Full Text Journal Articles by
Author Tracy J Abildskov

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Developmental Alterations in Cortical Organization and Socialization in Adolescents Who Sustained a Traumatic Brain Injury in Early Childhood.

Elisabeth A Wilde, Tricia L Merkley, Hannah M Lindsey, Erin D Bigler, Jill V Hunter, Linda Ewing-Cobbs, Mary E Aitken, Marianne C MacLeod, Gerri Hanten, Zili D Chu, Tracy J Abildskov, Linda J Noble-Haeusslein, Harvey S Levin,

This study investigated patterns of cortical organization in adolescents who had sustained a traumatic brain injury (TBI) during early childhood to determine ways in which early head injury may alter typical brain development. Increased gyrification in other patient populations is associated with polymicrogyria and aberrant development, but this has not ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, :]

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FreeSurfer 5.3 versus 6.0: are volumes comparable? A Chronic Effects of Neurotrauma Consortium study.

Erin D Bigler, Marc Skiles, Benjamin S C Wade, Tracy J Abildskov, Nick J Tustison, Randall S Scheibel, Mary R Newsome, Andrew R Mayer, James R Stone, Brian A Taylor, David F Tate, William C Walker, Harvey S Levin, Elisabeth A Wilde,

Automated neuroimaging methods like FreeSurfer ( https://surfer.nmr.mgh.harvard.edu/ ) have revolutionized quantitative neuroimaging analyses. Such analyses provide a variety of metrics used for image quantification, including magnetic resonance imaging (MRI) volumetrics. With the release of FreeSurfer version 6.0, it is important to assess its comparability to the widely-used previous version 5.3. ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2020, 14(5):1318-1327]

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Examining the Relationship between a Verbal Incidental Learning Measure from the WAIS-IV and Neuroimaging Biomarkers for Alzheimer's Pathology.

Dustin B Hammers, Amanda Kucera, Robert J Spencer, Tracy J Abildskov, Zane G Archibald, John M Hoffman, Elizabeth A Wilde,

Convergent validation of a verbal incidental learning (IL) task from the WAIS-IV using neuroimaging biomarkers is warranted to understand its sensitivity to Alzheimer's disease (AD) pathology. Fifty-five memory clinic patients aged 59 to 87 years received neuropsychological assessment, and measures of IL and quantitative brain imaging. Worse IL-Total Score and IL-Similarities ... Read more >>

Dev Neuropsychol (Developmental neuropsychology)
[2020, 45(3):95-109]

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Post-Acute Cortical Thickness in Children with Mild Traumatic Brain Injury versus Orthopedic Injury.

Ashley L Ware, Naomi J Goodrich-Hunsaker, Catherine Lebel, Ayushi Shukla, Elisabeth A Wilde, Tracy J Abildskov, Erin D Bigler, Daniel M Cohen, Leslie K Mihalov, Ann Bacevice, Barbara A Bangert, H Gerry Taylor, Keith Owen Yeates,

Studies of brain morphometry may illuminate the effects of pediatric mild traumatic brain injury (TBI; e.g., concussion). However, no published studies have examined cortical thickness in the early injury phases of pediatric mild TBI using an appropriate comparison group. The current study used an automated approach (i.e., FreeSurfer) to determine ... Read more >>

J. Neurotrauma (Journal of neurotrauma)
[2020, 37(17):1892-1901]

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Post-acute white matter microstructure predicts post-acute and chronic post-concussive symptom severity following mild traumatic brain injury in children.

Ashley L Ware, Ayushi Shukla, Naomi J Goodrich-Hunsaker, Catherine Lebel, Elisabeth A Wilde, Tracy J Abildskov, Erin D Bigler, Daniel M Cohen, Leslie K Mihalov, Ann Bacevice, Barbara A Bangert, H Gerry Taylor, Keith O Yeates,

INTRODUCTION:Mild traumatic brain injury (TBI) is a global public health concern that affects millions of children annually. Mild TBI tends to result in subtle and diffuse alterations in brain tissue, which challenges accurate clinical detection and prognostication. Diffusion tensor imaging (DTI) holds promise as a diagnostic and prognostic tool, but ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 25:102106]

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Methylphenidate Treatment of Cognitive Dysfunction in Adults After Mild to Moderate Traumatic Brain Injury: Rationale, Efficacy, and Neural Mechanisms.

