Full Text Journal Articles by
Author Valeria Villella

Advertisement

Find full text journal articles






Adherence to Prescribed E-Diary Recording by Patients With Seasonal Allergic Rhinitis: Observational Study.

Marco Di Fraia, Salvatore Tripodi, Stefania Arasi, Stephanie Dramburg, Sveva Castelli, Danilo Villalta, Francesca Buzzulini, Ifigenia Sfika, Valeria Villella, Ekaterina Potapova, Serena Perna, Maria Antonia Brighetti, Alessandro Travaglini, Pierluigi Verardo, Simone Pelosi, Anna Maria Zicari, Paolo Maria Matricardi,

BACKGROUND:Complete diagnosis and therapy of seasonal allergic rhinoconjunctivitis require evidence that exposure to the sensitizing pollen triggers allergic symptoms. Electronic clinical diaries, by recording disease severity scores and pollen exposure, can demonstrate this association. However, patients who spontaneously download an e-diary app show very low adherence to their recording. OBJECTIVE:The ... Read more >>

J. Med. Internet Res. (Journal of medical Internet research)
[2020, 22(3):e16642]

Cited: 0 times

View full text PDF listing >>



Impaired cholesterol metabolism in the mice model of cystic fibrosis. A vicious circle?

Felice Amato, Alice Castaldo, Giuseppe Castaldo, Gustavo Cernera, Gaetano Corso, Eleonora Ferrari, Monica Gelzo, Romina Monzani, Valeria Rachela Villella, Valeria Raia,

Abstract Patients with cystic fibrosis (CF) have low cholesterol absorption and, despite enhanced endogenous biosynthesis, low serum cholesterol. Herein, we investigated cholesterol metabolism in a murine CF model in comparison to wild type (WT) testing serum and liver surrogate biomarkers together with the hepatic expression of genes involved in cholesterol ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

To Be or Not to Be a Pathogen: Candida albicans and Celiac Disease.

Giorgia Renga, Marina M Bellet, Claudia Stincardini, Marilena Pariano, Vasilis Oikonomou, Valeria R Villella, Stefano Brancorsini, Carlo Clerici, Luigina Romani, Claudio Costantini,

Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of gluten and characterized by reversible small-bowel mucosal atrophy in genetically predisposed subjects. Although the prevalence of CD has increased, many aspects of this pathology are still unrecognized. Candida albicans, a commensal of the human gastrointestinal tract, has been ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:2844]

Cited: 0 times

View full text PDF listing >>



Succinate links mitochondria to deadly bacteria in cystic fibrosis.

Speranza Esposito, Valeria Rachela Villella, Federica Rossin, Antonella Tosco, Valeria Raia, Alessandro Luciani,

Ann Transl Med (Annals of translational medicine)
[2019, 7(Suppl 8):S263]

Cited: 0 times

View full text PDF listing >>



IgE antibody repertoire in nasal secretions of children and adults with seasonal allergic rhinitis: A molecular analysis.

Sveva Castelli, Stefania Arasi, Salvatore Tripodi, Danilo Villalta, Paola Martelli, Mariaelisabetta Conte, Valentina Panetta, Ilaria Simonelli, Alexander Rohrbach, Marco Di Fraia, Ifigenia Sfika, Valeria Villella, Andrea Di Rienzo Businco, Serena Perna, Stephanie Dramburg, Ekaterina Potapova, Paolo Maria Matricardi,

BACKGROUND:There is growing interest both in testing IgE in nasal secretions (NS) and in molecular diagnosis of seasonal allergic rhinitis (SAR). Yet, the reliability of nasal IgE detection with the newest molecular assays has never been assessed in a large cohort of pollen allergic patients. OBJECTIVE:To investigate with microarray technology ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31(3):273-280]

Cited: 0 times

View full text PDF listing >>



"Whole" vs "fragmented" approach to EAACI pollen season definitions: A multicenter study in six Southern European cities.

