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Author V Crosby

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Targeted Implementation of Joint Clinics in Resource-Stretched Services Improves Referral Rates.

M O'Cathail, R Bentley, V Crosby,

Ir Med J (Irish medical journal)
[2020, 112(10):1029]

Cited: 0 times

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Immediate versus delayed short-term integrated palliative care for advanced long-term neurological conditions: the OPTCARE Neuro RCT

Nilay Hepgul, Rebecca Wilson, Deokhee Yi, Catherine Evans, Sabrina Bajwah, Vincent Crosby, Andrew Wilcock, Fiona Lindsay, Anthony Byrne, Carolyn Young, Karen Groves, Clare Smith, Rachel Burman, K Ray Chaudhuri, Eli Silber, Irene J Higginson, Wei Gao,

BACKGROUND:Palliative care is recommended to help meet the needs of patients with progressive non-cancer conditions, such as long-term neurological conditions. However, few trials have tested palliative care in this population. OBJECTIVES:To determine the effectiveness and cost-effectiveness of short-term integrated palliative care in improving symptoms, improving patient- and caregiver-reported outcomes and ... Read more >>

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Effect of Short-term Integrated Palliative Care on Patient-Reported Outcomes Among Patients Severely Affected With Long-term Neurological Conditions: A Randomized Clinical Trial.

Wei Gao, Rebecca Wilson, Nilay Hepgul, Deokhee Yi, Catherine Evans, Sabrina Bajwah, Vincent Crosby, Andrew Wilcock, Fiona Lindsay, Anthony Byrne, Carolyn Young, Karen Groves, Clare Smith, Rachel Burman, K Ray Chaudhuri, Eli Silber, Irene J Higginson, ,

Importance:Palliative care has shown benefits in reducing symptom intensity and quality of life in patients with advanced cancer. However, high-quality evidence to support palliative care policy and service developments for patients with long-term neurological conditions (LTNCs) is lacking. Objective:To determine the effectiveness of a short-term integrated palliative care (SIPC) intervention ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(8):e2015061]

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Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility).

Irene J Higginson, Andrew Wilcock, Miriam J Johnson, Sabrina Bajwah, Natasha Lovell, Deokhee Yi, Simon P Hart, Vincent Crosby, Heather Poad, David Currow, Emma Best, Sarah Brown, ,

New treatments are required for severe breathlessness in advanced disease. We conducted a randomised feasibility trial of mirtazapine over 28 days in adults with a modified medical research council breathlessness scale score ā‰„3. Sixty-four patients were randomised (409 screened), achieving our primary feasibility endpoint of recruitment. Most patients had COPD ... Read more >>

Thorax (Thorax)
[2020, 75(2):176-179]

Cited: 0 times

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Defining patterns of care in the management of patients with brain metastases in a large oncology centre: A single-centre retrospective audit of 236 cases.

Rebecca Bentley, Micheal O'Cathail, Luis Aznar-Garcia, Vincent Crosby, Andrew Wilcock, Judith Christian,

AIMS:The role of selected treatments for brain metastases (BM) is well documented; however, the prevalence of these is not. We report on the patterns of care in the management of BM in a large oncology centre. MATERIALS AND METHODS:We retrospectively audited 236 cases of newly diagnosed BM from January 2016 ... Read more >>

Eur J Cancer Care (Engl) (European journal of cancer care)
[2019, 28(4):e13059]

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Weekend hospital discharge is associated with suboptimal care and outcomes: An observational Australian Stroke Clinical Registry study.

Monique F Kilkenny, Natasha A Lannin, Chris Levi, Steven G Faux, Helen M Dewey, Rohan Grimley, Kelvin Hill, Brenda Grabsch, Joosup Kim, Peter Hand, Vanessa Crosby, Michele Gardner, Juan Rois-Gnecco, Vincent Thijs, Craig S Anderson, Geoffrey Donnan, Sandy Middleton, Dominique A Cadilhac,

BACKGROUND:The quality of stroke care may diminish on weekends. AIMS:We aimed to compare the quality of care and outcomes for patients with stroke/transient ischemic attack discharged on weekdays compared with those discharged on weekends. METHODS:Data from the Australian Stroke Clinical Registry from January 2010 to December 2015 (nā€‰=ā€‰45 hospitals) were ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2019, 14(4):430-438]

Cited: 1 time

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Integrating palliative care into neurology services: what do the professionals say?

