Full Text Journal Articles by
Author Trevor T Hansel

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A Rare Mutation in SPLUNC1 Affects Bacterial Adherence and Invasion in Meningococcal Disease.

Bayarchimeg Mashbat, Evangelos Bellos, Stephanie Hodeib, Fadil Bidmos, Ryan S Thwaites, Yaxuan Lu, Victoria J Wright, Jethro A Herberg, Daniela S Klobassa, Werner Zenz, Trevor T Hansel, Simon Nadel, Paul R Langford, Luregn J Schlapbach, Ming-Shi Li, Matthew R Redinbo, Y Peter Di, Michael Levin, Vanessa Sancho-Shimizu,

BACKGROUND:Neisseria meningitidis (Nm) is a nasopharyngeal commensal carried by healthy individuals. However, invasive infections occurs in a minority of individuals, with devastating consequences. There is evidence that common polymorphisms are associated with invasive meningococcal disease (IMD), but the contributions of rare variants other than those in the complement system have ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(10):2045-2053]

Cited: 0 times

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Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza.

Akhilesh Jha, Jake Dunning, Tanushree Tunstall, Ryan S Thwaites, Long T Hoang, , Onn Min Kon, Maria C Zambon, Trevor T Hansel, Peter J Openshaw,

BACKGROUND:Patients with asthma are at risk of hospitalisation with influenza, but the reasons for this predisposition are unknown. STUDY SETTING:A prospective observational study of adults with PCR-confirmed influenza in 11 UK hospitals, measuring nasal, nasopharyngeal and systemic immune mediators and whole-blood gene expression. RESULTS:Of 133 admissions, 40 (30%) had previous ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2019, 54(4):]

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Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice, and humans.

Fränze Progatzky, Akhilesh Jha, Madina Wane, Ryan S Thwaites, Spyridon Makris, Robin J Shattock, Cecilia Johansson, Peter J Openshaw, Laurence Bugeon, Trevor T Hansel, Margaret J Dallman,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 144(1):342-345.e7]

Cited: 0 times

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Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Jake Dunning, Simon Blankley, Long T Hoang, Mike Cox, Christine M Graham, Philip L James, Chloe I Bloom, Damien Chaussabel, Jacques Banchereau, Stephen J Brett, , Miriam F Moffatt, Anne O'Garra, Peter J M Openshaw,

In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE project 602525. The error has been corrected in the HTML and PDF version of the article. ... Read more >>

Nat. Immunol. (Nature immunology)
[2019, 20(3):373]

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Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine.

Savino Spadaro, Mirae Park, Cecilia Turrini, Tanushree Tunstall, Ryan Thwaites, Tommaso Mauri, Riccardo Ragazzi, Paolo Ruggeri, Trevor T Hansel, Gaetano Caramori, Carlo Alberto Volta,

Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region of 40%. There has been slow but incremental progress in identification of biomarkers that contribute to ... Read more >>

J Inflamm (Lond) (Journal of inflammation (London, England))
[2019, 16:1]

Cited: 4 times

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IL-5 Levels in Nasosorption and Sputosorption Correlate with Sputum Eosinophilia in Allergic Asthma.

Jose T Melo, Tanushree Tunstall, Marcia M M Pizzichini, Rosemeri Maurici, Cristiane C Rocha, Felipe Dal-Pizzol, Jessica Gonçalves, Trevor T Hansel, Ryan S Thwaites, Emilio Pizzichini,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 199(2):240-243]

Cited: 2 times

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Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure.