Tara Maria Hoffmann, Aydan Acar Şahin, Xenophon Aggelidis, Stefania Arasi, Andrea Barbalace, Anne Bourgoin, Blerina Bregu, Maria Antonia Brighetti, Elsa Caeiro, Sule Caglayan Sozmen, Lucia Caminiti, Denis Charpin, Mariana Couto, Luís Delgado, Andrea Di Rienzo Businco, Claire Dimier, Maria V Dimou, João A Fonseca, Ozlem Goksel, Aykut Guvensen, Dolores Hernandez, Dah Tay Jang, Fusun Kalpaklioglu, Blerta Lame, Ruth Llusar, Michael P Makris, Michael P Makris, Angel Mazon, Eris Mesonjesi, Antonio Nieto, Ayse Öztürk, Laurie Pahus, Giovanni Battista Pajno, Ilenia Panasiti, Valentina Panetta, Nikolaos G Papadopoulos, Elisabetta Pellegrini, Simone Pelosi, Ana Margarida Pereira, Mariana Pereira, Munevver Pinar, Oliver Pfaar, Ekaterina Potapova, Alfred Priftanji, Fotis Psarros, Cansin Sackesen, Ifigenia Sfika, Javier Suarez, Michel Thibaudon, Alessandro Travaglini, Salvatore Tripodi, Valentine Verdier, Valeria Villella, Paraskevi Xepapadaki, Duygu Yazici, Paolo M Matricardi, Stephanie Dramburg,

BACKGROUND:The adequate definition of pollen seasons is essential to facilitate a correct diagnosis, treatment choice, and outcome assessment in patients with seasonal allergic rhinitis. A position paper by the European Academy of Allergy and Clinical Immunology (EAACI) proposed season definitions for Northern and Middle Europe. OBJECTIVE:To test the pollen season ... Read more >>

Allergy (Allergy)
[2019, :]

Cited: 0 times

View full text PDF listing >>



Cystic fibrosis transmembrane conductance regulator (CFTR) and autophagy: hereditary defects in cystic fibrosis versus gluten-mediated inhibition in celiac disease.

Luigi Maiuri, Valeria Raia, Mauro Piacentini, Antonella Tosco, Valeria Rachela Villella, Guido Kroemer,

Cystic Fibrosis (CF) is the most frequent lethal monogenetic disease affecting humans. CF is characterized by mutations in cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel whose malfunction triggers the activation of transglutaminase-2 (TGM2), as well as the inactivation of the Beclin-1 (BECN1) complex resulting in disabled autophagy. CFTR ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(43):4492-4500]

Cited: 0 times

View full text PDF listing >>



The gliadin-CFTR connection: new perspectives for the treatment of celiac disease.

Luigi Maiuri, Valeria R Villella, Valeria Raia, Guido Kroemer,

Familial loss-of-function mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) channel protein cause cystic fibrosis (CF), the most frequent inherited life-threatening disease in the Caucasian population. A recent study indicates that the gluten/gliadin-derived peptide (P31-43) can cause CFTR inhibition in intestinal epithelial cells, thus causing ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(1):40]

Cited: 1 time

View full text PDF listing >>



Genistein antagonizes gliadin-induced CFTR malfunction in models of celiac disease.

Speranza Esposito, Valeria Rachela Villella, Eleonora Ferrari, Romina Monzani, Antonella Tosco, Federica Rossin, Manuela D'Eletto, Alice Castaldo, Alessandro Luciani, Marco Silano, Gianni Bona, Gian Luigi Marseglia, Luigina Romani, Mauro Piacentini, Valeria Raia, Guido Kroemer, Luigi Maiuri,

In celiac disease (CD), an intolerance to dietary gluten/gliadin, antigenic gliadin peptides trigger an HLA-DQ2/DQ8-restricted adaptive Th1 immune response. Epithelial stress, induced by other non-antigenic gliadin peptides, is required for gliadin to become fully immunogenic. We found that cystic-fibrosis-transmembrane-conductance-regulator (CFTR) acts as membrane receptor for gliadin-derived peptide P31-43, as it ... Read more >>

Aging (Albany NY) (Aging)
[2019, 11(7):2003-2019]

Cited: 1 time

View full text PDF listing >>



Autophagy suppresses the pathogenic immune response to dietary antigens in cystic fibrosis.

