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Chronic graft-versus-host disease in children and adolescents with thalassemia after hematopoietic stem cell transplantation.

Oranooj Lertkovit, Usanarat Anurathapan, Suradej Hongeng, Nintita Sripaiboonkit Thokanit, Samart Pakakasama,

Data on chronic graft-versus-host disease (cGVHD) in patients with thalassemia after hematopoietic stem cell transplantation (HSCT) have not been specifically explored. The present study aimed to determine the incidence and clinical manifestations of cGVHD in children and adolescents with thalassemia who underwent HSCT and to compare healthcare utilization and medical ... Read more >>

Int J Hematol (International journal of hematology)
[2021, :]

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Immunogenicity of Vero Cell Culture-derived Japanese Encephalitis Vaccine in Pediatric and Young Hematopoietic Stem Cell Transplantation Recipients.

Surapat Assawawiroonhakarn, Nopporn Apiwattanakul, Samart Pakakasama, Suradej Hongeng, Usanarat Anurathapan, Sutee Yoksan, Chompunuch Klinmalai, Pattarana Sae-Chew, Chonnamet Techasaensiri,

<h4>Background</h4>Children and young adults undergoing hematopoietic stem cell transplantation (HSCT) typically lose their immunity to vaccine-preventable diseases, including Japanese encephalitis (JE). Revaccination against JE in this population has not been well characterized.<h4>Methods</h4>This prospective study evaluated the immunogenicity of inactivated Vero cell culture-derived JE vaccine in children and young adults (<25 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

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Strategies to Improve Chimeric Antigen Receptor Therapies for Neuroblastoma.

Piamsiri Sawaisorn, Korakot Atjanasuppat, Usanarat Anurathapan, Somchai Chutipongtanate, Suradej Hongeng,

Chimeric antigen receptors (CARs) are among the curative immunotherapeutic approaches that exploit the antigen specificity and cytotoxicity function of potent immune cells against cancers. Neuroblastomas, the most common extracranial pediatric solid tumors with diverse characteristics, could be a promising candidate for using CAR therapies. Several methods harness CAR-modified cells in ... Read more >>

Vaccines (Basel) (Vaccines)
[2020, 8(4):]

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RARE-38. CLINICAL PRESENTATION OF MGA-NUTM1 FUSION TRANSCRIPT SARCOMA

Pongpak Pongphitcha, Nongnuch Sirachainan, Artit Jinawat, Atthaporn Boonkird, Putipun Puataweepong, Chaiyos KhongKhatithum, Samart Pakakasama, Usanarat Anurathapan, Duantida Songdej, Eric Bouffet, Suradej Hongeng,

Abstract <h4>BACKGROUND</h4> MGA-NUTM1 fusion gene tumor are recently described as new subtype of NUTM1-rearranged tumors. Regarding its rarity, standard treatment has not been reported. Here we described clinical presentation, radiologic finding, immunohistological profile, and treatment of a boy with MGA-NUTM1 fusion gene tumor. CASE REPORT: A 13-year-old boy with 2-month ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(Suppl 3):iii450-iii450]

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LGG-06. LONG-TERM OUTCOME OF NEWLY DIAGNOSED LOW GRADE GLIOMA

Nongnuch Sirachainan, Attaporn Boongerd, Samart Pakakasama, Usanarat Anurathapan, Ake Hansasuta, Duantida Songdej, Pongpak Pongpicha, Mantana Dhanachai, Suradej Hongeng,

Abstract <h4>INTRODUCTION</h4> Low grade glioma (LGG) is the most common central nervous system (CNS) tumor in children accounted for 30–50%. Regarding benign characteristic of disease, surgical management remains the mainstay of treatment. However, surgical approach is limited in some conditions such as location at brainstem or infiltrative tumor. Chemotherapy and ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(Suppl 3):iii367-iii367]

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Autophagy and apoptosis induction by sesamin in MOLT-4 and NB4 leukemia cells.

