Full Text Journal Articles by
Author Umesh Sharma

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Elevated myocardial wall stress after percutaneous coronary intervention in acute ST elevation myocardial infraction is associated with increased mortality.

Sharma Kattel, Hardik Bhatt, Sharda Gurung, Badri Karthikeyan, Umesh C Sharma,

<h4>Background</h4>Despite early attempts to salvage myocardium-at-risk with percutaneous coronary intervention (PCI), changes in myocardial wall stress (MWS) leads to ventricular dilatation and dysfunction after acute ST-elevation myocardial infraction (STEMI). Whether this is transient or leads to long-term adverse outcomes major adverse cardiovascular events (MACE) is not known. We studied the ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2021, :]

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Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid Cardiomyopathy.

Abhinay Reddy, Vasvi Singh, Badri Karthikeyan, Leyi Jiang, Silva Kristo, Sharma Kattel, Ram Amuthan, Saraswati Pokharel, Umesh C Sharma,

Cardiac amyloidosis (CA) is a common and potentially fatal infiltrative cardiomyopathy. Contrast-enhanced cardiac MRI (CMR) is used as a diagnostic tool. However, utility of CMR for the comprehensive analysis of biventricular strains and strain rates is not reported as extensively as echocardiography. In addition, RV strain analysis using CMR has ... Read more >>

Cardiogenetics (Cardiogenetics)
[2021, 11(3):98-110]

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Clinical characteristics, time course, treatment and outcomes of patients with immune checkpoint inhibitor-associated myocarditis.

Igor Puzanov, Poornima Subramanian, Yan V Yatsynovich, David M Jacobs, Maya R Chilbert, Umesh C Sharma, Fumito Ito, Steven G Feuerstein, Filip Stefanovic, Benjamin Switzer, Mark D Hicar, Anne B Curtis, Edward J Spangenthal, Grace K Dy, Marc S Ernstoff, Pankit Vachhani, Brian J Page, Nikhil Agrawal, Arjun Khunger, Ankita Kapoor, Alexander Hattoum, Schentag J Jerome,

<h4>Background</h4>Immune checkpoint inhibitors (ICI) have emerged as a front-line therapy for a variety of solid tumors. With the widespread use of these agents, immune-associated toxicities are increasingly being recognized, including fatal myocarditis. There are limited data on the outcomes and prognostic utility of biomarkers associated with ICI-associated myocarditis. Our objective ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2021, 9(6):]

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IL-17 Is a Key Regulator of Mucin-Galectin-3 Interactions in Asthma.

Manoj J Mammen, Jamil Ali, Amita Aurora, Umesh C Sharma, Ravikumar Aalinkeel, Supriya D Mahajan, Mark Sands, Stanley A Schwartz,

Mucus hypersecretion and chronic airway inflammation are standard characteristics of several airway diseases, such as chronic obstructive pulmonary disease and asthma. Increased mucus secretion from increased mucin gene expression in the airway epithelium is associated with poor prognosis and mortality. We previously showed that the absence of tissue inhibitor of ... Read more >>

Int J Cell Biol (International journal of cell biology)
[2021, 2021:9997625]

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Critical Analysis of Outcome Between Ventral and Dorsal Onlay Urethroplasty In Female Urethral Stricture.

Varun Kumar Katiyar, Rajeev Sood, Umesh Sharma, Hemant Kumar Goel, Sumit Gahlawat, Dhaval Sagarbhai Desai,

<h4>Objectives</h4>To evaluate and compare the 2 surgical approaches of urethral reconstruction for management of refractory female urethral strictures (FUS) in a prospective randomized setting. Early surgical reconstruction is becoming the preferred management strategy for recurrent FUS. Reconstructive techniques have been described as using either dorsal (12-o'clock) or ventral approach (6-o'clock), ... Read more >>

Urology (Urology)
[2021, :]

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CBR3 V244M is associated with LVEF reduction in breast cancer patients treated with doxorubicin.

Jennifer K Lang, Badri Karthikeyan, Adolfo Quiñones-Lombraña, Rachael Hageman Blair, Amy P Early, Ellis G Levine, Umesh C Sharma, Javier G Blanco, Tracey O'Connor,

<h4>Background</h4>The CBR3 V244M single nucleotide polymorphism has been linked to the risk of anthracycline-related cardiomyopathy in survivors of childhood cancer. There have been limited prospective studies examining the impact of CBR3 V244M on the risk for anthracycline-related cardiotoxicity in adult cohorts.<h4>Objectives</h4>This study evaluated the presence of associations between CBR3 V244M ... Read more >>

Cardiooncology (Cardio-oncology (London, England))
[2021, 7(1):17]

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Extraction and Characterization of Sesbania cannabina (Retz.) Pers. (Dhaincha) Seed Oil for Potential Engineering Applications.

