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Editorial: understanding IBS pathophysiology through "converging channels" of research-authors' reply.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1215-1216]

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Universal Antifouling and Photothermal Antibacterial Surfaces Based on Multifunctional Metal-Phenolic Networks for Prevention of Biofilm Formation.

Yaran Wang, Yi Zou, Yong Wu, Ting Wei, Kunyan Lu, Luohuizi Li, Yuancheng Lin, Yan Wu, Chaobo Huang, Yanxia Zhang, Hong Chen, Qian Yu,

Biofilms formed from the pathogenic bacteria that attach to the surfaces of biomedical devices and implantable materials result in various persistent and chronic bacterial infections, posing serious threats to human health. Compared to the elimination of matured biofilms, prevention of the formation of biofilms is expected to be a more ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, :]

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The Effect of Smoking on the Immune Microenvironment and Immunogenicity and Its Relationship With the Prognosis of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer.

Yueqin Sun, Qi Yang, Jie Shen, Ting Wei, Weitao Shen, Nan Zhang, Peng Luo, Jian Zhang,

Background: The emergence of immune checkpoint inhibitors (ICIs) has opened a new chapter for the treatment of non-small cell lung cancer (NSCLC), and the best beneficiaries of ICI treatment are still being explored. Smoking status has been repeatedly confirmed to affect the efficacy of ICIs in NSCLC patients, but the ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:745859]

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Deep learning for differential diagnosis of malignant hepatic tumors based on multi-phase contrast-enhanced CT and clinical data.

Ruitian Gao, Shuai Zhao, Kedeerya Aishanjiang, Hao Cai, Ting Wei, Yichi Zhang, Zhikun Liu, Jie Zhou, Bing Han, Jian Wang, Han Ding, Yingbin Liu, Xiao Xu, Zhangsheng Yu, Jinyang Gu,

<h4>Background</h4>Liver cancer remains the leading cause of cancer death globally, and the treatment strategies are distinct for each type of malignant hepatic tumors. However, the differential diagnosis before surgery is challenging and subjective. This study aims to build an automatic diagnostic model for differentiating malignant hepatic tumors based on patients' ... Read more >>

J Hematol Oncol (Journal of hematology & oncology)
[2021, 14(1):154]

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High mutations in fatty acid metabolism contribute to a better prognosis of small-cell lung cancer patients treated with chemotherapy.

Qiong Lyu, Weiliang Zhu, Ting Wei, Weimin Ding, Manming Cao, Qiongyao Wang, Linlang Guo, Peng Luo, Jian Zhang,

<h4>Background</h4>The majority of patients with small-cell lung cancer (SCLC) show a good response in the early stages of treatment, but more than 90% of patients will develop drug resistance. Therefore, biomarkers are urgently needed to identify patients who can benefit from systemic treatment.<h4>Methods</h4>We prospectively enrolled 52 extensive-stage SCLC patients before ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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SPOP mutation induces DNA methylation via stabilizing GLP/G9a.

Jianong Zhang, Kun Gao, Hongyan Xie, Dejie Wang, Pingzhao Zhang, Ting Wei, Yuqian Yan, Yunqian Pan, Wenbin Ye, Huifen Chen, Qing Shi, Yao Li, Shi-Min Zhao, Xiaonan Hou, Saravut J Weroha, Yuzhuo Wang, Jun Zhang, R Jeffrey Karnes, Housheng Hansen He, Liguo Wang, Chenji Wang, Haojie Huang,

Mutations in SPOP E3 ligase gene are reportedly associated with genome-wide DNA hypermethylation in prostate cancer (PCa) although the underlying mechanisms remain elusive. Here, we demonstrate that SPOP binds and promotes polyubiquitination and degradation of histone methyltransferase and DNMT interactor GLP. SPOP mutation induces stabilization of GLP and its partner ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):5716]

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CAMOIP: A Web Server for Comprehensive Analysis on Multi-Omics of Immunotherapy in Pan-cancer

Anqi Lin, Ting Wei, Junyi Liang, Chang Qi, Mengyao Li, Peng Luo, Jian Zhang,

<h4>ABSTRACT</h4> Immune checkpoint inhibitors (ICIs) have completely changed the therapeutic approach for tumor patients. Immunotherapy has also produced much needed data about mutation, expression, and prognosis, providing an unprecedented opportunity for discovering candidate drug targets and screening for immunotherapy-relevant biomarkers. Although existing web tools enable biologists to analyze the expression, ... Read more >>

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Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

<h4>Background</h4>Irritable bowel syndrome (IBS) patients often experience meal-associated symptoms. However, the underlying mechanisms are unclear.<h4>Aim</h4>To determine small intestinal mechanisms of lipid-induced symptoms and rectal hypersensitivity in IBS METHODS: We recruited 26 IBS patients (12 IBS-C, 14 IBS-D) and 15 healthy volunteers (HV). In vivo permeability was assessed using saccharide excretion ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1179-1192]

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Correction: C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism.

