,000 neonates born in different hospitals of Delhi, India, from November 2014 to October 2016.<h4>Main outcome measures</h4>Correlation between initial and repeat capillary TSH level and subsequent venous free thyroxine (fT4) level.<h4>Results</h4>102 newborns with initial/ repeat capillary ... Read more >>

Indian Pediatr (Indian pediatrics)
[2019, 56(4):281-286]

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Growth Pattern and Clinical Profile of Indian Children with Classical 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia on Treatment.

H Meena, Manisha Jana, Vishwajeet Singh, Madhulika Kabra, Vandana Jain,

OBJECTIVE:To prospectively assess the growth parameters in a cohort of children with classical 21-hydroxylase deficiency congenital adrenal hyperplasia, comprehensively profile their clinical data and evaluate the prevalence of testicular adrenal rest tumors among affected boys. METHODS:Children with congenital adrenal hyperplasia aged 0-18 y were prospectively followed up for six mo ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2019, 86(6):496-502]

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Spectrum of Pathogenic Variants in SRD5A2 in Indian Children with 46,XY Disorders of Sex Development and Clinically Suspected Steroid 5α-Reductase 2 Deficiency.

Anil Kumar, Rajni Sharma, Mohammed Faruq, Varun Suroliya, Manoj Kumar, Shilpa Sharma, Ralf Werner, Olaf Hiort, Vandana Jain,

The aim of this study was to assess the prevalence of pathogenic variants in the SRD5A2 gene in children with 46,XY disorders of sex development (DSD) with normal to high serum testosterone levels and absence of Müllerian structures on imaging and to evaluate the genotype-phenotype correlation. Seventy-five patients with 46,XY ... Read more >>

Sex Dev (Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation)
[2019, 13(5-6):228-239]

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