Nilay Hepgul, Wei Gao, Catherine J Evans, Diana Jackson, Liesbeth M van Vliet, Anthony Byrne, Vincent Crosby, Karen E Groves, Fiona Lindsay, Irene J Higginson, ,

OBJECTIVES:Evaluations of new services for palliative care in non-cancer conditions are few. OPTCARE Neuro is a multicentre trial evaluating the effectiveness of short-term integrated palliative care (SIPC) for progressive long-term neurological conditions. Here, we present survey results describing the current levels of collaboration between neurology and palliative care services and ... Read more >>

BMJ Support Palliat Care (BMJ supportive & palliative care)
[2018, 8(1):41-44]

Cited: 7 times

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Lung cancer diagnosed following an emergency admission: exploring patient and carer perspectives on delay in seeking help.

Glenys Caswell, Jane Seymour, Vincent Crosby, Asmah Hussain, Cathann Manderson, Sarah Farnan, Sarah Freer, Alison Freemantle, Fran Littlewood, Andrew Wilcock,

Compared to others, patients diagnosed with lung cancer following an emergency, unplanned admission to hospital (DFEA) have more advanced disease and poorer prognosis. Little is known about DFEA patients' beliefs about cancer and its symptoms or about their help-seeking behaviours prior to admission.As part of a larger single-centre, prospective mixed-methods ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2017, 25(7):2259-2266]

Cited: 4 times

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Is clarithromycin a potential treatment for cachexia in people with lung cancer? A feasibility study.

Sarah Awan, Vincent Crosby, Vanessa Potter, Ivo Hennig, David Baldwin, Mehluli Ndlovu, Sharon Paradine, Andrew Wilcock,

Clarithromycin may improve cachexia and survival in non-small cell lung cancer (NSCLC), but adequately controlled data are lacking. This study was undertaken primarily to inform the feasibility and scale of a phase III trial. Eligible consenting patients with stage IV NSCLC and cachexia were to be randomized to receive either ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2017, 104:75-78]

Cited: 0 times

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Can body composition be used to optimize the dose of platinum chemotherapy in lung cancer? A feasibility study.

Vincent Crosby, Catherine D'Souza, Carina Bristow, Amy Proffitt, Asmah Hussain, Vanessa Potter, Ivo Hennig, Richard O'Connor, Vickie Baracos, Andrew Wilcock,

PURPOSE:Current methods of dosing platinum-based chemotherapy are suboptimal. Potentially, taking lean body mass into account may help. To inform the design of a future study, we first examined the feasibility and acceptability of such an approach using dual-energy X-ray absorptiometry (DEXA) and explored aspects suggestive of over- and under-dosing. METHODS:Patients ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2017, 25(4):1257-1261]

Cited: 9 times

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How integrated are neurology and palliative care services? Results of a multicentre mapping exercise.

Liesbeth M van Vliet, Wei Gao, Daniel DiFrancesco, Vincent Crosby, Andrew Wilcock, Anthony Byrne, Ammar Al-Chalabi, K Ray Chaudhuri, Catherine Evans, Eli Silber, Carolyn Young, Farida Malik, Rachel Quibell, Irene J Higginson, ,

BACKGROUND:Patients affected by progressive long-term neurological conditions might benefit from specialist palliative care involvement. However, little is known on how neurology and specialist palliative care services interact. This study aimed to map the current level of connections and integration between these services. METHODS:The mapping exercise was conducted in eight centres ... Read more >>

BMC Neurol (BMC neurology)
[2016, 16:63]

Cited: 16 times

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Lung cancer diagnosed following an emergency admission: Mixed methods study of the management, outcomes and needs and experiences of patients and carers.

