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Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction.

Olga M Sigalova, Andrei V Chaplin, Olga O Bochkareva, Pavel V Shelyakin, Vsevolod A Filaretov, Evgeny E Akkuratov, Valentina Burskaia, Mikhail S Gelfand,

BACKGROUND:Chlamydia are ancient intracellular pathogens with reduced, though strikingly conserved genome. Despite their parasitic lifestyle and isolated intracellular environment, these bacteria managed to avoid accumulation of deleterious mutations leading to subsequent genome degradation characteristic for many parasitic bacteria. RESULTS:We report pan-genomic analysis of sixteen species from genus Chlamydia including identification ... Read more >>

BMC Genomics (BMC genomics)
[2019, 20(1):710]

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