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Author Toshie Saito

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Monocyte released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition.

Shoichiro Otsuki, Toshie Saito, Shalina Taylor, Dan Li, Jan-Renier Moonen, David P Marciano, Rebecca L Harper, Aiqin Cao, Lingli Wang, Maria E Ariza, Marlene Rabinovitch,

Previously we reported heightened expression of human endogenous retroviral protein HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating monocytes and pulmonary arterial (PA) adventitial macrophages of PA hypertension (PAH) patients. Furthermore, recombinant HERV-K dUTPase increased IL6 in PA endothelial cells (PAECs) and caused pulmonary hypertension in rats. Here we show that ... Read more >>

JCI Insight (JCI insight)
[2021, :]

Cited: 0 times

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Impact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository.

Toshie Saito, Yue Wei, Li Wen, Chaitanya Srinivasan, Benjamin O Wolthers, Cheng-Yu Tsai, Marian H Harris, Kristen Stevenson, Craig Byersdorfer, Judy-April Oparaji, Christian Fernandez, Amitava Mukherjee, Maisam Abu-El-Haija, Sameer Agnihotri, Kjeld Schmiegelow, Megan R Showalter, Paul W Fogle, Scott McCulloch, Kevin Contrepois, Lewis B Silverman, Ying Ding, Sohail Z Husain,

<h4>Introduction</h4>Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the overall survival has increased to over 90%. However, the current challenge is to mitigate adverse events resulting from the complex therapy. Several chemotherapies intercept cancer metabolism, but little is known about ... Read more >>

Metabolomics (Metabolomics : Official journal of the Metabolomic Society)
[2021, 17(7):64]

Cited: 0 times

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iPSC-endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension.

Mingxia Gu, Michele Donato, Minzhe Guo, Neil Wary, Yifei Miao, Shuai Mao, Toshie Saito, Shoichiro Otsuki, Lingli Wang, Rebecca L Harper, Silin Sa, Purvesh Khatri, Marlene Rabinovitch,

Pulmonary arterial hypertension (PAH) is a progressive disorder leading to occlusive vascular remodeling. Current PAH therapies improve quality of life but do not reverse structural abnormalities in the pulmonary vasculature. Here, we used high-throughput drug screening combined with in silico analyses of existing transcriptomic datasets to identify a promising lead ... Read more >>

Sci Transl Med (Science translational medicine)
[2021, 13(592):]

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Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1-Mediated Metabolic and Epigenetic Changes.

Kazuya Miyagawa, Minyi Shi, Pin-I Chen, Jan K Hennigs, Zhixin Zhao, Mouer Wang, Caiyun G Li, Toshie Saito, Shalina Taylor, Silin Sa, Aiqin Cao, Lingli Wang, Michael P Snyder, Marlene Rabinovitch,

<h4>Rationale</h4>Maintaining endothelial cells (EC) as a monolayer in the vessel wall depends on their metabolic state and gene expression profile, features influenced by contact with neighboring cells such as pericytes and smooth muscle cells (SMC). Failure to regenerate a normal EC monolayer in response to injury can result in occlusive ... Read more >>

Circ Res (Circulation research)
[2019, 124(2):211-224]

Cited: 16 times

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Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension.

Rasa Tamosiuniene, Olga Manouvakhova, Paul Mesange, Toshie Saito, Jin Qian, Mrinmoy Sanyal, Yu-Chun Lin, Linh P Nguyen, Amir Luria, Allen B Tu, Joshua M Sante, Marlene Rabinovitch, Desmond J Fitzgerald, Brian B Graham, Aida Habtezion, Norbert F Voelkel, Laure Aurelian, Mark R Nicolls,

RATIONALE:Pulmonary arterial hypertension (PH) is a life-threatening condition associated with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently unknown whether and how abnormal Treg function differentially affects males and females. OBJECTIVE:To evaluate whether and how Treg deficiency differentially affects male and female rats in experimental ... Read more >>

Circ Res (Circulation research)
[2018, 122(12):1689-1702]

Cited: 27 times

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Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension.

