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Author Typhaine Billard Pomares

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Community-acquired bacterial meningitis in adults: in-hospital prognosis, long term disability and determinants of outcome in a multicentre prospective cohort.

Sarah Tubiana, Emmanuelle Varon, Charlotte Biron, Marie-Cecile Ploy, Bruno Mourvillier, Muhamed-Kheir Taha, Mathieu Revest, Claire Poyart, Guillaume Martin-Blondel, Marc Lecuit, Eric Cua, Blandine Pasquet, Marie Preau, Bruno Hoen, Xavier Duval, , , , , , , , ,

OBJECTIVES:To identify factors associated with unfavorable in-hospital outcome (death or disability) in adults with community-acquired bacterial meningitis (CABM). METHODS:In a prospective multicenter cohort study (COMBAT; February 2013-July 2015), all consecutive cases of CABM in the 69 participating centers in France were enrolled and followed up for 12 months. Factors associated with ... Read more >>

Clin. Microbiol. Infect. (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2020, :]

Cited: 0 times

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Fatal Legionella pneumophila serogroup 1 pleural empyema: A case report.

François Maillet, Nicolas Bonnet, Typhaine Billard-Pomares, Fatma El Alaoui Magdoud, Yacine Tandjaoui-Lambiotte,

BACKGROUND:Legionella pneumophila (L. pneumophila) is a gram-negative intracellular bacillus composed of sixteen different serogroups. It is mostly known to cause pneumonia in individuals with known risk factors as immunocompromised status, tobacco use, chronic organ failure or age older than 50 years. Although parapneumonic pleural effusion is frequent in legionellosis, pleural ... Read more >>

World J Crit Care Med (World journal of critical care medicine)
[2019, 8(6):99-105]

Cited: 0 times

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Proposition of a safe Mycobacterium tuberculosis complex denaturation method that does not compromise the integrity of DNA for whole-genome sequencing.

Typhaine Billard-Pomares, Alexandre Bleibtreu, Violaine Walewski, Samira Dziri, Allison Barbat, Jean-Ralph Zahar, Philippe Cruaud, Etienne Carbonnelle,

Whole-genome sequencing plays now a leading role in epidemiologic studies of tuberculosis. DNA extraction of Mycobacterium tuberculosis complex (MTBC) requires complete inactivation of the strains, to be handled for further molecular procedures. In this study we compared two chloroform-based denaturation methods (one with a step of heat killing, one without) ... Read more >>

Tuberculosis (Edinb) (Tuberculosis (Edinburgh, Scotland))
[2019, 117:62-64]

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Using SNOMED-CT to Help the Transition from Microbiological Data to ICD-10 Sepsis Codes.

Iris Ternois, Typhaine Billard-Pomares, Etienne Carbonelle, Loriane Franchinard, Catherine Duclos,

Assigning ICD-10 code of sepsis in regard of a pathogenic bacterium found in an haemoculture requires knowledge of microbiology because of the difference of granularity. The aim of this paper is to automate this coding thanks to the use of SNOMED-CT. A dichotomous classification of bacteria causing sepsis has been ... Read more >>

Stud Health Technol Inform (Studies in health technology and informatics)
[2019, 264:1604-1605]

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Specialization of small non-conjugative plasmids in Escherichia coli according to their family types.

Catherine Branger, Alice Ledda, Typhaine Billard-Pomares, Benoît Doublet, Valérie Barbe, David Roche, Claudine Médigue, Guillaume Arlet, Erick Denamur,

We undertook a comprehensive comparative analysis of a collection of 30 small (<25 kb) non-conjugative Escherichia coli plasmids previously classified by the gene sharing approach into 10 families, as well as plasmids found in the National Center for Biotechnology Information (NCBI) nucleotide database sharing similar genomic sequences. In total, 302 mobilizable ... Read more >>

Microb Genom (Microbial genomics)
[2019, 5(9):]

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The Arginine Deiminase Operon Is Responsible for a Fitness Trade-Off in Extended-Spectrum-β-Lactamase-Producing Strains of Escherichia coli.

