Full Text Journal Articles by
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Quality assurance in radiation oncology.

Thomas J FitzGerald, David Followill, Fran Laurie, Tom Boterberg, Richard Hanusik, Sandra Kessel, Kathryn Karolczuk, Matthew Iandoli, Kenneth Ulin, Karen Morano, Maryann Bishop-Jodoin, Stephen Kry, Jessica Lowenstein, Andrea Molineu, Janaki Moni, M Giulia Cicchetti, Fred Prior, Joel Saltz, Ashish Sharma, Henry C Mandeville, Valerie Bernier-Chastagner, Geert Janssens,

The Children's Oncology Group (COG) has a strong quality assurance (QA) program managed by the Imaging and Radiation Oncology Core (IROC). This program consists of credentialing centers and providing real-time management of each case for protocol compliant target definition and radiation delivery. In the International Society of Pediatric Oncology (SIOP), ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, 68 Suppl 2:e28609]

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Neuroblastoma.

Christine Chung, Tom Boterberg, John Lucas, Joseph Panoff, Dominique Valteau-Couanet, Barbara Hero, Rochelle Bagatell, Christine E Hill-Kayser,

The survival of patients with high-risk neuroblastoma has improved significantly with the use of intensive multimodality treatment regimens, including chemotherapy, surgery, radiation therapy, myeloablative chemotherapy followed by stem cell rescue, and immunotherapy. This report summarizes the current treatment strategies used in the COG and SIOP for children with neuroblastoma. The ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, 68 Suppl 2:e28473]

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Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise.

Joeri Mul, Patrick Melchior, Enrica Seravalli, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Kristin Gurtner, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Henry Mandeville, Tom Boterberg, Petra S Kroon, Alexis N T J Kotte, Bianca A W Hoeben, Peter S N van Rossum, Martine van Grotel, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe, Geert O Janssens,

<h4>Background and purpose</h4>Recently, the SIOP-RTSG developed a highly-conformal flank target volume definition for children with renal tumors. The aims of this study were to evaluate the inter-clinician delineation variation of this new target volume definition in an international multicenter setting and to explore the necessity of quality assurance.<h4>Materials and methods</h4>Six ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 28:39-47]

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Survival impact of incidental subventricular zone irradiation in IDH-wildtype glioblastoma.

Giorgio Hallaert, Harry Pinson, Caroline Van den Broecke, Caroline Sweldens, Dirk Van Roost, Jean-Pierre Kalala, Tom Boterberg,

<h4>Background and purpose</h4>The subventricular zone (SVZ) is an important niche for neural stem cells but probably also for brain tumor propagating cells, including the glioblastoma stem cell. The SVZ may become a target for radiation therapy in glioblastoma patients. However, reports studying the effect of irradiation of the SVZ on ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2021, 60(5):613-619]

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Assessment of the effect of therapy in a rat model of glioblastoma using [18F]FDG and [18F]FCho PET compared to contrast-enhanced MRI.

Julie Bolcaen, Benedicte Descamps, Karel Deblaere, Filip De Vos, Tom Boterberg, Giorgio Hallaert, Caroline Van den Broecke, Christian Vanhove, Ingeborg Goethals,

<h4>Objective</h4>We investigated the potential of [18F]fluorodeoxyglucose ([18F]FDG) and [18F]Fluoromethylcholine ([18F]FCho) PET, compared to contrast-enhanced MRI, for the early detection of treatment response in F98 glioblastoma (GB) rats.<h4>Methods</h4>When GB was confirmed on T2- and contrast-enhanced T1-weighted MRI, animals were randomized into a treatment group (n = 5) receiving MRI-guided 3D conformal ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0248193]

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Pain medication adherence in patients with cancer: a pragmatic review.

Lorenz Vanneste, Tessa Lefebvre, Laura Tack, Koen Van Eygen, Lieselot Cool, Patricia A Schofield, Tom Boterberg, Thomas De Rijdt, Anne Verhaeghe, Katy Verhelle, Philip R Debruyne,

<h4>Objective</h4>Adherence to pain medication in patients with cancer is crucial for successful pain therapy. This review aimed to investigate: the rate of adherence, which factors influence adherence, whether adherence differs in diverse patient populations, whether there are methods to improve adherence, and the relationship between adherence and pain relief.<h4>Methods</h4>This review ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2021, :]

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Adoption of single fraction radiotherapy for uncomplicated bone metastases in a tertiary centre.

