Full Text Journal Articles by
Author Ulrich Thormann


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A new small animal model for simulating a two-stage-revision procedure in implant-related methicillin-resistant Staphylococcus aureus bone infection.

Maximilian Brunotte, Markus Rupp, Sabine Stötzel, Ursula Sommer, Walid Mohammed, Ulrich Thormann, Christian Heiss, Katrin S Lips, Eugen Domann, Volker Alt,

<h4>Background</h4>Implant-related bone infections with methicillin-resistant Staphylococcus aureus (MRSA) remain a challenge for orthopedic surgeons. This devasting complication may lead to functional impairment and loss of the affected limbs. High failure rates in treatment make improvement of surgical treatment necessary. Beside an already established demanding and costly large animal model, a ... Read more >>

Injury (Injury)
[2019, 50(11):1921-1928]

Cited: 2 times

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Radiocarpal fusion and midcarpal resection interposition arthroplasty: long-term results in severely destroyed rheumatoid wrists.

Christoph Biehl, Thomas Braun, Ulrich Thormann, Amir Oda, Gabor Szalay, Stefan Rehart,

<h4>Background</h4>The aim of this retrospective study is to evaluate distal resection interposition arthroplasty of the wrist as a tool to restore mobility as well as to restore stability in severely destroyed wrist joints.<h4>Methods</h4>Thirty-four wrists in 28 rheumatoid arthritis patients were included. The mean follow-up time was 9 years after surgical treatment ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2018, 19(1):286]

Cited: 3 times

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Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing.

Seemun Ray, Ulrich Thormann, Marlen Eichelroth, Matthäus Budak, Christoph Biehl, Markus Rupp, Ursula Sommer, Thaqif El Khassawna, Francisca I Alagboso, Marian Kampschulte, Marcus Rohnke, Anja Henß, Klaus Peppler, Vanessa Linke, Peter Quadbeck, Axel Voigt, Florian Stenger, Daniel Karl, Reinhard Schnettler, Christian Heiss, Katrin S Lips, Volker Alt,

The purpose of this work was to investigate new bone formation in macroporous iron foams coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) and empty defect in a critical size metaphyseal bone defect model in ovariectomized rats. 60 female rats were subjected to bilateral ovariectomy ... Read more >>

Biomaterials (Biomaterials)
[2018, 157:1-16]

Cited: 8 times

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Diaphyseal long bone nonunions - types, aetiology, economics, and treatment recommendations.

Markus Rupp, Christoph Biehl, Matthäus Budak, Ulrich Thormann, Christian Heiss, Volker Alt,

The intention of the current article is to review the epidemiology with related socioeconomic costs, pathophysiology, and treatment options for diaphyseal long bone delayed unions and nonunions. Diaphyseal nonunions in the tibia and in the femur are estimated to occur 4.6-8% after modern intramedullary nailing of closed fractures with an ... Read more >>

Int Orthop (International orthopaedics)
[2018, 42(2):247-258]

Cited: 32 times

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Postembedding Decalcification of Mineralized Tissue Sections Preserves the Integrity of Implanted Biomaterials and Minimizes Number of Experimental Animals.

Thaqif El Khassawna, Diaa Eldin S Daghma, Sabine Stoetzel, Seemun Ray, Stefanie Kern, Deeksha Malhan, Volker Alt, Ulrich Thormann, Anja Henß, Marcus Rohnke, Annette Stengel, Fathi Hassan, Stefan Maenz, Klaus D Jandt, Michael Diefenbeck, Matthias Schumacher, Michael Gelinsky, Katrin Susanne Lips, Christian Heiss,

Bone histology of decalcified or undecalcified samples depends on the investigation. However, in research each method provides different information to answer the scientific question. Decalcification is the first step after sample fixation and governs what analysis is later feasible on the sections. Besides, decalcification is favored for immunostaining and in ... Read more >>

Biomed Res Int (BioMed research international)
[2017, 2017:2023853]

Cited: 1 time

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Effects of macroporous, strontium loaded xerogel-scaffolds on new bone formation in critical-size metaphyseal fracture defects in ovariectomized rats.

Seemun Ray, Ulrich Thormann, Ursula Sommer, Thaqif El Khassawna, Marvin Hundgeburth, Anja Henß, Marcus Rohnke, Katrin S Lips, Christian Heiss, Sascha Heinemann, Thomas Hanke, Lutz Dürselen, Reinhard Schnettler, Volker Alt,

New bone formation was studied in a metaphyseal fracture-defect in ovariectomized rats stimulated by a plain and a strontium-enriched macroporous silica/collagen scaffold (ScB30 and ScB30Sr20) and a compact silica/collagen xerogel (B30). 45 female Sprague-Dawley rats were randomly assigned to three different treatment groups: (1) ScB30 (n=15), (2) ScB30Sr20 (n=15), and ... Read more >>

Injury (Injury)
[2016, 47 Suppl 1:S52-61]

Cited: 11 times

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Neovascularization of osteoporotic metaphyseal bone defects: A morphometric micro-CT study.