Harvey Levin, Maya Troyanskaya, JoAnn Petrie, Elisabeth A Wilde, Jill V Hunter, Tracy J Abildskov, Randall S Scheibel,

Positive effects of methylphenidate (MPH) on attention and cognitive processing speed have been reported in studies of patients with moderate to severe traumatic brain injury (TBI). Studies which have acquired functional brain imaging before and while using MPH have also found alteration of brain activation while performing a cognitive task; ... Read more >>

(Frontiers in neurology)
[2019, 10:925]

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Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study.

Erin D Bigler, Tracy J Abildskov, Barry Eggleston, Brian A Taylor, David F Tate, Jo Ann Petrie, Mary R Newsome, Randall S Scheibel, Harvey Levin, William C Walker, Naomi Goodrich-Hunsaker, Nicholas J Tustison, James R Stone, Andrew R Mayer, Timothy D Duncan, Gerry E York, Elisabeth A Wilde,

OBJECTIVES:The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long-term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow-on ... Read more >>

Int J Methods Psychiatr Res (International journal of methods in psychiatric research)
[2019, 28(3):e1781]

Cited: 1 time

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Corrigendum to "Cortical thickness in pediatric mild traumatic brain injury including sports-related concussion" [Int. J. Psychophysiol. 132 (2018) 99-104].

Erin D Bigler, Chris Finuf, Tracy J Abildskov, Naomi J Goodrich-Hunsaker, Jo Ann Petrie, Dawn-Marie Wood, John R Hesselink, Elisabeth A Wilde, Jeffrey E Max,

Int J Psychophysiol (International journal of psychophysiology : official journal of the International Organization of Psychophysiology)
[2019, 139:74]

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Functional brain connectivity and cortical thickness in relation to chronic pain in post-911 veterans and service members with mTBI.

Mary R Newsome, Elisabeth A Wilde, Erin D Bigler, Qisheng Liu, Andrew R Mayer, Brian A Taylor, Joel L Steinberg, David F Tate, Tracy J Abildskov, Randall S Scheibel, William C Walker, Harvey S Levin,

OBJECTIVES:Investigate the relation of chronic pain interference to functional connectivity (FC) of brain regions and to cortical thickness in post-911 Veterans and Service Members (SMs) who sustained a mild traumatic brain injury (mTBI). METHODS:This is an observational study with cross-sectional analyses. A sample of 65 enrollees completing initial evaluation at ... Read more >>

Brain Inj (Brain injury)
[2018, 32(10):1236-1244]

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Cortical thickness in pediatric mild traumatic brain injury including sports-related concussion.

Erin D Bigler, Chris Finuf, Tracy J Abildskov, Naomi J Goodrich-Hunsaker, Jo Ann Petrie, Dawn-Marie Wood, John R Hesselink, Elisabeth A Wilde, Jeffrey E Max,

This investigation explored whether differences in cortical thickness could be detected in children who sustained a mild traumatic brain injury (mTBI) compared to those with orthopedic injury (OI) and whether cortical thickness related parental reporting of symptoms. To achieve this objective, FreeSurfer®-based cortical thickness measures were obtained in 330 children, ... Read more >>

Int J Psychophysiol (International journal of psychophysiology : official journal of the International Organization of Psychophysiology)
[2018, 132(Pt A):99-104]

Cited: 0 times

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ENIGMA MILITARY BRAIN INJURY: A COORDINATED META-ANALYSIS OF DIFFUSION MRI FROM MULTIPLE COHORTS.

