Full Text Journal Articles by
Author Tobias Schlesinger

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Current concepts in the evaluation and management of preoperative anemia.

Vanessa Neef, Suma Choorapoikayil, Florian Piekarski, Tobias Schlesinger, Patrick Meybohm, Kai Zacharowski,

<h4>Purpose of review</h4>In the past years, patient blood management (PBM) has evolved to improve patient's care and safety. Anemia is one of the most common medical diseases in the world and is an independent risk factor for morbidity and mortality. Iron deficiency is the main cause for anemia and constitutes ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):352-356]

Cited: 0 times

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Vitamin D deficiency in critically ill COVID-19 ARDS patients.

Quirin Notz, Johannes Herrmann, Tobias Schlesinger, Peter Kranke, Magdalena Sitter, Philipp Helmer, Jan Stumpner, Daniel Roeder, Karin Amrein, Christian Stoppe, Christopher Lotz, Patrick Meybohm,

<h4>Background & aims</h4>Vitamin D's pleiotropic effects include immune modulation, and its supplementation has been shown to prevent respiratory tract infections. The effectivity of vitamin D as a therapeutic intervention in critical illness remains less defined. The current study analyzed clinical and immunologic effects of vitamin D levels in patients suffering ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2021, :]

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Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression.

Isabel Taeuber, Stephanie Weibel, Eva Herrmann, Vanessa Neef, Tobias Schlesinger, Peter Kranke, Leila Messroghli, Kai Zacharowski, Suma Choorapoikayil, Patrick Meybohm,

<h4>Importance</h4>Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use.<h4>Objective</h4>To examine the association between intravenous TXA and total thromboembolic events (TEs) and mortality in patients of all ages and of any medical disciplines.<h4>Data ... Read more >>

JAMA Surg (JAMA surgery)
[2021, :e210884]

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

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<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, :]

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COVID-19 and the kidney: A retrospective analysis of 37 critically ill patients using machine learning

Anna Laura Herzog, Holger Jouanne-Diedrich, Christoph Wanner, Dirk Weismann, Tobias Schlesinger, Patrick Meybohm, Jan Stumpner,

<h4>Introduction: </h4> There is evidence that SARS-CoV2 has a particular affinity for kidney tissue and is often associated with kidney failure. <h4>Methods: </h4> We assessed whether proteinuria can be predictive of kidney failure, the development of chronic kidney disease, and mortality in 37 critically ill COVID-19 patients. We used machine ... Read more >>

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COVID-19 Induced Acute Respiratory Distress Syndrome-A Multicenter Observational Study.

Johannes Herrmann, Elisabeth Hannah Adam, Quirin Notz, Philipp Helmer, Michael Sonntagbauer, Peter Ungemach-Papenberg, Andreas Sanns, York Zausig, Thorsten Steinfeldt, Iuliu Torje, Benedikt Schmid, Tobias Schlesinger, Caroline Rolfes, Christian Reyher, Markus Kredel, Jan Stumpner, Alexander Brack, Thomas Wurmb, Daniel Gill-Schuster, Peter Kranke, Dirk Weismann, Hartwig Klinker, Peter Heuschmann, Viktoria Rücker, Stefan Frantz, Georg Ertl, Ralf Michael Muellenbach, Haitham Mutlak, Patrick Meybohm, Kai Zacharowski, Christopher Lotz,

<b>Background:</b> Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). <b>Methods:</b> This is a retrospective, observational multicentre study in five German secondary or tertiary ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:599533]

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Do Small Incisions Need Only Minimal Anesthesia?-Anesthetic Management in Laparoscopic and Robotic Surgery.

Sebastian Hottenrott, Tobias Schlesinger, Philipp Helmer, Patrick Meybohm, Ibrahim Alkatout, Peter Kranke,

Laparoscopic techniques have established themselves as a major part of modern surgery. Their implementation in every surgical discipline has played a vital part in the reduction of perioperative morbidity and mortality. Precise robotic surgery, as an evolution of this, is shaping the present and future operating theatre that an anesthetist ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(12):]

Cited: 1 time

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Severe neurological complications in critically ill COVID-19 patients.

Quirin Notz, Christopher Lotz, Johannes Herrmann, Marius Vogt, Tobias Schlesinger, Markus Kredel, Wolfgang Muellges, Dirk Weismann, Thomas Westermaier, Patrick Meybohm, Peter Kranke,

J Neurol (Journal of neurology)
[2021, 268(5):1576-1579]

Cited: 2 times

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Factors influencing the bias between blood gas analysis versus central laboratory hemoglobin testing. A secondary analysis of a randomized controlled trial.

