Full Text Journal Articles by
Author Tom Boterberg

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Towards homogenization of total body irradiation practices in pediatric patients across SIOPE affiliated centers. A survey by the SIOPE radiation oncology working group.

Bianca A W Hoeben, Montserrat Pazos, Michael H Albert, Enrica Seravalli, Mirjam E Bosman, Christoph Losert, Tom Boterberg, Farkhad Manapov, Inna Ospovat, Soraya Mico Milla, Candan Demiroz Abakay, Jacob Engellau, Gregor Kos, Stéphane Supiot, Marc Bierings, Geert O Janssens,

BACKGROUND AND PURPOSE:To reduce relapse risk, Total Body Irradiation (TBI) is part of conditioning regimens for hematopoietic stem cell transplantation (HSCT) in pediatric acute leukemia. The study purpose was to evaluate clinical practices regarding TBI, such as fractionation, organ shielding and delivery techniques, among SIOPE affiliated radiotherapy centers. METHODS:An electronic ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 155:113-119]

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Partial resection offers an overall survival benefit over biopsy in MGMT-unmethylated IDH-wildtype glioblastoma patients.

Giorgio Hallaert, Harry Pinson, Dimitri Vanhauwaert, Caroline Van den Broecke, Dirk Van Roost, Tom Boterberg, Jean-Pierre Kalala,

Background Isocitrate dehydrogenase (IDH)-wildtype glioblastoma patients with O6-methylguanine-DNA-methyltransferase (MGMT)-unmethylated tumors have the worst outcome of all glioblastoma patients. The overall survival (OS) benefit of partial resection of glioblastoma compared to biopsy only remains controversial specifically in relation to molecular factors. In this report, we analyzed the effect of incomplete resection ... Read more >>

Surg Oncol (Surgical oncology)
[2020, 35:515-519]

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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

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Global pediatric radiation therapy in resource-limited settings.

Clayton B Hess, Jeannette Parkes, Geert O Janssens, Chi Lin, Kenneth Wong, Mohamed S Zaghloul, Daniel G Marconi, Tom Boterberg, Natia Esiashvili,

This report provides a summary of the global burden of childhood cancer morbidity and mortality, which disproportionately affects low- and middle-income countries as well as low- and middle-income communities within high-income countries. We review past successes and current challenges to improving clinical pediatric radiotherapy, education, and research in these regions. ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28299]

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Acupuncture as a complementary therapy for cancer care: acceptability and preferences of patients and informal caregivers

Tessa Lefebvre, Laura Tack, Virginie Blieck, Lieselot Cool, Hans Pottel, Koen Van Eygen, Sofie Derijcke, Philippe Vergauwe, Patricia Schofield, Rebecca Chandler, Pauline Lane, Tom Boterberg, Philip Debruyne,

Abstract The authors have withdrawn this preprint due to author disagreement. ... Read more >>

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A Baseline Survey on the Treatment Workflow and Pediatric IGRT Practice Among European Members of the Project-Based Consortium and the Pediatric Radiation Oncology Society (PROS).

Coen A.A. Windmeijer, Arjan Bel, Rianne de Jong, Brian Balgobind, Marianne Aznar, Karen van Beek, Guillaume Beldjoudi, Tom Boterberg, Dana Cernea, Laurien Daniels, Karin Dieckmann, Andrea Filippi, Cornelis J.A. Haasbeek, Bianca Hoeben, Geert O.R. Janssens, Mirjana Josipovic, Hannes Jürgens, Adam Kouvelis, Yasmin Lassen, Anna Loginova, John Maduro, Barbora Ondrová, Barbara Rombi, Diana Steinmann, Camilla Stokkevag, Marilena Theodorou, Beate Timmermann, Vaska Vasileva-Kodeyh, Lorna Zadravec Zaletel, Irma W.E.M. van Dijk,

Abstract Background Image-guided radiotherapy (IGRT) enables high precision tumor treatment with potential for sparing healthy tissues. The value of pediatric IGRT is widely acknowledged, but there is no consensus on ‘best practice’. We aimed to assess clinical pediatric IGRT practice among European members of the Pediatric Radiation Oncology Society (PROS) ... Read more >>

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Developing and evaluating a participatory arts programme for cancer patients and their caregivers.

Tessa Lefebvre, Laura Tack, Marlies Meersman, Hilde Vanneste, Lieselot Cool, Koen Van Eygen, Karin Stellamans, Sofie Derijcke, Philippe Vergauwe, Jos De Backer, Rebecca Chandler, Pauline Lane, Tom Boterberg, Philip R Debruyne,

OBJECTIVES:Cancer patients, survivors and caregivers often encounter severe distress, having significant consequences to wellbeing, functionality and physical health. This study developed and evaluated a participatory arts programme to determine if such could help to improve the wellbeing of cancer patients and their caregivers. METHODS:To inform the development of a participatory ... Read more >>

Acta Clin Belg (Acta clinica Belgica)
[2020, :1-7]

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Effectiveness of Adjunctive Analgesics in Head and Neck Cancer Patients Receiving Curative (Chemo-) Radiotherapy: A Systematic Review.