Cedric Peters, Julie Vandewiele, Yolande Lievens, Marc van Eijkeren, Valérie Fonteyne, Tom Boterberg, Pieter Deseyne, Liv Veldeman, Wilfried De Neve, Chris Monten, Sabine Braems, Fréderic Duprez, Katrien Vandecasteele, Piet Ost,

<h4>Background</h4>Single-fraction radiotherapy (SFRT) offers equal pain relief for uncomplicated painful bone metastases as compared to multiple-fraction radiotherapy (MFRT). Despite this evidence, the adoption of SFRT has been poor with published rates of SFRT for uncomplicated bone metastases ranging from <10% to 70%. We aimed to evaluate the adoption of SFRT ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 27:64-69]

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Effectiveness of Adjunctive Analgesics in Head and Neck Cancer Patients Receiving Curative (Chemo-) Radiotherapy: A Systematic Review.

Tessa Lefebvre, Laura Tack, Michelle Lycke, Fréderic Duprez, Laurence Goethals, Sylvie Rottey, Lieselot Cool, Koen Van Eygen, Brendon Stubbs, Patricia Schofield, Hans Pottel, Tom Boterberg, Philip Debruyne,

<h4>Objective</h4>Our aim was to give an overview of the effectiveness of adjunctive analgesics in head and neck cancer (HNC) patients receiving (chemo-) radiotherapy.<h4>Design</h4>Systematic review.<h4>Interventions</h4>This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov were ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2021, 22(1):152-164]

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The spleen as an organ at risk in paediatric radiotherapy: A SIOP-Europe Radiation Oncology Working Group report.

Niruthiga Arunagiri, Sarah M Kelly, Cathy Dunlea, Olivia Dixon, Jessica Cantwell, Pravesh Bhudia, Tom Boterberg, Geert O Janssens, Jennifer E Gains, Yen-Ch'ing Chang, Mark N Gaze, ,

<h4>Background</h4>Radiation may cause long-term splenic dysfunction, risking potentially fatal late sepsis. We aimed to review this complication's magnitude in paediatric radiotherapy and gauge the level of awareness of the spleen as an organ at risk.<h4>Methods</h4>Clinical trial protocols and radiotherapy guidelines, patient/parent information sheets, and professional guidance documents were reviewed to assess ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 143:1-10]

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Towards homogenization of total body irradiation practices in pediatric patients across SIOPE affiliated centers. A survey by the SIOPE radiation oncology working group.

Bianca A W Hoeben, Montserrat Pazos, Michael H Albert, Enrica Seravalli, Mirjam E Bosman, Christoph Losert, Tom Boterberg, Farkhad Manapov, Inna Ospovat, Soraya Mico Milla, Candan Demiroz Abakay, Jacob Engellau, Gregor Kos, Stéphane Supiot, Marc Bierings, Geert O Janssens,

<h4>Background and purpose</h4>To reduce relapse risk, Total Body Irradiation (TBI) is part of conditioning regimens for hematopoietic stem cell transplantation (HSCT) in pediatric acute leukemia. The study purpose was to evaluate clinical practices regarding TBI, such as fractionation, organ shielding and delivery techniques, among SIOPE affiliated radiotherapy centers.<h4>Methods</h4>An electronic survey ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 155:113-119]

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Partial resection offers an overall survival benefit over biopsy in MGMT-unmethylated IDH-wildtype glioblastoma patients.

Giorgio Hallaert, Harry Pinson, Dimitri Vanhauwaert, Caroline Van den Broecke, Dirk Van Roost, Tom Boterberg, Jean-Pierre Kalala,

Background Isocitrate dehydrogenase (IDH)-wildtype glioblastoma patients with O<sup>6</sup>-methylguanine-DNA-methyltransferase (MGMT)-unmethylated tumors have the worst outcome of all glioblastoma patients. The overall survival (OS) benefit of partial resection of glioblastoma compared to biopsy only remains controversial specifically in relation to molecular factors. In this report, we analyzed the effect of incomplete resection ... Read more >>

Surg Oncol (Surgical oncology)
[2020, 35:515-519]

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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

Cited: 1 time

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Global pediatric radiation therapy in resource-limited settings.

Clayton B Hess, Jeannette Parkes, Geert O Janssens, Chi Lin, Kenneth Wong, Mohamed S Zaghloul, Daniel G Marconi, Tom Boterberg, Natia Esiashvili,

This report provides a summary of the global burden of childhood cancer morbidity and mortality, which disproportionately affects low- and middle-income countries as well as low- and middle-income communities within high-income countries. We review past successes and current challenges to improving clinical pediatric radiotherapy, education, and research in these regions. ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, 68 Suppl 2:e28299]

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Acupuncture as a complementary therapy for cancer care: acceptability and preferences of patients and informal caregivers

Tessa Lefebvre, Laura Tack, Virginie Blieck, Lieselot Cool, Hans Pottel, Koen Van Eygen, Sofie Derijcke, Philippe Vergauwe, Patricia Schofield, Rebecca Chandler, Pauline Lane, Tom Boterberg, Philip Debruyne,

The authors have withdrawn this preprint due to author disagreement. ... Read more >>

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A Baseline Survey on the Treatment Workflow and Pediatric IGRT Practice Among European Members of the Project-Based Consortium and the Pediatric Radiation Oncology Society (PROS).