Emily L Dennis, Elisabeth A Wilde, Mary R Newsome, Randall S Scheibel, Maya Troyanskaya, Carmen Velez, Benjamin S C Wade, Ann Marie Drennon, Gerald E York, Erin D Bigler, Tracy J Abildskov, Brian A Taylor, Carlos A Jaramillo, Blessen Eapen, Heather Belanger, Vikash Gupta, Rajendra Morey, Courtney Haswell, Harvey S Levin, Sidney R Hinds, William C Walker, Paul M Thompson, David F Tate,

Traumatic brain injury (TBI) is a significant cause of morbidity in military Veterans and Service Members. While most individuals recover fully from mild injuries within weeks, some continue to experience symptoms including headaches, disrupted sleep, and other cognitive, behavioral or physical symptoms. Diffusion magnetic resonance imaging (dMRI) shows promise in ... Read more >>

Proc IEEE Int Symp Biomed Imaging (Proceedings. IEEE International Symposium on Biomedical Imaging)
[2018, 2018:1386-1389]

Cited: 1 time

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High correlations between MRI brain volume measurements based on NeuroQuant® and FreeSurfer.

David E Ross, Alfred L Ochs, David F Tate, Umit Tokac, John Seabaugh, Tracy J Abildskov, Erin D Bigler,

NeuroQuant® (NQ) and FreeSurfer (FS) are commonly used computer-automated programs for measuring MRI brain volume. Previously they were reported to have high intermethod reliabilities but often large intermethod effect size differences. We hypothesized that linear transformations could be used to reduce the large effect sizes. This study was an extension ... Read more >>

Psychiatry Res Neuroimaging (Psychiatry research. Neuroimaging)
[2018, 278:69-76]

Cited: 1 time

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Auditory attention in autism spectrum disorder: An exploration of volumetric magnetic resonance imaging findings.

Sanam J Lalani, Tyler C Duffield, Haley G Trontel, Erin D Bigler, Tracy J Abildskov, Alyson Froehlich, Molly B D Prigge, Brittany G Travers, Jeffrey S Anderson, Brandon A Zielinski, Andrew Alexander, Nicholas Lange, Janet E Lainhart,

Studies have shown that individuals with autism spectrum disorder (ASD) tend to perform significantly below typically developing individuals on standardized measures of attention, even when controlling for IQ. The current study sought to examine within ASD whether anatomical correlates of attention performance differed between those with average to above-average IQ ... Read more >>

J Clin Exp Neuropsychol (Journal of clinical and experimental neuropsychology)
[2018, 40(5):502-517]

Cited: 1 time

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Assessment of quantitative magnetic resonance imaging metrics in the brain through the use of a novel phantom.

Elisabeth A Wilde, James M Provenzale, Brian A Taylor, Michael Boss, Anthony Zuccolotto, Rebecca Hachey, Sudhir Pathak, David F Tate, Tracy J Abildskov, Walter Schneider,

OBJECTIVE:Multisite and longitudinal neuroimaging studies are important in uncovering trajectories of recovery and neurodegeneration following traumatic brain injury (TBI) and concussion through the use of diffusion tensor imaging (DTI) and other imaging modalities. This study assessed differences in anisotropic diffusion measurement across four scanners using a human and a novel ... Read more >>

Brain Inj (Brain injury)
[2018, 32(10):1266-1276]

Cited: 2 times

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Age- and sex-related effects in children with mild traumatic brain injury on diffusion magnetic resonance imaging properties: A comparison of voxelwise and tractography methods.

Naomi J Goodrich-Hunsaker, Tracy J Abildskov, Garrett Black, Erin D Bigler, Daniel M Cohen, Leslie K Mihalov, Barbara A Bangert, H Gerry Taylor, Keith O Yeates,

Although there are several techniques to analyze diffusion-weighted imaging, any technique must be sufficiently sensitive to detect clinical abnormalities. This is especially critical in disorders like mild traumatic brain injury (mTBI), where pathology is likely to be subtle. mTBI represents a major public health concern, especially for youth under 15 ... Read more >>

J Neurosci Res (Journal of neuroscience research)
[2018, 96(4):626-641]

Cited: 7 times

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The Relation of Focal Lesions to Cortical Thickness in Pediatric Traumatic Brain Injury.

