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Author Tobias Klatte

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Reproducibility of CT-based radiomic features against image resampling and perturbations for tumour and healthy kidney in renal cancer patients.

Margherita Mottola, Stephan Ursprung, Leonardo Rundo, Lorena Escudero Sanchez, Tobias Klatte, Iosif Mendichovszky, Grant D Stewart, Evis Sala, Alessandro Bevilacqua,

Computed Tomography (CT) is widely used in oncology for morphological evaluation and diagnosis, commonly through visual assessments, often exploiting semi-automatic tools as well. Well-established automatic methods for quantitative imaging offer the opportunity to enrich the radiologist interpretation with a large number of radiomic features, which need to be highly reproducible ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):11542]

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Intermediate- and long-term oncological outcomes of active surveillance for localized renal masses: a systematic review and quantitative analysis.

Tobias Klatte, Alessandro Berni, Sergio Serni, Riccardo Campi,

<h4>Objective</h4>To evaluate intermediate- and long-term oncological outcomes of active surveillance (AS) for localized renal masses (LRMs).<h4>Methods</h4>This systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and registered on PROSPERO (CRD42021230416). Studies on AS for LRMs with at least 3 years' follow-up were eligible. ... Read more >>

BJU Int (BJU international)
[2021, :]

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The 2021 Updated European Association of Urology Guidelines on Renal Cell Carcinoma: Immune Checkpoint Inhibitor-based Combination Therapies for Treatment-naive Metastatic Clear-cell Renal Cell Carcinoma Are Standard of Care.

Jens Bedke, Laurence Albiges, Umberto Capitanio, Rachel H Giles, Milan Hora, Thomas B Lam, Börje Ljungberg, Lorenzo Marconi, Tobias Klatte, Alessandro Volpe, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernández Pello, Fabian Hofmann, Teele Kuusk, Rana Tahbaz, Thomas Powles, Axel Bex,

The recent randomized controlled phase III CLEAR trial results are the last to complement immune checkpoint inhibitor (ICI)-based doublet combination therapies for treatment-naïve metastatic clear-cell renal cell carcinoma. The CLEAR trial demonstrated an improved progression-free survival (PFS), overall survival (OS), and an objective response rate (ORR) benefit for the combination ... Read more >>

Eur Urol (European urology)
[2021, :]

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The European Association of Urology COVID Intermediate-priority Group is Poorly Predictive of Pathological High Risk Among Patients with Renal Tumours.

Pranav Satish, Teele Kuusk, Nick Campain, Yasmin Abu-Ghanem, Joana Neves, Ravi Barod, Soha El-Sheikh, Faiz Mumtaz, Prasad Patki, Maxine Tran, My-Anh Tran-Dang, Lee Grant, Tobias Klatte, Axel Bex,

Eur Urol (European urology)
[2021, 80(2):265-267]

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Corrigendum to 'Development of a Novel Risk Score to Select the Optimal Candidate for Cytoreductive Nephrectomy Among Patients with Metastatic Renal Cell Carcinoma. Results from a Multi-institutional Registry (REMARCC)' [European Urology Oncology 3 (2021) 256-263].

Michele Marchioni, Maximilian Kriegmair, Mathias Heck, Thomas Amiel, Francesco Porpiglia, Enrico Checcucci, Riccardo Campi, Andrea Minervini, Andrea Mari, Siska Van Bruwaene, Estefania Linares, Vital Hevia, Mireia Musquera, Mauricio D'Anna, Ithaar Derweesh, Aaron Bradshaw, Riccardo Autorino, Georgi Guruli, Alessandro Veccia, Eduard Roussel, Maarten Albersen, Nicola Pavan, Francesco Claps, Alessandro Antonelli, Carlotta Palumbo, Tobias Klatte, Selcuk Erdem, Maria Carmen Mir, ,

Eur Urol Oncol (European urology oncology)
[2021, 4(3):517]

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Pattern, timing and predictors of recurrence after surgical resection of chromophobe renal cell carcinoma.

