Full Text Journal Articles by
Author Tyler Moss


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Expression Analysis of Same-Patient Metachronous and Synchronous Upper Tract and Bladder Urothelial Carcinoma.

Firas G Petros, Woonyoung Choi, Yuan Qi, Tyler Moss, Roger Li, Xiaoping Su, Charles C Guo, Bogdan Czerniak, Colin Dinney, David J McConkey, Surena F Matin,

<h4>Purpose</h4>We compared upper tract urothelial carcinoma (UTUC) and bladder urothelial carcinoma (BUC) in same-patient metachronous UTUC and synchronous UTUC and BUC using next-generation sequencing.<h4>Materials and methods</h4>Consecutive untreated same-patient samples of UTUC and BUC were macrodissected from unstained formalin-fixed, paraffin-embedded slides after quality control. Samples were divided into 4 groups: 1) ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001788]

Cited: 0 times

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Muhammad Baig, David McCall, Tyler Moss, David Sandberg, Gregory Fuller, Susan McGovern, Arnold Paulino, Amer Najjar, Joya Chandra, Soumen Khatua, Wafik Zaky,

Abstract DNA mismatch repair machinery is an integral part of the human genome and its defect has been involved in tumorigenesis and treatment resistance. Heterozygous monoallelic germline loss of function in MLH-1, MSH-2, MSH-6 or PMS-2 is involved in Lynch syndrome, whereas biallelic mutations cause constitutional mismatch repair deficiency (CMMRD) ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(Suppl 3):iii446-iii446]

Cited: 0 times

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Whole-exome sequencing for ocular adnexal sebaceous carcinoma suggests PCDH15 as a novel mutation associated with metastasis.

Shiqiong Xu, Tyler J Moss, Maria Laura Rubin, Jing Ning, Karina Eterovic, Hong Yu, Renbing Jia, Xianqun Fan, Michael T Tetzlaff, Bita Esmaeli,

Ocular adnexal sebaceous carcinoma (OASeC) is an aggressive eyelid carcinoma. Analysis of molecular-genetic drivers of this disease could reveal new prognostic markers and actionable targets for treatment. To identify somatically acquired genomic mutations in OASeC and explore their associations with metastasis, whole-exome sequencing on DNA extracted from retrospectively collected tumor ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(7):1256-1263]

Cited: 2 times

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A Deep Learning Framework for Predicting Response to Therapy in Cancer.

Theodore Sakellaropoulos, Konstantinos Vougas, Sonali Narang, Filippos Koinis, Athanassios Kotsinas, Alexander Polyzos, Tyler J Moss, Sarina Piha-Paul, Hua Zhou, Eleni Kardala, Eleni Damianidou, Leonidas G Alexopoulos, Iannis Aifantis, Paul A Townsend, Mihalis I Panayiotidis, Petros Sfikakis, Jiri Bartek, Rebecca C Fitzgerald, Dimitris Thanos, Kenna R Mills Shaw, Russell Petty, Aristotelis Tsirigos, Vassilis G Gorgoulis,

A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a personalized basis. Using a pharmacogenomics database of 1,001 cancer cell lines, we trained deep neural networks for prediction of drug response and assessed their performance on multiple clinical cohorts. We demonstrate that deep neural networks ... Read more >>

Cell Rep (Cell reports)
[2019, 29(11):3367-3373.e4]

Cited: 19 times

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David McCall, Agda Eterovic, Tyler Moss, Muhammed Baig, Greg Fuller, Jason Huse, David I Sandberg, Michael Rytting, Jonathan Gill, Joya Chandra, Soumen Khatua, Kenna Shaw, Funda Meric-Bernstam, Wafik Zaky,

Abstract INTRODUCTION The new understanding of molecular pathways in cancer is paving the way towards personalized cancer medicine, especially in refractory disease. High-grade gliomas (HGG) are common pediatric brain tumors that tend to recur, with no available standard therapy upon recurrence. HGG are challenging tumors with illusive biology and poor ... Read more >>

Neuro Oncol (Neuro-oncology)
[2019, 21(Suppl 6):vi138-vi138]

Cited: 0 times

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Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling.

