Full Text Journal Articles by
Author Toby N Weingarten

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Postoperative respiratory depression after hysterectomy.

Mariana L Laporta, Michelle O Kinney, Darrell R Schroeder, Juraj Sprung, Toby N Weingarten,

To investigate if sex-specific physiologic characteristics could impact postoperative respiratory depression risks in women, we studied incidence and risk factors associated with postoperative respiratory depression in a gynecologic surgical cohort. Only hysterectomies performed under general anesthesia from 2012 to 2017 were included to minimize interprocedural variability. Respiratory depression was defined ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Prediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry: An International Prospective, Observational Trial.

Ashish K Khanna, Sergio D Bergese, Carla R Jungquist, Hiroshi Morimatsu, Shoichi Uezono, Simon Lee, Lian Kah Ti, Richard D Urman, Robert McIntyre, Carlos Tornero, Albert Dahan, Leif Saager, Toby N Weingarten, Maria Wittmann, Dennis Auckley, Luca Brazzi, Morgan Le Guen, Roy Soto, Frank Schramm, Sabry Ayad, Roop Kaw, Paola Di Stefano, Daniel I Sessler, Alberto Uribe, Vanessa Moll, Susan J Dempsey, Wolfgang Buhre, Frank J Overdyk, Marianne Tanios, Eva Rivas, Miluska Mejia, Kavita Elliott, Assad Ali, Juan Fiorda-Diaz, Ruben Carrasco-Moyano, Ana Mavarez-Martinez, Alicia Gonzalez-Zacarias, Cory Roeth, January Kim, Alan Esparza-Gutierrez, Carleara Weiss, Chiahui Chen, Arata Taniguchi, Yuko Mihara, Makiko Ariyoshi, Ichiro Kondo, Kentaro Yamakawa, Yoshifumi Suga, Kohei Ikeda, Koji Takano, Yuuki Kuwabara, Nicole Carignan, Joyce Rankin, Katherine Egan, Lakeisha Waters, Ming Ann Sim, Lyn Li Lean, Qi En Lydia Liew, Lawrence Siu-Chun Law, James Gosnell, Salina Shrestha, Chisom Okponyia, Mohammed H Al-Musawi, María José Parra Gonzalez, Claudia Neumann, Vera Guttenthaler, Olja Männer, Achilles Delis, Anja Winkler, Bahareh Marchand, Frauke Schmal, Fuad Aleskerov, Mohammedumer Nagori, Muhammad Shafi, Gloria McPhee, Cynthia Newman, Elizabeth Lopez, Sabrina Ma Har, Moumen Asbahi, Kim Nordstrom McCaw, Maurice Theunissen, Valerie Smit-Fun, , ,

BACKGROUND:Opioid-related adverse events are a serious problem in hospitalized patients. Little is known about patients who are likely to experience opioid-induced respiratory depression events on the general care floor and may benefit from improved monitoring and early intervention. The trial objective was to derive and validate a risk prediction tool ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 131(4):1012-1024]

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Postoperative Critical Events Associated With Obstructive Sleep Apnea: Results From the Society of Anesthesia and Sleep Medicine Obstructive Sleep Apnea Registry.

Norman Bolden, Karen L Posner, Karen B Domino, Dennis Auckley, Jonathan L Benumof, Seth T Herway, David Hillman, Shawn L Mincer, Frank Overdyk, David J Samuels, Lindsay L Warner, Toby N Weingarten, Frances Chung,

BACKGROUND:Obstructive sleep apnea (OSA) patients are at increased risk for pulmonary and cardiovascular complications; perioperative mortality risk is unclear. This report analyzes cases submitted to the OSA Death and Near Miss Registry, focusing on factors associated with poor outcomes after an OSA-related event. We hypothesized that more severe outcomes would ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2020, 131(4):1032-1041]

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New-Onset Atrial Fibrillation Detected by Continuous Capnography Monitoring: A Case Report.

Toby N Weingarten, Hiroshi Morimatsu, Juan Fiorda-Diaz, Sergio D Bergese, Makiko Ariyoshi, Juraj Sprung, Albert Dahan, Frank J Overdyk,

BACKGROUND Asymptomatic postoperative atrial fibrillation (AF) may go undetected. As part of a multicenter observational trial designed to develop a risk prediction score for respiratory depression, the respiratory patterns of patients admitted to standard wards were continuously assessed with capnography and pulse oximetry. The monitor measured end-tidal carbon dioxide, respiratory ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e925510]

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Intravenous Versus Oral Acetaminophen in Outpatient Cystoscopy Procedures: Retrospective Comparison of Postoperative Opioid Requirements and Analgesia Scores.