Toshie Saito, Kazuya Miyagawa, Shih-Yu Chen, Rasa Tamosiuniene, Lingli Wang, Orr Sharpe, Erik Samayoa, Daisuke Harada, Jan-Renier A J Moonen, Aiqin Cao, Pin-I Chen, Jan K Hennigs, Mingxia Gu, Caiyun G Li, Ryan D Leib, Dan Li, Christopher M Adams, Patricia A Del Rosario, Matthew Bill, Francois Haddad, Jose G Montoya, William H Robinson, Wendy J Fantl, Garry P Nolan, Roham T Zamanian, Mark R Nicolls, Charles Y Chiu, Maria E Ariza, Marlene Rabinovitch,

<h4>Background</h4>Immune dysregulation has been linked to occlusive vascular remodeling in pulmonary arterial hypertension (PAH) that is hereditary, idiopathic, or associated with other conditions. Circulating autoantibodies, lung perivascular lymphoid tissue, and elevated cytokines have been related to PAH pathogenesis but without a clear understanding of how these abnormalities are initiated, perpetuated, ... Read more >>

Circulation (Circulation)
[2017, 136(20):1920-1935]

Cited: 16 times

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Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica.

Yoshinobu Kariya, Yukiko Kariya, Toshie Saito, Shuhei Nishiyama, Takashi Honda, Keiko Tanaka, Mari Yoshida, Kazuo Fujihara, Yasuhiro Hashimoto,

<h4>Background</h4>Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system that predominantly affects the optic nerves and spinal cord. Although NMO has long been considered a subtype of multiple sclerosis (MS), the effects of interferon-β treatment are different between NMO and MS. Recent findings of NMO-IgG suggest that ... Read more >>

BBA Clin (BBA clinical)
[2015, 3:126-134]

Cited: 7 times

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In situ visualization of a glycoform of transferrin: localization of α2,6-sialylated transferrin in the liver.

Yuka Matsumoto, Toshie Saito, Kyoka Hoshi, Hiromi Ito, Yoshinobu Kariya, Masamichi Nagae, Yoshiki Yamaguchi, Yoshiaki Hagiwara, Noriaki Kinoshita, Ikuo Wada, Kiyoshi Saito, Takashi Honda, Yasuhiro Hashimoto,

We previously found that a lectin, Sambucus sieboldiana agglutinin (SSA), bound to α2,6-sialylated glycan epitopes on transferrin and inhibited anti-transferrin antibody binding to the antigen in ELISA (SSA inhibition). Here we report that SSA inhibition is applicable to immunohistochemistry, localizing α2,6-sialylated transferrin in the liver. Immunohistochemistry using anti-transferrin polyclonal antibody ... Read more >>

J Biochem (Journal of biochemistry)
[2015, 157(4):211-216]

Cited: 2 times

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Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.

Hirofumi Sawada, Toshie Saito, Nils P Nickel, Tero-Pekka Alastalo, Jason P Glotzbach, Roshelle Chan, Leila Haghighat, Gabriele Fuchs, Michael Januszyk, Aiqin Cao, Ying-Ju Lai, Vinicio de Jesus Perez, Yu-Mee Kim, Lingli Wang, Pin-I Chen, Edda Spiekerkoetter, Yoshihide Mitani, Geoffrey C Gurtner, Peter Sarnow, Marlene Rabinovitch,

Idiopathic pulmonary arterial hypertension (PAH [IPAH]) is an insidious and potentially fatal disease linked to a mutation or reduced expression of bone morphogenetic protein receptor 2 (BMPR2). Because intravascular inflammatory cells are recruited in IPAH pathogenesis, we hypothesized that reduced BMPR2 enhances production of the potent chemokine granulocyte macrophage colony-stimulating ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2014, 211(2):263-280]

Cited: 65 times

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High Throughput ELISAs to Measure a Unique Glycan on Transferrin in Cerebrospinal Fluid: A Possible Extension toward Alzheimer's Disease Biomarker Development.

Keiro Shirotani, Satoshi Futakawa, Kiyomitsu Nara, Kyoka Hoshi, Toshie Saito, Yuriko Tohyama, Shinobu Kitazume, Tatsuhiko Yuasa, Masakazu Miyajima, Hajime Arai, Atsushi Kuno, Hisashi Narimatsu, Yasuhiro Hashimoto,

We have established high-throughput lectin-antibody ELISAs to measure different glycans on transferrin (Tf) in cerebrospinal fluid (CSF) using lectins and an anti-transferrin antibody (TfAb). Lectin blot and precipitation analysis of CSF revealed that PVL (Psathyrella velutina lectin) bound an unique N-acetylglucosamine-terminated N-glycans on "CSF-type" Tf whereas SSA (Sambucus sieboldiana agglutinin) ... Read more >>

Int J Alzheimers Dis (International journal of Alzheimer's disease)
[2011, 2011:352787]

Cited: 5 times

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Increased urinary angiotensinogen is precedent to increased urinary albumin in patients with type 1 diabetes.

