Full Text Journal Articles by
Author Umit Yavuz Malkan

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Assessment of ST2 and Reg3a Levels in Patients with Acute Graft-versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation.

Elİfcan AladaĞ Karakulak, Haluk DemİroĞlu, Umit Yavuz Malkan, Umit Akman, Hakan GÖker, Yahya BÜyÜkaŞik,

BACKGROUND:Graft-versus-Host Disease (GVHD) is a crucial complication leading to significant morbidity and mortality allogeneic hematopoietic stem cell transplantation which occurs in approximately half of the transplant recipients. Suppression of tumorigenicity 2 (ST2) and Regenerating islet-derived 3-alpha (Reg3a) might be important biomarkers to predict acute GVHD. MATERIALS AND METHODS:In the present ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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What is the Impact of Enterococcus Faecalis Infection on Gastric Cancer; Friend or Foe?

Seyhan Türk, Can Türk, Elif Sena Temirci, Umit Yavuz Malkan, Gulberk Ucar, Sukru Volkan Ozguven,

Abstract Background: Enterococcus faecalis ( E. faecalis ) is an important commensal microbiota member of the human gastrointestinal tract. Many studies have shown that infection rates with E. faecalis increase significantly in gastric cancer. The infections that developed during the cancer progress are definitive scientific evidence, but it is still ... Read more >>

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Mitoxantrone-melphalan conditioning regimen for autologous stem cell transplantation in relapsed/refractory lymphoma

Müfide Okay, Yahya Büyükaşık, Haluk Demiroğlu, Ümit Yavuz Malkan, Rafiye Çiftçiler, Elifcan Aladağ, Salih Aksu, İbrahim Celallettin Haznedaroğlu, Nilgün Sayınalp, Osman İlhami Özcebe, Hakan Göker,

Background/aim:High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has become the standard approach for patients with relapsed/refractory Hodgkin’s lymphoma (HL) or non-Hodgkin’s lymphoma (NHL). In this study, we report the outcome of the mitoxantrone-melphalan conditioning regimen for lymphoma. Materials and methods:The study group included 53 patients who were relapsed/refractory HL (n ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2019, 49(4):985-992]

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A rare case of diffuse large B-cell lymphoma-associated hemophagocytic lymphohistiocytosis.

Umit Yavuz Malkan, Murat Albayrak, Abdulkerim Yildiz, Senem Maral, Hacer Berna Afacan Ozturk, Pinar Comert,

INTRODUCTION:Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. Herein, we aimed to report a diffuse large B-cell lymphoma (DLBCL) case that was presented as HLH. CASE REPORT:A 32-year-old man presented to a hospital with complaints of vomiting, nausea and diarrhea in October 2019. Fever and ... Read more >>

J Oncol Pharm Pract (Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners)
[2020, :1078155220929750]

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Pharmacobiological management of hemostasis within clinical backgrounds via Ankaferd hemostat (Ankaferd blood stopper).

Rafiye Ciftciler, Ali Erdinc Ciftciler, Umit Yavuz Malkan, Ibrahim C Haznedaroglu,

Ankaferd hemostat (Ankaferd blood stopper [ABS], Istanbul, Turkey) is a hemostatic agent affecting red blood cell-fibrinogen interactions. ABS has been traditionally used in Anatolia as a hemostatic agent for centuries. ABS contains a standardized combination of the plants namely Glycyrrhiza glabra, Thymus vulgaris, Alpinia officinarum, Vitis vinifera, and Urtica dioica. ... Read more >>

SAGE Open Med (SAGE open medicine)
[2020, 8:2050312120907811]

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The Impact of Early Versus Late Platelet and Neutrophil Recovery after Induction Chemotherapy on Survival Outcomes of Patients with Acute Myeloid Leukemia

Rafiye Çiftçiler, İbrahim C. Haznedaroğlu, Nilgün Sayınalp, Osman Özcebe, Salih Aksu, Haluk Demiroğlu, Hakan Göker, Ümit Yavuz Malkan, Yahya Büyükaşık,

Objective:The prognosis of patients with acute myeloid leukemia (AML) is affected by factors that are both patient- and disease-specific. The aim of this study is to evaluate the impact of early versus late platelet and neutrophil recovery after induction chemotherapy on survival outcomes of AML patients. Materials and Methods:A total ... Read more >>

Turk J Haematol (Turkish journal of haematology : official journal of Turkish Society of Haematology)
[2020, 37(2):116-120]

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Mantle cell lymphoma: a Turkish Multi-Center Study.