Typhaine Billard-Pomares, Olivier Clermont, Miguel Castellanos, Fatma Magdoud, Guilhem Royer, Bénédicte Condamine, Stéphanie Fouteau, Valérie Barbe, David Roche, Stéphane Cruveiller, Claudine Médigue, Dominique Pognard, Jeremy Glodt, Sara Dion, Odile Rigal, Bertrand Picard, Erick Denamur, Catherine Branger,

We previously identified an operon involved in an arginine deiminase (ADI) pathway (arc operon) on a CTX-M-producing plasmid from an O102-ST405 strain of Escherichia coli As the ADI pathway was shown to be involved in the virulence of various Gram-positive bacteria, we tested whether the ADI pathway could be involved ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2019, 63(8):]

Cited: 1 time

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Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014.

Béatrice La Combe, Olivier Clermont, Jonathan Messika, Matthieu Eveillard, Achille Kouatchet, Sigismond Lasocki, Stéphane Corvec, Karim Lakhal, Typhaine Billard-Pomares, Romain Fernandes, Laurence Armand-Lefevre, Sandra Bourdon, Jean Reignier, Vincent Fihman, Nicolas de Prost, Julien Bador, Julien Goret, Frederic Wallet, Erick Denamur, Jean-Damien Ricard, , ,

In a prospective, nationwide study in France of Escherichia coli responsible for pneumonia in patients receiving mechanical ventilation, we determined E. coli antimicrobial susceptibility, phylotype, O-type, and virulence factor gene content. We compared 260 isolates with those of 2 published collections containing commensal and bacteremia isolates. The preponderant phylogenetic group ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2019, 25(4):710-718]

Cited: 1 time

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Oropharyngeal Bacterial Colonization after Chlorhexidine Mouthwash in Mechanically Ventilated Critically Ill Patients.

Béatrice La Combe, Anne-Claire Mahérault, Jonathan Messika, Typhaine Billard-Pomares, Catherine Branger, Luce Landraud, Didier Dreyfuss, Fadia Dib, Laurent Massias, Jean-Damien Ricard,

WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Oropharyngeal care with chlorhexidine to prevent ventilator-associated pneumonia is currently questioned, and exhaustive microbiologic data assessing its efficacy are lacking. The authors therefore aimed to study the effect of chlorhexidine mouthwash on oropharyngeal bacterial growth, ... Read more >>

Anesthesiology (Anesthesiology)
[2018, 129(6):1140-1148]

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Risk factors for carbapenem-resistant Enterobacteriaceae infections: a French case-control-control study.

Marie-Hélène Nicolas-Chanoine, Marie Vigan, Cédric Laouénan, Jérôme Robert, ,

This study aimed to assess characteristics associated with infections due to carbapenem-resistant Enterobacteriaceae (CRE), producing (CPE) or not producing (non-CPE) carbapenemase, among hospitalised patients in 2014-2016 in France. Case-patients with CRE were compared to two control populations. In multivariate analysis comparing 160 CRE cases to 160 controls C1 (patients with ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2019, 38(2):383-393]

Cited: 2 times

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Extended-spectrum β-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.

Catherine Branger, Alice Ledda, Typhaine Billard-Pomares, Benoît Doublet, Stéphanie Fouteau, Valérie Barbe, David Roche, Stéphane Cruveiller, Claudine Médigue, Miguel Castellanos, Dominique Decré, Laurence Drieux-Rouze, Olivier Clermont, Jérémy Glodt, Olivier Tenaillon, Axel Cloeckaert, Guillaume Arlet, Erick Denamur,

To understand the evolutionary dynamics of extended-spectrum β-lactamase (ESBL)-encoding genes in Escherichia coli, we undertook a comparative genomic analysis of 116 whole plasmid sequences of human or animal origin isolated over a period spanning before and after the use of third-generation cephalosporins (3GCs) using a gene-sharing network approach. The plasmids ... Read more >>

Microb Genom (Microbial genomics)
[2018, 4(9):]

Cited: 6 times

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Hypervirulent Klebsiella pneumoniae, a 5-year study in a French ICU.

Cédric Rafat, Jonathan Messika, Guilène Barnaud, Nicolas Dufour, Fatma Magdoud, Typhaine Billard-Pomarès, Stéphane Gaudry, Didier Dreyfuss, Catherine Branger, Dominique Decré, Jean-Damien Ricard,

Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a leading cause of severe community-acquired pneumonia, liver abscess and disseminated infection in the Far East. Data regarding the incidence, clinical features and microbiological characteristics related to hvKp infections in the Western world are scarce.The incidence, clinical features and microbiological characteristics of hvKp ... Read more >>

J. Med. Microbiol. (Journal of medical microbiology)
[2018, 67(8):1083-1089]

Cited: 4 times

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Extensively-drug-resistant bacteria carriers among overseas travellers: one-third had not been hospitalized previously.

