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Author Valentina Grossi

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Serological tests confirm the low incidence of COVID-19 in chronic rheumatic inflammatory diseases treated with biological DMARD.

Maurizio Benucci, Arianna Damiani, Gianfranco Giannasi, Francesca Li Gobbi, Luca Quartuccio, Valentina Grossi, Maria Infantino, Mariangela Manfredi,

Ann. Rheum. Dis. (Annals of the rheumatic diseases)
[2020, :]

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A new diagnostic algorithm for pattern-oriented autoantibody testing according to the ICAP nomenclature: A pilot study.

Maria Infantino, Teresa Carbone, Mariangela Manfredi, Valentina Grossi, Antonio Antico, Maria Piera Panozzo, Ignazio Brusca, Maria Grazia Alessio, Giulia Previtali, Stefan Platzgummer, Luigi Cinquanta, Giusy Paura, Gaia Deleonardi, Maria Teresa Trevisan, Antonella Radice, Caterina Castiglione, Tiziana Imbastaro, Martina Fabris, Giampaola Pesce, Brunetta Porcelli, Lucia Terzuoli, Maria Concetta Sorrentino, Marilina Tampoia, Letizia Abbracciavento, Danilo Villalta, Mariaelisabetta Conte, Giuseppina Barberio, Nicoletta Gallo, Maurizio Benucci, Nicola Bizzaro, ,

The commercial tests currently available as second-level tests to detect ANA sub-specificities are generally used independently from the ANA immunofluorescence (IIF) pattern. The aim of this study was to evaluate the efficacy of the use of a customizable pattern-oriented antigenic panel by immunoblot (IB) using the International Consensus on ANA ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2020, :102588]

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COVID-19 pneumonia treated with Sarilumab: A clinical series of eight patients.

Maurizio Benucci, Gianfranco Giannasi, Paolo Cecchini, Francesca Li Gobbi, Arianna Damiani, Valentina Grossi, Maria Infantino, Mariangela Manfredi,

J. Med. Virol. (Journal of medical virology)
[2020, :]

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Therapeutic Potential of Ixekizumab in the Treatment of Ankylosing Spondylitis: A Review on the Emerging Clinical Data.

Maurizio Benucci, Arianna Damiani, Francesca Li Gobbi, Valentina Grossi, Maria Infantino, Mariangela Manfredi, Laura Niccoli, Fabrizio Cantini,

Over the last 20 years, the greatly improved knowledges of underlying pathogenic mechanisms of AS, including the role of tumor necrosis factor (TNF), the interleukin 23/Th17 axis, and interleukin-17 (Il-17), constituted the rationale to develop biologics selectively inhibiting these pathways. For more than 10 years, anti-TNF biologics were successfully employed ... Read more >>

Ther Clin Risk Manag (Therapeutics and Clinical Risk Management)
[2020, 16:287-297]

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Diagnostic accuracy of an automated chemiluminescent immunoassay for anti-SARS-CoV-2 IgM and IgG antibodies: an Italian experience.

Maria Infantino, Valentina Grossi, Barbara Lari, Riccardo Bambi, Alessandro Perri, Matteo Manneschi, Giovanni Terenzi, Irene Liotti, Giovanni Ciotta, Cristina Taddei, Maurizio Benucci, Patrizia Casprini, Francesca Veneziani, Sergio Fabbri, Adolfo Pompetti, Mariangela Manfredi,

A pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading throughout the world. Though molecular diagnostic tests are the gold standard for COVID-19, serological testing is emerging as a potential surveillance tool, in addition to its complementary role in COVID-19 diagnostics. ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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Serological Assays for SARS-CoV-2 Infectious Disease: Benefits, Limitations and Perspectives.