Mufide Okay, Ozgur Meletli, Engin Kelkitli, Umit Yavuz Malkan, Mehmet Turgut, Yahya Buyukasik, Fatma Tekin, Haluk Demiroglu, Hakan Goker,

PURPOSE:Mantle Cell Lymphoma (MCL) is a B-cell neoplasm with CCND1 [t(11;14)(q13;q32), cyclin D1] translocation. The guidelines recommend various treatment options based on age, performance status and comorbidities. Our purpose was to analyze the clinical features and evaluate prognostic factors for survival of 78 MCL patients. METHODS:We retrospectively analyzed all MCL ... Read more >>

J BUON (Journal of B.U.ON. : official journal of the Balkan Union of Oncology)
[2019, 24(5):2084-2089]

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The Factors Affecting Early Death in Newly Diagnosed APL Patients.

Rafiye Ciftciler, Ibrahim Celalettin Haznedaroglu, Salih Aksu, Osman Ozcebe, Nilgun Sayınalp, Umit Yavuz Malkan, Yahya Buyukasık,

Background and aim:In the past, acute promyelocytic leukemia (APL) was considered as one of the most rapidly lethal form of acute myeloid leukemia (AML). The objective of this study was to assess clinical parameters affecting early death (ED) in patients with APL. Materials and methods:Forty-three patients with APL who were ... Read more >>

(Open medicine (Warsaw, Poland))
[2019, 14:647-652]

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A Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience

Demet Çekdemir, Serkan Güvenç, Füsun Özdemirkıran, Ali Eser, Tayfur Toptaş, Vildan Özkocaman, Handan Haydaroğlu Şahin, Esra Ermiş Turak, Ramazan Esen, Melda Cömert, Sevil Sadri, Müzeyyen Aslaner, Bahar Uncu Ulu, Abdullah Karakuş, Derya Selim Bapur, İnci Alacacıoğlu, Demet Aydın, Atakan Tekinalp, Sinem Namdaroğlu, Funda Ceran, Pınar Tarkun, Demet Kiper, Mustafa Çetiner, Mustafa Yenerel, Ahmet Muzaffer Demir, Güven Yılmaz, Hatice Terzi, Erden Atilla, Ümit Yavuz Malkan, Kadir Acar, Erman Öztürk, Anıl Tombak, Cenk Sunu, Ozan Salim, Nevin Alayvaz, Özkan Sayan, Ülkü Ozan, Mesut Ayer, Zafer Gökgöz, Neslihan Andıç, Ebru Kızılkılıç, Figen Noyan, Mehmet Özen, Funda Pepedil Tanrıkulu, Güçhan Alanoğlu, Hasan Atilla Özkan, Vahap Aslan, Güven Çetin, Alev Akyol Erikçi, Burak Deveci, Fadime Ersoy Dursun, Hasan Dermenci, Pelin Aytan, Mehmet Gündüz, Volkan Karakuş, Can Özlü, Sinan Demircioğlu, Olga Meltem Akay Yanar, Düzgün Özatlı, Levent Ündar, Eyüp Naci Tiftik, Ayhan Gülsan Türköz Sucak, İbrahim Haznedaroğlu, Muhit Özcan, Mehmet Şencan, Murat Tombuloğlu, Gülsüm Özet, Oktay Bilgir, Burhan Turgut, Mehmet Ali Özcan, Kadriye Bahriye Payzın, Mehmet Sönmez, Orhan Ayyıldız, Mehmet Sinan Dal, Şehmus Ertop, Mehmet Turgut, Teoman Soysal, Emin Kaya, Ali Ünal, Mustafa Pehlivan, Işık Atagündüz, Tülin Tuğlular Fıratlı, Güray Saydam, Reyhan Diz Küçükkaya,

Objective:The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP). Materials and Methods:A total of 285 chronic ITP patients (187 women, 65.6%; 98 men, 34.4%) followed in 55 centers were enrolled in this ... Read more >>

Turk J Haematol (Turkish journal of haematology : official journal of Turkish Society of Haematology)
[2019, 36(4):230-237]

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Indications and Outcomes of Splenectomy for Hematological Disorders.

