Full Text Journal Articles by
Author Triana Amen

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Quantitative photoconversion analysis of internal molecular dynamics in stress granules and other membraneless organelles in live cells.

Triana Amen, Daniel Kaganovich,

Photoconversion enables real-time labeling of protein sub-populations inside living cells, which can then be tracked with submicrometer resolution. Here, we detail the protocol of comparing protein dynamics inside membraneless organelles in live HEK293T cells using a CRISPR-Cas9 PABPC1-Dendra2 marker of stress granules. Measuring internal dynamics of membraneless organelles provides insight ... Read more >>

STAR Protoc (STAR protocols)
[2020, 1(3):100217]

Cited: 0 times

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Vimentin protects differentiating stem cells from stress.

Sundararaghavan Pattabiraman, Gajendra Kumar Azad, Triana Amen, Shlomi Brielle, Jung Eun Park, Siu Kwan Sze, Eran Meshorer, Daniel Kaganovich,

Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is widely considered to be ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):19525]

Cited: 1 time

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Stress granules sense metabolic stress at the plasma membrane and potentiate recovery by storing active Pkc1.

Triana Amen, Daniel Kaganovich,

As the physical barrier between the cell and the outside environment, the plasma membrane is well-positioned to be the first responder to stress. The membrane is also highly vulnerable to many types of perturbation, including heat, force, osmotic pressure, lipid shortage, and starvation. To determine whether the structural changes in ... Read more >>

Sci Signal (Science signaling)
[2020, 13(623):]

Cited: 1 time

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Integrative modules for efficient genome engineering in yeast.

Triana Amen, Daniel Kaganovich,

We present a set of vectors containing integrative modules for efficient genome integration into the commonly used selection marker loci of the yeast <i>Saccharomyces cerevisiae</i>. A fragment for genome integration is generated via PCR with a unique set of short primers and integrated into <i>HIS3</i>, <i>URA3</i>, <i>ADE2</i>, and <i>TRP1</i> loci. ... Read more >>

Microb Cell (Microbial cell (Graz, Austria))
[2017, 4(6):182-190]

Cited: 3 times

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Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions.

Sandra Malmgren Hill, Xinxin Hao, Johan Grönvall, Stephanie Spikings-Nordby, Per O Widlund, Triana Amen, Anna Jörhov, Rebecca Josefson, Daniel Kaganovich, Beidong Liu, Thomas Nyström,

Age can be reset during mitosis in both yeast and stem cells to generate a young daughter cell from an aged and deteriorated one. This phenomenon requires asymmetry-generating genes (AGGs) that govern the asymmetrical inheritance of aggregated proteins. Using a genome-wide imaging screen to identify AGGs in Saccharomyces cerevisiae, we discovered ... Read more >>

Cell Rep (Cell reports)
[2016, 16(3):826-838]

Cited: 24 times

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Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress.

Michelle L Oeser, Triana Amen, Cory M Nadel, Amanda I Bradley, Benjamin J Reed, Ramon D Jones, Janani Gopalan, Daniel Kaganovich, Richard G Gardner,

Cells are often exposed to physical or chemical stresses that can damage the structures of essential biomolecules. Stress-induced cellular damage can become deleterious if not managed appropriately. Rapid and adaptive responses to stresses are therefore crucial for cell survival. In eukaryotic cells, different stresses trigger post-translational modification of proteins with ... Read more >>

PLoS Genet (PLoS genetics)
[2016, 12(1):e1005809]

Cited: 10 times

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Yeast screening platform identifies FDA-approved drugs that reduce Aβ oligomerization.

Triana Amen, Daniel Kaganovich,

Microb Cell (Microbial cell (Graz, Austria))
[2016, 3(3):97-100]

Cited: 4 times

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Architecture and Characteristics of Bacterial Nanotubes.