Tessa Lefebvre, Laura Tack, Michelle Lycke, Fréderic Duprez, Laurence Goethals, Sylvie Rottey, Lieselot Cool, Koen Van Eygen, Brendon Stubbs, Patricia Schofield, Hans Pottel, Tom Boterberg, Philip Debruyne,

OBJECTIVE:Our aim was to give an overview of the effectiveness of adjunctive analgesics in head and neck cancer (HNC) patients receiving (chemo-) radiotherapy. DESIGN:Systematic review. INTERVENTIONS:This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase, Web of Science, the Cochrane Library, and ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2020, :]

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Underrepresentation of vulnerable older patients with cancer in phase II and III oncology registration trials: A case-control study.

Laura Tack, Tessa Lefebvre, Michelle Lycke, Lies Pottel, Lieselot Cool, Lore Ketelaars, Jolien De Zutter, Evi Martens, Hans Pottel, Karin Stellamans, Koen Van Eygen, Patrick Werbrouck, Philippe Vergauwe, Hans Wildiers, Patricia Schofield, Tom Boterberg, Philip R Debruyne,

OBJECTIVES:We aimed to determine the proportion of "fit" versus "vulnerable" older patients with cancer included in phase II and III oncology registration trials, as compared to the proportions in a real life oncology setting. METHODS:Trial and patient characteristics of older (≥70years) patients treated at the OECI-designated clinical cancer centre in ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2020, 11(2):320-326]

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Radiation dose and pathological response in oesophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by surgery: a multi-institutional analysis.

Melissa Thomas, Alicia S Borggreve, Peter S N van Rossum, Christiaan Perneel, Johnny Moons, Elke Van Daele, Richard van Hillegersberg, Wei Deng, Piet Pattyn, Stella Mook, Tom Boterberg, Jelle P Ruurda, Philippe Nafteux, Steven H Lin, Karin Haustermans,

Purpose: To explore whether a higher neoadjuvant radiation dose increases the probability of a pathological complete response (pCR) or pathological major response (pMR) response in oesophageal cancer patients. Material and methods: Between 2000 and 2017, 1048 patients from four institutions were stratified according to prescribed neoadjuvant radiation doses of 36.0 Gy ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2019, 58(10):1358-1365]

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Technical feasibility of [18F]FET and [18F]FAZA PET guided radiotherapy in a F98 glioblastoma rat model.

Jeroen Verhoeven, Julie Bolcaen, Valerie De Meulenaere, Ken Kersemans, Benedicte Descamps, Sam Donche, Caroline Van den Broecke, Tom Boterberg, Jean-Pierre Kalala, Karel Deblaere, Christian Vanhove, Filip De Vos, Ingeborg Goethals,

BACKGROUND:Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolomide (TMZ). An accurate definition of the tumor volume is of utmost importance for guiding RT. In this project we investigated the feasibility ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2019, 14(1):89]

Cited: 1 time

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Radiotherapy practice for paediatric brain tumours across Europe and quality assurance initiatives: Current situation, international survey and future perspectives.

Teresa de Rojas, Enrico Clementel, Jordi Giralt, Ofelia Cruz, Tom Boterberg, Rolf-Dieter Kortmann, Mark N Gaze, Lucas Moreno, Geert O Janssens, ,

AIM:The aim of the study is to analyse radiotherapy quality assurance (RTQA) processes in the treatment of paediatric central nervous system (CNS) tumours across Europe. METHODS:The RTQA aspects of major past and current European trials for paediatric CNS tumours were reviewed based on study protocols and publications. A survey among ... Read more >>

Eur. J. Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 114:36-46]

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Subjective, but not objective, cognitive complaints impact long-term quality of life in cancer patients.

Michelle Lycke, Tessa Lefebvre, Lies Pottel, Hans Pottel, Lore Ketelaars, Karin Stellamans, Koen Van Eygen, Philippe Vergauwe, Patrick Werbrouck, Lieselot Cool, Tom Boterberg, Nick Liefhooghe, Patricia Schofield, Philip R Debruyne,

OBJECTIVES:Cognitive complaints, of objective or subjective nature, may negatively impact cancer patients' quality of life (QoL). Further, the early detection of cognitive alterations may lead to an improved QoL. However, the content of such screening is yet unclear. This paper presents long-term QoL data of cancer patients treated with curative ... Read more >>

J Psychosoc Oncol (Journal of psychosocial oncology)
[2019, 37(4):427-440]

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Detection of alcohol abuse in older patients with cancer: The integration of alcohol screening questionnaires in the comprehensive geriatric assessment.