Andrew Wilcock, Vincent Crosby, Asmah Hussain, Tricia M McKeever, Cathann Manderson, Sarah Farnan, Sarah Freer, Alison Freemantle, Fran Littlewood, Glenys Caswell, Jane Seymour,

In the UK, although 40% of patients with lung cancer are diagnosed following an emergency admission (EA), data is limited on their needs and experiences as they progress through diagnostic and treatment pathways.Prospective data collection using medical records, questionnaires and in-depth interviews. Multivariate logistic regression explored associations between diagnosis following ... Read more >>

Respir Med (Respiratory medicine)
[2016, 114:38-45]

Cited: 5 times

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AVERT2 (a very early rehabilitation trial, a very effective reproductive trigger): retrospective observational analysis of the number of babies born to trial staff.

Julie Bernhardt, Richard I Lindley, Erin Lalor, Fiona Ellery, Jan Chamberlain, John Van Holsteyn, Janice M Collier, Helen M Dewey, Brooke Parsons, Marjory Moodie, Sheila Lennon, Geoffrey A Donnan, Amanda G Thrift, Leonid Churilov, Peter Langhorne, ,

OBJECTIVE:To report the number of participants needed to recruit per baby born to trial staff during AVERT, a large international trial on acute stroke, and to describe trial management consequences. DESIGN:Retrospective observational analysis. SETTING:56 acute stroke hospitals in eight countries. PARTICIPANTS:1074 trial physiotherapists, nurses, and other clinicians. OUTCOME MEASURES:Number of ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2015, 351:h6432]

Cited: 4 times

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Exploring threats to generalisability in a large international rehabilitation trial (AVERT).

Julie Bernhardt, Audrey Raffelt, Leonid Churilov, Richard I Lindley, Sally Speare, Jacqueline Ancliffe, Md Ali Katijjahbe, Shahul Hameed, Sheila Lennon, Anna McRae, Dawn Tan, Jan Quiney, Hannah C Williamson, Janice Collier, Helen M Dewey, Geoffrey A Donnan, Peter Langhorne, Amanda G Thrift, ,

OBJECTIVE:The purpose of this paper is to examine potential threats to generalisability of the results of a multicentre randomised controlled trial using data from A Very Early Rehabilitation Trial (AVERT). DESIGN:AVERT is a prospective, parallel group, assessor-blinded randomised clinical trial. This paper presents data assessing the generalisability of AVERT. SETTING:Acute ... Read more >>

BMJ Open (BMJ open)
[2015, 5(8):e008378]

Cited: 5 times

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Lung cancer diagnosed following emergency admission: a mixed methods study protocol to improve understanding of patients' characteristics, needs, experiences and outcomes.

Andrew Wilcock, Vincent Crosby, Sarah Freer, Alison Freemantle, Glenys Caswell, Jane Seymour,

BACKGROUND:Lung cancer is the leading cause of death from cancer in England. About 40% of patients with lung cancer are diagnosed following an emergency admission (DFEA) to hospital. DFEA is more common in women, and more likely with increasing age and deprivation. Most have advanced disease and survival is poor, ... Read more >>

BMC Palliat Care (BMC palliative care)
[2013, 12:24]

Cited: 2 times

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Magnesium.

Vincent Crosby, Ronald J Elin, Robert Twycross, Mary Mihalyo, Andrew Wilcock,

J Pain Symptom Manage (Journal of pain and symptom management)
[2013, 45(1):137-144]

Cited: 2 times

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End-of-life care in rheumatolog: room for improvement.

Vincent Crosby, Andrew Wilcock,

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2011, 50(7):1187-1188]

Cited: 0 times

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Safer ambulatory syringe drivers: experiences of one acute hospital trust.

