Full Text Journal Articles by
Author Tobias Welte

Advertisement

Find full text journal articles






Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

Cited: 0 times

View full text PDF listing >>



Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

Cited: 0 times

View full text PDF listing >>



Advertisement

A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany

Christina Bahrs, Miriam Kesselmeier, Martin Kolditz, Santiago Ewig, Gernot Rohde, Grit Barten-Neiner, Jan Rupp, Martin Witzenrath, Tobias Welte, Mathias Pletz,

Recently, a 15-valent (PCV15) and a 20-valent pneumococcal conjugate vaccine (PCV20) have been licensed by the US Food and Drug Administration and are under evaluation by the European Medicines Agency.PCV15 contains all serotypes of the 13-valent conjugate vaccine (PCV13) plus serotype 22F and 33F and PCV20 includes PCV13 serotypes plus ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Fosfomycin single- and multiple-dose pharmacokinetics in patients undergoing prolonged intermittent renal replacement therapy.

Lisa K V Gerecke, Julius J Schmidt, Carsten Hafer, Gabriele Eden, Stefanie M Bode-Böger, Jens Martens-Lobenhoffer, Tobias Welte, Jan T Kielstein,

<h4>Background</h4>Fosfomycin is used increasingly in the treatment of MDR bacteria. It is eliminated by renal excretion, but data regarding dosing recommendations for patients undergoing modern means of renal replacement therapies are scarce.<h4>Objectives</h4>Evaluation of the pharmacokinetics (PK) of fosfomycin in patients undergoing prolonged intermittent renal replacement therapy (PIRRT) to guide dosing ... Read more >>

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations.

Stefano Aliberti, Pieter C Goeminne, Anne E O'Donnell, Timothy R Aksamit, Hamdan Al-Jahdali, Alan F Barker, Francesco Blasi, Wim G Boersma, Megan L Crichton, Anthony De Soyza, Katerina E Dimakou, Stuart J Elborn, Charles Feldman, Harm Tiddens, Charles S Haworth, Adam T Hill, Michael R Loebinger, Miguel Angel Martinez-Garcia, Jennifer J Meerburg, Rosario Menendez, Lucy C Morgan, Marlene S Murris, Eva Polverino, Felix C Ringshausen, Michal Shteinberg, Nicola Sverzellati, Gregory Tino, Antoni Torres, Thomas Vandendriessche, Montserrat Vendrell, Tobias Welte, Robert Wilson, Conroy A Wong, James D Chalmers,

Bronchiectasis refers to both a clinical disease and a radiological appearance that has multiple causes and can be associated with a range of conditions. Disease heterogeneity and the absence of standardised definitions have hampered clinical trials of treatments for bronchiectasis and are important challenges in clinical practice. In view of ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Between inflammation and thrombosis: endothelial cells in COVID-19.

Anna Birnhuber, Elisabeth Fließer, Gregor Gorkiewicz, Martin Zacharias, Benjamin Seeliger, Sascha David, Tobias Welte, Julius Schmidt, Horst Olschewski, Malgorzata Wygrecka, Grazyna Kwapiszewska,

Eur Respir J (The European respiratory journal)
[2021, 58(3):]

Cited: 1 time

View full text PDF listing >>



Clinical decision making is improved by BioFire Pneumonia Plus in suspected lower respiratory tract infection after lung transplantation: Results of the prospective DBATE-IT* study.

Moritz Z Kayser, Benjamin Seeliger, Christina Valtin, Jan Fuge, Stefan Ziesing, Tobias Welte, Mathias W Pletz, Patrick Chhatwal, Jens Gottlieb,

<h4>Background</h4>Lower respiratory tract infections (LRTIs) are a significant cause of morbidity and mortality in lung transplant (LTx) recipients. Timely and precise pathogen detection is vital to successful treatment. Multiplex PCR kits with short turnover times like the BioFire Pneumonia Plus (BFPPp) (manufactured by bioMérieux) may be a valuable addition to ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2021, :e13725]

Cited: 0 times

View full text PDF listing >>



Altered fibrin clot structure contributes to thrombosis risk in severe COVID-19

Malgorzata Wygrecka, Anna Birnhuber, Benjamin Seeliger, Laura Michalick, Oleg Pak, Astrid-Solveig Schultz, Fabian Schramm, Martin Zacharias, Gregor Gorkiewicz, Sascha David, Tobias Welte, Julius Schmidt, Norbert Weissmann, Ralph Schermuly, Guillermo Barreto, Liliana Schaefer, Philipp Markart, Markus Brack, Stefan Hippenstiel, Florian Kurth, Leif Sander, Martin Witzenrath, Wolfgang Kuebler, Grazyna Kwapiszewska, Klaus Preissner,

The high incidence of thrombotic events suggests a possible role of the contact system pathway in COVID-19 pathology. Here, we demonstrate altered levels of factor XII (FXII) and its activation products in two independent cohorts of critically ill COVID-19 patients in comparison to patients suffering from severe acute respiratory distress ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Prediction of lung emphysema in COPD by spirometry and clinical symptoms: results from COSYCONET.