Valeria R Villella, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Antonella Tosco, Federica Rossin, Alice Castaldo, Marco Silano, Gian Luigi Marseglia, Luigina Romani, Nikolai A Barlev, Mauro Piacentini, Valeria Raia, Guido Kroemer, Luigi Maiuri,

Under physiological conditions, a finely tuned system of cellular adaptation allows the intestinal mucosa to maintain the gut barrier function while avoiding excessive immune responses to non-self-antigens from dietary origin or from commensal microbes. This homeostatic function is compromised in cystic fibrosis (CF) due to loss-of-function mutations in the CF ... Read more >>

Cell Death Dis (Cell death & disease)
[2019, 10(4):258]

Cited: 1 time

View full text PDF listing >>



Personalization of therapies in rare diseases: a translational approach for the treatment of cystic fibrosis.

Valeria R Villella, Antonella Tosco, Speranza Esposito, Eleonora Ferrari, Gianni Bona, Guido Kroemer, Valeria Raia, Luigi Maiuri,

High variability in the response rates to treatments can make the interpretation of data from clinical trials very difficult, particularly in rare genetic diseases in which the enrolment of thousands of patients is problematic. Personalized medicine largely depends on the establishment of appropriate early detectors of drug efficacy that may ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2019, 71(4):362-370]

Cited: 0 times

View full text PDF listing >>



Defective proteostasis in celiac disease as a new therapeutic target.

Luigi Maiuri, Valeria R Villella, Mauro Piacentini, Valeria Raia, Guido Kroemer,

Cystic fibrosis (CF) is a disease caused by loss-of-function mutations affecting the CF transmembrane conductance regulator (CFTR), a chloride channel. Recent evidence indicates that CFTR is inhibited by a gluten/gliadin-derived peptide (P31-43), causing an acquired state of CFTR inhibition within the gut that contributes to the pathogenesis of celiac disease ... Read more >>

Cell Death Dis (Cell death & disease)
[2019, 10(2):114]

Cited: 2 times

View full text PDF listing >>



Inhaled medications in cystic fibrosis beyond antibiotics.

Angela Sepe, Valeria R Villella, Chiara Cimbalo, Alice Castaldo, Francesco Nunziata, Adele Corcione, Gianni Bona, Luigi Maiuri, Valeria Raia,

Structural lung disease begins very early in children with cystic fibrosis (CF), often in the first three months of life. Inhaled medications represent an attractive therapeutic approach in CF that are routinely used as early intervention strategies. Two aerosolized solutions, hypertonic saline and dornase alfa, have significant potential benefits by ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2019, 71(4):371-375]

Cited: 1 time

View full text PDF listing >>



Mutation-specific therapies and drug repositioning in cystic fibrosis.

Valeria R Villella, Antonella Tosco, Speranza Esposito, Gianni Bona, Valeria Raia, Luigi Maiuri,

Cystic fibrosis (CF) is an inherited, prematurely lethal rare disease affecting more than 85,000 people worldwide. CF is caused by more than 2000 loss-of-function mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). This review summarizes recent advances in the etiological therapies of CF that aim ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2019, 71(3):287-296]

Cited: 0 times

View full text PDF listing >>



Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort.

Francesca Cipriani, Salvatore Tripodi, Valentina Panetta, Serena Perna, Ekaterina Potapova, Arianna Dondi, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Carla Mastrorilli, Viviana Moschese, Simone Pelosi, Ifigenia Sfika, Elena Varin, Valeria Villella, Anna Maria Zicari, Giulia Brindisi, Giampaolo Ricci, Paolo Maria Matricardi, ,

BACKGROUND:Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross-sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. We investigated predictive biomarkers of disease evolution in a large ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2019, 30(3):325-334]

Cited: 0 times

View full text PDF listing >>



A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.