Coen A.A. Windmeijer, Arjan Bel, Rianne de Jong, Brian Balgobind, Marianne Aznar, Karen van Beek, Guillaume Beldjoudi, Tom Boterberg, Dana Cernea, Laurien Daniels, Karin Dieckmann, Andrea Filippi, Cornelis J.A. Haasbeek, Bianca Hoeben, Geert O.R. Janssens, Mirjana Josipovic, Hannes Jürgens, Adam Kouvelis, Yasmin Lassen, Anna Loginova, John Maduro, Barbora Ondrová, Barbara Rombi, Diana Steinmann, Camilla Stokkevag, Marilena Theodorou, Beate Timmermann, Vaska Vasileva-Kodeyh, Lorna Zadravec Zaletel, Irma W.E.M. van Dijk,

<h4>Background: </h4> Image-guided radiotherapy (IGRT) enables high precision tumor treatment with potential for sparing healthy tissues. The value of pediatric IGRT is widely acknowledged, but there is no consensus on ‘best practice’. We aimed to assess clinical pediatric IGRT practice among European members of the Pediatric Radiation Oncology Society (PROS) ... Read more >>

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Developing and evaluating a participatory arts programme for cancer patients and their caregivers.

Tessa Lefebvre, Laura Tack, Marlies Meersman, Hilde Vanneste, Lieselot Cool, Koen Van Eygen, Karin Stellamans, Sofie Derijcke, Philippe Vergauwe, Jos De Backer, Rebecca Chandler, Pauline Lane, Tom Boterberg, Philip R Debruyne,

<h4>Objectives</h4>Cancer patients, survivors and caregivers often encounter severe distress, having significant consequences to wellbeing, functionality and physical health. This study developed and evaluated a participatory arts programme to determine if such could help to improve the wellbeing of cancer patients and their caregivers.<h4>Methods</h4>To inform the development of a participatory arts ... Read more >>

Acta Clin Belg (Acta clinica Belgica)
[2020, :1-7]

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Underrepresentation of vulnerable older patients with cancer in phase II and III oncology registration trials: A case-control study.

Laura Tack, Tessa Lefebvre, Michelle Lycke, Lies Pottel, Lieselot Cool, Lore Ketelaars, Jolien De Zutter, Evi Martens, Hans Pottel, Karin Stellamans, Koen Van Eygen, Patrick Werbrouck, Philippe Vergauwe, Hans Wildiers, Patricia Schofield, Tom Boterberg, Philip R Debruyne,

OBJECTIVES:We aimed to determine the proportion of "fit" versus "vulnerable" older patients with cancer included in phase II and III oncology registration trials, as compared to the proportions in a real life oncology setting. METHODS:Trial and patient characteristics of older (≥70years) patients treated at the OECI-designated clinical cancer centre in ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2020, 11(2):320-326]

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Radiation dose and pathological response in oesophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by surgery: a multi-institutional analysis.

Melissa Thomas, Alicia S Borggreve, Peter S N van Rossum, Christiaan Perneel, Johnny Moons, Elke Van Daele, Richard van Hillegersberg, Wei Deng, Piet Pattyn, Stella Mook, Tom Boterberg, Jelle P Ruurda, Philippe Nafteux, Steven H Lin, Karin Haustermans,

<b>Purpose:</b> To explore whether a higher neoadjuvant radiation dose increases the probability of a pathological complete response (pCR) or pathological major response (pMR) response in oesophageal cancer patients. <b>Material and methods:</b> Between 2000 and 2017, 1048 patients from four institutions were stratified according to prescribed neoadjuvant radiation doses of 36.0 Gy ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2019, 58(10):1358-1365]

Cited: 2 times

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Technical feasibility of [18F]FET and [18F]FAZA PET guided radiotherapy in a F98 glioblastoma rat model.

Jeroen Verhoeven, Julie Bolcaen, Valerie De Meulenaere, Ken Kersemans, Benedicte Descamps, Sam Donche, Caroline Van den Broecke, Tom Boterberg, Jean-Pierre Kalala, Karel Deblaere, Christian Vanhove, Filip De Vos, Ingeborg Goethals,

<h4>Background</h4>Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolomide (TMZ). An accurate definition of the tumor volume is of utmost importance for guiding RT. In this project we investigated the feasibility ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2019, 14(1):89]

Cited: 3 times

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Radiotherapy practice for paediatric brain tumours across Europe and quality assurance initiatives: Current situation, international survey and future perspectives.