Brian D Robinson, Panagiotis J Vlachostergios, Bhavneet Bhinder, Weisi Liu, Kailyn Li, Tyler J Moss, Rohan Bareja, Kyung Park, Peyman Tavassoli, Joanna Cyrta, Scott T Tagawa, David M Nanus, Himisha Beltran, Ana M Molina, Francesca Khani, Juan Miguel Mosquera, Evanguelos Xylinas, Shahrokh F Shariat, Douglas S Scherr, Mark A Rubin, Seth P Lerner, Surena F Matin, Olivier Elemento, Bishoy M Faltas,

Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical phenotype. To define the biological features driving this phenotype, we performed an integrated analysis of whole-exome and RNA sequencing of UTUC. Here we report several key insights from our molecular dissection of this disease: 1) Most UTUCs are ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):2977]

Cited: 17 times

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Sebaceous carcinoma on the arm of a 10-year-old girl.

Stephen K Stacey, Tyler A Moss, Todd T Kobayashi,

We report a case of a 10 year-old girl diagnosed with sebaceous carcinoma of the posterior left arm. The presented case reviews the histopathological and immunohistochemical characteristics of this malignancy, including a review of the literature in pediatric patients regarding prognosis and treatment. Sebaceous carcinoma is a malignant neoplasm with ... Read more >>

Dermatol Online J (Dermatology online journal)
[2017, 23(6):]

Cited: 0 times

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Comprehensive Genomic Characterization of Upper Tract Urothelial Carcinoma.

Tyler J Moss, Yuan Qi, Liu Xi, Bo Peng, Tae-Beom Kim, Nader E Ezzedine, Maribel E Mosqueda, Charles C Guo, Bogdan A Czerniak, Michael Ittmann, David A Wheeler, Seth P Lerner, Surena F Matin,

<h4>Background</h4>Upper urinary tract urothelial cancer (UTUC) may have unique etiologic and genomic factors compared to bladder cancer.<h4>Objective</h4>To characterize the genomic landscape of UTUC and provide insights into its biology using comprehensive integrated genomic analyses.<h4>Design, setting, and participants</h4>We collected 31 untreated snap-frozen UTUC samples from two institutions and carried out whole-exome ... Read more >>

Eur Urol (European urology)
[2017, 72(4):641-649]

Cited: 54 times

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Serpiginous hypopigmentation secondary to intra-articular corticosteroid injection.

Danielle Neal, Jason Arnold, Tyler Moss,

Corticosteroids have been a mainstay of therapy for the treatment of many inflammatory diseases for well over 50 years. Cutaneous side effects of local corticosteroid therapy include striae, thinning of the skin, hypopigmentation, and atrophy, which are well known complications of this treatment modality.Herein, we present an unusual cutaneous adverse ... Read more >>

Dermatol Online J (Dermatology online journal)
[2017, 23(4):]

Cited: 0 times

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Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.

Lifeng Yang, Abhinav Achreja, Tsz-Lun Yeung, Lingegowda S Mangala, Dahai Jiang, Cecil Han, Joelle Baddour, Juan C Marini, Joseph Ni, Ryuichi Nakahara, Stephen Wahlig, Lisa Chiba, Sun Hye Kim, Joshua Morse, Sunila Pradeep, Archana Sidalaghatta Nagaraja, Monika Haemmerle, Noh Kyunghee, Mathew Derichsweiler, Thomas Plackemeier, Imelda Mercado-Uribe, Gabriel Lopez-Berestein, Tyler Moss, Prahlad T Ram, Jinsong Liu, Xiongbin Lu, Samuel C Mok, Anil K Sood, Deepak Nagrath,

Reactive stromal cells are an integral part of tumor microenvironment (TME) and interact with cancer cells to regulate their growth. Although targeting stromal cells could be a viable therapy to regulate the communication between TME and cancer cells, identification of stromal targets that make cancer cells vulnerable has remained challenging ... Read more >>

Cell Metab (Cell metabolism)
[2016, 24(5):685-700]

Cited: 116 times

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Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer.

