Full Text Journal Articles by
Author Tohru Morisada


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Nucleosome positioning on episomal human papillomavirus DNA in cultured cells

Isao Murakami, Takashi Iwata, Tohru Morisada, Kyoko Tanaka, Daisuke Aoki,

Several human papillomaviruses (HPV) are associated with the development of cervical carcinoma. HPV DNA synthesis is increased during the differentiation of infected host keratinocytes as they migrate from the basal layer of the epithelium to the spinous layer, but the molecular mechanism is unclear. Nucleosome positioning affects various cellular processes ... Read more >>

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The first-round results of a population-based cohort study of HPV testing in Japanese cervical cancer screening: baseline characteristics, screening results, and referral rate.

Kanako Kono, Tohru Morisada, Kumiko Saika, Eiko Saitoh Aoki, Etsuko Miyagi, Kiyoshi Ito, Hirokazu Takahashi, Tomio Nakayama, Hiroshi Saito, Daisuke Aoki,

<h4>Objective</h4>In 2013, a cohort study aimed to clarify the positive and negative effects of introducing the human papillomavirus (HPV) testing for population-based cervical cancer screening has been launched in Japan. This study included four screenings during the subsequent 7-year follow-up period. We aim to describe the results of the first ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e29]

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Impact of the COVID-19 epidemic at a high-volume facility in gynecological oncology in Tokyo, Japan: a single-center experience.

Yuya Nogami, Yusuke Kobayashi, Kosuke Tsuji, Megumi Yokota, Hiroshi Nishio, Masaru Nakamura, Wataru Yamagami, Tohru Morisada, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki,

<h4>Background</h4>The number of cases of novel coronavirus disease 2019 (COVID-19) in Japan have risen since the first case was reported on January 24, 2020, and 6225 infections have been reported as of June 30, 2020. On April 8, 2020, our hospital began screening patients via pre-admission reverse transcriptase-polymerase chain reaction ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):105]

Cited: 1 time

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Tumor-infiltrating lymphocytes predict survival outcomes in patients with cervical cancer treated with concurrent chemoradiotherapy.

Akiko Ohno, Takashi Iwata, Yuki Katoh, Shiho Taniguchi, Kohsei Tanaka, Hiroshi Nishio, Masaru Nakamura, Tohru Morisada, Guanliang Chen, Miyuki Saito, Tomonori Yaguchi, Yutaka Kawakami, Daisuke Aoki,

<h4>Objectives</h4>To (i) identify correlations between selected immunogenic factors and clinicopathological characteristics, (ii) determine whether intratumoral abundance of various specific tumor-infiltrating lymphocytes (TILs) is a prognostic indicator in women with Stage II and III cervical cancer who undergo treatment with cisplatin-based concurrent chemoradiotherapy (CCRT), and (iii) investigate subtypes of FOXP3<sup>+</sup> T ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(2):329-334]

Cited: 1 time

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Molecular epidemiology of human papillomavirus 18 infections in Japanese Women.

Mayuko Yamaguchi-Naka, Mamiko Onuki, Yuri Tenjimbayashi, Yusuke Hirose, Nobutaka Tasaka, Toyomi Satoh, Tohru Morisada, Takashi Iwata, Akihiko Sekizawa, Koji Matsumoto, Iwao Kukimoto,

Among the oncogenic genotypes of human papillomavirus (HPV), HPV18 is the second most common type detected in cervical cancer worldwide and is primarily involved in the generation of cervical adenocarcinoma. Although HPV intra-type variants confer different risks of cervical carcinogenesis, there is little information on the genetic diversity of HPV18 ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2020, 83:104345]

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Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter.

Nobumaru Hirao, Takashi Iwata, Kohsei Tanaka, Hiroshi Nishio, Masaru Nakamura, Tohru Morisada, Kenji Morii, Natsuki Maruyama, Yuki Katoh, Tomonori Yaguchi, Shigeki Ohta, Iwao Kukimoto, Daisuke Aoki, Yutaka Kawakami,

<h4>Objective</h4>To determine the involvement of homeobox D9 (HOXD9) in the survival, proliferation, and metastasis of cervical cancer cells through regulating the expression of human papillomavirus (HPV) 16 E6/E7 genes using the P97 promoter.<h4>Methods</h4>One hundred cases of cervical cancer (CC), CC cell lines SKG-I, SKG-II, SKG-IIIa, SKG-IIIb, HeLa, and SiHa, and ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 155(2):340-348]

Cited: 3 times

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Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions.

