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Author Toshiro Sato

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Population Difference in Allele Frequency of HLA-C*05 and Its Correlation with COVID-19 Mortality.

Atsushi Sakuraba, Haider Haider, Toshiro Sato,

BACKGROUND:coronavirus disease 2019 (COVID-19) causes severe illness including cytokine storms, but mortality among countries differs largely. In the present study, we investigated the association between human leukocyte antigen (HLA) class I, which plays a major role in susceptibility to viral infections, and the mortality of COVID-19. METHODS:data of allele frequencies ... Read more >>

Viruses (Viruses)
[2020, 12(11):]

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Wnt Signaling Shapes the Histological Variation in Diffuse Gastric Cancer.

Kazuhiro Togasaki, Shinya Sugimoto, Yuki Ohta, Kosaku Nanki, Mami Matano, Sirirat Takahashi, Masayuki Fujii, Takanori Kanai, Toshiro Sato,

BACKGROUND & AIMS:Diffuse type gastric cancer is currently subdivided into signet-ring cell carcinoma (SRCC) and non-SRCC referred to as poorly cohesive carcinoma not otherwise specified (PCC-NOS). Although these subtypes are considered to be independent, they often co-exist in the same tumors, raising a question whether they clonally differ or not. ... Read more >>

Gastroenterology (Gastroenterology)
[2020, :]

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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.

Kenta Kawasaki, Kohta Toshimitsu, Mami Matano, Masashi Fujita, Masayuki Fujii, Kazuhiro Togasaki, Toshiki Ebisudani, Mariko Shimokawa, Ai Takano, Sirirat Takahashi, Yuki Ohta, Kosaku Nanki, Ryo Igarashi, Kazuhiro Ishimaru, Hiroki Ishida, Yasutaka Sukawa, Shinya Sugimoto, Yoshimasa Saito, Kazuhiro Maejima, Shota Sasagawa, Hwajin Lee, Hong-Gee Kim, Kyungsik Ha, Junko Hamamoto, Koichi Fukunaga, Aya Maekawa, Minoru Tanabe, Soichiro Ishihara, Yasuo Hamamoto, Hiroyuki Yasuda, Shigeki Sekine, Atsushi Kudo, Yuko Kitagawa, Takanori Kanai, Hidewaki Nakagawa, Toshiro Sato,

Gastroenteropancreatic (GEP) neuroendocrine neoplasm (NEN) that consists of neuroendocrine tumor and neuroendocrine carcinoma (NEC) is a lethal but under-investigated disease owing to its rarity. To fill the scarcity of clinically relevant models of GEP-NEN, we here established 25 lines of NEN organoids and performed their comprehensive molecular characterization. GEP-NEN organoids ... Read more >>

Cell (Cell)
[2020, 183(5):1420-1435.e21]

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Coronavirus Disease 2019 (COVID-19) Meets Obesity: Strong Association between the Global Overweight Population and COVID-19 Mortality.

Jingzhou Wang, Toshiro Sato, Atsushi Sakuraba,

J Nutr (The Journal of nutrition)
[2020, :]

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Linking human intestinal scaffolds and organoids to combat intestinal failure.

Masayuki Fujii, Shinya Sugimoto, Toshiro Sato,

Nat Med (Nature medicine)
[2020, 26(10):1517-1518]

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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.

Rosalie T Zwiggelaar, Håvard T Lindholm, Madeleine Fosslie, Marianne Terndrup Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos R Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim B Jensen, Toshiro Sato, Menno J Oudhoff,

Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that lysine-specific demethylase ... Read more >>

Sci Adv (Science advances)
[2020, 6(37):]

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Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages.

Taku Sato, Shun Ishikawa, Jumpei Asano, Hirona Yamamoto, Masayuki Fujii, Toshiro Sato, Kouhei Yamamoto, Keisuke Kitagaki, Takumi Akashi, Ryuichi Okamoto, Toshiaki Ohteki,

Intestinal stem cells (ISCs) are located at the crypt base and fine-tune the balance of their self-renewal and differentiation1,2, but the physiological mechanism involved in regulating that balance remains unknown. Here we describe a transcriptional regulator that preserves the stemness of ISCs by restricting their differentiation into secretory-cell lineages. Interferon ... Read more >>

Nat Cell Biol (Nature cell biology)
[2020, 22(8):919-926]

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Football and COVID-19 risk: correlation is not causation.

Fares Ayoub, Toshiro Sato, Atsushi Sakuraba,

Clin Microbiol Infect (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2020, :]

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Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases.

Masayuki Fujii, Toshiro Sato,

Recent progress in our understanding of the regulation of epithelial tissue stem cells has allowed us to exploit their abilities and instruct them to self-organize into tissue-mimicking structures, so-called organoids. Organoids preserve the molecular, structural and functional characteristics of their tissues of origin, thus providing an attractive opportunity to study ... Read more >>

Nat Mater (Nature materials)
[2020, :]

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Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine.