Ryan S Thwaites, Matthew Coates, Kazuhiro Ito, Marwa Ghazaly, Calandra Feather, Farhana Abdulla, Tanushree Tunstall, Pooja Jain, Lindsey Cass, Garth Rapeport, Trevor T Hansel, Simon Nadel, Peter Openshaw,

RATIONALE:Respiratory syncytial virus (RSV) bronchiolitis is a major cause of morbidity and mortality in infancy. Severe disease is believed to result from uncontrolled viral replication, an excessive immune response, or both. OBJECTIVES:To determine RSV load and immune mediator levels in nasal mucosal lining fluid by serial sampling of nasal fluids ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2018, 198(8):1074-1084]

Cited: 7 times

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Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Jake Dunning, Simon Blankley, Long T Hoang, Mike Cox, Christine M Graham, Philip L James, Chloe I Bloom, Damien Chaussabel, Jacques Banchereau, Stephen J Brett, Miriam F Moffatt, Anne O'Garra, Peter J M Openshaw, ,

Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of local and systemic immunological mediators in 131 adults hospitalized with influenza, from whom extensive clinical and investigational data were obtained by MOSAIC investigators. Signatures ... Read more >>

Nat. Immunol. (Nature immunology)
[2018, 19(6):625-635]

Cited: 9 times

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Biphasic activation of complement and fibrinolysis during the human nasal allergic response.

Ryan S Thwaites, Natasha C Gunawardana, Verena Broich, Elizabeth H Mann, Josefin Ahnström, Gaynor A Campbell, Sarah Lindsley, Nehmat Singh, Tanushree Tunstall, David A Lane, Peter J Openshaw, Catherine M Hawrylowicz, Trevor T Hansel,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2018, 141(5):1892-1895.e6]

Cited: 0 times

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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples.

Ryan S Thwaites, Hannah C Jarvis, Nehmat Singh, Akhilesh Jha, Andy Pritchard, Hailing Fan, Tanushree Tunstall, Joan Nanan, Simon Nadel, Onn Min Kon, Peter J Openshaw, Trevor T Hansel,

The methods of nasal absorption (NA) and bronchial absorption (BA) use synthetic absorptive matrices (SAM) to absorb the mucosal lining fluid (MLF) of the human respiratory tract. NA is a non-invasive technique which absorbs fluid from the inferior turbinate, and causes minimal discomfort. NA has yielded reproducible results with the ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2018, (131):]

Cited: 3 times

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The effects of house dust mite sublingual immunotherapy tablet on immunologic biomarkers and nasal allergen challenge symptoms.

Natasha C Gunawardana, Qing Zhao, Leonidas N Carayannopoulos, Kuenhi Tsai, Vladislav A Malkov, Diana Selverian, Graham Clarke, Tim Mant, Brent D Butts, Kaare Lund, Trevor T Hansel, Hendrik Nolte,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2018, 141(2):785-788.e9]

Cited: 2 times

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Mucosal Type 2 Innate Lymphoid Cells Are a Key Component of the Allergic Response to Aeroallergens.

Jaideep Dhariwal, Aoife Cameron, Maria-Belen Trujillo-Torralbo, Ajerico Del Rosario, Eteri Bakhsoliani, Malte Paulsen, David J Jackson, Michael R Edwards, Batika M J Rana, David J Cousins, Trevor T Hansel, Sebastian L Johnston, Ross P Walton, ,

Newly characterized type 2 innate lymphoid cells (ILC2s) display potent type 2 effector functionality; however, their contribution to allergic airways inflammation and asthma is poorly understood. Mucosal biopsy used to characterize the airway mucosa is invasive, poorly tolerated, and does not allow for sequential sampling.To assess the role of ILC2s ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2017, 195(12):1586-1596]

Cited: 20 times

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Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis.

Ryan S Thwaites, Kazuhiro Ito, Jasmine M S Chingono, Matthew Coates, Hannah C Jarvis, Tanushree Tunstall, Lauren Anderson-Dring, Lindsey Cass, Garth Rapeport, Peter J Openshaw, Simon Nadel, Trevor T Hansel,

Background:Existing respiratory mucosal sampling methods are flawed, particularly in a pediatric bronchiolitis setting. Methods:Twenty-four infants with bronchiolitis were recruited: 12 were respiratory syncytial virus (RSV)-positive, 12 were RSV-negative. Infants were sampled by nasosorption and nasopharyngeal aspiration (NPA). Results:Nasosorption was well tolerated and identified all RSV+ samples. RSV load measured by ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2017, 215(8):1240-1244]

Cited: 7 times

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A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).