Marian Kampschulte, Gabriele A Krombach, Dana C Richards, Jonas Sender, Katrin S Lips, Ulrich Thormann, Thaqif El Khassawna, Seemun Ray, Volker Alt, Alexander C Langheinrich,

<h4>Purpose</h4>Neovascularization is essential for bone regeneration in fractures. This study aimed to investigate the microvascular morphology and distribution in the non-injured femur and the neovascularization of the metaphyseal critical size defect in a small animal model of osteoporosis.<h4>Materials and methods</h4>Female rats (n=7) were ovariectomized (OVX) and received a multideficiency diet. ... Read more >>

Microvasc Res (Microvascular research)
[2016, 105:7-14]

Cited: 4 times

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Impact of prophylactic CpG Oligodeoxynucleotide application on implant-associated Staphylococcus aureus bone infection.

Shneh Sethi, Ulrich Thormann, Ursula Sommer, Sabine Stötzel, Walid Mohamed, Reinhard Schnettler, Eugen Domann, Trinad Chakraborty, Volker Alt,

TLR-9 ligand CpG oligodeoxynucleotide type B (CpG ODN) induces a proinflammatory environment. We evaluated the effects of a preoperative CpG ODN application in an implant-associated Staphylococcus aureus bone infection model by monitoring bacterial loads and cytokine and chemokine levels. A total of 95 rats were used in four different groups: ... Read more >>

Bone (Bone)
[2015, 78:194-202]

Cited: 6 times

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Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats.

Thaqif El Khassawna, Wolfgang Böcker, Katharina Brodsky, David Weisweiler, Parameswari Govindarajan, Marian Kampschulte, Ulrich Thormann, Anja Henss, Marcus Rohnke, Natali Bauer, Robert Müller, Andreas Deutsch, Anita Ignatius, Lutz Dürselen, Alexander Langheinrich, Katrin S Lips, Reinhard Schnettler, Christian Heiss,

Bone loss is a symptom related to disease and age, which reflects on bone cells and ECM. Discrepant regulation affects cell proliferation and ECM localization. Rat model of osteoporosis (OVX) was investigated against control rats (Sham) at young and old ages. Biophysical, histological and molecular techniques were implemented to examine ... Read more >>

Histochem Cell Biol (Histochemistry and cell biology)
[2015, 144(5):491-507]

Cited: 10 times

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The biocompatibility of degradable magnesium interference screws: an experimental study with sheep.

Ulrich Thormann, Volker Alt, Lydia Heimann, Cyrille Gasquere, Christian Heiss, Gabor Szalay, Jörg Franke, Reinhard Schnettler, Katrin Susanne Lips,

Screws for ligament reconstruction are nowadays mostly made of poly-L-lactide (PLLA). However, magnesium-based biomaterials are gathering increased interest in this research field because of their good mechanical property and osteoanabolic influence on bone metabolism. The aim of this pilot study was to evaluate the biocompatibility of an interference screw for ... Read more >>

Biomed Res Int (BioMed research international)
[2015, 2015:943603]

Cited: 14 times

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Preliminary evaluation of different biomaterials for defect healing in an experimental osteoporotic rat model with dynamic PET-CT (dPET-CT) using F-18-sodium fluoride (NaF).

Caixia Cheng, Volker Alt, Leyun Pan, Ulrich Thormann, Reinhard Schnettler, Ludwig G Strauss, Matthias Schumacher, Michael Gelinsky, Antonia Dimitrakopoulou-Strauss,

<h4>Unlabelled</h4>The aim of the current study was to measure and compare the effect of calcium phosphate cement (CPC) and CPC enriched with strontium (SrCPC) for the healing of osteoporotic bone defects in the rat femur using (18)F-Sodium Fluoride dPET-CT.<h4>Methods</h4>Osteoporosis was induced by ovariectomy and a calcium restricted diet. After three ... Read more >>

Injury (Injury)
[2014, 45(3):501-505]

Cited: 7 times

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Differences of bone healing in metaphyseal defect fractures between osteoporotic and physiological bone in rats.