Anshuman Mishra, Piyush Kuchhal, Madiha Nasim, Umesh Chandra Sharma,

Sesbania cannabina (Retz.) Pers. (Dhaincha) is a member of family Fabaceae spread over several countries in tropical and subtropical regions of the world. Sesbania aculeata, Sesbania drummondii, Sesbania grandiflora, Sesbania rostrata, Sesbania sesban, and Sesbania speciosa are other members of this family. The agricultural, nutritional and pharmaceutical applications of Sesbania ... Read more >>

J Oleo Sci (Journal of oleo science)
[2021, 70(6):777-785]

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A comparison of the prognostic significance of changes in NT-proBNP levels in HFrEF and HFpEF.

Nishant Sahni, Umesh Sharma, Rashi Arora,

<h4>Background: </h4> Rising NT-proBNP are associated with reduced survival patients with HFrEF. However, it remains to be conclusively and formally demonstrated that the temporal trend in NT-proBNP level carries prognostic significance in HFpEF. <h4>Objective:</h4> To determine whether there is an association between rising NT-proBNP levels and 6-month survival in patients ... Read more >>

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Coronary revascularization in patients with stable coronary disease and diabetes mellitus.

Salman Bhat, Yan Yatsynovich, Umesh C Sharma,

<h4>Purpose of study</h4>Diabetes mellitus accelerates the development of atherosclerosis. Patients with diabetes mellitus have higher incidence and mortality rates from cardiovascular disease and undergo a disproportionately higher number of coronary interventions compared to the general population. Proper selection of treatment modalities is thus paramount. Treatment strategies include medical management and ... Read more >>

Diab Vasc Dis Res (Diabetes & vascular disease research)
[2021, 18(2):14791641211002469]

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Hyperlipidaemia and mortality among patients hospitalised with pneumonia: retrospective cohort and propensity score matched study.

Mohammed Yousufuddin, Umesh M Sharma, Sumit Bhagra, Mohammad Hassan Murad,

<h4>Objective</h4>To characterise the potential association of hyperlipidaemia (HLP) versus no HLP with all-cause mortality among patients hospitalised for pneumonia.<h4>Design</h4>Propensity score matched retrospective study.<h4>Participants</h4>The study cohort consisted of consecutive 8553 adults hospitalised at a large academic centre with a discharge diagnosis of pneumonia from 1996 through 2015, followed until death or ... Read more >>

BMJ Open Respir Res (BMJ open respiratory research)
[2021, 8(1):]

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Hemisensory loss in myasthenia gravis.

Brandon Marshall, Umesh Sharma, Lourdes Benes-Lima, Fabian H Rossi,

A 73-year-old white man presents with left-sided ptosis and diplopia in the absence of ophthalmoplegia, with left hemibody paresthesia. He reports intermittent dysphagia and dizziness for 1 month and diarrhoea for 2 months. Serum and electrodiagnostic studies confirmed the diagnosis of myasthenia gravis. This case highlights the non-classic presentation of ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(3):]

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Immune Checkpoint Inhibitors: Cardiotoxicity in Pre-clinical Models and Clinical Studies.

Shirley Xu, Umesh C Sharma, Cheyanna Tuttle, Saraswati Pokharel,

Since the approval of the first immune checkpoint inhibitor (ICI) 9 years ago, ICI-therapy have revolutionized cancer treatment. Lately, antibodies blocking the interaction of programmed cell death protein (PD-1) and ligand (PD-L1) are gaining momentum as a cancer treatment, with multiple agents and cancer types being recently approved for treatment ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:619650]

Cited: 1 time

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A Study of Proton Pump Inhibitors and Other Risk Factors in Warfarin-Associated Gastrointestinal Bleeding.