Toshie Saito, Maki Urushihara, Yumiko Kotani, Shoji Kagami, Hiroyuki Kobori,

<h4>Background</h4>We previously reported that kidney and urinary angiotensinogen levels were significantly increased before the development of diabetic nephropathy in diabetic rats. To address this system in humans, we have developed an enzyme-linked immunosorbent assay for human angiotensinogen and reported that urinary excretion of angiotensinogen levels is enhanced in patients with ... Read more >>

Am J Med Sci (The American journal of the medical sciences)
[2009, 338(6):478-480]

Cited: 71 times

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Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients.

Hiroyuki Kobori, A Brent Alper, Rajesh Shenava, Akemi Katsurada, Toshie Saito, Naro Ohashi, Maki Urushihara, Kayoko Miyata, Ryousuke Satou, L Lee Hamm, L Gabriel Navar,

We reported previously that urinary angiotensinogen (UAGT) levels provide a specific index of the intrarenal renin-angiotensin system (RAS) status in angiotensin II-dependent hypertensive rats. To study this system in humans, we recently developed a human angiotensinogen ELISA. To test the hypothesis that UAGT is increased in hypertensive patients, we recruited ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2009, 53(2):344-350]

Cited: 119 times

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Role of activated intrarenal reactive oxygen species and renin-angiotensin system in IgA nephropathy model mice.

Naro Ohashi, Akemi Katsurada, Kayoko Miyata, Ryousuke Satou, Toshie Saito, Maki Urushihara, Hiroyuki Kobori,

1. Using HIGA (high IgA of ddY) mice as an IgA nephropathy model and BALB/c mice as controls, we demonstrated that reactive oxygen species (ROS) and the renin-angiotensin system (RAS) were activated in kidneys of HIGA mice. However, it was difficult to establish an association between renal damage and changes ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2009, 36(8):750-755]

Cited: 30 times

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Activation of reactive oxygen species and the renin-angiotensin system in IgA nephropathy model mice.

Naro Ohashi, Akemi Katsurada, Kayoko Miyata, Ryousuke Satou, Toshie Saito, Maki Urushihara, Hiroyuki Kobori,

1. Although IgA nephropathy is the most common form of primary glomerulopathy, the detailed mechanisms underlying its development remain uncertain. 2. In the present study, we used male high IgA strain of ddY (HIGA) mice as the IgA nephropathy model and age-matched male BALB/c mice as the control. Recent studies ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2009, 36(5-6):509-515]

Cited: 18 times

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Urinary angiotensinogen as a potential biomarker of severity of chronic kidney diseases.

Hiroyuki Kobori, Naro Ohashi, Akemi Katsurada, Kayoko Miyata, Ryousuke Satou, Toshie Saito, Tatsuo Yamamoto,

We previously reported that urinary excretion rates of angiotensinogen (AGT) provide a specific index of the activity of the intrarenal renin-angiotensin system in angiotensin II-dependent hypertensive rats. Meanwhile, we have recently developed direct enzyme-linked immunosorbent assays (ELISAs) to measure plasma and urinary AGT in humans. This study was performed to ... Read more >>

J Am Soc Hypertens (Journal of the American Society of Hypertension : JASH)
[2008, 2(5):349-354]

Cited: 81 times

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Determination of plasma and urinary angiotensinogen levels in rodents by newly developed ELISA.

Hiroyuki Kobori, Akemi Katsurada, Kayoko Miyata, Naro Ohashi, Ryousuke Satou, Toshie Saito, Yoshiaki Hagiwara, Kazuya Miyashita, L Gabriel Navar,

We recently reported that urinary excretion rates of angiotensinogen provide a specific index of the intrarenal renin-angiotensin system status in angiotensin II-dependent hypertensive rats. Angiotensinogen concentrations in mouse plasma are thought to be much lower than those in rat plasma; however, detailed information is deficient due to lack of direct ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2008, 294(5):F1257-63]

Cited: 47 times

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