Joana B Neves, Leyre Vanaclocha Saiz, Yasmin Abu-Ghanem, Marta Marchetti, My-Anh Tran-Dang, Soha El-Sheikh, Ravi Barod, Christian Beisland, Umberto Capitanio, David Cullen, Tobias Klatte, Börje Ljungberg, Faiz Mumtaz, Prasad Patki, Grant D Stewart, Saeed Dabestani, Maxine G B Tran, Axel Bex, ,

<h4>Purpose</h4>Currently there are no specific guidelines for the post-operative follow-up of chromophobe renal cell carcinoma (chRCC). We aimed to evaluate the pattern, location and timing of recurrence after surgery for non-metastatic chRCC and establish predictors of recurrence and cancer-specific death.<h4>Methods</h4>Retrospective analysis of consecutive surgically treated non-metastatic chRCC cases from the ... Read more >>

World J Urol (World journal of urology)
[2021, :]

Cited: 1 time

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Should patients with low-risk renal cell carcinoma be followed differently after nephron-sparing surgery vs radical nephrectomy?

Yasmin Abu-Ghanem, Thomas Powles, Umberto Capitanio, Christian Beisland, Petrus Järvinen, Grant D Stewart, Eirikur Gudmundsson, Thomas B L Lam, Lorenzo Marconi, Sergio Fernandéz-Pello, Harry Nisen, Richard P Meijer, Alessandro Volpe, Börje Ljungberg, Tobias Klatte, Karim Bensalah, Saeed Dabestani, Axel Bex,

<h4>Objective</h4>To investigate whether pT1 renal cell carcinoma (RCC) should be followed differently after partial (PN) or radical nephrectomy (RN) based on a retrospective analysis of a multicentre database (RECUR).<h4>Subjects</h4>A retrospective study was conducted in 3380 patients treated for nonmetastatic RCC between January 2006 and December 2011 across 15 centres from ... Read more >>

BJU Int (BJU international)
[2021, :]

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

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<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, :]

Cited: 11 times

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Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study.

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Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 ... Read more >>

Anaesthesia (Anaesthesia)
[2021, 76(6):748-758]

Cited: 19 times

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Outcome after resection of occult and non-occult lymph node metastases at the time of nephrectomy.

Teele Kuusk, Tobias Klatte, Patricia Zondervan, Brunolf Lagerveld, Niels Graafland, Kees Hendricksen, Umberto Capitanio, Andrea Minervini, Grant D Stewart, Borje Ljungberg, Simon Horenblas, Axel Bex,

<h4>Purpose</h4>There is sparse evidence on outcomes of resected occult LN metastases at the time of nephrectomy (synchronous disease). We sought to analyse a large international cohort of patients and to identify clinico-pathological predictors of long-term survival.<h4>Materials and methods</h4>We collected data of consecutive patients who underwent nephrectomy and LND for T<sub>any</sub> ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Prevalence, Disease-free, and Overall Survival of Contemporary Patients With Renal Cell Carcinoma Eligible for Adjuvant Checkpoint Inhibitor Trials.

Lorenzo Marconi, Maxine Sun, Christian Beisland, Tobias Klatte, Boerje Ljungberg, Grant D Stewart, Saeed Dabestani, Toni K Choueiri, Axel Bex,

<h4>Introduction</h4>Designing adjuvant trials is challenging because of uncertainties of prevalence and outcome of high-risk renal cell cancer (RCC) despite use of validated risk scores. Our objective is to investigate how differences in eligibility criteria may impact on potential study results in RCC adjuvant trials.<h4>Patients and methods</h4>RECUR is a multicenter European ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, 19(2):e92-e99]

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Clinical, surgical, pathological and follow-up features of kidney cancer patients with Von Hippel-Lindau syndrome: novel insights from a large consortium.