Lou Macaux, Oulimata Ndoye, Hugues Cordel, Typhaine Billard Pomares, Delphine Seytre, Olivier Bouchaud, Yves Cohen, Jean-Ralph Zahar, Etienne Carbonnelle,

BACKGROUND:Extensively-drug-resistant bacteria (XDRB) have emerged as a major source of resistance. Hospitalization abroad seems to be the major risk factor associated with carriage, and numerous reports have warned about the risk of in-hospital transmission. However, little is known regarding possible community transmission. METHODS:A retrospective matched case-control study was conducted in ... Read more >>

Int. J. Antimicrob. Agents (International journal of antimicrobial agents)
[2018, 52(3):385-389]

Cited: 0 times

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Decreased susceptibility to chlorhexidine affects a quarter of Escherichia coli isolates responsible for pneumonia in ICU patients.

Béatrice La Combe, Alexandre Bleibtreu, Jonathan Messika, Romain Fernandes, Olivier Clermont, Catherine Branger, Typhaine Billard-Pomares, Guilène Barnaud, Fatma Magdoud, Matthieu Eveillard, Achille Kouatchet, Sigismond Lasocki, Pierre Asfar, Stéphane Corvec, Karim Lakhal, Laurence Armand-Lefevre, Michel Wolff, Jean-François Timsit, Sandrine Bourdon, Jean Reignier, Stéphanie Martin, Vincent Fihman, Nicolas de Prost, Julien Bador, Pierre-Emmanuel Charles, Julien Goret, Alexandre Boyer, Frederic Wallet, Emmanuelle Jaillette, Saad Nseir, Luce Landraud, Raymond Ruimy, Pierre-Eric Danin, Jean Dellamonica, Julie Cremniter, Jean-Pierre Frat, Françoise Jauréguy, Christophe Clec'h, Dominique Decré, Eric Maury, Didier Dreyfuss, Erick Denamur, Jean-Damien Ricard,

Intensive Care Med (Intensive Care Medicine)
[2018, 44(4):531-533]

Cited: 5 times

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Diagnosis in France of a Non-Toxigenic tox Gene-Bearing Strain of Corynebacterium diphtheriae in a Young Male Back From Senegal.

Typhaine Billard-Pomares, Cécile Rouyer, Violaine Walewski, Edgar Badell-Ocando, Marc Dumas, Coralie Zumelzu, Françoise Jaureguy, Sylvain Brisse, Frédéric Caux, Olivier Bouchaud, Etienne Carbonnelle,

Cutaneous diphtheria is uncommon in Europe. In this study, we report a case of imported cutaneous infection due to a non-toxigenic but tox gene-bearing (NTTB) strain of Corynebacterium diphtheriae. The NTTB strains are recognized as emerging pathogens across Europe, and physicians and bacteriologists should be aware of the circulation of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(1):ofw271]

Cited: 2 times

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Fatal transfusion-transmitted infection due to Citrobacter koseri.

Lisette Hauser, Senbetta Menasie, Stéphane Bonacorsi, Laurence Raoult, Nourredine AitOubelli, Marie Belloy, David Avran, Alexandre Beyloune, Marion Simonet, Typhaine Billard-Pomares, Béatrice Pangon, Philippe Bierling,

Transfusion-transmitted bacterial infection (TTBI) is still one of the most feared complications of blood transfusion.We report a fatal case involving an 8-year-old child with congenital dyskeratosis complicated by severe aplastic anemia who was regularly transfused with platelet (PLT) concentrates for 5 years. The patient received an apheresis PLT concentrate (APC) ... Read more >>

Transfusion (Transfusion)
[2016, :]

Cited: 2 times

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Five-year trends for ventilator-associated pneumonia: Correlation between microbiological findings and antimicrobial drug consumption.

Vincent Fihman, Jonathan Messika, David Hajage, Véronique Tournier, Stéphane Gaudry, Fatma Magdoud, Guilène Barnaud, Typhaine Billard-Pomares, Catherine Branger, Didier Dreyfuss, Jean-Damien Ricard,

The epidemiology of multidrug-resistant bacteria (MDRB) has changed significantly in European healthcare settings, with a decrease in frequency of meticillin-resistant Staphylococcus aureus and an increase in extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. Little is known about the effects of these changes on ventilator-associated pneumonia (VAP). A retrospective 5-year trend analysis of ICU ... Read more >>

Int. J. Antimicrob. Agents (International journal of antimicrobial agents)
[2015, 46(5):518-525]

Cited: 15 times

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Randomized intubation with polyurethane or conical cuffs to prevent pneumonia in ventilated patients.

