Full Text Journal Articles by
Author Tsukasa Sanosaka

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SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia.

Jun Takouda, Sayako Katada, Takuya Imamura, Tsukasa Sanosaka, Kinichi Nakashima,

The brain consists of three major cell types: neurons and two glial cell types (astrocytes and oligodendrocytes). Although they are generated from common multipotent neural stem/precursor cells (NS/PCs), embryonic NS/PCs cannot generate all of the cell types at the beginning of brain development. NS/PCs first undergo extensive self-renewal to expand ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00749]

Cited: 1 time

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Comparative analyses of gene expression in common marmoset and human pluripotent stem cells (PSCs) identify factors enhancing homologous recombination efficiency in the HPRT locus of human PSCs

Sho Yoshimatsu, Mayutaka Nakajima, Tsukasa Sanosaka, Tsukika Sato, Hideyuki Okano,

A previous study assessing the efficiency of the genome editing technology CRISPR-Cas9 for knock-in gene targeting in common marmoset (marmoset; Callithrix jacchus ) embryonic stem cells (ESCs) unexpectedly identified innately enhanced homologous recombination (HR) activity in marmoset ESCs (cmESCs). Here, we compared gene expression in marmoset and human pluripotent stem ... Read more >>

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Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species.

Sho Yoshimatsu, Mayutaka Nakajima, Aozora Iguchi, Tsukasa Sanosaka, Tsukika Sato, Mari Nakamura, Ryusuke Nakajima, Eri Arai, Mitsuru Ishikawa, Kent Imaizumi, Hirotaka Watanabe, Junko Okahara, Toshiaki Noce, Yuta Takeda, Erika Sasaki, Rüdiger Behr, Kazuya Edamura, Seiji Shiozawa, Hideyuki Okano,

Induced pluripotent stem cells (iPSCs) are capable of providing an unlimited source of cells from all three germ layers and germ cells. The derivation and usage of iPSCs from various animal models may facilitate stem cell-based therapy, gene-modified animal production, and evolutionary studies assessing interspecies differences. However, there is a ... Read more >>

Stem Cell Reports (Stem cell reports)
[2021, 16(4):754-770]

Cited: 1 time

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A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury.

Yasuhiro Kamata, Miho Isoda, Tsukasa Sanosaka, Reo Shibata, Shuhei Ito, Toshiki Okubo, Munehisa Shinozaki, Mitsuhiro Inoue, Ikuko Koya, Shinsuke Shibata, Tomoko Shindo, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano, Narihito Nagoshi, Jun Kohyama,

Cell-based therapy targeting spinal cord injury (SCI) is an attractive approach to promote functional recovery by replacing damaged tissue. We and other groups have reported the effectiveness of transplanting neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) in SCI animal models for neuronal replacement. Glial replacement ... Read more >>

Stem Cells Transl Med (Stem cells translational medicine)
[2021, 10(3):398-413]

Cited: 4 times

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Single-cell study of neural stem cells derived from human iPSCs reveals distinct progenitor populations with neurogenic and gliogenic potential.

Matti Lam, Tsukasa Sanosaka, Anders Lundin, Kent Imaizumi, Damla Etal, Fredrik H Karlsson, Maryam Clausen, Jonathan Cairns, Ryan Hicks, Jun Kohyama, Malin Kele, Hideyuki Okano, Anna Falk,

We used single-cell RNA sequencing (seq) on several human induced pluripotent stem (iPS) cell-derived neural stem cell (NSC) lines and one fetal brain-derived NSC line to study inherent cell type heterogeneity at proliferating neural stem cell stage and uncovered predisposed presence of neurogenic and gliogenic progenitors. We observed heterogeneity in ... Read more >>

Genes Cells (Genes to cells : devoted to molecular & cellular mechanisms)
[2019, 24(12):836-847]

Cited: 4 times

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Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression.

Hiroko Nakatsukasa, Mayumi Oda, Jinghua Yin, Shunsuke Chikuma, Minako Ito, Mana Koga-Iizuka, Kazue Someya, Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi, Ikuko Koya, Tsukasa Sanosaka, Jun Kohyama, Yu-Ichi Tsukada, Soichiro Yamanaka, Takeji Takamura-Enya, Qianjin Lu, Akihiko Yoshimura,

Ten-eleven translocation (TET) proteins regulate DNA methylation and gene expression by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Although Tet2/Tet3 deficiency has been reported to lead to myeloid cell, B-cell and invariant natural killer T (iNKT) cell malignancy, the effect of TET on regulatory T cells (Tregs) has not been elucidated. ... Read more >>

Int Immunol (International immunology)
[2019, 31(5):335-347]

Cited: 18 times

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Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain.