Kamolchanok Deesrisak, Chawalit Chatupheeraphat, Sittiruk Roytrakul, Usanarat Anurathapan, Dalina Tanyong,

Sesamin, the major furofuran lignan found in the seeds of <i>Sesamum indicum</i> L., has been investigated for its various medicinal properties. In the present study, the anti-leukemic effects of sesamin and its underlying mechanisms were investigated in MOLT-4 and NB4 acute leukemic cells. Leukemic cells were treated with various concentrations ... Read more >>

Oncol Lett (Oncology letters)
[2021, 21(1):32]

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Strategies to Improve Chimeric Antigen Receptors Therapies for Neuroblastoma

Piamsiri Sawaisorn, Korakot Atjanasuppat, Usanarat Anurathapan, Somchai Chutipongtanate, Suradej Hongeng,

Chimeric antigen receptors (CARs) is one of the curative immunotherapeutic approaches that exploit the antigen specificity and cytotoxicity function of potent immune cells against cancers. Neuroblastoma, the most common extracranial pediatric solid tumors with diverse comportment, could be a promising candidate for using CARs therapies. Several methods harness CARs modified ... Read more >>

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Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand.

Duangnate Rojanaporn, Taweevat Attaseth, Wimwipa Dieosuthichat, Kitikul Leelawongs, Samart Pakakasama, Usanarat Anurathapan, Ekachat Chanthanaphak, Sirintara Singhara Na Ayudhaya, Rangsima Aroonroch, Suradej Hongeng,

<h4>Purpose</h4>To investigate the clinical presentations and outcomes of retinoblastoma in relation to the advent of new multimodal treatments in Thailand. <i>Patients and Methods.</i> Retrospective case series. We evaluated the clinical presentation, staging, details of treatment, and treatment outcomes of retinoblastoma patients who were treated at Ramathibodi Hospital, Bangkok, Thailand, between ... Read more >>

J Ophthalmol (Journal of ophthalmology)
[2020, 2020:4231841]

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Production and characterization of haploidentical CD19 CAR T cells: Validated to induce a continuous complete remission in a patient with relapsed refractory B-cell ALL.

Somsak Prasongtanakij, Usanarat Anurathapan, Thitinee Vanichapol, Bunyada Jittorntrum, Korakot Atjanasuppat, Pongpak Pongpitcha, Samart Pakakasama, Duantida Songdej, Nongnuch Sirachainan, Karan Paisooksantivatana, Suparerk Borwaornpinyo, Borje S Andersson, Suradej Hongeng,

<h4>Aims</h4>The purpose of this study was to design and manufacture CD19 chimeric antigen receptor (CAR)-modified T cells for clinical use in Thailand, as a model for how this technology can be directly applied at individual institutions treating high-risk leukemia patients.<h4>Methods</h4>We constructed second-generation CAR T cells expressing CD19 scFV-CD28-CD3ζ with different ... Read more >>

Asia Pac J Clin Oncol (Asia-Pacific journal of clinical oncology)
[2020, :]

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No differences in hemostatic and endothelial activations between haploidentical and matched-donor hematopoietic stem cell transplantation in thalassemia disease.

Surapong Lertthammakiat, Peerasit Sitthirat, Usanarat Anurathapan, Duantida Songdej, Samart Pakakasama, Ampaiwan Chuansumrit, Nattaphat Putawornsub, Sawitt Sirasittikarn, Sataporn Wantanawijarn, Praguywan Kadegasem, Suradej Hongeng, Nongnuch Sirachainan,

Hemostatic changes and endothelial activations have been recognized in β-thalassemic patients after matched-donor hematopoietic stem cell transplantation (HSCT) but there are limited studies for haploidentical HSCT. This report demonstrates that the levels of hemostatic and endothelial markers, including thrombin antithrombin complex, prothrombin fragment, D-dimer, von Willebrand factor antigen and thrombomodulin ... Read more >>

Thromb J (Thrombosis journal)
[2020, 18(1):21]

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Immune responses to hepatitis B vaccination after hematopoietic stem cell transplantation in pediatric and young adult patients.