Umberto Capitanio, Giuseppe Rosiello, Selcuk Erdem, Isaline Rowe, Onder Kara, Eduard Roussel, Riccardo Campi, Tobias Klatte, Maximilian C Kriegmair, Mattia Sibona, Riccardo Bertolo, Idir Ouzaid, Maria Carmen Mir, Giancarlo Marra, Alessandro Larcher, Francesco Montorsi, Andrea Salonia, ,

<h4>Purpose</h4>To investigate the natural history and follow-up after kidney tumor treatment of Von Hippel-Lindau (VHL) patients.<h4>Materials and methods</h4>A multi-institutional European consortium of patients with VHL syndrome included 96 non-metastatic patients treated at 9 urological departments (1987-2018). Descriptive and survival analyses were performed.<h4>Results and limitations</h4>Median age at VHL diagnosis was 34 years ... Read more >>

World J Urol (World journal of urology)
[2021, :]

Cited: 2 times

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Development of a Novel Risk Score to Select the Optimal Candidate for Cytoreductive Nephrectomy Among Patients with Metastatic Renal Cell Carcinoma. Results from a Multi-institutional Registry (REMARCC).

Michele Marchioni, Maximilian Kriegmair, Mathias Heck, Thomas Amiel, Francesco Porpiglia, Enrico Ceccucci, Riccardo Campi, Andrea Minervini, Andrea Mari, Siska Van Bruwaene, Estefania Linares, Vital Hevia, Mireia Musquera, Mauricio D'Anna, Ithaar Derweesh, Aaron Bradshaw, Riccardo Autorino, Georgi Guruli, Alessandro Veccia, Eduard Roussel, Maarten Albersen, Nicola Pavan, Francesco Claps, Alessandro Antonelli, Carlotta Palumbo, Tobias Klatte, Selcuk Erdem, Maria Carmen Mir, ,

<h4>Background</h4>Selection of patients for upfront cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) has to be improved.<h4>Objective</h4>To evaluate a new scoring system for the prediction of overall mortality (OM) in mRCC patients undergoing CN.<h4>Design, setting, and participants</h4>We identified a total of 519 patients with synchronous mRCC undergoing CN between ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, 4(2):256-263]

Cited: 1 time

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Updated European Association of Urology Guidelines on Renal Cell Carcinoma: Nivolumab plus Cabozantinib Joins Immune Checkpoint Inhibition Combination Therapies for Treatment-naïve Metastatic Clear-Cell Renal Cell Carcinoma.

Jens Bedke, Laurence Albiges, Umberto Capitanio, Rachel H Giles, Milan Hora, Thomas B Lam, Börje Ljungberg, Lorenzo Marconi, Tobias Klatte, Alessandro Volpe, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernández-Pello, Fabian Hofmann, Teele Kuusk, Rana Tahbaz, Thomas Powles, Axel Bex,

Longer follow-up and new trial data from phase 3 randomised controlled trials investigating immune checkpoint blockade (PD-1 or its ligand PD-L1) in advanced clear-cell renal cell carcinoma (RCC) have recently become available. The CheckMate 9ER trial demonstrated an improved progression-free survival (PFS) and overall survival (OS) benefit for the combination ... Read more >>

Eur Urol (European urology)
[2021, 79(3):339-342]

Cited: 7 times

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The Impact of Histological Subtype on the Incidence, Timing, and Patterns of Recurrence in Patients with Renal Cell Carcinoma After Surgery-Results from RECUR Consortium.

Yasmin Abu-Ghanem, Thomas Powles, Umberto Capitanio, Christian Beisland, Petrus Järvinen, Grant D Stewart, Eiríkur Orri Gudmundsson, Thomas B Lam, Lorenzo Marconi, Sergio Fernandéz-Pello, Harry Nisen, Richard P Meijer, Alessandro Volpe, Börje Ljungberg, Tobias Klatte, Saeed Dabestani, Axel Bex,

<h4>Background</h4>Current follow-up strategies for patients with renal cell carcinoma (RCC) after curative surgery rely mainly on risk models and the treatment delivered, regardless of the histological subtype.<h4>Objective</h4>To determine the impact of RCC histological subtype on recurrence and to examine the incidence, pattern, and timing of recurrences to improve follow-up recommendations.<h4>Design, ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, 4(3):473-482]

Cited: 2 times

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Delaying surgery for patients with a previous SARS-CoV-2 infection.