François Philippart, Stéphane Gaudry, Laurent Quinquis, Nicolas Lau, Islem Ouanes, Samia Touati, Jean Claude Nguyen, Catherine Branger, Frédéric Faibis, Maha Mastouri, Xavier Forceville, Fekri Abroug, Jean Damien Ricard, Sophie Grabar, Benoît Misset, ,

The occurrence of ventilator-associated pneumonia (VAP) is linked to the aspiration of contaminated pharyngeal secretions around the endotracheal tube. Tubes with cuffs made of polyurethane rather than polyvinyl chloride or with a conical rather than a cylindrical shape increase tracheal sealing.To test whether using polyurethane and/or conical cuffs reduces tracheal ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2015, 191(6):637-645]

Cited: 35 times

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Risks of nonsteroidal antiinflammatory drugs in undiagnosed intensive care unit pneumococcal pneumonia: younger and more severely affected patients.

Jonathan Messika, Benjamin Sztrymf, Fabrice Bertrand, Typhaine Billard-Pomares, Guilene Barnaud, Catherine Branger, Didier Dreyfuss, Jean-Damien Ricard,

PURPOSE: The purpose of this study is to investigate whether exposure to nonsteroidal antiinflammatory drugs (NSAIDs) at the early stage of severe pneumococcal community-acquired pneumonia (CAP) requiring intensive care unit (ICU) admission may affect its presentation and outcome. MATERIAL AND METHODS: Medical records of ICU adult patients (12-year period) with ... Read more >>

J Crit Care (Journal of critical care)
[2014, 29(5):733-738]

Cited: 15 times

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Characterization of a P1-like bacteriophage carrying an SHV-2 extended-spectrum β-lactamase from an Escherichia coli strain.

Typhaine Billard-Pomares, Stéphanie Fouteau, Marie Elise Jacquet, David Roche, Valérie Barbe, Miguel Castellanos, Jean Yves Bouet, Stéphane Cruveiller, Claudine Médigue, Jorge Blanco, Olivier Clermont, Erick Denamur, Catherine Branger,

P1 bacteriophages lysogenize bacteria as independent plasmid-like elements. We describe here a P1-like bacteriophage, RCS47, carrying a blaSHV-2 gene, isolated from a clinical strain of Escherichia coli from phylogroup B1, and we report the prevalence of P1-like prophages in natural E. coli isolates. We found that 70% of the sequence ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2014, 58(11):6550-6557]

Cited: 23 times

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Complete nucleotide sequence of plasmid pTN48, encoding the CTX-M-14 extended-spectrum β-lactamase from an Escherichia coli O102-ST405 strain.

Typhaine Billard-Pomares, Olivier Tenaillon, Hervé Le Nagard, Zoé Rouy, Stéphane Cruveiller, Claudine Médigue, Guillaume Arlet, Erick Denamur, Catherine Branger,

The sequence of pTN48, a plasmid of the FII-FIB replicon type that encodes a CTX-M-14 enzyme in an Escherichia coli strain of the phylogenetic group D₂ O102-ST405 clone, was determined. pTN48 is, for the most part, a mosaic of virulence, antibiotic resistance, and addiction system modules found in various other ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2011, 55(3):1270-1273]

Cited: 14 times

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Application of quantitative PCR to the diagnosis and monitoring of Pseudomonas aeruginosa colonization in 5-18-year-old cystic fibrosis patients.

Typhaine Billard-Pomares, Stéphanie Herwegh, Nathalie Wizla-Derambure, Dominique Turck, René Courcol, Marie-Odile Husson,

Early detection of Pseudomonas aeruginosa and early aggressive treatment are recommended to delay chronic infection in cystic fibrosis (CF) patients. The aim of this study was to assess a quantitative PCR (q-PCR) assay for the diagnosis of early P. aeruginosa colonization in 23 young CF patients (group A, age range ... Read more >>

J. Med. Microbiol. (Journal of medical microbiology)
[2011, 60(Pt 2):157-161]

Cited: 7 times

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