Yu Zhang, Qian Yan, Lanqi Gong, Hang Xu, Beilei Liu, Xiaona Fang, Dandan Yu, Lei Li, Ting Wei, Ying Wang, Ching Ngar Wong, Zhaojie Lyu, Ying Tang, Pak Chung Sham, Xin-Yuan Guan,

Oncogene (Oncogene)
[2021, 40(35):5451-5453]

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The poisoning effect of K, Ca and Na on CeZrTiAl catalyst with nanosheet skeleton structure

Qianming Man, Pijun Gong, Yifei Jiang, Yulu Zhang, Ziqiang Chen, Ting Wei, Xumao Zhang,

The poisoning effect of KNO3, NaNO3, and Ca(NO3)2 on CeZrTiAl catalyst for selective catalytic reduction of NO with NH3 was investigated. It was found that the activity deactivation rate follows K> Na > Ca. SEM and BET showed that the accumulation of catalysts was severe after poisoning, and the nanosheet ... Read more >>

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A single mutation attenuates both the transcription termination and RNA-dependent RNA polymerase activity of T7 RNA polymerase.

Hui Wu, Ting Wei, Bingbing Yu, Rui Cheng, Fengtao Huang, Xuelin Lu, Yan Yan, Xionglue Wang, Chenli Liu, Bin Zhu,

Transcription termination is one of the least understood processes of gene expression. As the prototype model for transcription studies, the single-subunit T7 RNA polymerase (RNAP) is known to respond to two types of termination signals, but the mechanism underlying such termination, especially the specific elements of the polymerase involved, is ... Read more >>

RNA Biol (RNA biology)
[2021, :1-16]

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Study on the performance of carbonate-mineralized bacteria combined with eggshell for immobilizing Pb and Cd in water and soil.

Ting Wei, Noman Yashir, Fengqiu An, Syed Asad Imtiaz, Xian Li, Hong Li,

Microbially induced carbonate precipitation (MICP) is an advanced bioremediation approach to remediate heavy metal (HM)-contaminated water and soil. In this study, metal-tolerant urease-producing bacterial isolates, namely, UR1, UR16, UR20, and UR21, were selected based on their urease activity. The efficiency of these isolates in water for Pb and Cd immobilizations ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Reversibility of Historical and Future Climate Change with a Complex Earth System Model

Shili Yang, Di Tian, JieMing Chou, Ting Wei, Xian Zhu, WenJie Dong,

The reversibility of a wide range of components of the earth system was investigated by comparing forward and time-reversed historical and future simulations of a coupled earth system model known as the Beijing Normal University earth system model. Many characteristics of the climate system, including the surface temperature, ocean heat ... Read more >>

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GapClust is a light-weight approach distinguishing rare cells from voluminous single cell expression profiles.

Botao Fa, Ting Wei, Yuan Zhou, Luke Johnston, Xin Yuan, Yanran Ma, Yue Zhang, Zhangsheng Yu,

Single cell RNA sequencing (scRNA-seq) is a powerful tool in detailing the cellular landscape within complex tissues. Large-scale single cell transcriptomics provide both opportunities and challenges for identifying rare cells playing crucial roles in development and disease. Here, we develop GapClust, a light-weight algorithm to detect rare cell types from ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4197]

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Hf-Nd-Sr Isotopic Composition of the Tibetan Plateau Dust as a Fingerprint for Regional to Hemispherical Transport.

Ting Wei, Janice Brahney, Zhiwen Dong, Shichang Kang, Chunlei Zong, Junming Guo, Ling Yang, Xiang Qin,

Large areas of arid regions in the Tibetan Plateau (TP) are undergoing desertification and subsequent aeolian emission and transport. The contribution of TP soils to the atmospheric aerosol burden in Asia and elsewhere is not known. Here, we use Hf, Nd, and Sr isotopes to distinguish the TP from other ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2021, 55(14):10121-10132]

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FOXA1 overexpression suppresses interferon signaling and immune response in cancer.