Valeria R Villella, Andrea Venerando, Giorgio Cozza, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Mara C Spinella, Vasilis Oikonomou, Giorgia Renga, Antonella Tosco, Federica Rossin, Stefano Guido, Marco Silano, Enrico Garaci, Yu-Kai Chao, Christian Grimm, Alessandro Luciani, Luigina Romani, Mauro Piacentini, Valeria Raia, Guido Kroemer, Luigi Maiuri,

Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8-restricted TH1 immune and antibody response leading to celiac disease. Prior epithelial stress and innate immune activation ... Read more >>

EMBO J. (The EMBO journal)
[2019, 38(2):]

Cited: 6 times

View full text PDF listing >>



Author Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis.

Luigina Romani, Vasilis Oikonomou, Silvia Moretti, Rossana G Iannitti, Maria Cristina D'Adamo, Valeria R Villella, Marilena Pariano, Luigi Sforna, Monica Borghi, Marina M Bellet, Francesca Fallarino, Maria Teresa Pallotta, Giuseppe Servillo, Eleonora Ferrari, Paolo Puccetti, Guido Kroemer, Mauro Pessia, Luigi Maiuri, Allan L Goldstein, Enrico Garaci,

In the version of this article originally published, some labels in Fig. 1f are incorrect. The "β-actin" labels on the second and fourth rows of blots should instead be "β-tubulin". The error has been corrected in the HTML and PDF versions of this article. ... Read more >>

Nat. Med. (Nature medicine)
[2018, 24(9):1481]

Cited: 0 times

View full text PDF listing >>



Publisher Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis.

Luigina Romani, Vasilis Oikonomou, Silvia Moretti, Rossana G Iannitti, Maria Cristina D'Adamo, Valeria R Villella, Marilena Pariano, Luigi Sforna, Monica Borghi, Marina M Bellet, Francesca Fallarino, Maria Teresa Pallotta, Giuseppe Servillo, Eleonora Ferrari, Paolo Puccetti, Guido Kroemer, Mauro Pessia, Luigi Maiuri, Allan L Goldstein, Enrico Garaci,

In the version of this article originally published, the amino acid sequence for Tα1 described in the Online Methods is incorrect. The sequence is described as "Ac-SDAAVDTSSEITTJDLKEKKEVVEEAEN-OH". It should be "Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH". The error has been corrected in the HTML and PDF versions of this article. ... Read more >>

Nat. Med. (Nature medicine)
[2018, 24(9):1482]

Cited: 0 times

View full text PDF listing >>



A new molecular multiplex IgE assay for the diagnosis of pollen allergy in Mediterranean countries: A validation study.

Marco Di Fraia, Stefania Arasi, Sveva Castelli, Stephanie Dramburg, Ekaterina Potapova, Danilo Villalta, Salvatore Tripodi, Ifigenia Sfika, Anna Maria Zicari, Valeria Villella, Serena Perna, Alessandro Travaglini, Pier Luigi Verardo, Paolo Maria Matricardi,

BACKGROUND:The identification of the primary sensitizing pollen is difficult in Southern European patients with Seasonal Allergic Rhinitis (SAR) if sensitized to various pollen sources with overlapping seasonality. A more precise diagnosis is obtained by IgE assays to allergen molecules, currently available as singleplex or microarrays. OBJECTIVES:To test the analytical performance ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2019, 49(3):341-349]

Cited: 0 times

View full text PDF listing >>



TG2 regulates the heat-shock response by the post-translational modification of HSF1.

Federica Rossin, Valeria Rachela Villella, Manuela D'Eletto, Maria Grazia Farrace, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Luca Occhigrossi, Vittoria Pagliarini, Claudio Sette, Giorgio Cozza, Nikolai A Barlev, Laura Falasca, Gian Maria Fimia, Guido Kroemer, Valeria Raia, Luigi Maiuri, Mauro Piacentini,

Heat-shock factor 1 (HSF1) is the master transcription factor that regulates the response to proteotoxic stress by controlling the transcription of many stress-responsive genes including the heat-shock proteins. Here, we show a novel molecular mechanism controlling the activation of HSF1. We demonstrate that transglutaminase type 2 (TG2), dependent on its ... Read more >>

EMBO Rep. (EMBO reports)
[2018, 19(7):]

Cited: 7 times

View full text PDF listing >>



Cellular proteostasis: a new twist in the action of thymosin α1.