Todd M Kor, Julian Naranjo, Atousa Deljou, Kimberly D Evans, Darrell Schroeder, Juraj Sprung, Toby N Weingarten,

PURPOSE:To assess if the choice of acetaminophen formulation (intravenous vs oral) when administered preoperatively for ambulatory cystoscopy procedures is associated with differences in anesthetic outcomes. METHODS:Medical records of adult patients undergoing ambulatory cystoscopy procedures at an outpatient procedural center from July 1, 2014, through November 30, 2017, were abstracted. The ... Read more >>

Am Surg (The American surgeon)
[2020, :3134820945204]

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Individualized PEEP to optimise respiratory mechanics during abdominal surgery: a pilot randomised controlled trial.

Ana Fernandez-Bustamante, Juraj Sprung, Robert A Parker, Karsten Bartels, Toby N Weingarten, Carolina Kosour, B Taylor Thompson, Marcos F Vidal Melo,

BACKGROUND:Higher intraoperative driving pressures (ΔP) are associated with increased postoperative pulmonary complications (PPC). We hypothesised that dynamic adjustment of PEEP throughout abdominal surgery reduces ΔP, maintains positive end-expiratory transpulmonary pressures (Ptp_ee) and increases respiratory system static compliance (Crs) with PEEP levels that are variable between and within patients. METHODS:In a ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2020, 125(3):383-392]

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Anesthesia Management and Postanesthetic Recovery Following Endoscopic Sinus Surgery.

Mariana L Laporta, Erin K O'Brien, Janalee K Stokken, Garret Choby, Juraj Sprung, Toby N Weingarten,

OBJECTIVES:Delayed anesthesia recovery following endoscopic sinus surgery (ESS) can be an indicator of immediate complications and negatively impact healthcare efficiency. This study aims to examine clinical factors with a focus on improving clinical practice. METHODS:Medical records of patients undergoing ESS under general anesthesia from 2014 to 2018 were reviewed. Based ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, :]

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Anesthesia With and Without Nitrous Oxide and Long-term Cognitive Trajectories in Older Adults.

Juraj Sprung, Arnoley S Arney Abcejo, David S Knopman, Ronald C Petersen, Michelle M Mielke, Andrew C Hanson, Darrell R Schroeder, Phillip J Schulte, David P Martin, Toby N Weingarten, Jeffrey J Pasternak, David O Warner,

BACKGROUND:We evaluated the hypothesis that the rate of postoperative decline in global cognition is greater in older adults exposed to general anesthesia with nitrous oxide (N2O) compared to general anesthesia without N2O. METHODS:Longitudinal measures of cognitive function were analyzed in nondemented adults, 70-91 years of age, enrolled in the Mayo ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2020, 131(2):594-604]

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Postoperative outcomes in patients with treatment-emergent central sleep apnea: a case series.

Ross A Barman, Amanda R Fields, Austin J Eells, Ioanna Kouri, Meghna P Mansukhani, Bhargavi Gali, Juraj Sprung, Toby N Weingarten,

PURPOSE:Treatment-emergent central sleep apnea (TECSA) is a central sleep-related breathing disorder, characterized by either the persistence or emergence of central sleep apnea during the initiation of positive airway pressure therapy for obstructive sleep apnea. The purpose of this study was to review the perioperative course of patients diagnosed with TECSA. ... Read more >>

J Anesth (Journal of anesthesia)
[2020, :]

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Postoperative Nausea and Vomiting and Pain After Robotic-Assisted Mitral Valve Repair.

Melissa A Burtoft, Shane M Gillespie, Mariana L Laporta, Erica D Wittwer, Darrell R Schroeder, Juraj Sprung, Toby N Weingarten,

OBJECTIVE:To determine the rate and clinical factors associated with postoperative nausea and vomiting (PONV) and severe pain after robotic-assisted mitral valve repair. DESIGN:Retrospective chart review. SETTING:Major quaternary academic medical center. PARTICIPANTS:Adult patients undergoing robotic-assisted mitral valve repair from May 5, 2018 through September 13, 2019. INTERVENTIONS:Participant electronic medical records were ... Read more >>

J. Cardiothorac. Vasc. Anesth. (Journal of cardiothoracic and vascular anesthesia)
[2020, :]

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Respiratory depression in the post-anesthesia care unit: Mayo Clinic experience.

Mariana L Laporta, Juraj Sprung, Toby N Weingarten,

The anesthesia recovery is a complex physiologic process as systems recover from the effects of surgery and anesthesia. Inadequate recovery of respiratory physiology can lead to severe hypoxemia-induced end-organ damage and even death. Emerging evidence suggests that signs of respiratory depression during early anesthesia recovery may portend increased risk for ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Anesthesia for TORS for Oropharyngeal Carcinoma: Factors Associated with Prolonged Phase I Postanesthesia Recovery.