Yoichiro Kawamura, Sayako Katada, Hirofumi Noguchi, Hiroyuki Yamamoto, Tsukasa Sanosaka, Koji Iihara, Kinichi Nakashima,

Astrocytes, which support diverse neuronal functions, are generated from multipotent neural stem/precursor cells (NS/PCs) during brain development. Although many astrocyte-inducing factors have been identified and studied in vitro, the regions and/or cells that produce these factors in the developing brain remain elusive. Here, we show that meninges-produced factors induce astrocytic differentiation ... Read more >>

FEBS Lett (FEBS letters)
[2017, 591(22):3709-3720]

Cited: 4 times

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Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors.

MuhChyi Chai, Tsukasa Sanosaka, Hironobu Okuno, Zhi Zhou, Ikuko Koya, Satoe Banno, Tomoko Andoh-Noda, Yoshikuni Tabata, Rieko Shimamura, Tetsutaro Hayashi, Masashi Ebisawa, Yohei Sasagawa, Itoshi Nikaido, Hideyuki Okano, Jun Kohyama,

Multiple congenital disorders often present complex phenotypes, but how the mutation of individual genetic factors can lead to multiple defects remains poorly understood. In the present study, we used human neuroepithelial (NE) cells and CHARGE patient-derived cells as an in vitro model system to identify the function of chromodomain helicase ... Read more >>

Genes Dev (Genes & development)
[2018, 32(2):165-180]

Cited: 10 times

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CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations.

Hironobu Okuno, Francois Renault Mihara, Shigeki Ohta, Kimiko Fukuda, Kenji Kurosawa, Wado Akamatsu, Tsukasa Sanosaka, Jun Kohyama, Kanehiro Hayashi, Kazunori Nakajima, Takao Takahashi, Joanna Wysocka, Kenjiro Kosaki, Hideyuki Okano,

CHARGE syndrome is caused by heterozygous mutations in the chromatin remodeler, <i>CHD7,</i> and is characterized by a set of malformations that, on clinical grounds, were historically postulated to arise from defects in neural crest formation during embryogenesis. To better delineate neural crest defects in CHARGE syndrome, we generated induced pluripotent ... Read more >>

Elife (eLife)
[2017, 6:]

Cited: 22 times

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DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells.

Tsukasa Sanosaka, Takuya Imamura, Nobuhiko Hamazaki, MuhChyi Chai, Katsuhide Igarashi, Maky Ideta-Otsuka, Fumihito Miura, Takashi Ito, Nobuyuki Fujii, Kazuho Ikeo, Kinichi Nakashima,

Regulation of the epigenome during in vivo specification of brain stem cells is still poorly understood. Here, we report DNA methylome analyses of directly sampled cortical neural stem and progenitor cells (NS/PCs) at different development stages, as well as those of terminally differentiated cortical neurons, astrocytes, and oligodendrocytes. We found that sequential specification ... Read more >>

Cell Rep (Cell reports)
[2017, 20(12):2992-3003]

Cited: 13 times

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Whole-Genome DNA Methylation Analyses Revealed Epigenetic Instability in Tumorigenic Human iPS Cell-Derived Neural Stem/Progenitor Cells.

Tsuyoshi Iida, Akio Iwanami, Tsukasa Sanosaka, Jun Kohyama, Hiroyuki Miyoshi, Narihito Nagoshi, Rei Kashiwagi, Yoshiaki Toyama, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano,

Although human induced pluripotent stem cell (hiPSC) derivatives are considered promising cellular resources for regenerative medicine, their tumorigenicity potentially limits their clinical application in hiPSC technologies. We previously demonstrated that oncogenic hiPSC-derived neural stem/progenitor cells (hiPSC-NS/PCs) produced tumor-like tissues that were distinct from teratomas. To gain insight into the mechanisms ... Read more >>

Stem Cells (Stem cells (Dayton, Ohio))
[2017, 35(5):1316-1327]

Cited: 14 times

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Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader-Willi syndrome.

Hironobu Okuno, Kazuhiko Nakabayashi, Kousei Abe, Takayuki Ando, Tsukasa Sanosaka, Jun Kohyama, Wado Akamatsu, Manabu Ohyama, Takao Takahashi, Kenjiro Kosaki, Hideyuki Okano,

Prader-Will syndrome (PWS) is characterized by hyperphagia, growth hormone deficiency and central hypogonadism caused by the dysfunction of the hypothalamus. Patients with PWS present with methylation abnormalities of the PWS-imprinting control region in chromosome 15q11.2, subject to parent-of-origin-specific methylation and controlling the parent-of-origin-specific expression of other paternally expressed genes flanking ... Read more >>

Congenit Anom (Kyoto) (Congenital anomalies)
[2017, 57(4):96-103]

Cited: 5 times

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Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions.