Alison Freemantle, Daniel Clark, Vincent Crosby,

In December 2010 the National Patient Safety Agency released a Rapid Response Report citing evidence of harm and death necessitating the need to immediately address safety issues affecting ambulatory syringe drivers with rate settings in millimetres of travel. These devices are widely used in palliative care in the UK, both ... Read more >>

Int J Palliat Nurs (International journal of palliative nursing)
[2011, 17(2):86-91]

Cited: 1 time

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Acute health effects associated with exposure to volcanic air pollution (vog) from increased activity at Kilauea Volcano in 2008.

Bernadette M Longo, Wei Yang, Joshua B Green, Frederick L Crosby, Vickie L Crosby,

In 2008, the Kilauea Volcano on the island of Hawai'i increased eruption activity and emissions of sulfurous volcanic air pollution called vog. The purpose of this study was to promptly assess for a relative increase in cases of medically diagnosed acute illnesses in an exposed Hawaiian community. Using a within-clinic ... Read more >>

J. Toxicol. Environ. Health Part A (Journal of toxicology and environmental health. Part A)
[2010, 73(20):1370-1381]

Cited: 13 times

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Hospices and CPR guidelines. Sudden and unexpected death in a palliative care unit.

Andrew Wilcock, Vincent Crosby,

BMJ (BMJ (Clinical research ed.))
[2009, 338:b2343]

Cited: 2 times

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Idiopathic membranous nephropathy in pediatric patients: presentation, response to therapy, and long-term outcome.

Ashton Chen, Rachel Frank, Suzanne Vento, Virginia Crosby, Manju Chandra, Bernard Gauthier, Elsa Valderrama, Howard Trachtman,

Idiopathic membranous nephropathy (IMN) is one of the most common causes of primary nephrotic syndrome in adults. However, it is a relatively rare entity in the pediatric population and there is a paucity of data about the incidence, prognosis, and optimal treatment of IMN in children and adolescents. We conducted ... Read more >>

BMC Nephrol (BMC nephrology)
[2007, 8:11]

Cited: 11 times

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Urolithiasis in pediatric patients: a single center study of incidence, clinical presentation and outcome.

Kristy VanDervoort, Jonathan Wiesen, Rachel Frank, Suzanne Vento, Virginia Crosby, Manju Chandra, Howard Trachtman,

PURPOSE: The incidence of kidney stones in adults has increased in the last 30 years. This retrospective, single site review was done to test the hypotheses that the incidence of urolithiasis in pediatric patients increased from 1994 to 2005, and that metabolic abnormalities were more common in patients with renal ... Read more >>

J. Urol. (The Journal of urology)
[2007, 177(6):2300-2305]

Cited: 130 times

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Repeatability of breathlessness measurements in cancer patients.

A Wilcock, V Crosby, D Clarke, A Tattersfield,

Thorax (Thorax)
[1999, 54(4):375]

Cited: 15 times

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Use of upper limb exercise to assess breathlessness in patients with cancer: tolerability, repeatability, and sensitivity.

Andrew Wilcock, Georgina Walker, Cathann Manderson, Diane Carr, Debbie Broadhurst, Vincent Crosby, Hilary Pavis, Jane Edgecombe, Anne E Tattersfield,

We report the development of an arm exercise test to assess breathlessness in patients with lung cancer who are breathless at low levels of exertion. Exercise consisted of raising the arm over 40 cm, either the dominant arm only (n=10) or both arms alternating at minute intervals (n=12). Subjects breathed ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2005, 29(6):559-564]

Cited: 5 times

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Prolongation of the QT interval in palliative care patients.

Georgina Walker, Andrew Wilcock, Ann Marie Carey, Cathann Manderson, Rebecca Weller, Vincent Crosby,

Prolonged QT interval on the electrocardiogram (ECG) is associated with an increased risk of cardiac arrhythmia and sudden death. Many drugs used in palliative medicine increase the QT interval and several have had their licenses withdrawn or severely restricted. The relative importance of prolonged QT interval will increase for palliative ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2003, 26(3):855-859]

Cited: 9 times

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