Rafiye Ciftciler, Aysel Pasayeva, Salih Aksu, Osman Ozcebe, Nilgun Sayınalp, Umit Yavuz Malkan, Yahya Buyukasık, Ibrahim C Haznedaroglu,

Background and Aim:Splenectomy is a frequent component of the diagnosis and treatment of hematological disorders. The aim of this study was to define the indications and outcomes of splenectomy for benign and malign hematological disorders. Materials and Methods:One hundred and two patients with hematological disease who had splenectomy at Hacettepe ... Read more >>

(Open medicine (Warsaw, Poland))
[2019, 14:491-496]

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Combination of Novoseven and Feiba in Hemophiliac Patients with Inhibitors.

Umit Yavuz Malkan, Salih Aksu,

The aim of this study is to investigate the effective therapeutic combination of recombinant VIIa(Novoseven) and factor eight inhibitor bypass activity(FEIBA) drugs for the bleedings of adult hemophiliac patients with inhibitors.19 bleeding episodes of 5 hemophilia A patients who were using bypassing agents and followed-up between 2008 and 2016 in ... Read more >>

(Open medicine (Warsaw, Poland))
[2018, 13:618-621]

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Efficacy and Feasibility of Allogeneic Hematopoietic Stem-Cell Transplantation in the Treatment of Refractory Acute Myeloid Leukemia.

Rafiye Ciftciler, Haluk Demiroglu, Yahya Buyukasık, Elifcan Aladag, Salih Aksu, Ibrahim C Haznedaroglu, Nilgun Sayınalp, Osman Ozcebe, Umit Yavuz Malkan, Hakan Goker,

BACKGROUND:Refractory acute myeloid leukemia (AML) includes AML includes failure of disease to respond to standard induction chemotherapy, relapse within 6 months after first CR, and 2 or more relapses. The outcome of these patients is usually very poor; only a small proportion can be rescued by allogenic hematopoietic stem-cell transplantation ... Read more >>

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2019, 19(3):177-182]

Cited: 2 times

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Effect of postremission high dose cytarabine-based consolidation chemotherapy before allogenic stem cell transplantation in outcomes of acute myeloid leukemia patients.

Rafiye Ciftciler, Haluk Demiroglu, Yahya Buyukasık, Mufide Okay, Salih Aksu, Nilgun Sayınalp, Umit Yavuz Malkan, Ibrahim Celalettin Haznedaroglu, Osman Ozcebe, Hakan Goker,

BACKGROUND AND AIM:This is a retrospective study aiming to investigate the effect of the number of high dose cytarabine-based chemotherapy (HiDAC) courses in patients with acute myeloid leukemia before allogenic stem cell transplantation (ASCT). MATERIALS AND METHODS:A total of 110 patients with acute myeloid leukemia who received ASCT between 2001 ... Read more >>

Transfus. Apher. Sci. (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2018, 57(6):752-755]

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Extramedullary relapses of acute leukemias after allogeneic hematopoietic stem cell transplantation: clinical features, cumulative incidence, and risk factors.

Gursel Gunes, Hakan Goker, Haluk Demiroglu, Umit Yavuz Malkan, Yahya Buyukasik,

The aim of this study was to evaluate extramedullary (EM) relapses and its features in an allogeneic hematopoietic stem cell transplantation (alloHSCT) cohort, which consisted of patients with acute leukemia and advanced-phase chronic myeloid leukemia. One hundred and twenty-eight alloHSCT patients transplanted between the years 2001 and 2014 were analyzed. ... Read more >>

Bone Marrow Transplant. (Bone marrow transplantation)
[2019, 54(4):595-600]

Cited: 1 time

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Leukapheresis do not improve early death rates in acute myeloid leukemia patients with hyperleukocytosis.