Ulrich Thormann, Thaqif El Khawassna, Seemun Ray, Lutz Duerselen, Marian Kampschulte, Katrin Lips, Helena von Dewitz, Sascha Heinemann, Christian Heiss, Gabor Szalay, Alexander C Langheinrich, Anita Ignatius, Reinhard Schnettler, Volker Alt,

Discrepancies in bone healing between osteoporotic and non-osteoporotic bone remain uncertain. The focus of the current work is to evaluate potential healing discrepancies in a metaphyseal defect model in rat femora. Female Sprague-Dawley rats were either ovariectomized (OVX, n=14) and combined with a calcium-, phosphorus- and vitamin D3-, soy- and ... Read more >>

Injury (Injury)
[2014, 45(3):487-493]

Cited: 18 times

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Bone formation induced by strontium modified calcium phosphate cement in critical-size metaphyseal fracture defects in ovariectomized rats.

Ulrich Thormann, Seemun Ray, Ursula Sommer, Thaqif Elkhassawna, Tanja Rehling, Marvin Hundgeburth, Anja Henß, Marcus Rohnke, Jürgen Janek, Katrin S Lips, Christian Heiss, Gudrun Schlewitz, Gabor Szalay, Matthias Schumacher, Michael Gelinsky, Reinhard Schnettler, Volker Alt,

The first objective was to investigate new bone formation in a critical-size metaphyseal defect in the femur of ovariectomized rats filled with a strontium modified calcium phosphate cement (SrCPC) compared to calcium phosphate cement (CPC) and empty defects. Second, detection of strontium release from the materials as well as calcium ... Read more >>

Biomaterials (Biomaterials)
[2013, 34(34):8589-8598]

Cited: 49 times

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Evaluation of new bone formation in normal and osteoporotic rats with a 3-mm femur defect: functional assessment with dynamic PET-CT (dPET-CT) using 2-deoxy-2-[(18)F]fluoro-D-glucose ( (18)F-FDG) and (18)F-fluoride.

Caixia Cheng, Volker Alt, Antonia Dimitrakopoulou-Strauss, Leyun Pan, Ulrich Thormann, Reinhard Schnettler, Klaus Weber, Ludwig G Strauss,

<h4>Purpose</h4>The aim of the current study was to assess the formation of new bone in a 3-mm created defect in the femur and its adjacent bone tissue in osteoporotic and normal animals. The assessment is based on bone remodeling and glucose metabolism in a rat model with a 3-mm created ... Read more >>

Mol Imaging Biol (Molecular imaging and biology)
[2013, 15(3):336-344]

Cited: 12 times

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Association of clinical parameters of operatively treated thoracolumbar fractures with quality of life parameters.

Ulrich Thormann, Hans-Josef Erli, Marc Brügmann, Gabor Szalay, Gudrun Schlewitz, Hans-Christoph Pape, Reinhard Schnettler, Volker Alt,

<h4>Purpose</h4>The intention of the current work was to assess the association between clinical parameters and seven different quality of life (QoL) instruments after surgical treatment of thoracolumbar spinal fractures after an average follow-up of 4.2 years.<h4>Methods</h4>The following human-related quality of life and PRO measures of 66 patients were correlated to clinical ... Read more >>

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2013, 22(10):2202-2210]

Cited: 5 times

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Osteoporosis influences osteogenic but not angiogenic response during bone defect healing in a rat model.

Yifei Liu, Liji Cao, Seemun Ray, Ulrich Thormann, Jens Hillengass, Stefan Delorme, Reinhard Schnettler, Volker Alt, Tobias Bäuerle,

Angiogenesis is pivotal for bone metabolism and bone defect healing. Yet the role of vascularization in osteoporosis and osteoporotic bone repair mechanisms is unclear. Here we investigated effects of osteoporotic phenotype on vascularization during bone defect healing in a rodent osteotomy model using volumetric computed tomography (VCT), dynamic contrast-enhanced VCT ... Read more >>

Injury (Injury)
[2013, 44(7):923-929]

Cited: 6 times

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A new metaphyseal bone defect model in osteoporotic rats to study biomaterials for the enhancement of bone healing in osteoporotic fractures.

Volker Alt, Ulrich Thormann, Seemun Ray, Daniel Zahner, Lutz Dürselen, Katrin Lips, Thaqif El Khassawna, Christian Heiss, Alina Riedrich, Gudrun Schlewitz, Anita Ignatius, Marian Kampschulte, Helena von Dewitz, Sascha Heinemann, Reinhard Schnettler, Alexander Langheinrich,

The intention of this study was to establish a new critical size animal model that represents clinically relevant situations with osteoporotic bone status and internally fixated metaphyseal defect fractures in which biomaterials for the enhancement of fracture healing in osteoporotic fracture defects can be studied. Twenty-eight rats were ovariectomized (OVX) ... Read more >>

Acta Biomater (Acta biomaterialia)
[2013, 9(6):7035-7042]

Cited: 29 times

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Implications of combined ovariectomy/multi-deficiency diet on rat bone with age-related variation in bone parameters and bone loss at multiple skeletal sites by DEXA.