Jevon Tang, Umesh Sharma, Shreya Desai, Janos Molnar, Lawrence Perlmuter, Axel Feller, Pallavi Shah,

Background Warfarin users are at increased risk for gastrointestinal bleeding (GIB). History of GIB, stroke, cardiovascular or chronic kidney disease, age greater than 65 years, and drug interaction with proton pump inhibitors (PPI) have previously been identified as risk factors for GIB in warfarin users. We hypothesized that concomitant use ... Read more >>

Cureus (Cureus)
[2021, 13(1):e12624]

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Book review: cancer and the heart

Umesh C. Sharma, Saraswati Pokharel,

Cardiooncology (Cardio-oncology (London, England))
[2021, 7(1):]

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Initial and subsequent 3-year cost after hospitalization for first acute ischemic stroke and intracerebral hemorrhage.

Mohammed Yousufuddin, James P Moriarty, Kandace A Lackore, Ye Zhu, Jessica L Peters, Taylor Doyle, Kelsey L Jensen, Eimad M Ahmmad, Ruaa Y Al Ward, Hossam M Al-Zu'bi, Umesh M Sharma, Ashok Seshadri, Kogulavadanan Arumaithurai, Lawrence R Keenan, Sumit Bhagra, Mohammad Hassan Murad, Bijan J Borah,

<h4>Aims</h4>To examine 1) the major drivers of index hospitalization and 3-year post-acute follow-up care, 2) cost for rehabilitation and homecare, and 3) indirect cost from lost productivity after acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH).<h4>Methods</h4>Retrospective study of adults hospitalized with AIS (n = 811) and ICH (N = 145) between 2003 and 2014. ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2020, 419:117181]

Cited: 1 time

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Macrophage-specific protein perforin-2 is associated with poor neurological recovery and reduced survival after sudden cardiac arrest.

Sharma Kattel, Hardik Bhatt, Shirley Xu, Sharda Gurung, Saraswati Pokharel, Umesh C Sharma,

<h4>Background</h4>Biomarkers involved in inflammation and stress response were implicated in patients who were successfully resuscitated from out of hospital cardiac arrest (sR-OHCA). Here we report that macrophage-expressed gene, perforin-2, an evolutionarily conserved protein with membrane attack domain, is associated with poor neurological outcomes and mortality after sR-OHCA.<h4>Objectives</h4>To examine the association ... Read more >>

Resuscitation (Resuscitation)
[2020, 155:180-188]

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Initial evaluation of a convolutional neural network used for noninvasive assessment of coronary artery disease severity from coronary computed tomography angiography data.

Alexander R Podgorsak, Kelsey N Sommer, Abhinay Reddy, Vijay Iyer, Michael F Wilson, Frank J Rybicki, Dimitrios Mitsouras, Umesh Sharma, Shinchiro Fujimoto, Kanako K Kumamaru, Erin Angel, Ciprian N Ionita,

<h4>Purpose</h4>Coronary computed tomography angiography (CTA) has one of the highest diagnostic sensitivities for detection of the significance of coronary artery disease (CAD); however, sensitivity is moderate and may result in increased catheterization rates. We performed an efficacy study to determine whether a trained machine learning algorithm that uses coronary CTA ... Read more >>

Med Phys (Medical physics)
[2020, 47(9):3996-4004]

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Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis.

Meer Rabeel Zafar, Syed Farrukh Mustafa, Timothy W Miller, Talal Alkhawlani, Umesh C Sharma,

<h4>Background</h4>Cancer survivors with prior chest radiation therapy (C-XRT) frequently present with aortic stenosis (AS) as the first manifestation of radiation-induced heart disease. They are considered high-risk for surgical valve replacement. Transcatheter aortic valve replacement (TAVR) is as an attractive option for this patient population but the outcomes are not well ... Read more >>

Cardiooncology (Cardio-oncology (London, England))
[2020, 6:8]

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Outcomes After Transcatheter Aortic Valve Replacement in Cancer Survivors with Prior Chest Radiation Therapy: A Systematic Review and Meta-Analysis

Meer Rabeel Zafar, Syed Farrukh Mustafa, Timothy Miller, Talal Alkhawlani, Umesh Sharma,

<h4>Background: </h4> Cancer survivors with prior chest radiation therapy (C-XRT) frequently present with aortic stenosis (AS) as the first manifestation of radiation-induced heart disease. They are considered high-risk for surgical valve replacement. Transcatheter aortic valve replacement (TAVR) is as an attractive option for this patient population but the outcomes are ... Read more >>

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β2-Adrenergic receptor activation on donor cells ameliorates acute GvHD.