Yusuke Hirose, Mamiko Onuki, Yuri Tenjimbayashi, Mayuko Yamaguchi-Naka, Seiichiro Mori, Nobutaka Tasaka, Toyomi Satoh, Tohru Morisada, Takashi Iwata, Tohru Kiyono, Takashi Mimura, Akihiko Sekizawa, Koji Matsumoto, Iwao Kukimoto,

Recent large-scale genomics studies of human papillomaviruses (HPVs) have shown a high level of genomic variability of HPV16, the most prevalent genotype in HPV-associated malignancies, and provided new insights into the biological and clinical relevance of its genetic variations in cervical cancer development. Here, we performed deep sequencing analyses of ... Read more >>

Viruses (Viruses)
[2019, 11(4):]

Cited: 1 time

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Local anatomy around terminal ureter related to the anterior leaf of the vesicouterine ligament in radical hysterectomy.

Masaru Nakamura, Kyoko Tanaka, Shigenori Hayashi, Tohru Morisada, Takashi Iwata, Nobuaki Imanishi, Daisuke Aoki,

<h4>Objectives</h4>Radical hysterectomy is performed for invasive cervical cancer. In this surgery, separation of the anterior leaf and posterior leaves of the vesicouterine ligament (VUL) is important. We studied the local anatomy of the anterior leaf of the VUL, especially the branches of the umbilical artery from the view point of ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2019, 235:66-70]

Cited: 1 time

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Liquid-based cytology versus conventional cytology for detection of uterine cervical lesions: a prospective observational study.

Hiroshi Nishio, Takashi Iwata, Hidetaka Nomura, Tohru Morisada, Nobuhiro Takeshima, Hirokuni Takano, Hiroshi Sasaki, Eiji Nakatani, Satoshi Teramukai, Daisuke Aoki,

Liquid-based cytology (LBC) and conventional cytology (CS) are routine diagnostic techniques in cervical cytology, but few studies have compared their diagnostic performances with each other and with histologic diagnosis. This study aimed to compare the diagnostic performances of these techniques in subjects with abnormal cervical cytology of atypical cells of ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2018, 48(6):522-528]

Cited: 4 times

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Population-based cohort study assessing the efficacy of cervical cytology (Pap smear) and human papillomavirus (HPV) testing as modalities for cervical cancer screening.

Tohru Morisada, Kumiko Saika, Eiko Saito, Kanako Kono, Hiroshi Saito, Daisuke Aoki,

In cervical cancer screening, several trials have shown that human papillomavirus (HPV) testing or combined HPV testing and cytology leads to earlier detection of cervical intraepithelial neoplasia Grade 3 or worse (CIN3+) compared with cytology alone. However, the availability of similar evidence in our country remains limited. In 2013, 34 ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2018, 48(5):495-498]

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CITRUS, cervical cancer screening trial by randomization of HPV testing intervention for upcoming screening: Design, methods and baseline data of 18,471 women.

Tohru Morisada, Katsuhiro Teramoto, Hirokuni Takano, Ikuko Sakamoto, Hiroshi Nishio, Takashi Iwata, Akihiko Hashi, Ryohei Katoh, Aikou Okamoto, Hiroshi Sasaki, Eiji Nakatani, Satoshi Teramukai, Daisuke Aoki,

<h4>Background</h4>To assess the efficacy of screening with concurrent liquid-based cytology and human papillomavirus (HPV) testing for primary cervical cancer screening, we initiated a randomized trial entitled CervIcal cancer screening Trial by Randomization of HPV testing intervention for Upcoming Screening (CITRUS).<h4>Methods</h4>Between June 2013 and March 2015, women aged 30-64 years of ... Read more >>

Cancer Epidemiol (Cancer epidemiology)
[2017, 50(Pt A):60-67]

Cited: 4 times

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Whole-genome analysis of human papillomavirus genotypes 52 and 58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer.

Yuri Tenjimbayashi, Mamiko Onuki, Yusuke Hirose, Seiichiro Mori, Yoshiyuki Ishii, Takamasa Takeuchi, Nobutaka Tasaka, Toyomi Satoh, Tohru Morisada, Takashi Iwata, Shingo Miyamoto, Koji Matsumoto, Akihiko Sekizawa, Iwao Kukimoto,

<h4>Background</h4>Human papillomavirus genotypes 52 and 58 (HPV52/58) are frequently detected in patients with cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC) in East Asian countries including Japan. As with other HPV genotypes, HPV52/58 consist of multiple lineages of genetic variants harboring less than 10% differences between complete genome sequences ... Read more >>

Infect Agent Cancer (Infectious agents and cancer)
[2017, 12:44]

Cited: 3 times

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Neoadjuvant chemotherapy for locally advanced cervical cancer.