Parameswari Govindarajan, Gudrun Schlewitz, Nathalie Schliefke, David Weisweiler, Volker Alt, Ulrich Thormann, Katrin Susanne Lips, Sabine Wenisch, Alexander C Langheinrich, Daniel Zahner, Nasr Y Hemdan, Wolfgang Böcker, Reinhard Schnettler, Christian Heiss,

<h4>Background</h4>Osteoporosis is a multi-factorial, chronic, skeletal disease highly prevalent in post-menopausal women and is influenced by hormonal and dietary factors. Because animal models are imperative for disease diagnostics, the present study establishes and evaluates enhanced osteoporosis obtained through combined ovariectomy and deficient diet by DEXA (dual-energy X-ray absorptiometry) for a ... Read more >>

Med Sci Monit Basic Res (Medical science monitor basic research)
[2013, 19:76-86]

Cited: 16 times

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Induction of osteoporosis with its influence on osteoporotic determinants and their interrelationships in rats by DEXA.

Christian Heiss, Parameswari Govindarajan, Gudrun Schlewitz, Nasr Y A Hemdan, Nathalie Schliefke, Volker Alt, Ulrich Thormann, Katrin Susanne Lips, Sabine Wenisch, Alexander C Langheinrich, Daniel Zahner, Reinhard Schnettler,

<h4>Background</h4>As women are the population most affected by multifactorial osteoporosis, research is focused on unraveling the underlying mechanism of osteoporosis induction in rats by combining ovariectomy (OVX) either with calcium, phosphorus, vitamin C and vitamin D2/D3 deficiency, or by administration of glucocorticoid (dexamethasone).<h4>Material/methods</h4>Different skeletal sites of sham, OVX-Diet and OVX-Steroid ... Read more >>

Med Sci Monit (Medical science monitor : international medical journal of experimental and clinical research)
[2012, 18(6):BR199-207]

Cited: 22 times

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Assessment of angiogenesis in osseointegration of a silica-collagen biomaterial using 3D-nano-CT.

Volker Alt, Daniela Vera Kögelmaier, Katrin S Lips, Vera Witt, Sabine Pacholke, Christian Heiss, Marian Kampschulte, Sascha Heinemann, Thomas Hanke, Ulrich Thormann, Reinhard Schnettler, Alexander C Langheinrich,

Bony integration of biomaterials is a complex process in which angiogenesis plays a crucial role. We evaluated micro- and nano-CT imaging to demonstrate and quantify neovascularization in bony integration of a biomaterial and to give an image based estimation for the needed resolution for imaging angiogenesis in an animal model ... Read more >>

Acta Biomater (Acta biomaterialia)
[2011, 7(10):3773-3779]

Cited: 15 times

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A new animal model for implant-related infected non-unions after intramedullary fixation of the tibia in rats with fluorescent in situ hybridization of bacteria in bone infection.

Volker Alt, Katrin S Lips, Christoph Henkenbehrens, Dominik Muhrer, Márcia Cristina Oliveira Cavalcanti, Ursula Sommer, Ulrich Thormann, Gabor Szalay, Christian Heiss, Theodoros Pavlidis, Eugen Domann, Reinhard Schnettler,

There is no adequate animal model to mimic the difficult clinical situation of infected non-union of the tibia after intramedullary stabilization. The purpose was to establish an animal model of implant-related infected non-unions of the tibia in rats. Furthermore, it was evaluated if detection of bacteria by fluorescent in situ ... Read more >>

Bone (Bone)
[2011, 48(5):1146-1153]

Cited: 17 times

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Effects of gentamicin and gentamicin-RGD coatings on bone ingrowth and biocompatibility of cementless joint prostheses: an experimental study in rabbits.

Volker Alt, Achim Bitschnau, Felicitas Böhner, Katharina Elisabeth Heerich, Erika Magesin, Andreas Sewing, Theodoros Pavlidis, Gabor Szalay, Christian Heiss, Ulrich Thormann, Sonja Hartmann, Wolfgang Pabst, Sabine Wenisch, Reinhard Schnettler,

Antimicrobial coatings are of interest as a means to improve infection prophylaxis in cementless joint arthroplasty. However, those coatings must not interfere with the essential bony integration of the implants. Gentamicin-hydroxyapatite (gentamicin-HA) and gentamicin-RGD (arginine-glycine-aspartate)-HA coatings have recently been shown to significantly reduce infection rates in a rabbit infection prophylaxis ... Read more >>

Acta Biomater (Acta biomaterialia)
[2011, 7(3):1274-1280]

Cited: 16 times

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