Umit Yavuz Malkan, Osman Ilhami Ozcebe,

Hyperleukocytosis (HL) is defined as the clinical condition when the white blood cell (WBC) count is above 100,000/mm3 in peripheral blood. It has been already shown in the literature that leukapheresis, a conventional technique to decrease the serum WBC level, is ineffective for long-term survival in cases of hyperleukocytotic acute ... Read more >>

Transfus. Apher. Sci. (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2017, 56(6):880-882]

Cited: 2 times

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Lipotoxicity-Related Hematological Disorders in Obesity.

Ibrahim Celalettin Haznedaroglu, Umit Yavuz Malkan,

Lipotoxicity can mediate endothelial dysfunction in obesity. Altered endothelial cell phenotype during the pathobiological course of the lipotoxicity may lead to the hemostatic abnormalities, which is a hallmark of several hematological disorders. Impaired hemostasis could also be directly related to the numerous metabolic diseases such as hypertension, diabetes and atherosclerosis. ... Read more >>

Adv. Exp. Med. Biol. (Advances in experimental medicine and biology)
[2017, 960:469-487]

Cited: 2 times

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Growth inhibitory activity of Ankaferd hemostat on primary melanoma cells and cell lines.

Seyhan Turk, Umit Yavuz Malkan, Mehdi Ghasemi, Helin Hocaoglu, Duygu Mutlu, Gursel Gunes, Salih Aksu, Ibrahim Celalettin Haznedaroglu,

OBJECTIVE:Ankaferd hemostat is the first topical hemostatic agent about the red blood cell-fibrinogen relations tested in the clinical trials. Ankaferd hemostat consists of standardized plant extracts including Alpinia officinarum, Glycyrrhiza glabra, Thymus vulgaris, Urtica dioica, and Vitis vinifera. The aim of this study was to determine the effect of Ankaferd ... Read more >>

(SAGE open medicine)
[2017, 5:2050312116689519]

Cited: 3 times

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Ultrastructural analyses of the novel chimeric hemostatic agent generated via nanotechnology, ABS nanohemostat, at the renal tissue level.

Emre Huri, Engin Dogantekin, Murvet Hayran, Umit Yavuz Malkan, Mine Ergun, Aysegul Firat, Yavuz Beyazit, Huseyin Ustun, Murat Kekilli, Mumtaz Dadali, Muzeyyen Astarci, Ibrahim C Haznedaroglu,

Ankaferd Blood Stopper (ABS), a hemostatic agent of plant origin, has been registered for the prevention of clinical hemorrhages. Currently there is no data regarding the ultrastructural analysis of ABS at the tissue level. The aim of this study is to assess renal tissue effects via scanning electron microscopy (SEM) ... Read more >>

(SpringerPlus)
[2016, 5(1):1931]

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Clinical associations, biological risk factors and outcomes of cerebral venous sinus thrombosis.

Hafize Nalan Gunes, Burcu Gokce Cokal, Selda Keskin Guler, Tahir Kurtulus Yoldas, Umit Yavuz Malkan, Cemile Sencer Demircan, Mehmet Ilker Yon, Zeynep Yoldas, Gursel Gunes, Ibrahim Celalettin Haznedaroglu,

Objective Cerebral venous sinus thrombosis (CVST) is a rare cerebrovascular disease affecting young adults. The majority of the patients are female. The aim of this study is to assess the clinical associations, risk factors and outcomes of the patients with CVST. Methods The data of 75 patients with CVST admitted ... Read more >>

J. Int. Med. Res. (The Journal of international medical research)
[2016, 44(6):1454-1461]

Cited: 6 times

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Sole Infrequent Karyotypic Aberration Trisomy 6 in a Patient with Acute Myeloid Leukemia and Breast Cancer in Remission.