Christina Kellerer, Rudolf A Jörres, Antonius Schneider, Peter Alter, Hans-Ulrich Kauczor, Bertram Jobst, Jürgen Biederer, Robert Bals, Henrik Watz, Jürgen Behr, Diego Kauffmann-Guerrero, Johanna Lutter, Alexander Hapfelmeier, Helgo Magnussen, Franziska C Trudzinski, Tobias Welte, Claus F Vogelmeier, Kathrin Kahnert,

<h4>Background</h4>Lung emphysema is an important phenotype of chronic obstructive pulmonary disease (COPD), and CT scanning is strongly recommended to establish the diagnosis. This study aimed to identify criteria by which physicians with limited technical resources can improve the diagnosis of emphysema.<h4>Methods</h4>We studied 436 COPD patients with prospective CT scans from ... Read more >>

Respir Res (Respiratory research)
[2021, 22(1):242]

Cited: 0 times

View full text PDF listing >>



Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: a patient-level meta-analysis from randomized controlled trials.

Eva Heilmann, Claudia Gregoriano, Djillali Annane, Konrad Reinhart, Lila Bouadma, Michel Wolff, Jean Chastre, Charles-Edouard Luyt, Florence Tubach, Angela R Branche, Matthias Briel, Mirjam Christ-Crain, Tobias Welte, Caspar Corti, Evelien de Jong, Maarten Nijsten, Dylan W de Lange, Jos A H van Oers, Albertus Beishuizen, Armand R J Girbes, Rodrigo O Deliberato, Stefan Schroeder, Kristina B Kristoffersen, Nathalie Layios, Pierre Damas, Stella S S Lima, Vandack Nobre, Long Wei, Carolina F Oliveira, Yahya Shehabi, Daiana Stolz, Michael Tamm, Alessia Verduri, Jin-Xiang Wang, Sabine Drevet, Gaetan Gavazzi, Beat Mueller, Philipp Schuetz,

<h4>Background</h4>Older patients have a less pronounced immune response to infection, which may also influence infection biomarkers. There is currently insufficient data regarding clinical effects of procalcitonin (PCT) to guide antibiotic treatment in older patients.<h4>Objective and design</h4>We performed an individual patient data meta-analysis to investigate the association of age on effects ... Read more >>

Age Ageing (Age and ageing)
[2021, 50(5):1546-1556]

Cited: 0 times

View full text PDF listing >>



Safety and Efficacy of Mepolizumab in Hypereosinophilic Syndrome: An Open-Label Extension Study.

Gerald J Gleich, Florence Roufosse, Geoffrey Chupp, Stanislas Faguer, Bastian Walz, Andreas Reiter, Steven W Yancey, Jane H Bentley, Jonathan Steinfeld, ,

<h4>Background</h4>A double-blind, placebo-controlled, phase III study (200622) showed that mepolizumab reduces disease flares for patients with uncontrolled FIP1-like-1-platelet-derived growth factor receptor α-negative hypereosinophilic syndrome (HES) and two or more flares in the previous year.<h4>Objective</h4>To further characterize the safety, clinical benefit, and pharmacodynamics of mepolizumab.<h4>Methods</h4>Eligible patients from both treatment arms of ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Correction to: Key summary of German national treatment guidance for hospitalized COVID‑19 patients : Key pharmacologic recommendations from a national German living guideline using an Evidence to Decision Framework (last updated 17.05.2021).

Jakob J Malin, Christoph D Spinner, Uwe Janssens, Tobias Welte, Steffen Weber-Carstens, Gereon Schälte, Petra Gastmeier, Florian Langer, Martin Wepler, Michael Westhoff, Michael Pfeifer, Klaus F Rabe, Florian Hoffmann, Bernd W Böttiger, Julia Weinmann-Menke, Alexander Kersten, Peter Berlit, Marcin Krawczyk, Wiebke Nehls, Falk Fichtner, Sven Laudi, Miriam Stegemann, Nicole Skoetz, Monika Nothacker, Gernot Marx, Christian Karagiannidis, Stefan Kluge,

Infection (Infection)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Gender-specific differences in COPD symptoms and their impact for the diagnosis of cardiac comorbidities.

