Full Text Journal Articles by
Author Triantafyllia Karakousi

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Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids.

Sarah E LeBoeuf, Warren L Wu, Triantafyllia R Karakousi, Burcu Karadal, S RaElle Jackson, Shawn M Davidson, Kwok-Kin Wong, Sergei B Koralov, Volkan I Sayin, Thales Papagiannakopoulos,

Rewiring of metabolic pathways is a hallmark of tumorigenesis as cancer cells acquire novel nutrient dependencies to support oncogenic growth. A major genetic subtype of lung adenocarcinoma with KEAP1/NRF2 mutations, which activates the endogenous oxidative stress response, undergoes significant metabolic rewiring to support enhanced antioxidant production. We demonstrate that cancers with ... Read more >>

Cell Metab. (Cell metabolism)
[2020, 31(2):339-350.e4]

Cited: 0 times

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Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.

Luca Lignitto, Sarah E LeBoeuf, Harrison Homer, Shaowen Jiang, Manor Askenazi, Triantafyllia R Karakousi, Harvey I Pass, Arjun J Bhutkar, Aristotelis Tsirigos, Beatrix Ueberheide, Volkan I Sayin, Thales Papagiannakopoulos, Michele Pagano,

Approximately 30% of human lung cancers acquire mutations in either Keap1 or Nfe2l2, resulting in the stabilization of Nrf2, the Nfe2l2 gene product, which controls oxidative homeostasis. Here, we show that heme triggers the degradation of Bach1, a pro-metastatic transcription factor, by promoting its interaction with the ubiquitin ligase Fbxo22. ... Read more >>

Cell (Cell)
[2019, 178(2):316-329.e18]

Cited: 4 times

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Association of pesticide exposure with human congenital abnormalities.

Charikleia Kalliora, Charalampos Mamoulakis, Eleni Vasilopoulos, George A Stamatiades, Lydia Kalafati, Roza Barouni, Triantafyllia Karakousi, Mohammad Abdollahi, Aristidis Tsatsakis,

Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and applied pharmacology)
[2018, 346:58-75]

Cited: 1 time

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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.

Volkan I Sayin, Sarah E LeBoeuf, Simranjit X Singh, Shawn M Davidson, Douglas Biancur, Betul S Guzelhan, Samantha W Alvarez, Warren L Wu, Triantafyllia R Karakousi, Anastasia Maria Zavitsanou, Julian Ubriaco, Alexander Muir, Dimitris Karagiannis, Patrick J Morris, Craig J Thomas, Richard Possemato, Matthew G Vander Heiden, Thales Papagiannakopoulos,

During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathway, which promotes tumor cell growth. Despite the extensive characterization of NRF2-driven metabolic rewiring, little is known about ... Read more >>

Elife (eLife)
[2017, 6:]

Cited: 19 times

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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.

Rodrigo Romero, Rodrigo Romero, Volkan I Sayin, Shawn M Davidson, Matthew R Bauer, Simranjit X Singh, Sarah E LeBoeuf, Triantafyllia R Karakousi, Donald C Ellis, Arjun Bhutkar, Francisco J Sánchez-Rivera, Lakshmipriya Subbaraj, Britney Martinez, Roderick T Bronson, Justin R Prigge, Edward E Schmidt, Craig J Thomas, Chandra Goparaju, Angela Davies, Igor Dolgalev, Adriana Heguy, Viola Allaj, John T Poirier, Andre L Moreira, Charles M Rudin, Harvey I Pass, Matthew G Vander Heiden, Tyler Jacks, Thales Papagiannakopoulos,

Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequently co-occur with those in KRAS, which themselves may lead to therapeutic vulnerabilities in tumors. Approximately 20% ... Read more >>

Nat. Med. (Nature medicine)
[2017, 23(11):1362-1368]

Cited: 52 times

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