Gyanendra P Dubey, Ganesh Babu Malli Mohan, Anna Dubrovsky, Triana Amen, Shai Tsipshtein, Alex Rouvinski, Alex Rosenberg, Daniel Kaganovich, Eilon Sherman, Ohad Medalia, Sigal Ben-Yehuda,

Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously identified a mode of bacterial communication mediated by nanotubes bridging neighboring cells. Here, we elucidate nanotube architecture, dynamics, and molecular components. Utilizing Bacillus subtilis as a model organism, we found that ... Read more >>

Dev Cell (Developmental cell)
[2016, 36(4):453-461]

Cited: 24 times

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Structural Basis for Modulation of Quality Control Fate in a Marginally Stable Protein.

Kelly P Brock, Ayelet-chen Abraham, Triana Amen, Daniel Kaganovich, Jeremy L England,

The human von Hippel-Lindau (VHL) tumor suppressor is a marginally stable protein previously used as a model substrate of eukaryotic refolding and degradation pathways. When expressed in the absence of its cofactors, VHL cannot fold and is quickly degraded by the quality control machinery of the cell. We combined computational ... Read more >>

Structure (Structure (London, England : 1993))
[2015, 23(7):1169-1178]

Cited: 4 times

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Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies.

Ofer Moldavski, Triana Amen, Smadar Levin-Zaidman, Miriam Eisenstein, Ilana Rogachev, Alexander Brandis, Daniel Kaganovich, Maya Schuldiner,

Exposing cells to folding stress causes a subset of their proteins to misfold and accumulate in inclusion bodies (IBs). IB formation and clearance are both active processes, but little is known about their mechanism. To shed light on this issue, we performed a screen with over 4,000 fluorescently tagged yeast ... Read more >>

Dev Cell (Developmental cell)
[2015, 33(5):603-610]

Cited: 37 times

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Yeast red pigment modifies Amyloid beta growth in Alzheimer disease models in both Saccharomyces cerevisiae and Drosophila melanogaster.

Olga V Nevzglyadova, Ekaterina V Mikhailova, Triana R Amen, Valeriy V Zenin, Alexey V Artemov, Elena I Kostyleva, Daria A Mezhenskaya, Dmitry I Rodin, Alsu F Saifitdinova, Mikhail A Khodorkovskii, Svetlana V Sarantseva, Tonu R Soidla,

The effect of yeast red pigment on amyloid-β (Aβ) aggregation and fibril growth was studied in yeasts, fruit flies and in vitro. Yeast strains accumulating red pigment (red strains) contained less amyloid and had better survival rates compared to isogenic strains without red pigment accumulation (white strains). Confocal and fluorescent ... Read more >>

Amyloid (Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis)
[2015, 22(2):100-111]

Cited: 1 time

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Dynamic droplets: the role of cytoplasmic inclusions in stress, function, and disease.

Triana Amen, Daniel Kaganovich,

Neurodegenerative diseases and other proteinopathies constitute a class of several dozen illnesses etiologically linked to pathological protein misfolding and aggregation. Because of this strong association with disease pathology, cell death, and aging, accumulation of proteins in aggregates or aggregation-associated structures (inclusions) has come to be regarded by many as a ... Read more >>

Cell Mol Life Sci (Cellular and molecular life sciences : CMLS)
[2015, 72(3):401-415]

Cited: 23 times

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Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin.

Mikołaj Ogrodnik, Hanna Salmonowicz, Rachel Brown, Joanna Turkowska, Władysław Średniawa, Sundararaghavan Pattabiraman, Triana Amen, Ayelet-chen Abraham, Noam Eichler, Roman Lyakhovetsky, Daniel Kaganovich,

Aging is associated with the accumulation of several types of damage: in particular, damage to the proteome. Recent work points to a conserved replicative rejuvenation mechanism that works by preventing the inheritance of damaged and misfolded proteins by specific cells during division. Asymmetric inheritance of misfolded and aggregated proteins has ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(22):8049-8054]

Cited: 58 times

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