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Prediction model for hepatocellular carcinoma occurrence in patients with hepatitis C in the era of direct-acting anti-virals.

Yuki Tahata, Ryotaro Sakamori, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Hideki Hagiwara, Yasuharu Imai, Naoki Hiramatsu, Shinji Tamura, Keiji Yamamoto, Masahide Oshita, Kazuyoshi Ohkawa, Taizo Hijioka, Hiroyuki Fukui, Toshifumi Ito, Yoshinori Doi, Yukinori Yamada, Takayuki Yakushijin, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehara, ,

<h4>Background</h4>Several factors associated with hepatocellular carcinoma (HCC) occurrence after sustained virological response (SVR) in patients with hepatitis C have been reported. However, few validation studies have been performed in the era of direct-acting anti-virals (DAAs).<h4>Aims</h4>To develop a prediction model for HCC occurrence after DAA-mediated SVR and validate its usefulness.<h4>Methods</h4>We analysed ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Clinical course of hepatitis C virus-positive patients with decompensated liver cirrhosis in the era of direct-acting antiviral treatment.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Yuki Tahata, Masahide Oshita, Hideki Hagiwara, Mitsuru Sakakibara, Shinji Tamura, Naoki Hiramatsu, Masami Inada, Sadaharu Iio, Toshifumi Ito, Takayuki Yakushijin, Yoshinori Doi, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>The aim of the present study was to investigate the clinical course in hepatitis C virus (HCV)-positive patients with decompensated liver cirrhosis after direct-acting antivirals (DAAs) have been used for HCV infection.<h4>Methods</h4>This multicenter study prospectively analyzed a registered cohort composed of 73 HCV-positive patients with decompensated cirrhosis who attended our ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2021, 51(5):517-527]

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Therapeutic efficacy of lenvatinib in hepatocellular carcinoma patients with portal hypertension.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Ayako Urabe, Yuki Tahata, Masahide Oshita, Kazuyoshi Ohkawa, Eiji Mita, Hideki Hagiwara, Shinji Tamura, Toshifumi Ito, Takayuki Yakushijin, Sadaharu Iio, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>Preserved liver function may be an important factor affecting therapeutic efficacy in hepatocellular carcinoma patients treated with lenvatinib, but not all patients can be treated while preserving liver function. This study evaluated the therapeutic efficacy of lenvatinib in patients with poor liver function with and without portal hypertension.<h4>Methods</h4>This prospectively registered ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(9):1091-1100]

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Hypozincemia is associated with human hepatocarcinogenesis in hepatitis C virus-related liver cirrhosis.

Ryuta Shigefuku, Motoh Iwasa, Kazuhiro Katayama, Akiko Eguchi, Takumi Kawaguchi, Koichi Shiraishi, Toshifumi Ito, Kazutomo Suzuki, Chizu Koreeda, Takaaki Ohtake, Yoshio Tokumoto, Ryujin Endo, Naohiro Kawamura, Makoto Shiraki, Daiki Habu, Hironori Sakai, Akinobu Kato, Shuhei Nishiguchi, Hisataka Moriwaki, Kazuyuki Suzuki, Yoshiyuki Takei,

<h4>Aim</h4>Hypozincemia is associated with the progression of chronic liver diseases, but it is unknown whether hypozincemia promotes human hepatocarcinogenesis. Our aim is to evaluate the serum zinc levels in liver cirrhosis (LC) patients and clarify the relationship between the serum zinc levels and the development of hepatocellular carcinoma (HCC).<h4>Methods</h4>Cirrhotic patients ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2019, 49(10):1127-1135]

Cited: 8 times

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A novel handmade "multi-bending endoscope system" for endoscopic submucosal dissection of difficult-to-approach superficial gastric neoplasms.

Katsumi Yamamoto, Kohei Tanaka, Shiro Hayashi, Mariko Sawamura, Nobuyuki Tatsumi, Tomoki Michida, Toshifumi Ito,

Endoscopy (Endoscopy)
[2019, 51(4):E83-E84]

Cited: 0 times

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Possible involvement of Enterococcus infection in the pathogenesis of chronic pancreatitis and cancer.