Takashi Iwata, Azumi Miyauchi, Yukako Suga, Hiroshi Nishio, Masaru Nakamura, Akiko Ohno, Nobumaru Hirao, Tohru Morisada, Kyoko Tanaka, Hiroki Ueyama, Hidemichi Watari, Daisuke Aoki,

Neoadjuvant chemotherapy followed by surgery (NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy (NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of ... Read more >>

Chin J Cancer Res (Chinese journal of cancer research = Chung-kuo yen cheng yen chiu)
[2016, 28(2):235-240]

Cited: 6 times

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Pregnancy Outcomes After Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer: A 13-Year Experience in a Single Tertiary-Care Center.

Yoshifumi Kasuga, Hiroshi Nishio, Kei Miyakoshi, Suguru Sato, Juri Sugiyama, Tadashi Matsumoto, Kyoko Tanaka, Daigo Ochiai, Kazuhiro Minegishi, Toshio Hamatani, Takashi Iwata, Tohru Morisada, Masaru Nakamura, Takuma Fujii, Naoaki Kuji, Daisuke Aoki, Mamoru Tanaka,

OBJECTIVE:To investigate pregnancy outcomes in women after abdominal radical trachelectomy (RT) for early-stage cervical cancer. METHODS:The patients' background, fertility, and pregnancy outcomes were reviewed in a total of 61 pregnancies in 48 of 172 women who underwent abdominal RT at Keio University Hospital between September 2002 and December 2013. RESULTS:There ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2016, 26(1):163-168]

Cited: 14 times

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Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in Japanese women.

Yukari Azuma, Rika Kusumoto-Matsuo, Fumihiko Takeuchi, Asami Uenoyama, Kazunari Kondo, Hajime Tsunoda, Kazunori Nagasaka, Kei Kawana, Tohru Morisada, Takashi Iwata, Daisuke Aoki, Iwao Kukimoto,

<h4>Objective</h4>Human papillomavirus vaccines are being introduced worldwide and are expected to reduce the incidence of cervical cancer. Here we report a cross-sectional study using a validated human papillomavirus genotyping method to reveal the human papillomavirus prevalence and genotype distribution in Japanese women with cervical intraepithelial neoplasia Grade 2/3 and invasive ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2014, 44(10):910-917]

Cited: 24 times

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Cytokine profile in cervical mucosa of Japanese patients with cervical intraepithelial neoplasia.

Takashi Iwata, Takuma Fujii, Kenji Morii, Miyuki Saito, Juri Sugiyama, Hiroshi Nishio, Tohru Morisada, Kyoko Tanaka, Tomonori Yaguchi, Yutaka Kawakami, Daisuke Aoki,

<h4>Background</h4>Immune responses in the uterine cervix are considered to play an important role in persistent human papillomavirus (HPV) infection and carcinogenesis, but many aspects of the mechanism are still unclear. The goal of this study was to measure cytokines to analyze immune responses in patients with cervical intraepithelial neoplasia (CIN).<h4>Materials ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2015, 20(1):126-133]

Cited: 10 times

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Angiopoietin-2-driven vascular remodeling in airway inflammation.

Sebastien P Tabruyn, Katharine Colton, Tohru Morisada, Jonas Fuxe, Stanley J Wiegand, Gavin Thurston, Anthony J Coyle, Jane Connor, Donald M McDonald,

Vascular remodeling is a feature of chronic inflammation during which capillaries transform into venules that expand the region of the vasculature in which leakage and leukocyte emigration both occur. Recently, we found that angiopoietin/Tie2 receptor signaling drives the transformation of capillaries into venules at an early stage of the sustained ... Read more >>

Am J Pathol (The American journal of pathology)
[2010, 177(6):3233-3243]

Cited: 38 times

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Angiopoietins contribute to lung development by regulating pulmonary vascular network formation.

Tai Hato, Yoshishige Kimura, Tohru Morisada, Gou Young Koh, Keishi Miyata, Mitsuhisa Tabata, Tsuyoshi Kadomatsu, Motoyoshi Endo, Takashi Urano, Fumio Arai, Kimi Araki, Toshio Suda, Koichi Kobayashi, Yuichi Oike,

Angiopoietin (Ang) signaling through the Tie2 receptor regulates vasculature. The role of Ang signaling in pulmonary hypertension is well investigated, but its role in lung development is not elucidated. Here, we show that the Tie2 agonist ligand, Ang1, was detected in lung tissue at birth and its expression gradually increased ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2009, 381(2):218-223]

Cited: 17 times

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Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model.

