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Author Tun Jie

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Cell intrinsic signaling in MEN1 mutant pancreatic neuroendocrine tumors unveils novel signaling pathways associated with de-differentiation

Brenna Rheinheimer, Ronald Heimark, Adam Grant, Luis Camacho, Megha Padi, Tun Jie,

Abstract Objectives Preliminary genomic analysis of primary pancreatic neuroendocrine tumors revealed a complex mutational landscape with four common oncogenic events; however, critical activation pathways responsible for pancreatic neuroendocrine tumor progression and metastasis have yet to be elucidated. Here, we analyzed six primary pancreatic neuroendocrine tumors to determine which pathways are ... Read more >>

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Inhibition of Sphingosine-1-Phosphate signaling in pancreatic ductal adenocarcinoma leads to downregulation of growth and invasion

Brenna Rheinheimer, Alex Cardenas, Luis Camacho, Evan Ong, Tun Jie, Ronald Heimark,

Abstract Background Deregulated phosphorylation of sphingosine by the sphingosine kinases and signaling through the EDG family of receptors enhances growth and survival in many cell types. Therefore, we sought to elucidate the effect of alterations in the ceramide/sphingosine/S1P rheostat on driving human pancreatic ductal adenocarcinoma towards a malignant phenotype. Methods ... Read more >>

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A Primer on Machine Learning.

Audrene S Edwards, Bruce Kaplan, Tun Jie,

Transplantation (Transplantation)
[2020, :]

Cited: 0 times

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Neoadjuvant Chemoradiation Therapy Is Associated with Adverse Outcomes in Patients Undergoing Pancreaticoduodenectomy for Pancreatic Cancer.

Hassan Aziz, Muhammad Zeeshan, Tun Jie, Felipe B Maegawa,

The use of neoadjuvant chemoradiation therapy in patients with pancreatic adenocarcinoma is emerging as an acceptable therapy option. The effects of neoadjuvant therapy on 30 days' outcomes in patients with pancreatic cancer are not well defined in the literature. NSQIP (2009-2012) was used. Only patients with a diagnosis of pancreatic ... Read more >>

Am Surg (The American surgeon)
[2019, 85(11):1276-1280]

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Transfer of peanut allergy from donor to recipient after liver transplant.

Avin Aggarwal, Rilwan Balogun, Tara F Carr, Archita P Desai, Tun Jie, Jen-Jung Pan,

31 years old female with a history of contact dermatitis, eczema, allergic rhinitis, pernicious anemia, alopecia areata and latent tuberculosis was treated concurrently with methotrexate along with isoniazid and pyridoxine. Five months into the therapy she developed acute onset jaundice progressing into fulminant liver failure with altered mentation and worsening ... Read more >>

Ann Hepatol (Annals of hepatology)
[2019, 18(3):508-513]

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Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Amanda Ruiz, Jared Sivinski, Sejin Chung, Adam Grant, Paris Vail, Shailender S Chauhan, Tun Jie, Taylor S Riall, Agnieszka K Witkiewicz,

Pancreatic ductal adenocarcinoma (PDAC), like many KRAS-driven tumors, preferentially loses CDKN2A that encodes an endogenous CDK4/6 inhibitor to bypass the RB-mediated cell cycle suppression. Analysis of a panel of patient-derived cell lines and matched xenografts indicated that many pancreatic cancers have intrinsic resistance to CDK4/6 inhibition that is not due ... Read more >>

Oncogene (Oncogene)
[2019, 38(18):3355-3370]

Cited: 5 times

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Association Between Noninvasive Fibrosis Markers and Postoperative Mortality After Hepatectomy for Hepatocellular Carcinoma.

Felipe B Maegawa, Lauren Shehorn, Hassan Aziz, John Kettelle, Tun Jie, Taylor S Riall,

Importance:The selection criteria for hepatectomy for hepatocellular carcinoma (HCC) is not well established. The role of noninvasive fibrosis markers in this setting is unknown in the US population. Objective:To evaluate whether aspartate aminotransferase-platelet ratio index (APRI) and fibrosis 4 (Fib4) values are associated with perioperative mortality and overall survival after ... Read more >>

JAMA Netw Open (JAMA network open)
[2019, 2(1):e187142]

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Transmission of Balamuthia mandrillaris by Organ Transplantation.