Tomohiro Maekawa, Risako Fukaya, Shinji Takamatsu, Saki Itoyama, Tomoya Fukuoka, Makoto Yamada, Tomoki Hata, Satoshi Nagaoka, Koichi Kawamoto, Hidetoshi Eguchi, Kohei Murata, Takashi Kumada, Toshifumi Ito, Masahiro Tanemura, Kahoko Fujimoto, Yasuhiko Tomita, Toru Tobe, Yoshihiro Kamada, Eiji Miyoshi,

(Aim) Bacterial infection underlies the pathogenesis of many human diseases, including acute and chronic inflammation. Here, we investigated a possible role for bacterial infection in the progression of chronic pancreatitis. (Materials and Methods) Pancreatic juice was obtained from patients with pancreatic cancer (n = 20) or duodenal cancer/bile duct cancer (n = 16) and ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2018, 506(4):962-969]

Cited: 18 times

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Endoscopic submucosal dissection to relieve a flexure of the gastric conduit after esophagectomy.

Katsumi Yamamoto, Hiroshi Noro, Yu Sato, Akira Kusakabe, Nobuyuki Tatsumi, Tomoki Michida, Toshifumi Ito,

Background and study aims  A 70-year-old-man underwent an esophagectomy and posterior mediastinal reconstruction for esophageal cancer that was curatively resected. Although the patient was allowed to eat after surgery, he repeatedly vomited after drinking water or eating meals and required continuous hospitalization. An upper gastrointestinal series and endoscopic examination revealed ... Read more >>

Endosc Int Open (Endoscopy international open)
[2018, 6(3):E350-E353]

Cited: 0 times

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Luseogliflozin, an SGLT2 Inhibitor, in Japanese Patients With Mild/Moderate Hepatic Impairment: A Pharmacokinetic Study.

Yoshishige Samukawa, Michio Sata, Kenichi Furihata, Toshifumi Ito, Naohiko Ueda, Hidekazu Ochiai, Soichi Sakai, Yuji Kumagai,

This open-label, parallel-group study evaluated the effect of mild and moderate hepatic impairment on the pharmacokinetics of a single dose of luseogliflozin in Japanese subjects. Thirteen subjects with hepatic impairment (mild, n = 8; moderate, n = 5) and 6 healthy subjects received a single 5-mg dose of luseogliflozin. Serial ... Read more >>

Clin Pharmacol Drug Dev (Clinical pharmacology in drug development)
[2017, 6(5):439-447]

Cited: 2 times

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Clinical use of molecular targeted agents for primary small bowel adenocarcinoma: A multicenter retrospective cohort study by the Osaka Gut Forum.

Motohiro Hirao, Masato Komori, Tsutomu Nishida, Hideki Iijima, Shinjiro Yamaguchi, Ryu Ishihara, Yuichi Yasunaga, Ichizo Kobayashi, Osamu Kishida, Masahide Oshita, Hideki Hagiwara, Toshifumi Ito, Kunio Suzuki, Yoshito Hayashi, Takahiro Inoue, Masahiko Tsujii, Harumasa Yoshihara, Tetsuo Takehara,

Primary small bowel adenocarcinoma (SBA) is a rare cancer for which effective treatment strategies have not yet been established. The results of previous retrospective studies suggest that chemotherapy contributes to a longer survival time in patients with SBA. However, there are few case reports about the efficacy of molecular targeted ... Read more >>

Oncol Lett (Oncology letters)
[2017, 14(2):1628-1636]

Cited: 3 times

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Ultra-deep sequencing analysis of resistance-associated variants during retreatment with simeprevir-based triple therapy after failure of telaprevir-based triple therapy in patients with genotype 1 hepatitis C virus infection.

Naoki Morishita, Naoki Hiramatsu, Tsugiko Oze, Ayako Urabe, Yuki Tahata, Ryoko Yamada, Takayuki Yakushijin, Atsushi Hosui, Sadaharu Iio, Akira Yamada, Hideki Hagiwara, Eiji Mita, Yukinori Yamada, Toshifumi Ito, Masami Inada, Kazuhiro Katayama, Iwao Yabuuchi, Yasuharu Imai, Hayato Hikita, Ryotaro Sakamori, Yuichi Yoshida, Tomohide Tatsumi, Norio Hayashi, Tetsuo Takehara,

<h4>Aim</h4>Simeprevir (SMV)-based triple therapy is an effective retreatment option following failure of telaprevir (TVR)-based triple therapy. However, it is unclear whether the persistence of resistance-associated variants (RAVs) induced by TVR-based therapy may reduce the treatment effect of SMV-based therapy.<h4>Methods</h4>The factors associated with the treatment effect, including RAVs in the NS3 ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2017, 47(8):773-782]

Cited: 2 times

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Safety and short-term outcomes of endoscopic submucosal dissection for early gastric cancer in elderly patients.