Krittiya Chaichotjinda, Usanarat Anurathapan, Sophida Boonsathorn, Sujittra Chaisavaneeyakorn, Suporn Treepongkaruna, Chonnamet Techasaensiri, Nopporn Apiwattanakul,

<b>Background: </b>Hematopoietic stem cell transplantation (HSCT) recipients require hepatitis B (HBV) revaccination. Hepatitis B surface antibody (anti-HBs) seroconversion rates after revaccination range from 64% to 79% in these patients. The seroconversion rate and factors associated with non-seroconversion have not been clearly elucidated in pediatric and young adult recipients after HSCT.<br><br><b>Objectives: ... Read more >>

Clin Transplant (Clinical transplantation)
[2020, 34(10):e14024]

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Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway.

Chawalit Chatupheeraphat, Chanin Nantasenamat, Kamolchanok Deesrisak, Sittiruk Roytrakul, Usanarat Anurathapan, Dalina Tanyong,

6-gingerol is a traditional medicine that possesses anti-cancer activity against several types of cancer. However, the mechanism of action still remains unclear. Therefore, this study explored the effects of 6-gingerol on anti-leukemic mechanisms in NB4, MOLT4, and Raji leukemic cell. Results indicated that 6-gingerol inhibited cell proliferation and induced cell ... Read more >>

EXCLI J (EXCLI journal)
[2020, 19:582-595]

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Hematopoietic stem cell transplantation from an infected SARS-CoV2 donor sibling.

Usanarat Anurathapan, Nopporn Apiwattanakul, Samart Pakakasama, Pongpak Pongphitcha, Arunee Thitithanyanont, Ekawat Pasomsub, Suradej Hongeng,

Bone Marrow Transplant (Bone marrow transplantation)
[2020, 55(12):2359-2360]

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NUDT15 genetic variants are related to thiopurine-induced neutropenia in Thai children with acute lymphoblastic leukemia.

Apichaya Puangpetch, Rawiporn Tiyasirichokchai, Samart Pakakasama, Supaporn Wiwattanakul, Usanarat Anurathapan, Suradej Hongeng, Chonlaphat Sukasem,

Aim: 6-Mercaptopurine (6MP) is key to the treatment of acute lymphoblastic leukemia (ALL) as part of maintenance therapy. NUDT15 was identified as a novel thiopurine regulator conferring 6MP sensitivity. The aim of this study was to evaluate the influence of NUDT15 variants on 6MP-induced neutropenia in Thai children with ALL. Materials & ... Read more >>

Pharmacogenomics (Pharmacogenomics)
[2020, 21(6):403-410]

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Iodine-131 metaiodobenzylguanidine (131I-mIBG) treatment in relapsed/refractory neuroblastoma.

Yoch Anongpornjossakul, Wattanun Sriwatcharin, Kanungnij Thamnirat, Wichana Chamroonrat, Arpakorn Kositwattanarerk, Chirawat Utamakul, Chanika Sritara, Payap Chokesuwattanasakul, Nintita Sripaiboonkij Thokanit, Samart Pakakasama, Usanarat Anurathapan, Pongpak Pongphitcha, Chanisa Chotipanich, Suradej Hongeng,

<h4>Background</h4>I-meta-iodo-benzylguanidine (I-mIBG) therapy has been used in treatment of for advanced neuroblastoma for many years with promising results. There are several studies regarding predictors and outcomes of I-mIBG therapies in relapsed/refractory neuroblastoma patients.<h4>Objective</h4>To identify the predictors and outcomes of I-mIBG treatment in relapsed/refractory neuroblastoma.<h4>Methods</h4>This study was a retrospective review of ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2020, 41(4):336-343]

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Hematopoietic Stem Cell Transplantation for Severe Thalassemia Patients from Haploidentical Donors Using a Novel Conditioning Regimen.

Usanarat Anurathapan, Suradej Hongeng, Samart Pakakasama, Duantida Songdej, Nongnuch Sirachainan, Pongpak Pongphitcha, Ampaiwan Chuansumrit, Pimlak Charoenkwan, Arunee Jetsrisuparb, Kleebsabai Sanpakit, Piya Rujkijyanont, Arunotai Meekaewkunchorn, Yujinda Lektrakul, Pornchanok Iamsirirak, Pacharapan Surapolchai, Somtawin Sirireung, Rosarin Sruamsiri, Pustika Amalia Wahidiyat, Borje S Andersson,