Hemn Mohammadpour, Joseph L Sarow, Cameron R MacDonald, George L Chen, Jingxin Qiu, Umesh C Sharma, Xuefang Cao, Megan M Herr, Theresa E Hahn, Bruce R Blazar, Elizabeth A Repasky, Philip L McCarthy,

Acute graft versus host disease (aGvHD) remains a major impediment to successful allogeneic hematopoietic cell transplantation (allo-HCT). To solve this problem, a greater knowledge of factors that regulate the differentiation of donor T cells toward cytotoxic cells or Tregs is necessary. We report that the β2-adrenergic receptor (β2-AR) is critical ... Read more >>

JCI Insight (JCI insight)
[2020, 5(12):]

Cited: 2 times

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Patient-specific 3D-printed coronary models based on coronary computed tomography angiography volumes to investigate flow conditions in coronary artery disease.

Kelsey N Sommer, Lauren M Shepard, Dimitrios Mitsouras, Vijay Iyer, Erin Angel, Michael F Wilson, Frank J Rybicki, Kanako Kunishima Kumamaru, Umesh C Sharma, Abhinay Reddy, Shinichiro Fujimoto, Ciprian N Ionita,

<h4>Background</h4>3D printed patient-specific coronary models have the ability to enable repeatable benchtop experiments under controlled blood flow conditions. This approach can be applied to CT-derived patient geometries to emulate coronary flow and related parameters such as Fractional Flow Reserve (FFR).<h4>Methods</h4>This study uses 3D printing to compare such benchtop FFR results ... Read more >>

Biomed Phys Eng Express (Biomedical physics & engineering express)
[2020, 6(4):045007]

Cited: 1 time

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Physician Burnout: Cause and Prevention Strategies.

Umesh Sharma, Shashank R Joshi, Amit Ghosh,

Ongoing evolution in healthcare places physicians under an ever-increasing pressure to consistently perform at a higher level, leading to a significant number of physicians including those in training feeling "burnt-out". Burnout is a result of interplay between personal charateristics and environmental factors. Unadressed physician burnout negatively affects the individual, work ... Read more >>

J Assoc Physicians India (The Journal of the Association of Physicians of India)
[2020, 68(4):60-63]

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Association of a Remotely Offered Infectious Diseases eConsult Service With Improved Clinical Outcomes.

Aaron J Tande, Elie F Berbari, Priya Ramar, Shiva P Ponamgi, Umesh Sharma, Lindsey Philpot, John C O'Horo,

We performed a case-control study to evaluate an electronic, asynchronous infectious diseases consultative service at 2 rural hospitals within our health system. Patients with consultation via this platform (n = 100) had a significantly decreased odds of death at 30 days compared with propensity-matched controls (n = 300; adjusted odds ratio, 0.3; 95% confidence ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(1):ofaa003]

Cited: 5 times

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Association between hyperlipidemia and mortality after incident acute myocardial infarction or acute decompensated heart failure: a propensity score matched cohort study and a meta-analysis.

Mohammed Yousufuddin, Paul Y Takahashi, Brittny Major, Eimad Ahmmad, Hossam Al-Zubi, Jessica Peters, Taylor Doyle, Kelsey Jensen, Ruaa Y Al Ward, Umesh Sharma, Ashok Seshadri, Zhen Wang, Vinaya Simha, M Hassan Murad,

<h4>Objective</h4>To examine the effect of HLP, defined as having a pre-existing or a new in-hospital diagnosis based on low density lipoprotein cholesterol (LDL-C) level ≥100 mg/dL during index hospitalisation or within the preceding 6 months, on all-cause mortality after hospitalisation for acute myocardial infarction (AMI) or acute decompensated heart failure (ADHF) ... Read more >>

BMJ Open (BMJ open)
[2019, 9(12):e028638]

Cited: 5 times

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Reining in Sternal Wound Infections: The Achilles' Heel of Bilateral Internal Thoracic Artery Grafting.

Aisha Zia, Marium Hasan, Sidra Ilyas, Hafiz Umair Siddiqui, Bassman Tappuni, Shayan Marsia, M Mujeeb Zubair, Sajjad Raza, Rami R Mustafa, Zulfiqar Qutrio Baloch, Salil V Deo, Umesh M Sharma, Mohammad Adil Sheikh,

<b><i>Background:</i></b> Although the survival advantage of bilateral internal thoracic artery grafting (BITA) is well known in patients undergoing coronary artery bypass grafting (CABG), this technique has not been widely adopted. This is mainly because of the increased risk of deep sternal wound infections (DSWI) associated with its use. However, in ... Read more >>

Surg Infect (Larchmt) (Surgical infections)
[2020, 21(4):323-331]

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