Minoru Kato, Tomoki Michida, Akira Kusakabe, Ayako Sakai, Chihiro Hibino, Mina Kato, Yuki Tokuda, Tomoyo Kawai, Mina Hamano, Miho Chiba, Kosaku Maeda, Katsumi Yamamoto, Masafumi Naito, Toshifumi Ito,

<h4>Background and study aims</h4>Endoscopic submucosal dissection (ESD) has become widely accepted as a minimally invasive treatment for early gastric cancer (EGC), and opportunities to use ESD to treat EGC in elderly patients are increasing. The objective of this study was to elucidate the safety and efficacy of ESD in elderly ... Read more >>

Endosc Int Open (Endoscopy international open)
[2016, 4(5):E521-6]

Cited: 5 times

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Impact of ribavirin dosage in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin combination therapy.

Yuki Tahata, Naoki Hiramatsu, Tsugiko Oze, Ayako Urabe, Naoki Morishita, Ryoko Yamada, Takayuki Yakushijin, Atsushi Hosui, Masahide Oshita, Akira Kaneko, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Yukinori Yamada, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Yasuharu Imai, Hayato Hikita, Ryotaro Sakamori, Yuichi Yoshida, Tomohide Tatsumi, Norio Hayashi, Tetsuo Takehara,

The factors associated with sustained virologic response (SVR) in chronic hepatitis C (CH-C) genotype 1 patients treated with simeprevir (SMV), pegylated interferon (Peg-IFN) plus ribavirin (RBV) triple therapy have not been fully investigated. Two hundred and twenty-nine treatment-naïve CH-C patients treated with SMV triple therapy were enrolled in this study. ... Read more >>

J Med Virol (Journal of medical virology)
[2016, 88(10):1776-1784]

Cited: 1 time

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Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis.

Tomohiro Maekawa, Yoshihiro Kamada, Yusuke Ebisutani, Makiko Ueda, Tomoki Hata, Koichi Kawamoto, Shinji Takamatsu, Kayo Mizutani, Mayuka Shimomura, Tomoaki Sobajima, Hironobu Fujii, Kotarosumitomo Nakayama, Kimihiro Nishino, Makoto Yamada, Takashi Kumada, Toshifumi Ito, Hidetoshi Eguchi, Hiroaki Nagano, Eiji Miyoshi,

<h4>Aim</h4>To determine the efficacy of Mac-2 binding protein (Mac-2bp) for diagnosis of chronic pancreatitis.<h4>Methods</h4>Fifty-nine healthy volunteers (HV), 162 patients with chronic pancreatitis (CP), and 94 patients with pancreatic ductal adenocarcinoma (PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables ... Read more >>

World J Gastroenterol (World journal of gastroenterology)
[2016, 22(17):4403-4410]

Cited: 7 times

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Specific increase in serum core-fucosylated haptoglobin in patients with chronic pancreatitis.

Makiko Ueda, Yoshihiro Kamada, Shinji Takamatsu, Mayuka Shimomura, Tomohiro Maekawa, Tomoaki Sobajima, Hironobu Fujii, Kotarosumitomo Nakayama, Kimihiro Nishino, Makoto Yamada, Yuka Kobayashi, Takashi Kumada, Toshifumi Ito, Hidetoshi Eguchi, Hiroaki Nagano, Eiji Miyoshi,

<h4>Background/objectives</h4>Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all malignancies, and its diagnosis in early stages is the most important prognostic factor. Chronic pancreatitis (CP), a common background of PDAC occurrence, is morphologically defined as progressive pancreatic fibrosis and inflammation accompanied by pancreatic exocrine cell atrophy. We recently found ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2016, 16(2):238-243]

Cited: 12 times

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The impact of an inosine triphosphate pyrophosphatase genotype on bilirubin increase in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin.

Yuki Tahata, Naoki Hiramatsu, Tsugiko Oze, Naoki Morishita, Naoki Harada, Ryoko Yamada, Takayuki Yakushijin, Eiji Mita, Hideki Hagiwara, Yukinori Yamada, Toshifumi Ito, Taizo Hijioka, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Keiko Irishio, Michio Kato, Hayato Hikita, Ryotaro Sakamori, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Toshimitsu Hamasaki, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>Hyperbilirubinemia, mild or moderate, is a commonly observed laboratory abnormality in chronic hepatitis C patients treated with simeprevir with pegylated interferon (Peg-IFN) plus ribavirin. In this prospective, multicenter study, we aimed to investigate the clinical features and factors associated with bilirubin increases during the therapy.<h4>Methods</h4>A total of 192 patients with ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2016, 51(3):252-259]

Cited: 7 times

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Colorectal endoscopic submucosal dissection: Recent technical advances for safe and successful procedures.

