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Author Ulla Hohenthal

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Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements.

Juha Rannikko, Ville Holmberg, Matti Karppelin, Pertti Arvola, Reetta Huttunen, Eero Mattila, Niina Kerttula, Teija Puhto, Ülle Tamm, Irma Koivula, Risto Vuento, Jaana Syrjänen, Ulla Hohenthal,

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):]

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Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.

, Manu Shankar-Hari, Claire L Vale, Peter J Godolphin, David Fisher, Julian P T Higgins, Francesca Spiga, Jelena Savovic, Jayne Tierney, Gabriel Baron, Julie S Benbenishty, Lindsay R Berry, Niklas Broman, Alexandre Biasi Cavalcanti, Roos Colman, Stefanie L De Buyser, Lennie P G Derde, Pere Domingo, Sharifah Faridah Omar, Ana Fernandez-Cruz, Thijs Feuth, Felipe Garcia, Rosario Garcia-Vicuna, Isidoro Gonzalez-Alvaro, Anthony C Gordon, Richard Haynes, Olivier Hermine, Peter W Horby, Nora K Horick, Kuldeep Kumar, Bart N Lambrecht, Martin J Landray, Lorna Leal, David J Lederer, Elizabeth Lorenzi, Xavier Mariette, Nicolas Merchante, Nor Arisah Misnan, Shalini V Mohan, Michael C Nivens, Jarmo Oksi, Jose A Perez-Molina, Reuven Pizov, Raphael Porcher, Simone Postma, Reena Rajasuriar, Athimalaipet V Ramanan, Philippe Ravaud, Pankti D Reid, Abraham Rutgers, Aranzazu Sancho-Lopez, Todd B Seto, Sumathi Sivapalasingam, Arvinder Singh Soin, Natalie Staplin, John H Stone, Garth W Strohbehn, Jonas Sunden-Cullberg, Julian Torre-Cisneros, Larry W Tsai, Hubert van Hoogstraten, Tom van Meerten, Viviane Cordeiro Veiga, Peter E Westerweel, Srinivas Murthy, Janet V Diaz, John C Marshall, Jonathan A C Sterne,

<h4>Importance</h4>Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.<h4>Objective</h4>To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.<h4>Data sources</h4>Trials were identified through systematic searches of electronic ... Read more >>

JAMA (JAMA)
[2021, :]

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Oral Doxycycline Compared to Intravenous Ceftriaxone in the Treatment of Lyme Neuroborreliosis: A Multicenter, Equivalence, Randomized, Open-label Trial.

Elisa Kortela, Mari J Kanerva, Juha Puustinen, Saija Hurme, Laura Airas, Anneli Lauhio, Ulla Hohenthal, Päivi Jalava-Karvinen, Tuomas Nieminen, Taru Finnilä, Tony Häggblom, Annukka Pietikäinen, Mari Koivisto, Johanna Vilhonen, Minna Marttila-Vaara, Jukka Hytönen, Jarmo Oksi,

<h4>Background</h4>Lyme neuroborreliosis (LNB) is often treated with intravenous ceftriaxone even if doxycycline is suggested to be noninferior to ceftriaxone. We evaluated the efficacy of oral doxycycline in comparison to ceftriaxone in the treatment of LNB.<h4>Methods</h4>Patients with neurological symptoms suggestive of LNB without other obvious reasons were recruited. The inclusion criteria ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 72(8):1323-1331]

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Prosthetic Valve Candida Endocarditis: A Case Report with 18F-FDG-PET/CT as Part of the Diagnostic Workup.

Soile Pauliina Salomäki, Antti Saraste, Päivi Jalava-Karvinen, Laura Pirilä, Ulla Hohenthal,

Diagnosis of <i>Candida</i> spp. infective endocarditis (IE) is challenging, and diagnostic delays are common. We describe two patients with <i>Candida</i> spp. prosthetic valve endocarditis (PVE) and <sup>18</sup>fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG-PET/CT) as a part of diagnostic workup. We also refer to 5 other cases we found from the published ... Read more >>

Case Rep Cardiol (Case reports in cardiology)
[2020, 2020:4921380]

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18F-FDG positron emission tomography/computed tomography of cardiac implantable electronic device infections.