Taku Sato, Miwako Sase, Shun Ishikawa, Mihoko Kajita, Jumpei Asano, Toshiro Sato, Yoshiyuki Mori, Toshiaki Ohteki,

The small intestine has a robust regenerative capacity, and various cell types serve as "cells-of-origin" in the epithelial regeneration process after injury. However, how much each population contributes to regeneration remains unclear. Using lineage tracing, we found that Lgr5-expressing cell derivatives contained radioresistant intestinal stem cells (ISCs) crucial for epithelial ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8308]

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MK-7 and Its Effects on Bone Quality and Strength.

Toshiro Sato, Naoko Inaba, Takatoshi Yamashita,

Vitamin K acts as a cofactor and is required for post-translational γ-carboxylation of vitamin K-dependent proteins (VKDP). The current recommended daily intake (RDI) of vitamin K in most countries has been established based on normal coagulation requirements. Vitamin K1 and menaquinone (MK)-4 has been shown to decrease osteocalcin (OC) γ-carboxylation ... Read more >>

Nutrients (Nutrients)
[2020, 12(4):]

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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

Rosalie Zwiggelaar, Håvard Lindholm, Madeleine Fosslie, Marianne Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim Jensen, Toshiro Sato, Menno Oudhoff,

ABSTRACT Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify new regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that ... Read more >>

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Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium.

Nobuo Sasaki, Kentaro Miyamoto, Kendle M Maslowski, Hiroshi Ohno, Takanori Kanai, Toshiro Sato,

Gastroenterology (Gastroenterology)
[2020, 159(1):388-390.e5]

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Organoid Derivation and Orthotopic Xenotransplantation for Studying Human Intestinal Stem Cell Dynamics.

Shinya Sugimoto, Masayuki Fujii, Toshiro Sato,

Intestinal stem cells continuously self-renew throughout life to maintain gut homeostasis. With the advent of the organoid culture system, we are now able to indefinitely expand healthy and diseased tissue-derived human intestinal stem cells in vitro and use them for various applications. Nonetheless, investigating the behavior of human intestinal stem ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2020, 2171:303-320]

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Somatic inflammatory gene mutations in human ulcerative colitis epithelium.

Kosaku Nanki, Masayuki Fujii, Mariko Shimokawa, Mami Matano, Shingo Nishikori, Shoichi Date, Ai Takano, Kohta Toshimitsu, Yuki Ohta, Sirirat Takahashi, Shinya Sugimoto, Kazuhiro Ishimaru, Kenta Kawasaki, Yoko Nagai, Ryota Ishii, Kosuke Yoshida, Nobuo Sasaki, Toshifumi Hibi, Soichiro Ishihara, Takanori Kanai, Toshiro Sato,

With ageing, normal human tissues experience an expansion of somatic clones that carry cancer mutations1-7. However, whether such clonal expansion exists in the non-neoplastic intestine remains unknown. Here, using whole-exome sequencing data from 76 clonal human colon organoids, we identify a unique pattern of somatic mutagenesis in the inflamed epithelium ... Read more >>

Nature (Nature)
[2020, 577(7789):254-259]

Cited: 6 times

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Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma.

Kenta Kawasaki, Masayuki Fujii, Shinya Sugimoto, Keiko Ishikawa, Mami Matano, Yuki Ohta, Kohta Toshimitsu, Sirirat Takahashi, Naoki Hosoe, Shigeki Sekine, Takanori Kanai, Toshiro Sato,

BACKGROUND & AIMS:Traditional serrated adenomas (TSAs) are rare colorectal polyps with unique histologic features. Fusions in R-spondin genes have been found in TSAs, but it is not clear whether these are sufficient for TSA development, due to the lack of a chromosome engineering platform for human tissues. We studied the ... Read more >>

Gastroenterology (Gastroenterology)
[2020, 158(3):638-651.e8]

Cited: 1 time

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High-Flow Nasal Cannula Therapy With Early Extubation for Subjects Undergoing Off-Pump Coronary Artery Bypass Graft Surgery.

Wataru Tatsuishi, Toshiro Sato, Go Kataoka, Atsuhiko Sato, Ryota Asano, Kiyoharu Nakano,

BACKGROUND:The effects of high-flow nasal cannula (HFNC) therapy on postoperative atelectasis and duration of oxygen therapy after off-pump coronary artery bypass graft are unknown. The purpose of this study was to compare the effects of HFNC therapy for subjects who underwent off-pump coronary artery bypass graft with the effects of ... Read more >>

Respir Care (Respiratory care)
[2020, 65(2):183-190]

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Author Correction: Efficient genetic engineering of human intestinal organoids using electroporation.

Masayuki Fujii, Mami Matano, Kosaku Nanki, Toshiro Sato,

The version of this paper originally published shows incorrect units for two plasmid concentrations. In the "Reagent Setup" section, the instructions for sgRNA-Cas9 plasmid should read "Adjust the concentration of each plasmid to 1 μg μl-1," rather than "to 1 μg ml-1." Similarly, all concentrations in the tables in Steps ... Read more >>

Nat Protoc (Nature protocols)
[2019, 14(8):2595]

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Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis.