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Br J Surg (The British journal of surgery)
[2020, 107(12):e601-e602]

Cited: 24 times

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Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

James C Glasbey, Dmitri Nepogodiev, Joana F F Simoes, Omar Omar, Elizabeth Li, Mary L Venn, Pgdme, Mohammad K Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G Edwards, Jonathan P Evans, Marco Fiore, Jose Flavio Videria, Samuel J Ford, Ian Ganly, Ewen A Griffiths, Rohan R Gujjuri, Angelos G Kolias, Haytham M A Kaafarani, Ana Minaya-Bravo, Siobhan C McKay, Helen M Mohan, Keith J Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J Smart, Grant D Stewart, Sudha Sundar Mrcog, Raghavan Vidya, Aneel A Bhangu, ,

<h4>Purpose</h4>As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway.<h4>Patients and methods</h4>This international, ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, 39(1):66-78]

Cited: 40 times

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Surgical Management and Outcomes of Renal Tumors Arising from Horseshoe Kidneys: Results from an International Multicenter Collaboration.

Eduard Roussel, Giovanni Tasso, Riccardo Campi, Maximilian C Kriegmair, Önder Kara, Tobias Klatte, Umberto Capitanio, Riccardo Bertolo, Alexandre Ingels, Selcuk Erdem, Loïc Baekelandt, Maria C Mir, Idir Ouzaid, Nicola Pavan, Benoit Beuselinck, Mauro Gacci, Andrea Minervini, Alessandro Volpe, Maarten Albersen, ,

<h4>Background</h4>Despite being the most frequent renal fusion anomaly, tumors arising from horseshoe kidneys (HSKs) are extremely rare and management guidance is lacking.<h4>Objective</h4>To evaluate the perioperative, oncological, and functional outcomes of surgically treated HSK tumors.<h4>Design, setting, and participants</h4>A retrospective, multicenter cohort study of 43 HSK tumors in 40 patients was conducted, ... Read more >>

Eur Urol (European urology)
[2021, 79(1):133-140]

Cited: 1 time

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Incidence and preoperative predictors for major complications following radical nephroureterectomy.

Neil J Kocher, David Canes, Karim Bensalah, Morgan Roupret, Costas Lallas, Vitaly Margulis, Shahrokh Shariat, Pierre Colin, Surena Matin, Chad Tracy, Evanguelos Xylinas, Andrew Wagner, Mathieu Roumiguie, Wassim Kassouf, Tobias Klatte, Jay D Raman,

<h4>Background</h4>Radical nephroureterectomy (RNU) is the referent standard for managing bulky, invasive, or high grade upper-tract urothelial carcinoma (UTUC). The UTUC patient population, however, generally harbor medical comorbidities thereby placing them at risk of surgical complications. This study reviews a large international cohort of RNU patients to define the risk of ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1786-1793]

Cited: 0 times

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[Current practice patterns of perioperative cystectomy management in Germany: a questionnaire survey].

Franz F Dressler, Serkan Dogan, Martin Hennig, Tanja Frank, Julian Struck, Angelika Cebulla, Johannes Salem, Hendrik Borgmann, Tobias Klatte, Mario W Kramer, Sebastian Hofbauer,

<h4>Objective</h4> Radical cystectomy (RCX) is the standard treatment for muscle-invasive and treatment-refractory non-invasive bladder cancer, but that is associated with high morbidity. We now survey current practice patterns on perioperative management among German urological departments of all sizes METHODS:  Members of the German Association of Urology and the German Society of ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2021, 52(1):82-87]

Cited: 0 times

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The 1999 and 2010 WHO reference values for human semen analysis to predict sperm DNA damage: A comparative study.

Artin Aghazarian, Wolfgang Huf, Heinz Pflüger, Tobias Klatte,

Standard semen parameters are often used to predict male fertility, but whether the 2010 World Health Organization (WHO 2010) thresholds are better predictors than the 1999 thresholds has not been investigated. In this study, we addressed this issue using sperm DNA fragmentation (SDF) as a marker of male fertility in ... Read more >>

Reprod Biol (Reproductive biology)
[2020, 20(3):379-383]

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Chronic Kidney Disease After Partial Nephrectomy in Patients With Preoperative Inconspicuous Renal Function - Curiosity or Relevant Issue?