Sumaira Amir, Catalina Simion, Maxine Umeh-Garcia, Sheryl Krig, Tyler Moss, Kermit L Carraway, Colleen Sweeney,

<h4>Background</h4>The Tbx3 transcription factor is over-expressed in breast cancer, where it has been implicated in proliferation, migration and regulation of the cancer stem cell population. The mechanisms that regulate Tbx3 expression in cancer have not been fully explored. In this study, we demonstrate that Tbx3 is repressed by the tumour ... Read more >>

Br J Cancer (British journal of cancer)
[2016, 114(10):1125-1134]

Cited: 15 times

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Genome-wide perturbations by miRNAs map onto functional cellular pathways, identifying regulators of chromatin modifiers.

Tyler J Moss, Zijun Luo, Elena G Seviour, Vasudha Sehgal, Yiling Lu, Steven M Hill, Rajesha Rupaimoole, Ju-Seog Lee, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Anil K Sood, Robert Azencott, Joe W Gray, Sach Mukherjee, Gordon B Mills, Prahlad T Ram,

<h4>Background</h4>Regulation of gene expression by microRNAs (miRNAs) is critical for determining cellular fate and function. Dysregulation of miRNA expression contributes to the development and progression of multiple diseases. miRNA can target multiple mRNAs, making deconvolution of the effects of miRNA challenging and the complexity of regulation of cellular pathways by ... Read more >>

NPJ Syst Biol Appl (NPJ systems biology and applications)
[2015, 1:15001]

Cited: 1 time

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Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer.

Pradeep Chaluvally-Raghavan, Kang Jin Jeong, Sunila Pradeep, Andreia Machado Silva, Shuangxing Yu, Wenbin Liu, Tyler Moss, Cristian Rodriguez-Aguayo, Dong Zhang, Prahlad Ram, Jinsong Liu, Yiling Lu, Gabriel Lopez-Berestein, George A Calin, George A Calin, Anil K Sood, Gordon B Mills,

3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome. Importantly, miR551b-3p contributes to resistance to apoptosis and increased survival and proliferation of cancer cells in vitro and in vivo. miR551b-3p upregulates STAT3 protein levels, and STAT3 is required for the effects of miR551b-3p ... Read more >>

Cell Rep (Cell reports)
[2016, 15(7):1493-1504]

Cited: 32 times

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Robust Selection Algorithm (RSA) for Multi-Omic Biomarker Discovery; Integration with Functional Network Analysis to Identify miRNA Regulated Pathways in Multiple Cancers.

Vasudha Sehgal, Elena G Seviour, Tyler J Moss, Gordon B Mills, Robert Azencott, Prahlad T Ram,

MicroRNAs (miRNAs) play a crucial role in the maintenance of cellular homeostasis by regulating the expression of their target genes. As such, the dysregulation of miRNA expression has been frequently linked to cancer. With rapidly accumulating molecular data linked to patient outcome, the need for identification of robust multi-omic molecular ... Read more >>

PLoS One (PloS one)
[2015, 10(10):e0140072]

Cited: 5 times

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The Atlastin C-terminal tail is an amphipathic helix that perturbs the bilayer structure during endoplasmic reticulum homotypic fusion.

Joseph E Faust, Tanvi Desai, Avani Verma, Idil Ulengin, Tzu-Lin Sun, Tyler J Moss, Miguel A Betancourt-Solis, Huey W Huang, Tina Lee, James A McNew,

Fusion of tubular membranes is required to form three-way junctions found in reticular subdomains of the endoplasmic reticulum. The large GTPase Atlastin has recently been shown to drive endoplasmic reticulum membrane fusion and three-way junction formation. The mechanism of Atlastin-mediated membrane fusion is distinct from SNARE-mediated membrane fusion, and many ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2015, 290(8):4772-4783]

Cited: 28 times

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Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.