Erin D Bigler, Brandon A Zielinski, Naomi Goodrich-Hunsaker, Garrett M Black, B S Trevor Huff, Zachary Christiansen, Dawn-Marie Wood, Tracy J Abildskov, Maureen Dennis, H Gerry Taylor, Kenneth Rubin, Kathryn Vannatta, Cynthia A Gerhardt, Terry Stancin, Keith Owen Yeates,

In a sample of children with traumatic brain injury, this magnetic resonance imaging (MRI)-based investigation examined whether presence of a focal lesion uniquely influenced cortical thickness in any brain region. Specifically, the study explored the relation of cortical thickness to injury severity as measured by Glasgow Coma Scale score and ... Read more >>

J Child Neurol (Journal of child neurology)
[2016, 31(11):1302-1311]

Cited: 3 times

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Day of injury CT and late MRI findings: Cognitive outcome in a paediatric sample with complicated mild traumatic brain injury.

Erin D Bigler, Paul B Jantz, Thomas J Farrer, Tracy J Abildskov, Maureen Dennis, Cynthia A Gerhardt, Kenneth H Rubin, Terry Stancin, H Gerry Taylor, Kathryn Vannatta, Keith Owen Yeates,

OBJECTIVES:Complicated mild traumatic brain injury (mTBI) or cmTBI is based on the presence of visibly identifiable brain pathology on the day-of-injury computed tomography (CT) scan. In a paediatric sample the relation of DOI CT to late MRI findings and neuropsychological outcome was examined. METHODS:MRI (>12 months) was obtained in paediatric ... Read more >>

Brain Inj (Brain injury)
[2015, 29(9):1062-1070]

Cited: 7 times

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Comparison of Automated Brain Volume Measures obtained with NeuroQuant and FreeSurfer.

Alfred L Ochs, David E Ross, Megan D Zannoni, Tracy J Abildskov, Erin D Bigler, ,

To examine intermethod reliabilities and differences between FreeSurfer and the FDA-cleared congener, NeuroQuant, both fully automated methods for structural brain MRI measurements.MRI scans from 20 normal control subjects, 20 Alzheimer's disease patients, and 20 mild traumatically brain-injured patients were analyzed with NeuroQuant and with FreeSurfer. Intermethod reliability was evaluated.Pairwise correlation ... Read more >>

J Neuroimaging (Journal of neuroimaging : official journal of the American Society of Neuroimaging)
[2015, 25(5):721-727]

Cited: 16 times

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Mesial temporal lobe and memory function in autism spectrum disorder: an exploration of volumetric findings.

Haley G Trontel, Tyler C Duffield, Erin D Bigler, Tracy J Abildskov, Alyson Froehlich, Molly B D Prigge, Brittany G Travers, Jeffrey S Anderson, Brandon A Zielinski, Andrew L Alexander, Nicholas Lange, Janet E Lainhart,

Studies have shown that individuals with autism spectrum disorder (ASD) tend to perform significantly below typical developing individuals on standardized measures of memory, even when not significantly different on measures of IQ. The current study sought to examine within ASD whether anatomical correlates of memory performance differed between those with ... Read more >>

J Clin Exp Neuropsychol (Journal of clinical and experimental neuropsychology)
[2015, 37(2):178-192]

Cited: 5 times

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Longitudinal changes in cortical thickness in autism and typical development.