Teresa de Rojas, Enrico Clementel, Jordi Giralt, Ofelia Cruz, Tom Boterberg, Rolf-Dieter Kortmann, Mark N Gaze, Lucas Moreno, Geert O Janssens, ,

<h4>Aim</h4>The aim of the study is to analyse radiotherapy quality assurance (RTQA) processes in the treatment of paediatric central nervous system (CNS) tumours across Europe.<h4>Methods</h4>The RTQA aspects of major past and current European trials for paediatric CNS tumours were reviewed based on study protocols and publications. A survey among radiation ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 114:36-46]

Cited: 1 time

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Subjective, but not objective, cognitive complaints impact long-term quality of life in cancer patients.

Michelle Lycke, Tessa Lefebvre, Lies Pottel, Hans Pottel, Lore Ketelaars, Karin Stellamans, Koen Van Eygen, Philippe Vergauwe, Patrick Werbrouck, Lieselot Cool, Tom Boterberg, Nick Liefhooghe, Patricia Schofield, Philip R Debruyne,

<h4>Objectives</h4>Cognitive complaints, of objective or subjective nature, may negatively impact cancer patients' quality of life (QoL). Further, the early detection of cognitive alterations may lead to an improved QoL. However, the content of such screening is yet unclear. This paper presents long-term QoL data of cancer patients treated with curative ... Read more >>

J Psychosoc Oncol (Journal of psychosocial oncology)
[2019, 37(4):427-440]

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Detection of alcohol abuse in older patients with cancer: The integration of alcohol screening questionnaires in the comprehensive geriatric assessment.

Michelle Lycke, Evi Martens, Lore Ketelaars, Jolien Dezutter, Tessa Lefebvre, Hans Pottel, Koen Van Eygen, Lieselot Cool, Patricia Schofield, Tom Boterberg, Philip R Debruyne,

OBJECTIVES:We aimed to evaluate the feasibility of implementing an alcohol screening questionnaire as part of the comprehensive geriatric assessment (CGA) by reporting the prevalence of alcohol abuse in a group of older patients with cancer in a Belgian cancer centre. MATERIALS AND METHODS:Patients were recruited at the Geriatric Oncology Clinic ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2019, 10(5):819-823]

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The added value of an assessment of the patient's hand grip strength to the comprehensive geriatric assessment in G8-abnormal older patients with cancer in routine practice.

Michelle Lycke, Lore Ketelaars, Evi Martens, Tessa Lefebvre, Hans Pottel, Koen Van Eygen, Lieselot Cool, Lies Pottel, Cindy Kenis, Patricia Schofield, Tom Boterberg, Philip R Debruyne,

<h4>Objectives</h4>A comprehensive geriatric assessment (CGA) is the key treatment approach to guide decisions in older patients with cancer. In this paper, the added value of an assessment of the patient's hand grip strength to predict survival in patients with an abnormal G8-questionnaire (G8) score is investigated.<h4>Materials and methods</h4>Patients were screened ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2019, 10(6):931-936]

Cited: 1 time

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The Path Toward PET-Guided Radiation Therapy for Glioblastoma in Laboratory Animals: A Mini Review.

Sam Donche, Jeroen Verhoeven, Benedicte Descamps, Julie Bolcaen, Karel Deblaere, Tom Boterberg, Caroline Van den Broecke, Christian Vanhove, Ingeborg Goethals,

Glioblastoma is the most aggressive and malignant primary brain tumor in adults. Despite the current state-of-the-art treatment, which consists of maximal surgical resection followed by radiation therapy, concomitant, and adjuvant chemotherapy, progression remains rapid due to aggressive tumor characteristics. Several new therapeutic targets have been investigated using chemotherapeutics and targeted ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2019, 6:5]

Cited: 3 times

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Screening Methods for Age-Related Hearing Loss in Older Patients with Cancer: A Review of the Literature.

Michelle Lycke, Tessa Lefebvre, Lieselot Cool, Koen Van Eygen, Tom Boterberg, Patricia Schofield, Philip R Debruyne,

As people grow older, they may experience loss in hearing sensitivity. Age-related hearing loss may negatively affect the patient's quality of life as it may lead to social isolation. In older patients with cancer, hearing loss can seriously interfere with the patient's ability to deal properly with all aspects of ... Read more >>

Geriatrics (Basel) (Geriatrics (Basel, Switzerland))
[2018, 3(3):]

Cited: 1 time

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