Katsumi Yamamoto, Tomoki Michida, Tsutomu Nishida, Shiro Hayashi, Masafumi Naito, Toshifumi Ito,

Endoscopic submucosal dissection (ESD) is very useful in en bloc resection of large superficial colorectal tumors but is a technically difficult procedure because the colonic wall is thin and endoscopic maneuverability is poor because of colonic flexure and extensibility. A high risk of perforation has been reported in colorectal ESD. ... Read more >>

World J Gastrointest Endosc (World journal of gastrointestinal endoscopy)
[2015, 7(14):1114-1128]

Cited: 18 times

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Effective use of the "clip-flap" method for the endoscopic submucosal dissection of a difficult-to-approach superficial gastric tumor.

Katsumi Yamamoto, Shiro Hayashi, Tsutomu Nishida, Hirotsugu Saiki, Masafumi Naito, Tomoki Michida, Toshifumi Ito,

Endoscopy (Endoscopy)
[2015, 47 Suppl 1 UCTN:E318-9]

Cited: 2 times

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A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile.

Nobuyasu Fukutake, Makoto Ueno, Nobuyoshi Hiraoka, Kazuaki Shimada, Koichi Shiraishi, Nobuhiro Saruki, Toshifumi Ito, Minoru Yamakado, Nobukazu Ono, Akira Imaizumi, Shinya Kikuchi, Hiroshi Yamamoto, Kazuhiro Katayama,

<h4>Background</h4>The incidence of pancreatic cancer (PC) continues to increase in the world, while most patients are diagnosed with advanced stages and survive <12 months. This poor prognosis is attributable to difficulty of early detection. Here we developed and evaluated a multivariate index composed of plasma free amino acids (PFAAs) for ... Read more >>

PLoS One (PloS one)
[2015, 10(7):e0132223]

Cited: 39 times

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Clinicopathological Significance of Leucine-Rich α2-Glycoprotein-1 in Sera of Patients With Pancreatic Cancer.

Kenta Furukawa, Koichi Kawamoto, Hidetoshi Eguchi, Masahiro Tanemura, Tsukasa Tanida, Yoshito Tomimaru, Hirofumi Akita, Naoki Hama, Hiroshi Wada, Shogo Kobayashi, Yuji Nonaka, Shinji Takamatsu, Shinichiro Shinzaki, Takashi Kumada, Shinji Satomura, Toshifumi Ito, Satoshi Serada, Tetsuji Naka, Masaki Mori, Yuichiro Doki, Eiji Miyoshi, Hiroaki Nagano,

<h4>Objectives</h4>Leucine-rich α2-glycoprotein-1 (LRG-1) is an inflammatory protein. Serum LRG-1 levels can reportedly be used as a cancer biomarker for several types of carcinoma. In the present study, we investigated the clinical usefulness of serum LRG-1 levels as a biomarker of pancreatic cancer.<h4>Methods</h4>A total of 124 patients with pancreatic cancer, 35 ... Read more >>

Pancreas (Pancreas)
[2015, 44(1):93-98]

Cited: 24 times

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Effect of zinc on liver cirrhosis with hyperammonemia: a preliminary randomized, placebo-controlled double-blind trial.

Kazuhiro Katayama, Masanori Saito, Takumi Kawaguchi, Ryujin Endo, Kei Sawara, Shuhei Nishiguchi, Akinobu Kato, Hiroshi Kohgo, Kazutomo Suzuki, Isao Sakaida, Yoshiyuki Ueno, Daiki Habu, Toshifumi Ito, Hisataka Moriwaki, Kazuyuki Suzuki,

<h4>Objective</h4>To our knowledge, no randomized study has shown whether zinc replacement therapy is effective for hyperammonemia in liver cirrhosis; therefore, we performed a double-blind, placebo-controlled trial to examine efficacy and safety of the zinc replacement therapy.<h4>Methods</h4>Patients with liver cirrhosis and hyperammonemia (at or above the institutional reference value) and hypozincemia ... Read more >>

Nutrition (Nutrition (Burbank, Los Angeles County, Calif.))
[2014, 30(11-12):1409-1414]

Cited: 24 times

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Spontaneous regression of a large hepatocellular carcinoma with multiple lung metastases.