Michelle Lycke, Evi Martens, Lore Ketelaars, Jolien Dezutter, Tessa Lefebvre, Hans Pottel, Koen Van Eygen, Lieselot Cool, Patricia Schofield, Tom Boterberg, Philip R Debruyne,

OBJECTIVES:We aimed to evaluate the feasibility of implementing an alcohol screening questionnaire as part of the comprehensive geriatric assessment (CGA) by reporting the prevalence of alcohol abuse in a group of older patients with cancer in a Belgian cancer centre. MATERIALS AND METHODS:Patients were recruited at the Geriatric Oncology Clinic ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2019, 10(5):819-823]

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The Path Toward PET-Guided Radiation Therapy for Glioblastoma in Laboratory Animals: A Mini Review.

Sam Donche, Jeroen Verhoeven, Benedicte Descamps, Julie Bolcaen, Karel Deblaere, Tom Boterberg, Caroline Van den Broecke, Christian Vanhove, Ingeborg Goethals,

Glioblastoma is the most aggressive and malignant primary brain tumor in adults. Despite the current state-of-the-art treatment, which consists of maximal surgical resection followed by radiation therapy, concomitant, and adjuvant chemotherapy, progression remains rapid due to aggressive tumor characteristics. Several new therapeutic targets have been investigated using chemotherapeutics and targeted ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2019, 6:5]

Cited: 3 times

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The added value of an assessment of the patient's hand grip strength to the comprehensive geriatric assessment in G8-abnormal older patients with cancer in routine practice.

Michelle Lycke, Lore Ketelaars, Evi Martens, Tessa Lefebvre, Hans Pottel, Koen Van Eygen, Lieselot Cool, Lies Pottel, Cindy Kenis, Patricia Schofield, Tom Boterberg, Philip R Debruyne,

OBJECTIVES:A comprehensive geriatric assessment (CGA) is the key treatment approach to guide decisions in older patients with cancer. In this paper, the added value of an assessment of the patient's hand grip strength to predict survival in patients with an abnormal G8-questionnaire (G8) score is investigated. MATERIALS AND METHODS:Patients were ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2019, 10(6):931-936]

Cited: 1 time

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Screening Methods for Age-Related Hearing Loss in Older Patients with Cancer: A Review of the Literature.

Michelle Lycke, Tessa Lefebvre, Lieselot Cool, Koen Van Eygen, Tom Boterberg, Patricia Schofield, Philip R Debruyne,

As people grow older, they may experience loss in hearing sensitivity. Age-related hearing loss may negatively affect the patient's quality of life as it may lead to social isolation. In older patients with cancer, hearing loss can seriously interfere with the patient's ability to deal properly with all aspects of ... Read more >>

Geriatrics (Basel) (Geriatrics (Basel, Switzerland))
[2018, 3(3):]

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Intraoperative radiation therapy for rectal cancer and recurrent intra-abdominal sarcomas.

Thomas Monbailliu, Piet Pattyn, Tom Boterberg, Dirk Van de Putte, Wim Ceelen, Yves Van Nieuwenhove,

PURPOSE:The aim of this study was to evaluate the effect of high-dose-rate intraoperative radiation therapy (HDR-IORT) in a multimodality treatment on the local control (LC) and the overall survival (OS) rate in locally advanced rectal cancer (LARC), locally recurrent rectal cancer (LRRC) and recurrent intra-abdominal sarcomas (RS). MATERIALS AND METHODS:A ... Read more >>

Acta Chir Belg (Acta chirurgica Belgica)
[2019, 119(2):95-102]

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Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation.

Joke Tommelein, Elly De Vlieghere, Laurine Verset, Elodie Melsens, Justine Leenders, Benedicte Descamps, Annelies Debucquoy, Christian Vanhove, Patrick Pauwels, Christian P Gespach, Anne Vral, Astrid De Boeck, Karin Haustermans, Pascal de Tullio, Wim Ceelen, Pieter Demetter, Tom Boterberg, Marc Bracke, Olivier De Wever,

Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF). Although CAFs are abundantly present, the effects of RT to CAF and its impact on cancer cells are unknown. We evaluated the damage responses of CAF to RT ... Read more >>

Cancer Res. (Cancer research)
[2018, 78(3):659-670]

Cited: 19 times

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In Vivo DCE-MRI for the Discrimination Between Glioblastoma and Radiation Necrosis in Rats.