Maria Infantino, Arianna Damiani, Francesca Li Gobbi, Valentina Grossi, Barbara Lari, Donatella Macchia, Patrizia Casprini, Francesca Veneziani, Danilo Villalta, Nicola Bizzaro, Piero Cappelletti, Martina Fabris, Luca Quartuccio, Maurizio Benucci, Mariangela Manfredi,

Isr. Med. Assoc. J. (The Israel Medical Association journal : IMAJ)
[2020, 22(4):203-210]

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Do new and old biomarkers of early undifferentiated arthritis correlate with Arthritis Impact Measurement Scales?

Francesca Bandinelli, Maurizio Benucci, Fausto Salaffi, Mirko Manetti, Maria Infantino, Arianna Damiani, Mariangela Manfredi, Valentina Grossi, Alessandra Matucci, Francesca Li Gobbi, Gabriella Marin,

In early undifferentiated arthritis (EUA), the relationship between inflammatory biomarkers and disability is still unclear. The aim of this study was to correlate inflammatory biomarkers with the Arthritis Impact Measurement Scales (AIMS) in EUA. Seventy patients with EUA were compared with 20 patients with established rheumatoid arthritis (RA). The association ... Read more >>

Clin. Exp. Rheumatol. (Clinical and experimental rheumatology)
[2020, :]

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Laboratory Monitoring of Biological Therapies in Rheumatology: The Role of Immunogenicity.

Maurizio Benucci, Valentina Grossi, Mariangela Manfredi, Arianna Damiani, Maria Infantino, Paolo Moscato, Luigi Cinquanta, Elisa Gremese, Barbara Tolusso, Luca Petricca, Anna Laura Fedele, Stefano Alivernini, Fabiola Atzeni, Giovanni Minisola, Roberto Verna,

Biological drugs, such as proteins and immunogens, are increasingly used to treat various diseases, including tumors and autoimmune diseases, and biological molecules have almost completely replaced synthetic drugs in rheumatology. Although biological treatments such as anti-tumor necrosis factor (TNF) drugs seem to be quite safe, they cause some undesirable effects, ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2020, 40(2):101-113]

Cited: 1 time

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Anti-adalimumab and anti-certolizumab antibodies titers after discontinuation of adalimumab: two case reports.

Valentina Grossi, Maria Infantino, Mariangela Manfredi, Umberto Basile, Francesca Gulli, Mariapaola Marino, Francesca Li Gobbi, Arianna Damiani, Fabiola Atzeni, Maurizio Benucci,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(4):e105-e108]

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Efficacy of Tocilizumab in Limbic Encephalitis with Anti-CASPR2 Antibodies.

Maurizio Benucci, Luciana Tramacere, Maria Infantino, Mariangela Manfredi, Valentina Grossi, Arianna Damiani, Francesca Li Gobbi, Maristella Piccininni, Gaetano Zaccara, Massimo Cincotta,

We report the case of a 64-year-old man who presented with subacute memory, balance impairment, behavioral and mood changes, and epileptic seizures. Magnetic resonance imaging (MRI) showed bilateral hippocampal abnormalities. Brain [18F]-FDG fluorodeoxyglucose positron emission tomography (PET) revealed hypometabolism in both the temporal lobe as well as in the left ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:5697670]

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The new era of LED microscopes in immunofluorescence anti-nuclear antibody (ANA) testing.

Maria Infantino, Mariangela Manfredi, Valentina Grossi, Mario Merone, Paolo Soda,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Only monospecific anti-DFS70 antibodies aid in the exclusion of antinuclear antibody associated rheumatic diseases: an Italian experience.

Maria Infantino, Francesca Pregnolato, Chelsea Bentow, Michael Mahler, Maurizio Benucci, Francesca Li Gobbi, Arianna Damiani, Valentina Grossi, Franco Franceschini, Caterina Bodio, Maria Orietta Borghi, Mariangela Manfredi,

Background The dense fine speckled (DFS) is one of the most common patterns that can be observed as a result of the anti-nuclear antibodies (ANA) test on HEp-2 cells and is mostly caused by antibodies to DFS70 as the main antigenic target. As was recently demonstrated, isolated anti-DFS70 positivity can ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2019, 57(11):1764-1769]

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Gastric polyposis and desmoid tumours as a new familial adenomatous polyposis clinical variant associated with APC mutation at the extreme 3'-end.