Trevor T Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico Del-Rosario, Jaideep Dhariwal, Paul D W Kirk, Michael P H Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M Hunt, Trevor L Hunt, Duncan G Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J Jackson, Sebastian L Johnston,

BACKGROUND:Rhinovirus infection is a major cause of asthma exacerbations. OBJECTIVES:We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. METHODS:We used nasosorption on days 0, 2-5 and 7 and bronchosorption at baseline and day 4 to sample mucosal lining fluid to investigate airway mucosal responses to rhinovirus ... Read more >>

EBioMedicine (EBioMedicine)
[2017, 19:128-138]

Cited: 15 times

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Medical Swab Analysis Using Desorption Electrospray Ionization Mass Spectrometry: A Noninvasive Approach for Mucosal Diagnostics.

Pamela Pruski, David A MacIntyre, Holly V Lewis, Paolo Inglese, Gonçalo D S Correia, Trevor T Hansel, Phillip R Bennett, Elaine Holmes, Zoltan Takats,

Medical swabs are routinely used worldwide to sample human mucosa for microbiological screening with culture methods. These are usually time-consuming and have a narrow focus on screening for particular microorganism species. As an alternative, direct mass spectrometric profiling of the mucosal metabolome provides a broader window into the mucosal ecosystem. ... Read more >>

Anal. Chem. (Analytical chemistry)
[2017, 89(3):1540-1550]

Cited: 4 times

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Local chemokine profiling in eosinophilic esophagitis: The synthetic absorptive matrix test.

Eleanor Minshall, Harsita Patel, Nicholas Francis, Trevor T Hansel, John O Warner, Robert J Boyle, John Fell, Jenny Epstein,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2017, 28(1):100-102]

Cited: 0 times

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Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study.

Donatella Poletti, Valeria Iannini, Paolo Casolari, Marco Contoli, Alberto Papi, Paul Kirkham, Trevor T Hansel, Kian Fan Chung, Peter J Barnes, Antonio Pastore, Stefano Pelucchi, Ian M Adcock, Gaetano Caramori,

The pathogenesis of non-allergic rhinitis (NAR) is still largely unknown. Furthermore, it is unclear whether there is a correlation between the effect of nasal glucocorticoids on nasal inflammation and on nasal symptoms and quality of life.In this pilot study we recruited 12 healthy subjects and 24 patients with recently diagnosed ... Read more >>

J Inflamm (Lond) (Journal of inflammation (London, England))
[2016, 13:26]

Cited: 0 times

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Picornavirus-Induced Airway Mucosa Immune Profile in Asymptomatic Neonates.

Helene M Wolsk, Nilofar V Følsgaard, Sune Birch, Susanne Brix, Trevor T Hansel, Sebastian L Johnston, Tatiana Kebadze, Bo L Chawes, Klaus Bønnelykke, Hans Bisgaard,

Bacterial airway colonization is known to alter the airway mucosa immune response in neonates whereas the impact of viruses is unknown. The objective was therefore to examine the effect of respiratory viruses on the immune signature in the airways of asymptomatic neonates.Nasal aspirates from 571 asymptomatic 1-month-old neonates from the ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2016, 213(8):1262-1270]

Cited: 7 times

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Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness.

Jaideep Dhariwal, Jeremy Kitson, Reema E Jones, Grant Nicholson, Tanushree Tunstall, Ross P Walton, Grace Francombe, Jane Gilbert, Andrew J Tan, Robert Murdoch, Onn Min Kon, Peter J Openshaw, Trevor T Hansel,

BACKGROUND:Practical methods of monitoring innate immune mucosal responsiveness are lacking. Lipopolysaccharide (LPS) is a component of the cell wall of Gram negative bacteria and a potent activator of Toll-like receptor (TLR)-4. To measure LPS responsiveness of the nasal mucosa, we administered LPS as a nasal spray and quantified chemokine and ... Read more >>

PLoS ONE (PloS one)
[2015, 10(9):e0135363]

Cited: 7 times

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An autologous endothelial cell:peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics.