Soile Pauliina Salomäki, Antti Saraste, Jukka Kemppainen, Saija Hurme, Juhani Knuuti, Pirjo Nuutila, Marko Seppänen, Anne Roivainen, Juhani Airaksinen, Tiina Salo, Jarmo Oksi, Laura Pirilä, Ulla Hohenthal,

<h4>Background</h4>The diagnosis of cardiac implantable electronic device (CIED) infection is challenging because of its variable presentations. We studied the value of 2-[<sup>18</sup>F]fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT) in the detection of CIED infection.<h4>Methods and results</h4>Thirty patients with suspected CIED infection underwent <sup>18</sup>F-FDG-PET/CT. The control group was ten patients with ... Read more >>

J Nucl Cardiol (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology)
[2020, :]

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The Clinical Impact of Using 18F-FDG-PET/CT in the Diagnosis of Suspected Vasculitis: The Effect of Dose and Timing of Glucocorticoid Treatment.

Kirsi Taimen, Soile P Salomäki, Ulla Hohenthal, Markku Mali, Sami Kajander, Marko Seppänen, Pirjo Nuutila, Antti Palomäki, Anne Roivainen, Laura Pirilä, Jukka Kemppainen,

<sup>18</sup>F-Fluorodeoxyglucose positron-emission tomography (<sup>18</sup>F-FDG-PET) with computed tomography (CT) is effective for diagnosing large vessel vasculitis, but its usefulness in accurately diagnosing suspected, unselected vasculitis remains unknown. We evaluated the feasibility of <sup>18</sup>F-FDG-PET/CT in real-life cohort of patients with suspicion of vasculitis. The effect of the dose and the timing of ... Read more >>

Contrast Media Mol Imaging (Contrast media & molecular imaging)
[2019, 2019:9157637]

Cited: 2 times

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A single-tube two-color flow cytometric method for distinguishing between febrile bacterial and viral infections.

Jari Nuutila, Ulla Hohenthal, Jarmo Oksi, Päivi Jalava-Karvinen,

The aim of this study was to develop a rapid single-tube two-color flow cytometric method to distinguish between febrile bacterial and viral infections. In this prospective comparative study, the quantitative flow cytometric analysis of CD35 and CD64 on isolated human leukocytes was obtained from 286 hospitalized febrile patients, of which ... Read more >>

J Microbiol Methods (Journal of microbiological methods)
[2018, 152:61-68]

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Capnocytophaga canimorsus: a rare case of conservatively treated prosthetic valve endocarditis.

Päivi Jalava-Karvinen, Juha O Grönroos, Helena Tuunanen, Jukka Kemppainen, Jarmo Oksi, Ulla Hohenthal,

We describe a rare case of prosthetic valve endocarditis caused by the canine bacterium Capnocytophaga canimorsus in a male aged 73 years. The diagnosis of infective endocarditis was unequivocal, as it blood cultures were positive for C. canimorsus and vegetations were detected on transesophageal echocardiography; the modified Duke criteria were fulfilled. PET-CT ... Read more >>

APMIS (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica)
[2018, 126(5):453-456]

Cited: 2 times

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Head-to-Head Comparison of 68Ga-Citrate and 18F-FDG PET/CT for Detection of Infectious Foci in Patients with Staphylococcus aureus Bacteraemia.