Linda Tanner, Simone Lindau, Markus Velten, Tobias Schlesinger, Maria Wittmann, Peter Kranke, Kira Berg, Florian Piekarski, Christoph Füllenbach, Suma Choorapoikayil, Dirk Hasenclever, Kai Zacharowski, Patrick Meybohm,

<h4>Background</h4>Anemia is the most important complication during major surgery and transfusion of red blood cells is the mainstay to compensate for life threating blood loss. Therefore, accurate measurement of hemoglobin (Hb) concentration should be provided in real-time. Blood Gas Analysis (BGA) provides rapid point-of-care assessment using smaller sampling tubes compared ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0240721]

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Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.

Stephanie Weibel, Gerta Rücker, Leopold Hj Eberhart, Nathan L Pace, Hannah M Hartl, Olivia L Jordan, Debora Mayer, Manuel Riemer, Maximilian S Schaefer, Diana Raj, Insa Backhaus, Antonia Helf, Tobias Schlesinger, Peter Kienbaum, Peter Kranke,

<h4>Background</h4>Postoperative nausea and vomiting (PONV) is a common adverse effect of anaesthesia and surgery. Up to 80% of patients may be affected. These outcomes are a major cause of patient dissatisfaction and may lead to prolonged hospital stay and higher costs of care along with more severe complications. Many antiemetic ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 10:CD012859]

Cited: 0 times

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Pro- and Anti-Inflammatory Responses in Severe COVID-19-Induced Acute Respiratory Distress Syndrome-An Observational Pilot Study.

Quirin Notz, Marc Schmalzing, Florian Wedekink, Tobias Schlesinger, Michael Gernert, Johannes Herrmann, Lena Sorger, Dirk Weismann, Benedikt Schmid, Magdalena Sitter, Nicolas Schlegel, Peter Kranke, Jörg Wischhusen, Patrick Meybohm, Christopher Lotz,

<h4>Objectives</h4>The severity of Coronavirus Disease 2019 (COVID-19) is largely determined by the immune response. First studies indicate altered lymphocyte counts and function. However, interactions of pro- and anti-inflammatory mechanisms remain elusive. In the current study we characterized the immune responses in patients suffering from severe COVID-19-induced acute respiratory distress syndrome ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:581338]

Cited: 4 times

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Coronavirus Threatens Blood Supply: Patient Blood Management Now!

Tobias Schlesinger, Peter Kranke, Kai Zacharowski, Patrick Meybohm,

Ann Surg (Annals of surgery)
[2020, 272(2):e74]

Cited: 1 time

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COVID-19 Induced Acute Respiratory Distress Syndrome—A Multicenter Observational Study

Johannes Herrmann, Elisabeth Hannah Adam, Quirin Notz, Philipp Helmer, Michael Sonntagbauer, Peter Ungemach-Papenberg, Andreas Sanns, York Zausig, Thorsten Steinfeldt, Iuliu Torje, Benedikt Schmid, Tobias Schlesinger, Caroline Rolfes, Christian Reyher, Markus Kredel, Jan Stumpner, Alexander Brack, Thomas Wurmb, Daniel Gill-Schuster, Peter Kranke, Dirk Weismann, Hartwig Klinker, Peter Heuschmann, Viktoria Rücker, Stefan Frantz, Georg Ertl, Ralf Michael Muellenbach, Haitham Mutlak, Patrick Meybohm, Kai Zacharowski, Christopher Lotz,

Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). Methods: This is a retrospective, observational multicentre study in five German secondary or tertiary ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:]

Cited: 0 times

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Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study).

Karin Amrein, Dhruv Parekh, Sabine Westphal, Jean-Charles Preiser, Andrea Berghold, Regina Riedl, Philipp Eller, Peter Schellongowski, David Thickett, Patrick Meybohm, ,

<h4>Introduction</h4>Observational studies have demonstrated an association between vitamin D deficiency and increased risk of morbidity and mortality in critically ill patients. Cohort studies and pilot trials have suggested promising beneficial effects of vitamin D replacement in the critical ill, at least in patients with severe vitamin D deficiency. As vitamin ... Read more >>

BMJ Open (BMJ open)
[2019, 9(11):e031083]

Cited: 5 times

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