Cassandra L Puccinelli, Eric J Moore, Linda X Yin, Daniel L Price, Jeffrey R Janus, Toby N Weingarten, Kathryn M Van Abel,

OBJECTIVES:Clinical variables affecting anesthetic recovery following transoral robotic surgery (TORS) to resect oropharyngeal squamous cell carcinoma have not been described. We aimed to explore risk factors associated with prolonged postanesthesia recovery following TORS. STUDY DESIGN:Retrospective case-control study. SETTING:Tertiary referral center, January 2010 to November 2016. SUBJECTS AND METHODS:Patients included adults ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2020, 163(3):531-537]

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Risk factors and outcomes of postoperative emergency response team activation: a matched case-control study.

Matthew I Hardman, S Chandralekha Kruthiventi, Michelle R Schmugge, Alexandre N Cavalcante, Jeffrey B Jensen, Darrell R Schroeder, Juraj Sprung, Toby N Weingarten,

OBJECTIVE:To determine patient and perioperative characteristics associated with unexpected postoperative clinical deterioration as determined for the need of a postoperative emergency response team (ERT) activation. DESIGN:Retrospective case-control study. SETTING:Tertiary academic hospital. PARTICIPANTS:Patients who underwent general anaesthesia discharged to regular wards between 1 January 2013 and 31 December 2015 and required ... Read more >>

Crit Care Resusc (Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine)
[2020, 22(1):6-14]

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Exposure to surgery with regional anesthesia and cortical thickness in older adults.

Juraj Sprung, David S Knopman, Ronald C Petersen, Prashanthi Vemuri, Michelle M Mielke, Toby N Weingarten, Phillip J Schulte, Darrell R Schroeder, David O Warner,

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2020, 6(1):e12012]

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Exposure to surgery with general anaesthesia during adult life is not associated with increased brain amyloid deposition in older adults.

Juraj Sprung, David O Warner, David S Knopman, Ronald C Petersen, Michelle M Mielke, Clifford R Jack, Val J Lowe, David P Martin, Andrew C Hanson, Darrell R Schroeder, Scott A Przybelski, Phillip J Schulte, Toby N Weingarten, Prashanthi Vemuri,

BACKGROUND:Exposure to surgery with general anaesthesia (surgery/GA) is associated with cortical atrophy, but the aetiology remains unknown. Amyloid-β (Aβ) deposition is one of the hallmark pathological characteristics of Alzheimer's disease (AD). We examined brain Aβ burden in study participants exposed to surgery/GA. METHODS:We performed a cross-sectional analysis of residents of ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2020, 124(5):594-602]

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Preoperative cognitive impairment associated with oversedation during recovery from anesthesia.

S Chandralekha Kruthiventi, Mariana L Laporta, Atousa Deljou, David S Knopman, Ronald C Petersen, Darrell R Schroeder, Juraj Sprung, Toby N Weingarten,

PURPOSE:Our objective was to examine the association between preoperative cognitive status and postoperative recovery from anesthesia. METHODS:We included patients (70-91 years old) from the Mayo Clinic Study of Aging who received general anesthesia and were admitted to the postanesthesia care unit from January 1, 2010 through April 30, 2018. Procedures were ... Read more >>

J Anesth (Journal of anesthesia)
[2020, 34(3):390-396]

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Postoperative nausea and vomiting after bariatric surgery and dexmedetomidine anesthetic: a propensity-weighted analysis.

S Chandralekha Kruthiventi, Roger E Hofer, Mary E Warner, Juraj Sprung, Todd A Kellogg, Toby N Weingarten,

BACKGROUND:Patients undergoing laparoscopic bariatric surgery have high rates of postoperative nausea and vomiting (PONV). Dexmedetomidine based anesthetic could reduce PONV rates. OBJECTIVES:To determine if PONV rates differ in patients undergoing laparoscopic bariatric surgery with anesthesia primarily based on dexmedetomidine or standard anesthetic management with inhalational agents and opioids. SETTING:University hospital. ... Read more >>

Surg Obes Relat Dis (Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery)
[2020, 16(4):545-553]

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Postoperative pulmonary complications in contemporary cohort of patients with pulmonary hypertension.

S Chandralekha Kruthiventi, Garvan C Kane, Juraj Sprung, Toby N Weingarten, Mary Ellen Warner,

Patients with pulmonary hypertension are at increased risk for postoperative pulmonary complications (PPCs). Herein, we review PPCs in pulmonary hypertension patients undergoing non-cardiac procedures under general anesthesia. The medical records of pulmonary hypertension patients who underwent surgery with general anesthesia between 2010 and 2017 were reviewed for PPCs. In addition ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2019, 19(4):392-399]

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Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults.