Brandon A Zielinski, Molly B D Prigge, Jared A Nielsen, Alyson L Froehlich, Tracy J Abildskov, Jeffrey S Anderson, P Thomas Fletcher, Kristen M Zygmunt, Brittany G Travers, Nicholas Lange, Andrew L Alexander, Erin D Bigler, Janet E Lainhart,

The natural history of brain growth in autism spectrum disorders remains unclear. Cross-sectional studies have identified regional abnormalities in brain volume and cortical thickness in autism, although substantial discrepancies have been reported. Preliminary longitudinal studies using two time points and small samples have identified specific regional differences in cortical thickness ... Read more >>

Brain (Brain : a journal of neurology)
[2014, 137(Pt 6):1799-1812]

Cited: 115 times

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Heterogeneity of brain lesions in pediatric traumatic brain injury.

Erin D Bigler, Tracy J Abildskov, Joann Petrie, Thomas J Farrer, Maureen Dennis, Nevena Simic, H Gerry Taylor, Kenneth H Rubin, Kathryn Vannatta, Cynthia A Gerhardt, Terry Stancin, Keith Owen Yeates,

OBJECTIVE: Magnetic resonance imaging (MRI) provides a method to identify and quantify abnormalities resulting from traumatic brain injury (TBI). MRI abnormalities in children with TBI have not been fully characterized according to the frequency, location, and quantitative measurement of a range of pathologies critical for studies of neuropsychological outcome. Here, ... Read more >>

Neuropsychology (Neuropsychology)
[2013, 27(4):438-451]

Cited: 41 times

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Corpus Callosum Area in Children and Adults with Autism.

Molly B D Prigge, Nicholas Lange, Erin D Bigler, Tricia L Merkley, E Shannon Neeley, Tracy J Abildskov, Alyson L Froehlich, Jared A Nielsen, Jason R Cooperrider, Annahir N Cariello, Caitlin Ravichandran, Andrew L Alexander, Janet E Lainhart,

Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with ... Read more >>

Res Autism Spectr Disord (Research in autism spectrum disorders)
[2013, 7(2):221-234]

Cited: 24 times

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The emergence of cognitive discrepancies in preclinical Alzheimer's disease: a six-year case study.

Mark W Jacobson, Dean C Delis, Guerry M Peavy, Spencer R Wetter, Erin D Bigler, Tracy J Abildskov, Mark W Bondi, David P Salmon,

We present neuropsychological data from an 81-year-old individual who was followed over a six-year period, initially as a healthy control participant. She performed above age-adjusted cutoff scores for impairment on most neuropsychological tests, including learning and memory measures, until the final assessment when she received a diagnosis of probable Alzheimer's ... Read more >>

Neurocase (Neurocase)
[2009, 15(4):278-293]

Cited: 3 times

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Diffuse damage in pediatric traumatic brain injury: a comparison of automated versus operator-controlled quantification methods.

Erin D Bigler, Tracy J Abildskov, Elisabeth A Wilde, Stephen R McCauley, Xiaoqi Li, Tricia L Merkley, Michael A Fearing, Mary R Newsome, Randall S Scheibel, Jill V Hunter, Zili Chu, Harvey S Levin,

This investigation had two main objectives: 1) to assess the comparability of volumes determined by operator-controlled image quantification with automated image analysis in evaluating atrophic brain changes related to traumatic brain injury (TBI) in children, and 2) to assess the extent of diffuse structural changes throughout the brain as determined ... Read more >>

Neuroimage (NeuroImage)
[2010, 50(3):1017-1026]

Cited: 45 times

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Volumetric and voxel-based morphometry findings in autism subjects with and without macrocephaly.

Erin D Bigler, Tracy J Abildskov, Jo Ann Petrie, Michael Johnson, Nicholas Lange, Jonathan Chipman, Jeffrey Lu, William McMahon, Janet E Lainhart,

This study sought to replicate Herbert et al. (2003a), which found increased overall white matter (WM) volume in subjects with autism, even after controlling for head size differences. To avoid the possibility that greater WM volume in autism is merely an epiphenomena of macrocephaly overrepresentation associated with the disorder, the ... Read more >>

Dev Neuropsychol (Developmental neuropsychology)
[2010, 35(3):278-295]

Cited: 20 times

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