Miho Isoda, Jun Kohyama, Akio Iwanami, Tsukasa Sanosaka, Keiko Sugai, Ryo Yamaguchi, Takuya Matsumoto, Masaya Nakamura, Hideyuki Okano,

Neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) are expected to be a valuable cell source for cell therapies that target central nervous system disorders. For clinical applications, NS/PCs should be induced and maintained under clinical grade conditions, which are challenging to achieve. In the present ... Read more >>

Neurosci Res (Neuroscience research)
[2016, 110:18-28]

Cited: 9 times

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Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation.

Kenji Ito, Tsukasa Sanosaka, Katsuhide Igarashi, Maky Ideta-Otsuka, Akira Aizawa, Yuichi Uosaki, Azumi Noguchi, Hirokazu Arakawa, Kinichi Nakashima, Takumi Takizawa,

Chromosomes and genes are non-randomly arranged within the mammalian cell nucleus, and gene clustering is of great significance in transcriptional regulation. However, the relevance of gene clustering and their expression during the differentiation of neural precursor cells (NPCs) into astrocytes remains unclear. We performed a genome-wide enhanced circular chromosomal conformation ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:23903]

Cited: 11 times

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Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid.

Berry Juliandi, Kentaro Tanemura, Katsuhide Igarashi, Takashi Tominaga, Yusuke Furukawa, Maky Otsuka, Noriko Moriyama, Daigo Ikegami, Masahiko Abematsu, Tsukasa Sanosaka, Keita Tsujimura, Minoru Narita, Jun Kanno, Kinichi Nakashima,

Prenatal exposure to valproic acid (VPA), an established antiepileptic drug, has been reported to impair postnatal cognitive function in children born to VPA-treated epileptic mothers. However, how these defects arise and how they can be overcome remain unknown. Using mice, we found that comparable postnatal cognitive functional impairment is very ... Read more >>

Stem Cell Reports (Stem cell reports)
[2015, 5(6):996-1009]

Cited: 29 times

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Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.

Tomoko Andoh-Noda, Wado Akamatsu, Kunio Miyake, Takuya Matsumoto, Ryo Yamaguchi, Tsukasa Sanosaka, Yohei Okada, Tetsuro Kobayashi, Manabu Ohyama, Kinichi Nakashima, Hiroshi Kurosawa, Takeo Kubota, Hideyuki Okano,

<h4>Background</h4>Rett syndrome (RTT) is one of the most prevalent neurodevelopmental disorders in females, caused by de novo mutations in the X-linked methyl CpG-binding protein 2 gene, MECP2. Although abnormal regulation of neuronal genes due to mutant MeCP2 is thought to induce autistic behavior and impaired development in RTT patients, precise ... Read more >>

Mol Brain (Molecular brain)
[2015, 8:31]

Cited: 42 times

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Prenatal exposure to suberoylanilide hydroxamic acid perturbs corticogenesis.

Nunung Yuniarti, Berry Juliandi, Chai MuhChyi, Hirofumi Noguchi, Tsukasa Sanosaka, Kinichi Nakashima,

Suberoylanilide hydroxamic acid (SAHA) is one of the epidrugs developed for cancer treatment that works epigenetically by inhibiting histone deacetylases (HDACs). SAHA has been reported to diffuse across the placenta and found in fetal plasma in preclinical study, implying that it can influence fetus if taken by pregnant cancer patients. ... Read more >>

Neurosci Res (Neuroscience research)
[2013, 77(1-2):42-49]

Cited: 3 times

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Chromatin accessibility at a STAT3 target site is altered prior to astrocyte differentiation.

Satoshi Urayama, Katsunori Semi, Tsukasa Sanosaka, Yukina Hori, Masakazu Namihira, Jun Kohyama, Takumi Takizawa, Kinichi Nakashima,

DNA demethylation of astrocyte-specific gene promoters and STAT3 activation in neural precursor cells (NPCs) are essential for astrogliogenesis in the developing brain. To date, it remains unclear whether DNA methylation is the sole epigenetic determinant responsible for suppressing astrocyte-specific genes. Here, we used mouse embryonic stem cells (TKO ESCs) that ... Read more >>

Cell Struct Funct (Cell structure and function)
[2013, 38(1):55-66]

Cited: 22 times

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Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells.