Claudia Stincardini, Giorgia Renga, Valeria Villella, Marilena Pariano, Vasilis Oikonomou, Monica Borghi, Marina M Bellet, Luigi Sforna, Claudio Costantini, Allan L Goldstein, Enrico Garaci, Luigina Romani,

INTRODUCTION:Thymosin alpha 1 (Tα1) is a naturally occurring polypeptide of 28 amino acids, whose mechanism of action is thought to be related to its ability to signal through innate immune receptors. Tα1 (ZADAXIN®) is used worldwide for treating viral infections, immunodeficiencies, and malignancies. Owing to its ability to activate the ... Read more >>

Expert Opin Biol Ther (Expert opinion on biological therapy)
[2018, 18(sup1):43-48]

Cited: 1 time

View full text PDF listing >>



Reply to 'F508del-CFTR is not corrected by thymosin α1'.

Luigina Romani, Claudia Stincardini, Stefano Giovagnoli, Maurizio Paci, Valeria R Villella, Luigi Sforna, Giorgia Renga, Marina M Bellet, Claudio Costantini, Paolo Puccetti, Guido Kroemer, Luigi Maiuri, Mauro Pessia, Allan Goldstein, Enrico Garaci,

Nat. Med. (Nature medicine)
[2018, 24(7):891-893]

Cited: 1 time

View full text PDF listing >>



IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut.

Giorgia Renga, Silvia Moretti, Vasilis Oikonomou, Monica Borghi, Teresa Zelante, Giuseppe Paolicelli, Claudio Costantini, Marco De Zuani, Valeria Rachela Villella, Valeria Raia, Rachele Del Sordo, Andrea Bartoli, Monia Baldoni, Jean-Christophe Renauld, Angelo Sidoni, Enrico Garaci, Luigi Maiuri, Carlo Pucillo, Luigina Romani,

Candida albicans is implicated in intestinal diseases. Identifying host signatures that discriminate between the pathogenic versus commensal nature of this human commensal is clinically relevant. In the present study, we identify IL-9 and mast cells (MCs) as key players of Candida commensalism and pathogenicity. By inducing TGF-β in stromal MCs, IL-9 ... Read more >>

Cell Rep (Cell reports)
[2018, 23(6):1767-1778]

Cited: 7 times

View full text PDF listing >>



The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways.

Antonella De Luca, Marilena Pariano, Barbara Cellini, Claudio Costantini, Valeria Rachela Villella, Shyam Sushama Jose, Melissa Palmieri, Monica Borghi, Claudia Galosi, Giuseppe Paolicelli, Luigi Maiuri, Jan Fric, Teresa Zelante,

The interleukin 17 (IL-17) cytokine and receptor family is central to antimicrobial resistance and inflammation in the lung. Mice lacking IL-17A, IL-17F, or the IL-17RA subunit were compared with wild-type mice for susceptibility to airway inflammation in models of infection and allergy. Signaling through IL-17RA was required for efficient microbial ... Read more >>

Cell Rep (Cell reports)
[2017, 20(7):1667-1680]

Cited: 10 times

View full text PDF listing >>



Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis.

Luigina Romani, Vasilis Oikonomou, Silvia Moretti, Rossana G Iannitti, Maria Cristina D'Adamo, Valeria R Villella, Marilena Pariano, Luigi Sforna, Monica Borghi, Marina M Bellet, Francesca Fallarino, Maria Teresa Pallotta, Giuseppe Servillo, Eleonora Ferrari, Paolo Puccetti, Guido Kroemer, Mauro Pessia, Luigi Maiuri, Allan L Goldstein, Enrico Garaci,

Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that compromise its chloride channel activity. The most common mutation, p.Phe508del, results in the production of a misfolded CFTR protein, which has residual channel activity but is prematurely degraded. Because of the ... Read more >>

Nat. Med. (Nature medicine)
[2017, 23(5):590-600]

Cited: 35 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0683 s