Juraj Sprung, S Chandralekha Kruthiventi, David O Warner, David S Knopman, Ronald C Petersen, Michelle M Mielke, Clifford R Jack, Jonathan Graff-Radford, David P Martin, Andrew C Hanson, Darrell R Schroeder, Scott A Przybelski, Phillip J Schulte, Toby N Weingarten, Prashanthi Vemuri,

BACKGROUND:Preclinical studies suggest that exposure to general anaesthesia (GA) could cause neurodegeneration consistent with Alzheimer's disease (AD) pathology. Brain magnetic resonance imaging (MRI) is useful to study structural brain changes. We tested the hypothesis that exposure to surgery with GA (surgery/GA) is associated with greater cortical thinning and increased frequency ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2019, 123(6):808-817]

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Outcomes After Noncardiac Surgery for Patients with Pulmonary Hypertension: A Historical Cohort Study.

Atousa Deljou, Moldovan Sabov, Garvan C Kane, Robert P Frantz, Hilary M DuBrock, David P Martin, Darrell R Schroeder, Madeline Q Johnson, Toby N Weingarten, Juraj Sprung,

OBJECTIVE:Pulmonary hypertension (PH) is a substantial preoperative risk factor. For this study, morbidity and mortality were examined after noncardiac surgery in patients with precapillary PH. DESIGN:A retrospective cohort study. SETTING:Quaternary medical center in Rochester, MN. PARTICIPANTS:Adults with PH undergoing noncardiac surgery. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:The PH and surgical databases ... Read more >>

J. Cardiothorac. Vasc. Anesth. (Journal of cardiothoracic and vascular anesthesia)
[2020, 34(6):1506-1513]

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Postoperative Respiratory Depression May Be Related to Undiagnosed Sleep-Disordered Breathing or Obstructive Sleep Apnea.

Liselotte M Elleby, Juraj Sprung, Toby N Weingarten,

Anesth. Analg. (Anesthesia and analgesia)
[2019, 129(3):e104-e105]

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Cognitive function after surgery with regional or general anesthesia: A population-based study.

Juraj Sprung, Phillip J Schulte, David S Knopman, Michelle M Mielke, Ronald C Petersen, Toby N Weingarten, David P Martin, Andrew C Hanson, Darrell R Schroeder, David O Warner,

INTRODUCTION:Our aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA). METHODS:Longitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global and domain-specific cognition ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2019, 15(10):1243-1252]

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Postoperative Corneal Injuries: Incidence and Risk Factors.

Atousa Deljou, Toby N Weingarten, Michael A Mahr, Juraj Sprung, David P Martin,

BACKGROUND:Previous studies of postoperative corneal injury rates relied on provider-initiated incident reports, which may underestimate the true incidence. Postoperative administration of proparacaine eye drops is used almost exclusively to diagnose corneal injury; therefore, identifying instances of administration may provide a better estimate of corneal injuries. We compared proparacaine administration versus ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2019, 129(3):737-742]

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Effects of Sugammadex on Time of First Postoperative Bowel Movement: A Retrospective Analysis.

Atousa Deljou, Darrell R Schroeder, Beth A Ballinger, Juraj Sprung, Toby N Weingarten,

Objective:To determine whether time to first postoperative bowel movement after intraperitoneal surgery differs among neuromuscular blockade reversal with either anticholinesterase/anticholinergic combination vs sugammadex. Patients and Methods:Sugammadex was introduced to our practice in October 2016. Patients were identified who underwent intraperitoneal surgery between January 1, through June 30, 2016, and January ... Read more >>

(Mayo Clinic proceedings. Innovations, quality & outcomes)
[2019, 3(3):294-301]

Cited: 2 times

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Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults.

Phillip J Schulte, David O Warner, David P Martin, Atousa Deljou, Michelle M Mielke, David S Knopman, Ronald C Petersen, Toby N Weingarten, Matthew A Warner, Alejandro A Rabinstein, Andrew C Hanson, Darrell R Schroeder, Juraj Sprung,

OBJECTIVES:Patients requiring admission to an ICU may subsequently experience cognitive decline. Our objective was to investigate longitudinal cognitive trajectories in older adults hospitalized in ICUs. We hypothesized that individuals hospitalized for critical illness develop greater cognitive decline compared with those who do not require ICU admission. DESIGN:A retrospective cohort study ... Read more >>

Crit Care Med (Critical care medicine)
[2019, 47(8):1116-1124]

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