Franziska C Trudzinski, Christina Kellerer, Rudolf A Jörres, Peter Alter, Johanna I Lutter, Frederik Trinkmann, Felix J F Herth, Marion Frankenberger, Henrik Watz, Claus F Vogelmeier, Hans-Ulrich Kauczor, Tobias Welte, Jürgen Behr, Robert Bals, Kathrin Kahnert,

<h4>Background</h4>In chronic obstructive pulmonary disease (COPD), gender-specific differences in the prevalence of symptoms and comorbidity are known.<h4>Research question</h4>We studied whether the relationship between these characteristics depended on gender and carried diagnostic information regarding cardiac comorbidities.<h4>Study design and methods</h4>The analysis was based on 2046 patients (GOLD grades 1-4, 795 women; 38.8%) ... Read more >>

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by α-1 Antitrypsin.

Srinu Tumpara, Anna R Gründing, Kokilavani Sivaraman, Sabine Wrenger, Beata Olejnicka, Tobias Welte, Maria J Wurm, Paco Pino, Divor Kiseljak, Florian M Wurm, Sabina Janciauskiene,

For the treatment of severe COVID-19, supplementation with human plasma-purified α-1 antitrypsin (AAT) to patients is currently considered. AAT inhibits host proteases that facilitate viral entry and possesses broad anti-inflammatory and immunomodulatory activities. Researchers have demonstrated that an interaction between SARS-CoV-2 spike protein (S) and lipopolysaccharides (LPS) enhances pro-inflammatory responses ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(15):]

Cited: 0 times

View full text PDF listing >>



Measurement of urinary Dickkopf-3 uncovered silent progressive kidney injury in patients with chronic obstructive pulmonary disease.

Stefan J Schunk, Christoph Beisswenger, Felix Ritzmann, Christian Herr, Martina Wagner, Sarah Triem, Gregor Hütter, David Schmit, Stephen Zewinger, Tamim Sarakpi, Anja Honecker, Peer Mahadevan, Peter Boor, Stefan Wagenpfeil, Rudolf Jörres, Henrik Watz, Tobias Welte, Claus F Vogelmeier, Hermann-Josef Gröne, Danilo Fliser, Thimoteus Speer, Robert Bals,

Chronic kidney disease (CKD) represents a global public health problem with high disease related morbidity and mortality. Since CKD etiology is heterogeneous, early recognition of patients at risk for progressive kidney injury is important. Here, we evaluated the tubular epithelial derived glycoprotein dickkopf-3 (DKK3) as a urinary marker for the ... Read more >>

Kidney Int (Kidney international)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Effects of Therapeutic Plasma Exchange on the Endothelial Glycocalyx in Septic Shock

Klaus Stahl, Uta Carola Hillebrand, Yulia Kiyan, Julius Schmidt, Benjamin Seeliger, Heiko Schenk, Thorben Pape, Bernhard Schmidt, Tobias Welte, Marius Hoeper, Agnes Sauer, Malgorzata Wygrecka, Christian Bode, Heiner Wedemeyer, Hermann Haller, Sascha David,

<h4>Background: </h4> Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes. Besides this biomarker function, increased blood concentrations of shedded eGC constituents might play a mechanistic role in septic organ failure. We hypothesized that therapeutic plasma exchange ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury.

Konrad Peukert, Mario Fox, Susanne Schulz, Caroline Feuerborn, Stilla Frede, Christian Putensen, Hermann Wrigge, Beate Mareike Kümmerer, Sascha David, Benjamin Seeliger, Tobias Welte, Eicke Latz, Dennis Klinman, Christoph Wilhelm, Folkert Steinhagen, Christian Bode,

<b>Rationale:</b> Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with a mortality of up to 40%. Precision medicine approaches targeting patients on the basis of their molecular phenotypes of ARDS might help to identify effective pharmacotherapies. The inflammasome-caspase-1 pathway contributes to the development of ARDS via IL-1β and IL-18 ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(1):53-63]

Cited: 3 times

View full text PDF listing >>



Interobserver agreement in interpretation of chest radiographs for pediatric community acquired pneumonia: Findings of the pedCAPNETZ-cohort.