Mürüvvet Seda Aydın, Süreyya Bozkurt, Gürsel Güneş, Ümit Yavuz Malkan, Tuncay Aslan, Sezgin Etgül, Yahya Büyükaşık, İbrahim Celalettin Haznedaroğlu, Nilgün Sayınalp, Hakan Göker, Haluk Demiroğlu, Osman İlhami Özcebe, Salih Aksu,

Turk J Haematol (Turkish journal of haematology : official journal of Turkish Society of Haematology)
[2017, 34(1):103-104]

Cited: 1 time

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The Prognosis of Adult Burkitt's Cell Leukemia in Real-Life Clinical Practice.

Ümit Yavuz Malkan, Gürsel Güneş, Hakan Göker, İbrahim C Haznedaroğlu, Kadir Acar, Eylem Eliaçık, Sezgin Etgül, Tuncay Aslan, Seda Balaban, Haluk Demiroğlu, Osman I Özcebe, Nilgün Sayınalp, Salih Aksu, Yahya Büyükaşık,

Many studies reported an improved prognosis in patients with Burkitt's lymphoma obviating the need of stem cell transplantation. However, prognosis of the advanced disease [i.e. Burkitt's cell leukemia (BCL)] has not been reported with current treatment modalities except for a few prospective trials. The aim of this study is to ... Read more >>

Turk J Haematol (Turkish journal of haematology : official journal of Turkish Society of Haematology)
[2016, 33(4):281-285]

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Clinicopathological associations of acquired erythroblastopenia.

Gursel Gunes, Umit Yavuz Malkan, Hatime Arzu Yasar, Eylem Eliacik, Ibrahim Celalettin Haznedaroglu, Haluk Demiroglu, Nilgun Sayinalp, Salih Aksu, Sezgin Etgul, Tuncay Aslan, Hakan Goker, Osman Ilhami Ozcebe, Yahya Buyukasik,

INTRODUCTION:Acquired erythroblastopenia (AE) is a rare clinical situation. It is characterized by the reduction of erythroid precursors in the bone marrow together with the low reticulocyte counts in the peripheral blood. BACKGROUND:Main secondary causes of AE are drugs, Parvovirus B19 and other infectious reasons, lymphoid and myeloid neoplasia, autoimmune diseases, ... Read more >>

(International journal of clinical and experimental medicine)
[2015, 8(12):22515-22519]

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Treatment of pyoderma gangrenosum with thalidomide in a myelodysplastic syndrome case.

Umit Yavuz Malkan, Gursel Gunes, Eylem Eliacik, Ibrahim Celalettin Haznedaroglu,

Thalidomide may be used as a treatment option for pyoderma gangrenosum (PG) and myelodysplastic syndrome (MDS). Herein, we aimed to report a patient who was treated well with thalidomide and whose diagnosis was PG with MDS. A 61-year-old man with painless ecchymotic lesions in his right upper extremity was admitted ... Read more >>

(International medical case reports journal)
[2016, 9:61-64]

Cited: 1 time

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The factors affecting early death after the initial therapy of acute myeloid leukemia.

Umit Yavuz Malkan, Gursel Gunes, Eylem Eliacik, Ibrahim Celalettin Haznedaroglu, Sezgin Etgul, Tuncay Aslan, Okan Yayar, Seda Aydin, Haluk Demiroglu, Osman Ilhami Ozcebe, Nilgun Sayinalp, Hakan Goker, Salih Aksu, Yahya Buyukasik,

There are some improvements in management of acute myeloid leukemia (AML). However, induction-induced deaths still remain as a major problem. The aim of this study is to assess clinical parameters affecting early death in patients with AML. 199 AML patients, who were treated with intensive, non-intensive or supportive treatment between ... Read more >>

(International journal of clinical and experimental medicine)
[2015, 8(12):22564-22569]

Cited: 1 time

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Chimeric antigen receptor T cell treatment in hematologic malignancies.

Hakan Goker, Umit Yavuz Malkan, Haluk Demiroglu, Yahya Buyukasik,

Adoptive transfer of T cells that have genetically engineered chimeric antigen receptors (CARs) is an encouraging treatment modality in the hematological malignancies. These T cells are capable of selectively recognizing tumor-associated antigens. There are a variety of reported, as well as ongoing studies on the utilization of CAR-T cells in ... Read more >>

Transfus. Apher. Sci. (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2016, 54(1):35-40]

Cited: 1 time

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