Soile P Salomäki, Jukka Kemppainen, Ulla Hohenthal, Pauliina Luoto, Olli Eskola, Pirjo Nuutila, Marko Seppänen, Laura Pirilä, Jarmo Oksi, Anne Roivainen,

<h4>Purpose</h4>This study evaluated the potential of <sup>68</sup>Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with <i>Staphylococcus aureus</i> bacteraemia by comparing it with 2-[<sup>18</sup>F]fluoro-2-deoxy-<i>D</i>-glucose (<sup>18</sup>F-FDG) PET/CT.<h4>Methods</h4>Four patients admitted to hospital due to <i>S. aureus</i> bacteraemia underwent both <sup>18</sup>F-FDG and <sup>68</sup>Ga-citrate whole-body PET/CT scans to detect ... Read more >>

Contrast Media Mol Imaging (Contrast media & molecular imaging)
[2017, 2017:3179607]

Cited: 6 times

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Clinical picture and overall status of newly diagnosed HIV patients at Turku University Hospital in 2013.

Saara Eskola, Taru Finnilä, Ulla Hohenthal, Jarmo Oksi,

Our patient material consists of the 12 patients diagnosed during one year. In all cases, sex was the likely mode of transmission, the number of partners having been high for some patients. Some of the cases were originally detected as a result of contact tracing. In two patients the disease ... Read more >>

Duodecim (Duodecim; laaketieteellinen aikakauskirja)
[2016, 132(21):2001-2008]

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Scedosporium apiospermum as a rare cause of central skull base osteomyelitis.

Päivi Jalava-Karvinen, Mikko Nyman, Maria Gardberg, Inka Harju, Ulla Hohenthal, Jarmo Oksi,

We report a case of Scedosporium apiospermum mold causing ear infection, central skull base osteomyelitis and finally, occlusion of carotid artery in a 48-year-old diabetic man. The exact diagnosis was established and the severity of the disease understood several months after the onset of symptoms. Despite of appropriate antifungal therapy, ... Read more >>

Med Mycol Case Rep (Medical mycology case reports)
[2016, 11:28-30]

Cited: 1 time

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18F-FDG positron emission tomography/computed tomography in infective endocarditis.

Soile Pauliina Salomäki, Antti Saraste, Jukka Kemppainen, Jeroen J Bax, Juhani Knuuti, Pirjo Nuutila, Marko Seppänen, Anne Roivainen, Juhani Airaksinen, Laura Pirilä, Jarmo Oksi, Ulla Hohenthal,

<h4>Background</h4>The diagnosis of infective endocarditis (IE), especially the diagnosis of prosthetic valve endocarditis (PVE) is challenging since echocardiographic findings are often scarce in the early phase of the disease. We studied the use of 2-[<sup>18</sup>F]fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT) in IE.<h4>Methods</h4>Sixteen patients with suspected PVE and 7 patients ... Read more >>

J Nucl Cardiol (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology)
[2017, 24(1):195-206]

Cited: 16 times

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Constant high adrenal FDG uptake in PET/CT associated with mitochondrial disease.

Mika H Martikainen, Ulla Hohenthal, Laura Pirilä, Jukka Kemppainen,

We describe a patient with the m.3243A>G mitochondrial DNA mutation who developed sepsis caused by Streptococcus constellatus. In the acute phase of illness, abnormally high uptake of (18)F-FDG was observed in both adrenal glands that appeared anatomically normal. In repeated imaging six months later the adrenal uptake had diminished but ... Read more >>

J Inherit Metab Dis (Journal of inherited metabolic disease)
[2014, 37(5):863-864]

Cited: 0 times

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Widespread vascular inflammation in a patient with antineutrophil cytoplasmic antibody-associated vasculitis as detected by positron emission tomography.

Soile P Salomäki, Jukka Kemppainen, Heikki Aho, Ulla Hohenthal, Renate Kain, Niina Koivuviita, Robert M Badeau, Marko Seppänen, Antti Silvoniemi, Anne Roivainen, Laura Pirilä,

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2014, 41(11):2167-2168]

Cited: 1 time

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Patch testing and sensitization to multiple drugs.

Jussi Liippo, Kati Pummi, Ulla Hohenthal, Kaija Lammintausta,

<h4>Background</h4>Adverse drug reactions pose an increasing diagnostic challenge in hospitals and in outpatient clinics. When consecutive or repeated allergic drug eruptions are suspected, patch testing is a useful diagnostic tool for determining the causative drugs.<h4>Objectives</h4>The aim of the study was to identify patient cases with multiple delayed-type drug sensitizations by ... Read more >>

Contact Dermatitis (Contact dermatitis)
[2013, 69(5):296-302]

Cited: 3 times

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[Cerebral nocardiosis as surprising cause of a convulsive seizure].