Tamiko Saito, Masafumi Naito, Yuki Matsumura, Hisaaki Kita, Tomoyo Kanno, Yuki Nakada, Mina Hamano, Miho Chiba, Kosaku Maeda, Tomoki Michida, Toshifumi Ito,

A 75-year-old Japanese man with chronic hepatitis C was found to have a large liver tumor and multiple nodules in the bilateral lungs. We diagnosed the tumor as hepatocellular carcinoma (HCC) with multiple lung metastases based on imaging studies and high titers of HCC tumor markers. Remarkably, without any anticancer ... Read more >>

Gut Liver (Gut and liver)
[2014, 8(5):569-574]

Cited: 6 times

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Branched-chain amino acids prevent hepatocarcinogenesis and prolong survival of patients with cirrhosis.

Takumi Kawaguchi, Koichi Shiraishi, Toshifumi Ito, Kazutomo Suzuki, Chizu Koreeda, Takaaki Ohtake, Motoh Iwasa, Yoshio Tokumoto, Ryujin Endo, Nao-hiro Kawamura, Makoto Shiraki, Daiki Habu, Satoru Tsuruta, Yoshiyuki Miwa, Atsushi Kawaguchi, Tatsuyuki Kakuma, Hironori Sakai, Norifumi Kawada, Tatsunori Hanai, Shin-ichi Takahashi, Akinobu Kato, Morikazu Onji, Yoshiyuki Takei, Yutaka Kohgo, Toshihito Seki, Masaya Tamano, Kazuhiro Katayama, Tetsuya Mine, Michio Sata, Hisataka Moriwaki, Kazuyuki Suzuki,

<h4>Background & aims</h4>Although a low plasma level of branched-chain amino acids (BCAAs) is a marker of cirrhosis, it is not clear whether BCAA supplements affect disease progression. We performed a multicenter study to evaluate the effects of BCAA supplementation on hepatocarcinogenesis and survival in patients with cirrhosis.<h4>Methods</h4>We enrolled 299 patients ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2014, 12(6):1012-8.e1]

Cited: 34 times

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Post-treatment levels of α-fetoprotein predict incidence of hepatocellular carcinoma after interferon therapy.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Masanori Miyazaki, Akira Yamada, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Hiroyuki Fukui, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Akinori Kasahara, Toshimitsu Hamasaki, Norio Hayashi, Tetsuo Takehara, ,

<h4>Background & aims</h4>In patients with chronic hepatitis C virus (HCV) infection, lack of sustained virologic response (SVR) 24 weeks after the end of interferon therapy is a significant risk factor for hepatocellular carcinoma (HCC). Although many pretreatment factors are known to affect HCC incidence, less is known about post-treatment factors-many ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2014, 12(7):1186-1195]

Cited: 47 times

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Diuretics aggravate zinc deficiency in patients with liver cirrhosis by increasing zinc excretion in urine.

Miho Chiba, Kazuhiro Katayama, Risato Takeda, Rie Morita, Kiyoshi Iwahashi, Yoshiki Onishi, Hisaaki Kita, Akira Nishio, Tomoyo Kanno, Tamiko Saito, Kosaku Maeda, Masafumi Naito, Tomoki Michida, Toshifumi Ito,

<h4>Aim</h4>Liver cirrhosis is often accompanied by zinc deficiency. The exact mechanisms underlying zinc deficiency remain unclear. This study was undertaken to clarify the influence of diuretics on blood zinc levels and zinc excretion in urine in liver cirrhosis.<h4>Methods</h4>Seventy-nine outpatients with liver cirrhosis were divided into four groups: (i) patients receiving ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2013, 43(4):365-373]

Cited: 7 times

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Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin.

Tsugiko Oze, Naoki Hiramatsu, Changho Song, Takayuki Yakushijin, Sadaharu Iio, Yoshinobu Doi, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Yoshiaki Inui, Taizo Hijioka, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Masanori Miyazaki, Atsushi Hosui, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>The timing to the first undetectable hepatitis C virus (HCV) RNA level is strongly associated with sustained virologic response in pegylated interferon (Peg-IFN) plus ribavirin combination therapy for patients with chronic hepatitis C (CH-C) with genotype 1. This study was conducted to clarify the impact of drug exposure to Peg-IFN ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2012, 47(3):334-342]

Cited: 2 times

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