Yusuke Fujimoto, Masahiko Abematsu, Anna Falk, Keita Tsujimura, Tsukasa Sanosaka, Berry Juliandi, Katsunori Semi, Masakazu Namihira, Setsuro Komiya, Austin Smith, Kinichi Nakashima,

Because of their ability to self-renew, to differentiate into multiple lineages, and to migrate toward a damaged site, neural stem cells (NSCs), which can be derived from various sources such as fetal tissues and embryonic stem cells, are currently considered to be promising components of cell replacement strategies aimed at ... Read more >>

Stem Cells (Stem cells (Dayton, Ohio))
[2012, 30(6):1163-1173]

Cited: 133 times

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Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation.

Atsushi Saito, Soshi Kanemoto, Noritaka Kawasaki, Rie Asada, Hideo Iwamoto, Mami Oki, Hidetaka Miyagi, Soutarou Izumi, Tsukasa Sanosaka, Kinichi Nakashima, Kazunori Imaizumi,

OASIS is a member of the CREB/ATF family of transcription factors and modulates cell- or tissue-specific unfolded protein response signalling. Here we show that this modulation has a critical role in the differentiation of neural precursor cells into astrocytes. Cerebral cortices of mice specifically deficient in OASIS (Oasis(-/-)) contain fewer ... Read more >>

Nat Commun (Nature communications)
[2012, 3:967]

Cited: 38 times

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Oxygen levels epigenetically regulate fate switching of neural precursor cells via hypoxia-inducible factor 1α-notch signal interaction in the developing brain.

Tetsuji Mutoh, Tsukasa Sanosaka, Kei Ito, Kinichi Nakashima,

Oxygen levels in tissues including the embryonic brain are lower than those in the atmosphere. We reported previously that Notch signal activation induces demethylation of astrocytic genes, conferring astrocyte differentiation ability on midgestational neural precursor cells (mgNPCs). Here, we show that the oxygen sensor hypoxia-inducible factor 1α (HIF1α) plays a ... Read more >>

Stem Cells (Stem cells (Dayton, Ohio))
[2012, 30(3):561-569]

Cited: 22 times

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Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid.

Berry Juliandi, Masahiko Abematsu, Tsukasa Sanosaka, Keita Tsujimura, Austin Smith, Kinichi Nakashima,

Within the developing mammalian cortex, neural progenitors first generate deep-layer neurons and subsequently more superficial-layer neurons, in an inside-out manner. It has been reported recently that mouse embryonic stem cells (mESCs) can, to some extent, recapitulate cortical development in vitro, with the sequential appearance of neurogenesis markers resembling that in ... Read more >>

Neurosci Res (Neuroscience research)
[2012, 72(1):23-31]

Cited: 23 times

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Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb.

Tomoko Kuwabara, Mohamedi N Kagalwala, Yasuko Onuma, Yuzuru Ito, Masaki Warashina, Kazuyuki Terashima, Tsukasa Sanosaka, Kinichi Nakashima, Fred H Gage, Makoto Asashima,

In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB-derived neural stem ... Read more >>

EMBO Mol Med (EMBO molecular medicine)
[2011, 3(12):742-754]

Cited: 52 times

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BMP-induced REST regulates the establishment and maintenance of astrocytic identity.

Jun Kohyama, Tsukasa Sanosaka, Akinori Tokunaga, Eriko Takatsuka, Keita Tsujimura, Hideyuki Okano, Kinichi Nakashima,

Once they have differentiated, cells retain their individual character and repress genes that are specifically expressed in other cell lineages, but how alternative fate choice is restricted during and/or after differentiation remains unclear. In the mammalian central nervous system, neurons, astrocytes, and oligodendrocytes are generated throughout life from common tripotent ... Read more >>

J Cell Biol (The Journal of cell biology)
[2010, 189(1):159-170]

Cited: 46 times

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Astrocyte differentiation of neural precursor cells is enhanced by retinoic acid through a change in epigenetic modification.

Hirotsugu Asano, Makoto Aonuma, Tsukasa Sanosaka, Jun Kohyama, Masakazu Namihira, Kinichi Nakashima,

Neurons, astrocytes, and oligodendrocytes-the three major cell types that comprise the central nervous system-are generated from common multipotent neural precursor cells (NPCs). Members of the interleukin-6 family of cytokines, including leukemia inhibitory factor (LIF), induce astrocyte differentiation of NPCs by activating the transcription factor signal transducer and activator of transcription ... Read more >>

Stem Cells (Stem cells (Dayton, Ohio))
[2009, 27(11):2744-2752]

Cited: 69 times

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