Shimpei Matsui, Koji Okabayashi, Masashi Tsuruta, Kohei Shigeta, Ryo Seishima, Takashi Ishida, Takayuki Kondo, Yoshiyuki Suzuki, Hirotoshi Hasegawa, Masayuki Shimoda, Shinya Sugimoto, Toshiro Sato, Yuko Kitagawa,

The incidence of colorectal cancer (CRC) has been on the rise, which is linked to the increasing prevalence of obesity, based on global epidemiological evidence. Although chronic inflammation is implicated in tumor development, the mechanisms underlying obesity-associated CRC remain unknown. Here, we sought to identify the inflammatory cytokines and their ... Read more >>

Cancer Sci. (Cancer science)
[2019, 110(7):2156-2165]

Cited: 6 times

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Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia.

Daisuke Yamazaki, Ayaka Hasegawa, Yosuke Funato, Ha Nam Tran, Masayuki X Mori, Yasuo Mori, Toshiro Sato, Hiroaki Miki,

CNNM4 is a Mg2+ transporter highly expressed in the colon epithelia. Its importance in regulating intracellular Mg2+ levels and cancer development has been documented, but how CNNM4 function affects the dynamic homeostasis of the epithelial tissue remains unclear. Here, we show that Cnnm4 deficiency promotes cell proliferation and partly suppresses ... Read more >>

Oncogene (Oncogene)
[2019, 38(20):3962-3969]

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Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.

Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Wataru Suda, Toshiaki Teratani, Takahiro Suzuki, Yuzo Koda, Po-Sung Chu, Nobuhito Taniki, Akihiro Yamaguchi, Mitsuhiro Kanamori, Nobuhiko Kamada, Masahira Hattori, Hiroshi Ashida, Michiie Sakamoto, Koji Atarashi, Seiko Narushima, Akihiko Yoshimura, Kenya Honda, Toshiro Sato, Takanori Kanai,

Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithelial barrier dysfunction. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC, yet its underlying mechanism remains unknown. Here, we identify Klebsiella pneumonia in the microbiota ... Read more >>

Nat Microbiol (Nature microbiology)
[2019, 4(3):492-503]

Cited: 14 times

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Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.

Akiko Mito, Yukiko Nakano, Takako Saitoh, Sabine S S Gouraud, Yoshiki Yamaguchi, Toshiro Sato, Nobuo Sasaki, Kyoko Kojima-Aikawa,

Zymogen granule protein 16 (ZG16p) is a soluble lectin that binds to both mannose and heparin/heparan sulfate. It is highly expressed in the human digestive tract and is secreted into the mucus. In this study, we investigated the effect of ZG16p on the proliferation of human colorectal cancer cells. Overexpression ... Read more >>

Glycobiology (Glycobiology)
[2018, 28(1):21-31]

Cited: 1 time

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Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.

Masayuki Fujii, Mami Matano, Kohta Toshimitsu, Ai Takano, Yohei Mikami, Shingo Nishikori, Shinya Sugimoto, Toshiro Sato,

Cellular diversity that shapes tissue architecture and function is governed by multiple niche signals. Nonetheless, maintaining cellular diversity in human intestinal organoids has been challenging. Based on niche ligands present in the natural stem cell milieu, we establish a refined organoid culture condition for intestinal epithelia that allows human intestinal ... Read more >>

Cell Stem Cell (Cell stem cell)
[2018, 23(6):787-793.e6]

Cited: 22 times

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Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids.

Masayuki Fujii, Hans Clevers, Toshiro Sato,

Insights into the stem cell niche have allowed researchers to cultivate adult tissue stem cells as organoids that display structural and phenotypic features of healthy and diseased epithelial tissues. Organoids derived from patients' tissues are used as models of disease and to test drugs. CRISPR-Cas9 technology can be used to ... Read more >>

Gastroenterology (Gastroenterology)
[2019, 156(3):562-576]

Cited: 9 times

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Soyasapogenols reduce cellular triglyceride levels in 3T3-L1 mouse adipocyte cells by accelerating triglyceride lipolysis.

Kazuko Iwamoto, Shuichi Kamo, Yuichi Takada, Ayana Ieda, Takatoshi Yamashita, Toshiro Sato, Nobuhiro Zaima, Tatsuya Moriyama,

Soyasapogenol is a soyasaponin aglycone, which has been suggested to exert a more potent function than the glycoside form. In this study, the effect of soyasapogenol A and B on cultured adipocyte cell function was investigated using mouse 3T3-L1 adipocyte cells. 3T3-L1 cells were treated with insulin, dexamethasone, and 3-isobutyl-1-methylxanthine ... Read more >>

Biochem Biophys Rep (Biochemistry and biophysics reports)
[2018, 16:44-49]

Cited: 0 times

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