Patients with severe thalassemia commonly have a survival that is significantly shorter than that of the general population. Allogeneic hematopoietic stem cell transplantation (allo-SCT) is the only established treatment that is potentially curative, but it is limited by the availability of donors and the medical condition of the patient. To ... Read more >>

Biol Blood Marrow Transplant (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2020, 26(6):1106-1112]

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No differences in hemostatic and endothelial activations between haploidentical and matched-donor hematopoietic stem cell transplantation in thalassemia disease

Surapong Lertthammakiat, Peerasit Sitthirat, Usanarat Anurathapan, Duantida Songdej, Samart Pakakasama, Ampaiwan Chuansumrit, Nattaphat Putawornsub, Sawitt Sirasittikarn, Sataporn Wantanawijarn, Praguywan Kadegasem, Suradej Hongeng, Nongnuch Sirachainan,

Hemostatic changes and endothelial activations have been recognized in β-thalassemic patients after matched-donor hematopoietic stem cell transplantation (HSCT) but there are limited studies for haploidentical HSCT. This report demonstrates that the levels of hemostatic and endothelial markers, including thrombin antithrombin complex, prothrombin fragment, D-dimer, von Willebrand factor antigen and thrombomodulin ... Read more >>

Thromb J (Thrombosis journal)
[2020, 18:]

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CMV-Reactive NK Cells in Pediatric Post-Hematopoietic Stem Cell Transplant.

Nopporn Apiwattanakul, Suradej Hongeng, Usanarat Anurathapan, Samart Pakakasama, Supanart Srisala, Chompunuch Klinmalai, Borje S Andersson,

<h4>Background</h4>Immune reconstitution of T cells has been proven to be a protective factor against cytomegalovirus (CMV) reactivation in patients post-hematopoietic stem cell transplant. Recently, more evidence has suggested that natural killer (NK) cells also play role in the protection against CMV reactivation in these patients.<h4>Methods</h4>CMV-specific T cells and CMV-reactive NK ... Read more >>

Transplant Proc (Transplantation proceedings)
[2020, 52(1):353-359]

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Successful haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide in a child with X-linked chronic granulomatous disease: A first report in Asia.

Chawisa Janjindamai, Wiparat Manuyakorn, Usanarat Anurathapan, Samart Pakakasama, Duangrurdee Wattanasirichaigoon, Wasu Kamchaisatian, Suwat Benjaponpitak, Suradej Hongeng,

<h4>Backgound</h4>HLA-matched hematopoietic stem cell transplantation (HSCT) is the curative treatment for chronic granulomatous disease (CGD).<h4>Objective</h4>To report a case of X-linked CGD with active infection successfully treated by haploidentical HSCT with post-transplant high dose cyclophosphamide (PTCY).<h4>Methods</h4>A 5-year-old Thai boy with CGD was undergone for haploidentical HSCT using PTCY with correction of ... Read more >>

Asian Pac J Allergy Immunol (Asian Pacific journal of allergy and immunology)
[2019, :]

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Clinical outcomes and prognostic factors to predict treatment response in high risk neuroblastoma patients receiving topotecan and cyclophosphamide containing induction regimen: a prospective multicenter study.

Piya Rujkijyanont, Apichat Photia, Chanchai Traivaree, Chalinee Monsereenusorn, Usanarat Anurathapan, Panya Seksarn, Darintr Sosothikul, Piti Techavichit, Kleebsabai Sanpakit, Kamon Phuakpet, Surapon Wiangnon, Thirachit Chotsampancharoen, Su-On Chainansamit, Somjai Kanjanapongkul, Arunotai Meekaewkunchorn, Suradej Hongeng,

BACKGROUND:Neuroblastoma is the most common extra-cranial solid tumor among children. Despite intensive treatment, patients with advanced disease mostly experience dismal outcomes. Here, we proposed the use of topotecan and cyclophosphamide containing induction regimen as an upfront therapy to high risk neuroblastoma patients. METHODS:Patients with high risk neuroblastoma undergoing ThaiPOG high ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):961]

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Carboplatin-based regimen in pediatric intracranial germ-cell tumors (IC-GCTs): effectiveness and ototoxicity.