Eileen C Farnon, Kenneth E Kokko, Philip J Budge, Chukwuma Mbaeyi, Emily C Lutterloh, Yvonne Qvarnstrom, Alexandre J da Silva, Wun-Ju Shieh, Sharon L Roy, Christopher D Paddock, Rama Sriram, Sherif R Zaki, Govinda S Visvesvara, Matthew J Kuehnert, , Joli Weiss, Ken Komatsu, Richard Manch, Alberto Ramos, Leonor Echeverria, Ann Moore, Phil Zakowski, Michelle Kittleson, Jon Kobashigawa, Jonathan Yoder, Michael Beach, William Mahle, Kirk Kanter, P J Geraghty, Eileen Navarro, Christine Hahn, Shiro Fujita, Jim Stinson, Joel Trachtenberg, Paul Byers, Michele Cheung, Tun Jie, Bruce Kaplan, Rainer Gruessner, Erica Bracamonte, Chad Viscusi, Regino Gonzalez-Peralta, Robert Lawrence, Jonathan Fratkin, Fauzia Butt,

BACKGROUND:During 2009 and 2010, 2 clusters of organ transplant-transmitted Balamuthia mandrillaris, a free-living ameba, were detected by recognition of severe unexpected illness in multiple recipients from the same donor. METHODS:We investigated all recipients and the 2 donors through interview, medical record review, and testing of available specimens retrospectively. Surviving recipients ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2016, 63(7):878-888]

Cited: 8 times

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Erratum to: Age and Obesity are Independent Predictors of Bile Duct Injuries in Patients Undergoing Laparoscopic Cholecystectomy.

Hassan Aziz, Viraj Pandit, Bellal Joseph, Tun Jie, Evan Ong,

World J Surg (World journal of surgery)
[2015, 39(7):1809]

Cited: 1 time

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Nuclear Myocardial Perfusion Imaging Versus Stress Echocardiography in the Preoperative Evaluation of Patients for Kidney Transplantation.

Janice N Thai, Aiden Abidov, Tun Jie, Elizabeth A Krupinski, Phillip H Kuo,

The goal of this study was to evaluate the diagnostic accuracy, cost-effectiveness, and appropriate use of SPECT myocardial perfusion imaging (SMPI) versus stress echocardiography in the preoperative evaluation of patients for kidney transplantation.A single-institution, retrospective study was performed. SMPI was performed with regadenoson and stress echocardiography predominantly with dobutamine. Findings ... Read more >>

J Nucl Med Technol (Journal of nuclear medicine technology)
[2015, 43(3):201-205]

Cited: 2 times

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Age and Obesity are Independent Predictors of Bile Duct Injuries in Patients Undergoing Laparoscopic Cholecystectomy.

Hassan Aziz, Viraj Pandit, Bellal Joseph, Tun Jie, Evan Ong,

Iatrogenic bile duct injury is a serious complication of cholecystectomy. The aim of this study was to assess predictors of bile duct injury using a national database.The Nationwide Inpatient Sample (2010-2012) was queried for laparoscopic cholecystectomy. We used a) diagnoses for bile duct injury and b) bile duct injury repair ... Read more >>

World J Surg (World journal of surgery)
[2015, 39(7):1804-1808]

Cited: 6 times

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Magnetic resonance imaging: a tool to monitor and optimize enzyme distribution during porcine pancreas distention for islet isolation.

William E Scott, Bradley P Weegman, Appakalai N Balamurugan, Joana Ferrer-Fabrega, Takayuki Anazawa, Theodore Karatzas, Tun Jie, Bruce E Hammer, Shuchiro Matsumoto, Efstathios S Avgoustiniatos, Kristen S Maynard, David E R Sutherland, Bernhard J Hering, Klearchos K Papas,

Porcine islet xenotransplantation is emerging as a potential alternative for allogeneic clinical islet transplantation. Optimization of porcine islet isolation in terms of yield and quality is critical for the success and cost-effectiveness of this approach. Incomplete pancreas distention and inhomogeneous enzyme distribution have been identified as key factors for limiting ... Read more >>

Xenotransplantation (Xenotransplantation)
[2014, 21(5):473-479]

Cited: 1 time

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Colon and pancreas tumors enhance coagulation: role of hemeoxygenase-1.