Gesche M Voigt, Dominik Thiele, Martin Wetzke, Jürgen Weidemann, Patricia-Maria Parpatt, Tobias Welte, Jürgen Seidenberg, Christian Vogelberg, Holger Koster, Gernot G U Rohde, Christoph Härtel, Gesine Hansen, Matthias V Kopp,

Although chest radiograph (CXR) is commonly used in diagnosing pediatric community acquired pneumonia (pCAP), limited data on interobserver agreement among radiologists exist. PedCAPNETZ is a prospective, observational, and multicenter study on pCAP. N = 233 CXR from patients with clinical diagnosis of pCAP were retrieved and n = 12 CXR without pathological findings were ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2021, 56(8):2676-2685]

Cited: 0 times

View full text PDF listing >>



Real-World Multicenter Experience with Mepolizumab and Benralizumab in the Treatment of Uncontrolled Severe Eosinophilic Asthma Over 12 Months.

Moritz Z Kayser, Nora Drick, Katrin Milger, Jan Fuge, Nikolaus Kneidinger, Stephanie Korn, Roland Buhl, Jürgen Behr, Tobias Welte, Hendrik Suhling,

<h4>Purpose</h4>Treatment of severe eosinophilic asthma (SEA) has been revolutionized by the development of monoclonal antibodies targeting underlying immunological pathways of eosinophilic asthma. Two of the most frequently used antibodies in clinical practice are mepolizumab, targeting interleukin (IL) 5 and benralizumab, targeting the IL5 receptor alpha. The comparative treatment efficacy of ... Read more >>

J Asthma Allergy (Journal of asthma and allergy)
[2021, 14:863-871]

Cited: 0 times

View full text PDF listing >>



Endothelial dysfunction determines severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

Louisa Ruhl, Isabell Pink, Jenny Kühne, Kerstin Beushausen, Jana Keil, Stella Christoph, Andrea Sauer, Lennart Boblitz, Julius Schmidt, Sascha David, Hans-Martin Jäck, Edith Roth, Markus Cornberg, Thomas Schulz, Tobias Welte, Marius Höper, Christine Falk,

The systemic processes involved in the manifestation of life-threatening COVID-19 and in disease recovery are still incompletely understood, despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 infection. To define hallmarks of severe COVID-19 and disease recovery in convalescent patients, we combined analyses of immune cells and cytokine/chemokine ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Impact of the COVID-19 pandemic on the behaviour and health status of patients with COPD: results from the German COPD cohort COSYCONET.

Kathrin Kahnert, Johanna I Lutter, Tobias Welte, Peter Alter, Jürgen Behr, Felix Herth, Hans-Ulrich Kauczor, Sandra Söhler, Michael Pfeifer, Henrik Watz, Claus F Vogelmeier, Robert Bals, Rudolf A Jörres, Franziska C Trudzinski,

<h4>Background</h4>Infection control measures for coronavirus disease 2019 (COVID-19) might have affected management and clinical state of patients with COPD. We analysed to which extent this common notion is fact-based.<h4>Methods</h4>Patients of the COSYCONET cohort were contacted with three recurring surveys (COVID1, 2 and 3 at 0, 3 and 6 months, respectively). The ... Read more >>

ERJ Open Res (ERJ open research)
[2021, 7(3):]

Cited: 0 times

View full text PDF listing >>



Key summary of German national treatment guidance for hospitalized COVID-19 patients : Key pharmacologic recommendations from a national German living guideline using an Evidence to Decision Framework (last updated 17.05.2021).

Jakob J Malin, Christoph D Spinner, Uwe Janssens, Tobias Welte, Steffen Weber-Carstens, Gereon Schälte, Petra Gastmeier, Florian Langer, Martin Wepler, Michael Westhoff, Michael Pfeifer, Klaus F Rabe, Florian Hoffmann, Bernd W Böttiger, Julia Weinmann-Menke, Alexander Kersten, Peter Berlit, Marcin Krawczyk, Wiebke Nehls, Falk Fichtner, Sven Laudi, Miriam Stegemann, Nicole Skoetz, Monika Nothacker, Gernot Marx, Christian Karagiannidis, Stefan Kluge,

<h4>Purpose</h4>This executive summary of a national living guideline aims to provide rapid evidence based recommendations on the role of drug interventions in the treatment of hospitalized patients with COVID-19.<h4>Methods</h4>The guideline makes use of a systematic assessment and decision process using an evidence to decision framework (GRADE) as recommended standard WHO ... Read more >>

Infection (Infection)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Shifting the paradigm: unilateral infiltrates and ARDS?

Antoni Torres, Enric Barbeta, Tobias Welte,

Eur Respir J (The European respiratory journal)
[2021, 57(6):]

Cited: 0 times

View full text PDF listing >>



Impfstoffe gegen das SARS-Coronavirus-2.

Tobias Welte,

Pneumo News (Pneumo news)
[2021, 13(3):29-33]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

1.1489 s