Vittoria Disciglio, Candida Fasano, Filomena Cariola, Giovanna Forte, Valentina Grossi, Paola Sanese, Martina Lepore Signorile, Nicoletta Resta, Claudio Lotesoriere, Alessandro Stella, Ivan Lolli, Cristiano Simone,

Germline mutations of the APC gene, which encodes a multidomain protein of 2843 amino acid residues, cause familial adenomatous polyposis (FAP). Three FAP clinical variants are correlated with the location of APC mutations: (1) classic FAP with profuse polyposis (>1000 adenomas), associated with mutations from codon 1250 to 1424; (2) ... Read more >>

J. Med. Genet. (Journal of medical genetics)
[2020, 57(5):356-360]

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Are Anti-DFS70 Autoantibodies Protective?

Maria Infantino, Teresa Carbone, Mariangela Manfredi, Valentina Grossi, Maurizio Benucci, Miri Blank, Yehuda Shoenfeld, Nicola Bizzaro,

Isr. Med. Assoc. J. (The Israel Medical Association journal : IMAJ)
[2019, 21(8):509-511]

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Abatacept: from a budget impact model to cost-effectiveness analysis - data from RCT and real life.

Maurizio Benucci, Arianna Damiani, Mariangela Manfredi, Maria Infantino, Valentina Grossi, Francesca Li Gobbi,

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that affects joints with swelling and progressive joint destruction. The pathology leads to a progressive disability with an impact on the quality of life of the patients. Strategies to reduce in-patient care costs could have a considerable impact on lowering the direct ... Read more >>

Clinicoecon Outcomes Res (ClinicoEconomics and outcomes research : CEOR)
[2019, 11:405-409]

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Two Novel Technologies for the Detection of Anti-cardiolipin and Anti β2-Glycoprotein Antibodies in the Real Life: Chemiluminescent in Comparison to the Addressable Laser Bead Immunoassays.

Valentina Grossi, Maria Infantino, Maurizio Benucci, Francesca Li Gobbi, Francesca Bandinelli, Arianna Damiani, Caterina Bodio, Maria Orietta Borghi, Michael Mahler, Mary Ann Aure, Chelsea Bentow, Mariangela Manfredi,

In the present study, we evaluated two novel technologies, the chemiluminescent immunoassay (CIA) QUANTA Flash on BIO-FLASH (Inova Diagnostics, San Diego, CA, USA) and the addressable laser bead immunoassay (ALBIA) on BioPlex™ 2200 (Bio-Rad, Hercules, CA, USA) for the detection of anti-cardiolipin IgG/IgM (aCL) and anti-β2-glycoprotein IgG/IgM (aβ2GPI) antibodies. The ... Read more >>

Immunol. Invest. (Immunological investigations)
[2020, 49(1-2):58-68]

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The Laboratory Role in anti-TNF Biological Therapy Era.

Valentina Grossi, Francesca Gulli, Maria Infantino, Annunziata Stefanile, Cecilia Napodano, Maurizio Benucci, Krizia Pocino, Francesca Li Gobbi, Arianna Damiani, Antonella Di Pino, Mariangela Manfredi, Mariapaola Marino, Valerio Basile, Gian Ludovico Rapaccini, Umberto Basile,

Along years, the advent of biological therapy widely modified treatment of rheumatic diseases and other disorders. However, many agents may elicit in anti-drug antibodies (ADAbs) upon consecutive infusions, with a loss of response. For the right strategy of a personalized medicine, the therapeutic monitoring of TNF-α inhibitors and ADAbs represents ... Read more >>

Immunol. Invest. (Immunological investigations)
[2020, 49(3):317-332]

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Germline pathogenic variant in PIK3CA leading to symmetrical overgrowth with marked macrocephaly and mild global developmental delay.