Vance G Nielsen, Valentine N Nfonsam, Ryan W Matika, Evan S Ong, Tun Jie, James A Warneke, Evangelina B Steinbrenner,

Colon and pancreatic cancer are associated with significant thrombophilia. Colon and pancreas tumor cells have an increase in hemeoxygenase-1 (HO-1) activity, the endogenous enzyme responsible for carbon monoxide production. Given that carbon monoxide enhances plasmatic coagulation, we determined if patients undergoing resection of colon and pancreatic tumors had an increase ... Read more >>

Blood Coagul Fibrinolysis (Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis)
[2014, 25(5):435-438]

Cited: 3 times

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Temperature profiles of different cooling methods in porcine pancreas procurement.

Bradley P Weegman, Thomas M Suszynski, William E Scott, Joana Ferrer Fábrega, Efstathios S Avgoustiniatos, Takayuki Anazawa, Timothy D O'Brien, Michael D Rizzari, Theodore Karatzas, Tun Jie, David E R Sutherland, Bernhard J Hering, Klearchos K Papas,

Porcine islet xenotransplantation is a promising alternative to human islet allotransplantation. Porcine pancreas cooling needs to be optimized to reduce the warm ischemia time (WIT) following donation after cardiac death, which is associated with poorer islet isolation outcomes. This study examines the effect of four different cooling Methods on core ... Read more >>

Xenotransplantation (Xenotransplantation)
[2014, 21(6):574-581]

Cited: 4 times

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Tissue-type plasminogen activator-induced fibrinolysis is enhanced in patients with breast, lung, pancreas and colon cancer.

Vance G Nielsen, Ryan W Matika, Michele L B Ley, Amy L Waer, Farid Gharagozloo, Samuel Kim, Valentine N Nfonsam, Evan S Ong, Tun Jie, James A Warneke, Evangelina B Steinbrenner,

Although cancer-mediated changes in hemostatic proteins unquestionably promote hypercoagulation, the effects of neoplasia on fibrinolysis in the circulation are less well defined. The goals of the present investigation were to determine if plasma obtained from patients with breast, lung, pancreas and colon cancer was less or more susceptible to lysis ... Read more >>

Blood Coagul Fibrinolysis (Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis)
[2014, 25(3):248-253]

Cited: 4 times

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Gallstone pancreatitis: a review.

Daniel Cucher, Narong Kulvatunyou, Donald J Green, Tun Jie, Evan S Ong,

Gallstone disease is the most common cause of acute pancreatitis in the Western world. In most cases, gallstone pancreatitis is a mild and self-limiting disease, and patients may proceed without complications to cholecystectomy to prevent future recurrence. Severe disease occurs in about 20% of cases and is associated with significant ... Read more >>

Surg Clin North Am (The Surgical clinics of North America)
[2014, 94(2):257-280]

Cited: 9 times

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Early liver retransplantation in adults.

Abbas Rana, Henrik Petrowsky, Bruce Kaplan, Tun Jie, Marian Porubsky, Shahid Habib, Horacio Rilo, Angelika C Gruessner, Rainer W G Gruessner,

Up to 23% of liver allografts fail post-transplant. Retransplantation is only the recourse but remains controversial due to inferior outcomes. The objective of our study was to identify high-risk periods for retransplantation and then compare survival outcomes and risk factors. We performed an analysis of United Network for Organ Sharing ... Read more >>

Transpl Int (Transplant international : official journal of the European Society for Organ Transplantation)
[2014, 27(2):141-151]

Cited: 10 times

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Recognition of complications after pancreaticoduodenectomy for cancer determines inpatient mortality.

Evan S Glazer, Albert Amini, Tun Jie, Rainer W G Gruessner, Robert S Krouse, Evan S Ong,

CONTEXT: While perioperative mortality after pancreaticoduodenectomy is decreasing, key factors remain to be elucidated. OBJECTIVE: The purpose of this study was to investigate inpatient mortality after pancreaticoduodenectomy in the Nationwide Inpatient Sample (NIS), a representative inpatient database in the USA. METHODS: Patient discharge data (diagnostic and procedure codes) and hospital ... Read more >>

JOP (JOP : Journal of the pancreas)
[2013, 14(6):626-631]

Cited: 8 times

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Panresistant cytomegalovirus in a kidney transplant recipient.

Sarah E Yost, Angela Echeverria, Tun Jie, Bruce Kaplan,

Cytomegalovirus (CMV) is an important pathogen often encountered after solid organ transplantation and is associated with increased morbidity and mortality. Resistance of CMV to antiviral agents is becoming more common but with few treatment strategies. Two specific mutations in the CMV genome--the UL97 and UL54 genes--correlate with antiviral drug resistance. ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2014, 34(1):e1-3]

Cited: 0 times

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A critical analysis of early death after adult liver transplants.