Daniel M Reed, Koralia E Paschalaki, Richard D Starke, Nura A Mohamed, Giles Sharp, Bernard Fox, David Eastwood, Adrian Bristow, Christina Ball, Sandrine Vessillier, Trevor T Hansel, Susan J Thorpe, Anna M Randi, Richard Stebbings, Jane A Mitchell,

There is an urgent unmet need for human tissue bioassays to predict cytokine storm responses to biologics. Current bioassays that detect cytokine storm responses in vitro rely on endothelial cells, usually from umbilical veins or cell lines, cocultured with freshly isolated peripheral blood mononuclear cells (PBMCs) from healthy adult volunteers. ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2015, 29(6):2595-2602]

Cited: 7 times

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Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: monitoring the nasal and systemic immune response using a network biology approach.

Clare L Ross, Neil Galloway-Phillipps, Paul C Armstrong, Jane A Mitchell, Timothy D Warner, Christopher Brearley, Mari Ito, Tanushree Tunstall, Sarah Elkin, Onn Min Kon, Trevor T Hansel, Mark J Paul-Clark,

INTRODUCTION:Cigarette smoke contributes to a diverse range of diseases including chronic obstructive pulmonary disease (COPD), cardiovascular disorders and many cancers. There currently is a need for human challenge models, to assess the acute effects of a controlled cigarette smoke stimulus, followed by serial sampling of blood and respiratory tissue for ... Read more >>

BMJ Open (BMJ open)
[2015, 5(1):e005750]

Cited: 1 time

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Smoking cessation in COPD causes a transient improvement in spirometry and decreases micronodules on high-resolution CT imaging.

Jaideep Dhariwal, Rachel C Tennant, David M Hansell, John Westwick, Christoph Walker, Simon P Ward, Neil Pride, Peter J Barnes, Onn Min Kon, Trevor T Hansel, ,

Smoking cessation is of major importance for all smokers; however, in patients with COPD, little information exists on how smoking cessation influences lung function and high-resolution CT (HRCT) scan appearances.In this single-center study, we performed screening spirometry in a group of heavy smokers aged 40 to 80 years (N = ... Read more >>

Chest (Chest)
[2014, 145(5):1006-1015]

Cited: 9 times

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New drug therapies for COPD.

Clare L Ross, Trevor T Hansel,

Clinical trials with new drugs for chronic obstructive pulmonary disease (COPD) have been performed. Viruses exacerbate COPD and bacteria may play a part in severe COPD; therefore, antibiotic and antiviral approaches have a sound rationale. Antiinflammatory approaches have been studied. Advances in understanding the molecular basis of other processes have ... Read more >>

Clin. Chest Med. (Clinics in chest medicine)
[2014, 35(1):219-239]

Cited: 3 times

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Microbes and mucosal immune responses in asthma.

Trevor T Hansel, Sebastian L Johnston, Peter J Openshaw,

The substantial increase in the worldwide prevalence of asthma and atopy has been attributed to lifestyle changes that reduce exposure to bacteria. A recent insight is that the largely bacterial microbiome maintains a state of basal immune homoeostasis, which modulates immune responses to microbial pathogens. However, some respiratory viral infections ... Read more >>

Lancet (Lancet (London, England))
[2013, 381(9869):861-873]

Cited: 77 times

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A simple whole blood bioassay detects cytokine responses to anti-CD28SA and anti-CD52 antibodies.

Lucy Bailey, Laura Moreno, Tobias Manigold, Sebastian Krasniqi, Harald Kropshofer, Heather Hinton, Thomas Singer, Laura Suter, Trevor T Hansel, Jane A Mitchell,

In 2006 the anti-CD28 superagonistic IgG4 TGN1412, having passed pre-clinical safety screens, caused a severe 'cytokine storm' in 6 healthy volunteers. Others have shown that for TGN1412 to induce an inflammatory signal in human peripheral blood mononuclear cells (PBMCs) or in human diluted blood, endothelial cells or bound monoclonal antibody ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2013, 68(2):231-239]

Cited: 4 times

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