Antti Kontturi, Pirkko Sonninen, Merja Soilu-Hänninen, Lauri Talve, Melissa Rahi, Jarmo Oksi, Ulla Hohenthal,

Underlying a convulsive seizure of an adult patient many different types of cause can be detected, such as alcohol withdrawal, disturbance of the cerebral circulation, cerebral hemorrhage, brain tumor, metabolic disturbances, drugs or infection. In connection with severe central nervous system infections, such as brain abscesses, convulsive seizures occur in ... Read more >>

Duodecim (Duodecim; laaketieteellinen aikakauskirja)
[2014, 130(15):1531-1535]

Cited: 0 times

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Candida dubliniensis spondylodiscitis in an immunocompetent patient. Case report and review of the literature.

Jarmo Oksi, Taru Finnilä, Ulla Hohenthal, Kaisu Rantakokko-Jalava,

We describe what appears to be the first case of spondylodiscitis due to Candida dubliniensis. Our case adds to the current literature of the importance of C. dubliniensis as a cause of fungemia and subsequent deep seated infections. It highlights the importance of taking fungal as well as bacterial culture ... Read more >>

Med Mycol Case Rep (Medical mycology case reports)
[2014, 3:4-7]

Cited: 7 times

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Bacterial infection (BI)-INDEX: an improved and simplified rapid flow cytometric bacterial infection marker.

Jari Nuutila, Päivi Jalava-Karvinen, Ulla Hohenthal, Pirkko Kotilainen, Tarja-Terttu Pelliniemi, Jukka Nikoskelainen, Esa-Matti Lilius,

The aim of this study was to develop a rapid and simple flow cytometric bacterial infection marker. In this prospective comparative study, quantitative flow cytometric analysis of CD10, CD35, CD66b, CD282, and MHC Class I molecules on human neutrophils, monocytes, and B-lymphocytes from 141 hospitalized febrile patients with suspected infection ... Read more >>

Diagn Microbiol Infect Dis (Diagnostic microbiology and infectious disease)
[2014, 78(2):116-126]

Cited: 4 times

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Visualization of pericarditis by fluorodeoxyglucose PET.

Soile Pauliina Salomäki, Ulla Hohenthal, Jukka Kemppainen, Laura Pirilä, Antti Saraste,

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2014, 15(3):291]

Cited: 6 times

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Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections.

Jari Nuutila, Päivi Jalava-Karvinen, Ulla Hohenthal, Pirkko Kotilainen, Tarja-Terttu Pelliniemi, Jukka Nikoskelainen, Esa-Matti Lilius,

Several complement regulatory proteins exist on self-cells to prevent damage by the serum complement system. In the present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymphocytes from healthy controls (n=36) and ... Read more >>

Hum Immunol (Human immunology)
[2013, 74(5):522-530]

Cited: 16 times

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Estimating the burden of pneumococcal pneumonia among adults: a systematic review and meta-analysis of diagnostic techniques.

Maria A Said, Hope L Johnson, Bareng A S Nonyane, Maria Deloria-Knoll, Katherine L O'Brien, , Felipe Andreo, Bojana Beovic, Silvia Blanco, Wim G Boersma, David R Boulware, Jay C Butler, Jordi Carratalà, Feng-Yee Chang, Patrick G P Charles, Alejandro A Diaz, Jose Domínguez, Naomi Ehara, Henrik Endeman, Vicenç Falcó, Miquel Falguera, Kiyoyasu Fukushima, Carolina Garcia-Vidal, Daniel Genne, Igor A Guchev, Felix Gutierrez, Susanne S Hernes, Andy I M Hoepelman, Ulla Hohenthal, Niclas Johansson, Vitezslav Kolek, Roman S Kozlov, Tsai-Ling Lauderdale, Ivana Mareković, Mar Masiá, Matta A Matta, Òscar Miró, David R Murdoch, Eric Nuermberger, Richard Paolini, Rafael Perelló, Dominic Snijders, Vanda Plečko, Roger Sordé, Kristoffer Strålin, Menno M van der Eerden, Angel Vila-Corcoles, James P Watt,

