Full Text Journal Articles by
Author Ute Splittgerber

Advertisement

Find full text journal articles








Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays.

Glenn Noronha, Kathy Barrett, Antonio Boccia, Tessa Brodhag, Jianguo Cao, Chun P Chow, Elena Dneprovskaia, John Doukas, Richard Fine, Xianchang Gong, Colleen Gritzen, Hong Gu, Ehab Hanna, John D Hood, Steven Hu, Xinshan Kang, Jann Key, Boris Klebansky, Ahmed Kousba, Ge Li, Dan Lohse, Chi Ching Mak, Andrew McPherson, Moorthy S S Palanki, Ved P Pathak, Joel Renick, Feng Shi, Richard Soll, Ute Splittgerber, Silva Stoughton, Suhan Tang, Shiyin Yee, Binqi Zeng, Ningning Zhao, Hong Zhu,

We describe the identification of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine (3), a potent, orally active Src inhibitor with desirable PK properties, demonstrated activity in human tumor cell lines and in animal models of tumor growth. ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & Medicinal Chemistry Letters)
[2007, 17(3):602-608]

Cited: 23 times

View full text PDF listing >>



Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors.

Glenn Noronha, Kathy Barrett, Jianguo Cao, Elena Dneprovskaia, Richard Fine, Xianchang Gong, Colleen Gritzen, John Hood, Xinshan Kang, Boris Klebansky, G Li, W Liao, Dan Lohse, Chi Ching Mak, Andrew McPherson, Moorthy S S Palanki, Ved P Pathak, Joel Renick, Richard Soll, Ute Splittgerber, Wolfgang Wrasidlo, Binqi Zeng, Ningning Zhao, Y Zhou,

We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as kinase inhibitors. The 3-(2-(1-pyrrolidinyl)ethoxy)phenyl analogue (43) was identified as one of ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & Medicinal Chemistry Letters)
[2006, 16(21):5546-5550]

Cited: 11 times

View full text PDF listing >>



Advertisement

Benzotriazine inhibitors of kinases

GLENN NORONHA, KATHY BARRETT, JIANGUO CAO, COLLEEN GRITZEN, XIANCHANG GONG, JOHN HOOD, CHING MAK CHI, ANDREW MCPHERSON, PRAKASH PATHAK VED, JOEL RENICK, RICHARD SOLL, UTE SPLITTGERBER, WOLFGANG WRASIDLO, BINQI ZENG, NINGNING ZHAO, ELENA DNEPROVSKAIA,

The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases. ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Benzotriazine inhibitors of kinases

GLENN NORONHA, KATHY BARRETT, JIANGUO CAO, COLLEEN GRITZEN, XIANCHANG GONG, JOHN HOOD, CHING MAK CHI, ANDREW MCPHERSON, PRAKASH PATHAK VED, JOEL RENICK, RICHARD SOLL, UTE SPLITTGERBER, WOLFGANG WRASIDLO, BINQI ZENG, NINGNING ZHAO, ELENA DNEPROVSKAIA,

()
[, :]

Cited: 0 times

View full text PDF listing >>



Pyrimidine inhibitors of kinases

JIANGUO CAO, GLENN NORONHA, KATHY BARRETT, COLLEEN GRITZEN, ANDREW MCPHERSON, VED PATHAK, JOEL RENICK, UTE SPLITTGERBER, BINQI ZENG,

()
[, :]

Cited: 0 times

View full text PDF listing >>



Simultaneous identification of multiple protein targets by using complementary-DNA phage display and a natural-product-mimetic probe.

Kathleen M McKenzie, Elizabeth J Videlock, Ute Splittgerber, David J Austin,

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2004, 43(31):4052-4055]

Cited: 9 times

View full text PDF listing >>





Advertisement

Disclaimer
0.5995 s