Takashi Urano, Yasuhiro Ito, Masaki Akao, Tomohiro Sawa, Keishi Miyata, Mitsuhisa Tabata, Tohru Morisada, Tai Hato, Masato Yano, Tsuyoshi Kadomatsu, Kunio Yasunaga, Rei Shibata, Toyoaki Murohara, Takaaki Akaike, Hidenobu Tanihara, Toshio Suda, Yuichi Oike,

<h4>Objective</h4>Transgenic mice overexpressing angiopoietin-related growth factor (AGF) exhibit enhanced angiogenesis, suggesting that AGF may be a useful drug target in ischemic disease. Our goal was to determine whether AGF enhances blood flow in a mouse hind-limb ischemia model and to define molecular mechanisms underlying AGF signaling in endothelial cells.<h4>Methods and ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2008, 28(5):827-834]

Cited: 25 times

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Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades.

Koichi Mishima, Tetsuro Watabe, Akira Saito, Yasuhiro Yoshimatsu, Natsuko Imaizumi, Shinji Masui, Masanori Hirashima, Tohru Morisada, Yuichi Oike, Makoto Araie, Hitoshi Niwa, Hajime Kubo, Toshio Suda, Kohei Miyazono,

During embryonic lymphatic development, a homeobox transcription factor Prox1 plays important roles in sprouting and migration of a subpopulation of blood vessel endothelial cells (BECs) toward VEGF-C-expressing cells. However, effects of Prox1 on endothelial cellular behavior remain to be elucidated. Here, we show that Prox1, via induction of integrin alpha9 ... Read more >>

Mol Biol Cell (Molecular biology of the cell)
[2007, 18(4):1421-1429]

Cited: 78 times

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Angiogenic role of LYVE-1-positive macrophages in adipose tissue.

Chung-Hyun Cho, Young Jun Koh, Jinah Han, Hoon-Ki Sung, Hyuek Jong Lee, Tohru Morisada, Reto A Schwendener, Rolf A Brekken, Guson Kang, Yuichi Oike, Tae-Saeng Choi, Toshio Suda, Ook-Joon Yoo, Gou Young Koh,

Here we report the discovery of a characteristic dense vascular network (DVN) in the tip portion of epididymal adipose tissue in adult mice. The DVN is formed by angiogenesis rather than by vasculogenesis, and has functional blood circulation. This DVN and its subsequent branching may provide a new functional route ... Read more >>

Circ Res (Circulation research)
[2007, 100(4):e47-57]

Cited: 137 times

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Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.

Koji Taniguchi, Ri-Ichiro Kohno, Toranoshin Ayada, Reiko Kato, Kenji Ichiyama, Tohru Morisada, Yuichi Oike, Yoshikazu Yonemitsu, Yoshihiko Maehara, Akihiko Yoshimura,

Spred/Sprouty family proteins negatively regulate growth factor-induced ERK activation. Although the individual physiological roles of Spred-1 and Spred-2 have been investigated using gene-disrupted mice, the overlapping functions of Spred-1 and Spred-2 have not been clarified. Here, we demonstrate that the deletion of both Spred-1 and Spred-2 resulted in embryonic lethality ... Read more >>

Mol Cell Biol (Molecular and cellular biology)
[2007, 27(12):4541-4550]

Cited: 72 times

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Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis.

Hoon Ki Sung, Tohru Morisada, Chung-Hyun Cho, Yuichi Oike, Jayhun Lee, Eon Ki Sung, Jae Hoon Chung, Toshio Suda, Gou Young Koh,

Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2006, 345(2):545-551]

Cited: 10 times

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Angiopoietins and angiopoietin-like proteins in angiogenesis.

Tohru Morisada, Yoshiaki Kubota, Takashi Urano, Toshio Suda, Yuichi Oike,

Vascular network formation requires several endothelial cell growth factors. These factors have a potent angiogenic effect, and their precise coordination is essential for vascular development. Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling. It has been reported that the angiopoietin/Tie2 ... Read more >>

Endothelium (Endothelium : journal of endothelial cell research)
[2006, 13(2):71-79]

Cited: 58 times

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Distribution of lymphatic vessels in mouse thymus: immunofluorescence analysis.

Chikako Odaka, Tohru Morisada, Yuichi Oike, Toshio Suda,

Thymic blood and lymphatic vessels in humans and laboratory animals have been investigated in morphological studies. However, occasionally a clear distinction between blood vessels and lymphatic vessels cannot be made from morphological characteristics of the vasculature. To visualize thymic lymphatics in normal adult BALB/c mice, we used antibodies against specific ... Read more >>

Cell Tissue Res (Cell and tissue research)
[2006, 325(1):13-22]

Cited: 20 times

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