<h4>Background</h4>Pneumococcal pneumonia causes significant morbidity and mortality among adults. Given limitations of diagnostic tests for non-bacteremic pneumococcal pneumonia, most studies report the incidence of bacteremic or invasive pneumococcal disease (IPD), and thus, grossly underestimate the pneumococcal pneumonia burden. We aimed to develop a conceptual and quantitative strategy to estimate the ... Read more >>

PLoS One (PloS one)
[2013, 8(4):e60273]

Cited: 183 times

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A rapid flow cytometric method for distinguishing between febrile bacterial and viral infections.

Jari Nuutila, Päivi Jalava-Karvinen, Ulla Hohenthal, Pirkko Kotilainen, Tarja-Terttu Pelliniemi, Jukka Nikoskelainen, Esa-Matti Lilius,

Antibiotic resistance due to the inappropriate use of antimicrobials is one of the most critical public health problems worldwide. A major factor underlying the unnecessary use of antibiotics is the lack of rapid and accurate diagnostic tests. Therefore, we aimed to develop a novel rapid flow cytometric method for distinguishing ... Read more >>

J Microbiol Methods (Journal of microbiological methods)
[2013, 92(1):64-72]

Cited: 9 times

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[Sodium thiosulfate--new hope for the treatment of calciphylaxis].

Maija Heiro, Leeni Mäkelä, Niina Koivuviita, Ilkka Manner, Risto Tertti, Ulla Hohenthal, Kaj Metsärinne,

Calciphylaxis is a rare disease primarily affecting patients dependent on dialysis. It is characterised by small vessel media calcification leading to cutaneous ischemia and necrosis. The mortality rate is high with infection and sepsis being the most common causes of death. Calcium salts, vitamin D and high levels of serum ... Read more >>

Duodecim (Duodecim; laaketieteellinen aikakauskirja)
[2011, 127(16):1690-1696]

Cited: 0 times

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Simultaneous quantitative analysis of Fc gamma RI (CD64) and CR1 (CD35) on neutrophils in distinguishing between bacterial infections, viral infections, and inflammatory diseases.

Päivi Jalava-Karvinen, Ulla Hohenthal, Iina Laitinen, Pirkko Kotilainen, Allan Rajamäki, Jukka Nikoskelainen, Esa-Matti Lilius, Jari Nuutila,

A flow cytometric quantitative analysis of receptors on neutrophils can be exploited in distinguishing between inflammatory and infectious diseases. In this prospective comparative study, simultaneous quantitative analysis of CD64 and CD35 on peripheral blood neutrophils was performed in febrile patients in order to differentiate between bacterial infections (n=89), viral infections ... Read more >>

Clin Immunol (Clinical immunology (Orlando, Fla.))
[2009, 133(3):314-323]

Cited: 20 times

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Comparison of degranulation of easily mobilizable intracellular granules by human phagocytes in healthy subjects and patients with infectious diseases.

Jari Nuutila, Päivi Jalava-Karvinen, Ulla Hohenthal, Iina Laitinen, Pirkko Kotilainen, Allan Rajamäki, Jukka Nikoskelainen, Esa-Matti Lilius,

The aim of this study was to compare degranulation of easily mobilizable secretory vesicles (SVs) or secretory vesicle-like granules (SVLGs) in neutrophils, monocytes, and eosinophils of healthy controls (n = 60) and febrile patients with microbiologically confirmed or clinically diagnosed bacterial (n = 89) and viral (n = 46) infections. ... Read more >>

Hum Immunol (Human immunology)
[2009, 70(10):813-819]

Cited: 8 times

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