Marcella Zollino, Carlotta Ranieri, Valentina Grossi, Chiara Leoni, Serena Lattante, Daniela Mazzà, Cristiano Simone, Nicoletta Resta,

BACKGROUND:Activating pathogenic variants in PIK3CA gene usually occur at a mosaic status and underlie a variety of segmental overgrowth phenotypes. Germline variants in PIK3CA have been rarely reported, described in a total of 12 patients with macrocephaly to date. Clinical and prognostic features of these germline variants have not been ... Read more >>

Mol Genet Genomic Med (Molecular genetics & genomic medicine)
[2019, 7(8):e845]

Cited: 1 time

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The long-awaited 'pseudo-DFS pattern'.

Maria Infantino, Nicola Bizzaro, Valentina Grossi, Mariangela Manfredi,

Expert Rev Clin Immunol (Expert review of clinical immunology)
[2019, 15(5):445]

Cited: 1 time

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FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs.

Paola Sanese, Giovanna Forte, Vittoria Disciglio, Valentina Grossi, Cristiano Simone,

Health span is driven by a precise interplay between genes and the environment. Cell response to environmental cues is mediated by signaling cascades and genetic variants that affect gene expression by regulating chromatin plasticity. Indeed, they can promote the interaction of promoters with regulatory elements by forming active chromatin hubs. ... Read more >>

Comput Struct Biotechnol J (Computational and structural biotechnology journal)
[2019, 17:737-745]

Cited: 1 time

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Letter to the Editor relating to Clin Chem Lab Med 2018;56(7):1090-1099.

Maria Infantino, Valentina Grossi, Maurizio Benucci, Mariangela Manfredi,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2019, 57(4):e45-e46]

Cited: 0 times

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Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape.

Valentina Grossi, Candida Fasano, Valentina Celestini, Martina Lepore Signorile, Paola Sanese, Cristiano Simone,

Colorectal cancer (CRC) poses a formidable challenge in terms of molecular heterogeneity, as it involves a variety of cancer-related pathways and molecular changes unique to an individual's tumor. On the other hand, recent advances in DNA sequencing technologies provide an unprecedented capacity to comprehensively identify the genetic alterations resulting in ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(3):]

Cited: 1 time

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Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma.

Giuseppe Lucarelli, Monica Rutigliano, Fabio Sallustio, Domenico Ribatti, Andrea Giglio, Martina Lepore Signorile, Valentina Grossi, Paola Sanese, Anna Napoli, Eugenio Maiorano, Cristina Bianchi, Roberto A Perego, Matteo Ferro, Elena Ranieri, Grazia Serino, Lauren N Bell, Pasquale Ditonno, Cristiano Simone, Michele Battaglia,

An altered metabolism is involved in the development of clear cell - renal cell carcinoma (ccRCC), and in this tumor many altered genes play a fundamental role in controlling cell metabolic activities. We delineated a large-scale metabolomic profile of human ccRCC, and integrated it with transcriptomic data to connect the ... Read more >>

Aging (Albany NY) (Aging)
[2018, 10(12):3957-3985]

Cited: 7 times

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Anti-DFS70 autoantibodies in undifferentiated connective tissue diseases subjects: what's on the horizon?

Maria Infantino, Ora Shovman, Dolores Pérez, Mariangela Manfredi, Valentina Grossi, Maurizio Benucci, Francesca Li Gobbi, Francesca Bandinelli, Arianna Damiani, Paolo Moscato, Danielle Azoulay, Boris Gilburd, Yehuda Shoenfeld,

OBJECTIVE:The main objective was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role. METHODS:Immunological and clinical records of 91 long-standing UCTD patients were studied. DFS pattern was determined using the IIF ANA test ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2018, 57(7):1293-1298]

Cited: 2 times

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