Pradeep Chaluvally-Raghavan, Fan Zhang, Sunila Pradeep, Mark P Hamilton, Xi Zhao, Rajesha Rupaimoole, Tyler Moss, Yiling Lu, Shuangxing Yu, Chad V Pecot, Miriam R Aure, Sylvain Peuget, Cristian Rodriguez-Aguayo, Hee-Dong Han, Dong Zhang, Avinashnarayan Venkatanarayan, Marit Krohn, Vessela N Kristensen, Mihai Gagea, Prahlad Ram, Wenbin Liu, Gabriel Lopez-Berestein, Philip L Lorenzi, Anne-Lise Børresen-Dale, Koei Chin, Joe Gray, Nelson J Dusetti, Sean E McGuire, Elsa R Flores, Anil K Sood, Gordon B Mills,

Small noncoding miRNAs represent underexplored targets of genomic aberrations and emerging therapeutic targets. The 3q26.2 amplicon is among the most frequent genomic aberrations in multiple cancer lineages including ovarian and breast cancers. We demonstrate that hsa-miR-569 (hereafter designated as miR569), which is overexpressed in a subset of ovarian and breast ... Read more >>

Cancer Cell (Cancer cell)
[2014, 26(6):863-879]

Cited: 21 times

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Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks.

Hua-Sheng Chiu, David Llobet-Navas, Xuerui Yang, Wei-Jen Chung, Alberto Ambesi-Impiombato, Archana Iyer, Hyunjae Ryan Kim, Elena G Seviour, Zijun Luo, Vasudha Sehgal, Tyler Moss, Yiling Lu, Prahlad Ram, José Silva, Gordon B Mills, Andrea Califano, Pavel Sumazin,

We introduce a method for simultaneous prediction of microRNA-target interactions and their mediated competitive endogenous RNA (ceRNA) interactions. Using high-throughput validation assays in breast cancer cell lines, we show that our integrative approach significantly improves on microRNA-target prediction accuracy as assessed by both mRNA and protein level measurements. Our biochemical ... Read more >>

Genome Res (Genome research)
[2015, 25(2):257-267]

Cited: 46 times

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Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.

Lifeng Yang, Tyler Moss, Lingegowda S Mangala, Juan Marini, Hongyun Zhao, Stephen Wahlig, Guillermo Armaiz-Pena, Dahai Jiang, Abhinav Achreja, Julia Win, Rajesha Roopaimoole, Cristian Rodriguez-Aguayo, Imelda Mercado-Uribe, Gabriel Lopez-Berestein, Jinsong Liu, Takashi Tsukamoto, Anil K Sood, Prahlad T Ram, Deepak Nagrath,

Glutamine can play a critical role in cellular growth in multiple cancers. Glutamine-addicted cancer cells are dependent on glutamine for viability, and their metabolism is reprogrammed for glutamine utilization through the tricarboxylic acid (TCA) cycle. Here, we have uncovered a missing link between cancer invasiveness and glutamine dependence. Using isotope ... Read more >>

Mol Syst Biol (Molecular systems biology)
[2014, 10:728]

Cited: 113 times

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Palmoplantar keratoderma with progressive gingivitis and recurrent pyodermas.

Tyler A Moss, Anne P Spillane, Sam F Almquist, Patrick E McCleskey, Oliver J Wisco,

Papillon-Lefèvre syndrome (PLS) is a rare inherited palmoplantar keratoderma (PPK) that is associated with progressive gingivitis and recurrent pyodermas. We present a case exhibiting classic features of this autosomal-recessive condition and review the current understanding of its pathophysiology, diagnosis, and treatment. Additionally, a review of pertinent transgredient PPKs is undertaken, ... Read more >>

Cutis (Cutis)
[2014, 93(4):193-198]

Cited: 3 times

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A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.