Julie Bolcaen, Benedicte Descamps, Marjan Acou, Karel Deblaere, Caroline Van den Broecke, Tom Boterberg, Christian Vanhove, Ingeborg Goethals,

PURPOSE:In this study, the potential of semiquantitative and quantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) was investigated to differentiate glioblastoma (GB) from radiation necrosis (RN) in rats. PROCEDURES:F98 GB growth was seen on MRI 8-23 days post-inoculation (n = 15). RN lesions developed 6-8 months post-irradiation (n = 10). DCE-MRI was acquired using ... Read more >>

Mol Imaging Biol (Molecular imaging and biology)
[2017, 19(6):857-866]

Cited: 4 times

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The use of uHear™ to screen for hearing loss in older patients with cancer as part of a comprehensive geriatric assessment.

Michelle Lycke, Philip R Debruyne, Tessa Lefebvre, Evi Martens, Lore Ketelaars, Hans Pottel, Koen Van Eygen, Sofie Derijcke, Patrick Werbrouck, Philippe Vergauwe, Karin Stellamans, Philippe Clarysse, Ingeborg Dhooge, Patricia Schofield, Tom Boterberg,

We previously validated uHear™ to screen for hearing loss in older patients with cancer without a known hearing loss, as part of a comprehensive geriatric assessment (CGA). In view of low specificity, we tested a new modified uHear™ scoring system as described by Handzel.Patients, aged ≥70 years, were evaluated by uHear™ ... Read more >>

Acta Clin Belg (Acta clinica Belgica)
[2018, 73(2):132-138]

Cited: 1 time

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Long-term outcome of 18 F-fluorodeoxyglucose-positron emission tomography-guided dose painting for head and neck cancer: Matched case-control study.

Dieter Berwouts, Indira Madani, Frédéric Duprez, AnaMaria Luiza Olteanu, Tom Vercauteren, Tom Boterberg, Philippe Deron, Katrien Bonte, Wouter Huvenne, Wilfried De Neve, Ingeborg Goethals,

BACKGROUND:The purpose of this study was to report the long-term outcome of 18 F-fluorodeoxyglucose-positron emission tomography (18 F-FDG-PET)-guided dose painting for head and neck cancer in comparison to conventional intensity-modulated radiotherapy (IMRT) in a matched case-control study. METHODS:Seventy-two patients with nonmetastatic head and neck cancer treated with dose painting were ... Read more >>

Head Neck (Head & neck)
[2017, 39(11):2264-2275]

Cited: 5 times

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The distress thermometer predicts subjective, but not objective, cognitive complaints six months after treatment initiation in cancer patients.

Michelle Lycke, Tessa Lefebvre, Lies Pottel, Hans Pottel, Lore Ketelaars, Karin Stellamans, Koen Van Eygen, Philippe Vergauwe, Patrick Werbrouck, Laurence Goethals, Patricia Schofield, Tom Boterberg, Philip R Debruyne,

Research has indicated that cancer-related cognitive impairments (CRCI) may be influenced by psychosocial factors such as distress, worry and fatigue. Therefore, we aimed to validate the distress thermometer (DT) as a screening tool to detect CRCI six months post-treatment-initiation in a group of general cancer patients.Patients (≥18 years, n = 125) ... Read more >>

J Psychosoc Oncol (Journal of psychosocial oncology)
[2017, 35(6):741-757]

Cited: 2 times

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Distant metastases in head and neck cancer.

Fréderic Duprez, Dieter Berwouts, Wilfried De Neve, Katrien Bonte, Tom Boterberg, Philippe Deron, Wouter Huvenne, Sylvie Rottey, Marc Mareel,

BACKGROUND:Most trials in head and neck cancer emphasize locoregional control, as this is the main pattern of therapy failure. However, up to 15% of patients develop distant metastases. The purpose of this study was to present the investigated factors associated with distant metastasis in a single-center patient cohort. METHODS:A retrospective ... Read more >>

Head Neck (Head & neck)
[2017, 39(9):1733-1743]

Cited: 17 times

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18F-FCho PET and MRI for the prediction of response in glioblastoma patients according to the RANO criteria.

Julie Bolcaen, Marjan Acou, Tom Boterberg, Christian Vanhove, Filip De Vos, Caroline Van den Broecke, Roel Van Holen, Karel Deblaere, Ingeborg Goethals,

In this study, we investigated fluorine-18 fluoromethylcholine (F-FCho) PET and contrast-enhanced MRI for predicting therapy response in glioblastoma (GB) patients according to the Response Assessment in Neuro-Oncology criteria. Our second aim was to investigate which imaging modality enabled prediction of treatment response first.Eleven GB patients who underwent no surgery or ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2017, 38(3):242-249]

Cited: 1 time

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