Abbas Rana, Bruce Kaplan, Tun Jie, Marian Porubsky, Shahid Habib, Horacio Rilo, Angelika C Gruessner, Rainer W G Gruessner,

INTRODUCTION: The 15% mortality rate of liver transplant recipients at one yr may be viewed as a feat in comparison with the waiting list mortality, yet it nonetheless leaves room for much improvement. Our aim was to critically examine the mortality rates to identify high-risk periods and to incorporate cause ... Read more >>

Clin Transplant (Clinical transplantation)
[2013, 27(4):E448-53]

Cited: 4 times

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The survival outcomes following liver transplantation (SOFT) score: validation with contemporaneous data and stratification of high-risk cohorts.

Abbas Rana, Tun Jie, Marian Porubsky, Shahid Habib, Horacio Rilo, Bruce Kaplan, Angelika Gruessner, Rainer Gruessner,

Models to project survival after liver transplantation are important to optimize outcomes. We introduced the survival outcomes following liver transplantation (SOFT) score in 2008 (1) and designed to predict survival in liver recipients at three months post-transplant with a C statistic of 0.70. Our objective was to validate the SOFT ... Read more >>

Clin Transplant (Clinical transplantation)
[2013, 27(4):627-632]

Cited: 14 times

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Robotic-assisted cystogastrostomy for a patient with a pancreatic pseudocyst.

Alex Cardenas, Andrew Abrams, Evan Ong, Tun Jie,

Pancreatic pseudocysts are generally treated by endoscopic cystogastrostomy. However, difficult cases involving abscess, necrosis, or risk of hemorrhage often require surgical intervention. Here, we report a case of a robotically assisted cystogastrostomy. The patient presented with an infected pseudocyst with adjacent varices. Use of the da Vinci Surgical System allowed ... Read more >>

J Robot Surg (Journal of robotic surgery)
[2014, 8(2):181-184]

Cited: 2 times

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Effect of epidural analgesia on postoperative complications following pancreaticoduodenectomy.

Albert Amini, Asad E Patanwala, Felipe B Maegawa, Grant H Skrepnek, Tun Jie, Rainer W Gruessner, Evan S Ong,

BACKGROUND: The purpose of this study was to evaluate the effect of epidural analgesia use on postoperative complications in patients undergoing pancreaticoduodenectomy. METHODS: This retrospective cohort study used the 2009 Nationwide Inpatient Sample from the Agency for Healthcare Research and Quality. Patients who underwent pancreaticoduodenectomy were grouped on the basis ... Read more >>

Am. J. Surg. (American journal of surgery)
[2012, 204(6):1000-4; discussion 1004-6]

Cited: 21 times

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MRI prediction of islet yield for autologous transplantation after total pancreatectomy for chronic pancreatitis.

Khalid M Khan, Chirag S Desai, Bobby Kalb, Charmi Patel, Brianna M Grigsby, Tun Jie, Rainer W G Gruessner, Horacio Rodriguez-Rilo,

OBJECTIVE: The relationship between magnetic resonance imaging (MRI), histopathology, and islet yield was examined for chronic pancreatitis patients undergoing total pancreatectomy and autologous islet cell transplant (TP-AIT) to determine if the yield can be predicted by pre-operative MRI. METHODS: MRI sequences and histopathology were scored and compared for patients from ... Read more >>

Dig. Dis. Sci. (Digestive diseases and sciences)
[2013, 58(4):1116-1124]

Cited: 9 times

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Single-incision robotic-assisted living donor nephrectomy: case report and description of surgical technique.

Carlos A Galvani, Ulises Garza, Marcie Leeds, Amit Kaul, Angela Echeverria, Chirag S Desai, Tun Jie, Robert Diana, Rainer W G Gruessner,

The introduction of laparoscopic surgery, and more recently of robotics, has increased the number of living donor kidney transplants. This approach has already improved living donor acceptance rates. Even newer developments in the field have now been introduced with the purpose of further reducing postoperative pain and length of hospital ... Read more >>

Transpl. Int. (Transplant international : official journal of the European Society for Organ Transplantation)
[2012, 25(8):e89-92]

Cited: 7 times

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