Taichiro Nishikawa, Nadège Bellance, Aaron Damm, Han Bing, Zhen Zhu, Kan Handa, Mladen I Yovchev, Vasudha Sehgal, Tyler J Moss, Michael Oertel, Prahlad T Ram, Iraklis I Pipinos, Alejandro Soto-Gutierrez, Ira J Fox, Deepak Nagrath,

<h4>Background & aims</h4>The cause of hepatic failure in the terminal stages of chronic injury is unknown. Cellular metabolic adaptations in response to the microenvironment have been implicated in cellular breakdown.<h4>Methods</h4>To address the role of energy metabolism in this process we studied mitochondrial number, respiration, and functional reserve, as well as ... Read more >>

J Hepatol (Journal of hepatology)
[2014, 60(6):1203-1211]

Cited: 40 times

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In Arabidopsis, the spatial and dynamic organization of the endoplasmic reticulum and Golgi apparatus is influenced by the integrity of the C-terminal domain of RHD3, a non-essential GTPase.

Giovanni Stefano, Luciana Renna, Tyler Moss, James A McNew, Federica Brandizzi,

The mechanisms underlying the organization and dynamics of plant endomembranes are largely unknown. Arabidopsis RHD3, a distant member of the dynamin superfamily, has recently been implicated in plant ER morphology and Golgi movement through analyses of dominant-negative mutants of the putative GTPase domain in a heterologous system. Whether RHD3 is ... Read more >>

Plant J (The Plant journal : for cell and molecular biology)
[2012, 69(6):957-966]

Cited: 36 times

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The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells.

Kakajan Komurov, Jen-Te Tseng, Melissa Muller, Elena G Seviour, Tyler J Moss, Lifeng Yang, Deepak Nagrath, Prahlad T Ram,

Dynamic interactions between intracellular networks regulate cellular homeostasis and responses to perturbations. Targeted therapy is aimed at perturbing oncogene addiction pathways in cancer, however, development of acquired resistance to these drugs is a significant clinical problem. A network-based computational analysis of global gene expression data from matched sensitive and acquired ... Read more >>

Mol Syst Biol (Molecular systems biology)
[2012, 8:596]

Cited: 61 times

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Alopecia with perifollicular papules and pustules.

Tyler A Moss, Thomas M Beachkofsky, Samuel F Almquist, Oliver J Wisco, Michael R Murchland,

J Fam Pract (The Journal of family practice)
[2011, 60(2):95-98]

Cited: 0 times

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GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusion.

Diana Pendin, Jessica Tosetto, Tyler J Moss, Camilla Andreazza, Stefano Moro, James A McNew, Andrea Daga,

The mechanisms governing atlastin-mediated membrane fusion are unknown. Here we demonstrate that a three-helix bundle (3HB) within the middle domain is required for oligomerization. Mutation of core hydrophobic residues within these helices inactivates atlastin function by preventing membrane tethering and the subsequent fusion. GTP binding induces a conformational change that ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2011, 108(39):16283-16288]

Cited: 19 times

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SNARE proteins are required for macroautophagy.

Usha Nair, Anjali Jotwani, Jiefei Geng, Noor Gammoh, Diana Richerson, Wei-Lien Yen, Janice Griffith, Shanta Nag, Ke Wang, Tyler Moss, Misuzu Baba, James A McNew, Xuejun Jiang, Fulvio Reggiori, Thomas J Melia, Daniel J Klionsky,

Macroautophagy mediates the degradation of long-lived proteins and organelles via the de novo formation of double-membrane autophagosomes that sequester cytoplasm and deliver it to the vacuole/lysosome; however, relatively little is known about autophagosome biogenesis. Atg8, a phosphatidylethanolamine-conjugated protein, was previously proposed to function in autophagosome membrane expansion, based on the ... Read more >>

Cell (Cell)
[2011, 146(2):290-302]

Cited: 245 times

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