Malin Nientiedt, Riccardo Bertolo, Riccardo Campi, Umberto Capitanio, Selcuk Erdem, Önder Kara, Tobias Klatte, Alessandro Larcher, Maria Carmen Mir, Idir Ouzaid, Eduard Roussel, Maciej Salagierski, Frank Waldbillig, Maximillian Christian Kriegmair,

<h4>Background</h4>Chronic kidney disease (CKD) is a severe long-term complication after partial nephrectomy (PN). Clinical and scientific focus lies on patients with impaired renal function at the time of surgery. Little data is available on patients with normal preoperative renal function (NPRF).<h4>Patients and methods</h4>Patients who underwent PN with a preoperative estimated ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2020, 18(6):e754-e761]

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Chest computed tomography for staging renal tumours: validation and simplification of a risk prediction model from a large contemporary retrospective cohort.

James Voss, Tamsin Drake, Hannah Matthews, James Jenkins, Stanley Tang, Joshua Doherty, Keith Chan, Harriet Dawe, Tittu Thomas, Samantha Kearley, James Manners, Charles Carter, Salah Al-Buheissi, Tobias Klatte,

OBJECTIVES:To externally validate a nomogram recently proposed by Larcher et al. (BJU Int. 2017; 120: 490) and to develop a simplified model with comparable accuracy to guide on the need for staging chest computed tomography (CT) for patients with new renal masses. PATIENTS AND METHODS:We analysed the data of 1082 ... Read more >>

BJU Int (BJU international)
[2020, 125(4):561-567]

Cited: 0 times

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Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors.

Christopher G Smith, Tina Moser, Florent Mouliere, Johanna Field-Rayner, Matthew Eldridge, Anja L Riediger, Dineika Chandrananda, Katrin Heider, Jonathan C M Wan, Anne Y Warren, James Morris, Irena Hudecova, Wendy N Cooper, Thomas J Mitchell, Davina Gale, Andrea Ruiz-Valdepenas, Tobias Klatte, Stephan Ursprung, Evis Sala, Antony C P Riddick, Tevita F Aho, James N Armitage, Samantha Perakis, Martin Pichler, Maximilian Seles, Gabriel Wcislo, Sarah J Welsh, Athena Matakidou, Tim Eisen, Charles E Massie, Nitzan Rosenfeld, Ellen Heitzer, Grant D Stewart,

<h4>Background</h4>Cell-free tumor-derived DNA (ctDNA) allows non-invasive monitoring of cancers, but its utility in renal cell cancer (RCC) has not been established.<h4>Methods</h4>Here, a combination of untargeted and targeted sequencing methods, applied to two independent cohorts of patients (n = 91) with various renal tumor subtypes, were used to determine ctDNA content in plasma ... Read more >>

Genome Med (Genome medicine)
[2020, 12(1):23]

Cited: 11 times

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Deferred Cytoreductive Nephrectomy Following Presurgical Vascular Endothelial Growth Factor Receptor-targeted Therapy in Patients with Primary Metastatic Clear Cell Renal Cell Carcinoma: A Pooled Analysis of Prospective Trial Data.

Roderick de Bruijn, Akhila Wimalasingham, Bernadett Szabados, Grant D Stewart, Sarah J Welsh, Teele Kuusk, Christian Blank, John Haanen, Tobias Klatte, Michael Staehler, Thomas Powles, Axel Bex,

<h4>Background</h4>Cancer du Rein Métastatique Nephrectomie et Antiangiogéniques (CARMENA) concluded that sunitinib alone is not inferior to cytoreductive nephrectomy (CN) followed by vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) in patients with metastatic renal cell carcinoma. It remains uncertain whether deferred CN is beneficial in this setting.<h4>Objective</h4>The aim of ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(2):168-173]

Cited: 1 time

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