Rasin Worawongsakul, Nongnuch Sirachainan, Apimid Rojanawatsirivej, Atthaporn Boongird, Arunee Singhsnaeh, Thiti Swangsilpa, Mantana Dhanachai, Putipun Puataweepong, Rawee Ruangkanchanasetr, Samart Pakakasama, Usanarat Anurathapan, Duantida Songdej, Pongpak Pongphitcha, Chaiyos Khongkhatithum, Ake Hansasuta, Nintita Sripaiboonkij Thokanit, Apasri Lusawat, Sarunya Yuthagovit, Samasuk Thammachantha, Danupon Muangruk, Suradej Hongeng,

Background:Induction chemotherapy with carboplatin followed by radiotherapy has been used for many years for treating intracranial germ-cell tumors (IC-GCTs) in Thailand. The objective of this study was to assess treatment outcomes, focusing on survival and ototoxicity. Methods:The outcomes of all patients with IC-GCT treated at Ramathibodi Hospital and the Prasat ... Read more >>

Neurooncol Pract (Neuro-oncology practice)
[2020, 7(2):202-210]

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Long-Term Outcomes of Modified St Jude Children's Research Hospital Total Therapy XIIIB and XV Protocols for Thai Children With Acute Lymphoblastic Leukemia.

Pacharapan Surapolchai, Usanarat Anurathapan, Arpatsorn Sermcheep, Samart Pakakasama, Nongnuch Sirachainan, Duantida Songdej, Pongpak Pongpitcha, Suradej Hongeng,

<h4>Background</h4>We studied long-term outcomes and prognostic features of Thai children with acute lymphoblastic leukemia treated with modified St Jude Children's Research Hospital (SJCRH) protocols.<h4>Patients and methods</h4>Pediatric patients newly diagnosed with acute lymphoblastic leukemia were included. From 1997 to 2003, the first group received modified Total Therapy XIIIB (previous protocol). From ... Read more >>

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2019, 19(8):497-505]

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Pediatric non-Hodgkin lymphoma: Characteristics, stratification, and treatment at a single institute in Thailand.

Worawut Choeyprasert, Usanarat Anurathapan, Samart Pakakasama, Nongnuch Sirachainan, Duantida Songdej, Surapong Lertthammakiat, Suradej Hongeng,

<h4>Background</h4>In the modern era of chemotherapy, the outcome of pediatric non-Hodgkin lymphoma (NHL) continues to improve internationally. Limited data such as information on epidemiology and survival, however, are available in Asian countries.<h4>Methods</h4>Children (≤15 years old) diagnosed with histologically proven NHL from 1998 to 2014 were retrospectively analyzed.<h4>Results</h4>In total, 114 patients were ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, 61(1):49-57]

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Monitoring of cytomegalovirus infection in non-transplant pediatric acute lymphoblastic leukemia patients during chemotherapy.

Nonthapan Phasuk, Jiraporn Keatkla, Sasivimol Rattanasiri, Chonnamet Techasaensiri, Usanarat Anurathapan, Nopporn Apiwattanakul,

Cytomegalovirus (CMV) infection is a significant cause of morbidity and mortality in the posttransplant setting; however, it is increasingly recognized in pediatric leukemia during chemotherapy. This study assessed the prevalence and associated factors of CMV infection in pediatric non-transplant leukemia patients.This was a cross-sectional study of 50 pediatric acute lymphoblastic ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(4):e14256]

Cited: 2 times

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Spectrum of germline RB1 mutations and clinical manifestations in retinoblastoma patients from Thailand.

Duangnate Rojanaporn, Tatpong Boontawon, Takol Chareonsirisuthigul, Onrampa Thanapanpanich, Taweevat Attaseth, Duangporn Saengwimol, Usanarat Anurathapan, Tharikarn Sujirakul, Rossukon Kaewkhaw, Suradej Hongeng,

<h4>Purpose</h4>Retinoblastoma (RB) is a retinal tumor that most commonly occurs in children. Approximately 40% of RB patients carry germline mutations in the <i>RB1</i> gene. RB survivors with germline mutations are at increased risk of passing on the disease to future offspring and of secondary cancer in adulthood. This highlights the ... Read more >>

Mol Vis (Molecular vision)
[2018, 24:778-788]

Cited: 4 times

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