Yundong He, Liguo Wang, Ting Wei, Yu-Tian Xiao, Haoyue Sheng, Hengchuan Su, Daniel P Hollern, Xiaoling Zhang, Jian Ma, Simeng Wen, Hongyan Xie, Yuqian Yan, Yunqian Pan, Xiaonan Hou, Xiaojia Tang, Vera J Suman, Jodi M Carter, Richard Weinshilboum, Liewei Wang, Krishna R Kalari, Saravut J Weroha, Alan H Bryce, Judy C Boughey, Haidong Dong, Charles M Perou, Dingwei Ye, Matthew P Goetz, Shancheng Ren, Haojie Huang,

Androgen receptor-positive prostate cancer (PCa) and estrogen receptor-positive luminal breast cancer (BCa) are generally less responsive to immunotherapy compared with certain tumor types such as melanoma. However, the underlying mechanisms are not fully elucidated. In this study, we found that FOXA1 overexpression inversely correlated with interferon (IFN) signature and antigen ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(14):]

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CpGtools: a python package for DNA methylation analysis.

Ting Wei, Jinfu Nie, Nicholas B Larson, Zhenqing Ye, Jeanette E Eckel-Passow, Keith D Robertson, Jean-Pierre A Kocher, Liguo Wang,

<h4>Motivation</h4>DNA methylation can be measured at the single CpG level using sodium bisulfite conversion of genomic DNA followed by sequencing or array hybridization. Many analytic tools have been developed, yet there is still a high demand for a comprehensive and multifaceted tool suite to analyze, annotate, QC and visualize the ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2021, 37(11):1598-1599]

Cited: 3 times

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Re-Evaluate Fusion Genes in Prostate Cancer.

Ting Wei, Ji Lu, Tao Ma, Haojie Huang, Jean-Pierre Kocher, Liguo Wang,

<h4>Background</h4>Thousands of gene fusions have been reported in prostate cancer, but their authenticity, incidence, and tumor specificity have not been thoroughly evaluated, nor have their genomic characteristics been carefully explored.<h4>Methods</h4>We developed FusionVet to dedicatedly validate known fusion genes using RNA-seq alignments. Using FusionVet, we re-assessed 2727 gene fusions reported from ... Read more >>

Cancer Inform (Cancer informatics)
[2021, 20:11769351211027592]

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Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors.

Yang Wen, Anqi Lin, Weiliang Zhu, Ting Wei, Peng Luo, Linlang Guo, Jian Zhang,

<b>Background:</b> Lung cancer has always been the most prevalent cancer. Lung adenocarcinoma (LUAD) is the most common lung cancer subtype and has a high tumor mutation rate. In addition to KRAS, EGFR, ALK, HER2, ROS1, and BRAF, which are known to have high mutation rates, we discovered some new mutated ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:645862]

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MET Amplification Attenuates LungTumor Response to Immunotherapy by Inhibiting STING.

Yong Zhang, Qifan Yang, Xiangyu Zeng, Manxiang Wang, Shuang Dong, Bin Yang, Xinyi Tu, Ting Wei, Wenzhuan Xie, Chao Zhang, Qiang Guo, Jake A Kloeber, Yueyu Cao, Guijie Guo, Qin Zhou, Fei Zhao, Jinzhou Huang, Li Liu, Kai Zhang, Mingwei Wang, Ping Yin, Kuntian Luo, Min Deng, Wootae Kim, Jing Hou, Yu Shi, Qian Zhu, Lifeng Chen, Sheng Hu, Junqiu Yue, Guoliang Pi, Zhenkun Lou,

Immune checkpoint blockade (ICB) has revolutionized cancer therapy. However, the response of patients to ICB is difficult to predict. Here, we examined 81 patients with lung cancer under ICB treatment and found that patients with <i>MET</i> amplification were resistant to ICB and had a poor progression-free survival. Tumors with <i>MET</i> ... Read more >>

Cancer Discov (Cancer discovery)
[2021, :]

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High-Dimensional Mediation Analysis With Confounders in Survival Models.

Zhangsheng Yu, Yidan Cui, Ting Wei, Yanran Ma, Chengwen Luo,

Mediation analysis is a common statistical method for investigating the mechanism of environmental exposures on health outcomes. Previous studies have extended mediation models with a single mediator to high-dimensional mediators selection. It is often assumed that there are no confounders that influence the relations among the exposure, mediator, and outcome. ... Read more >>

Front Genet (Frontiers in genetics)
[2021, 12:688871]

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The concordance in lesion detection and characteristics between the Anatomical Intelligence and conventional breast ultrasound Scan method.

Juan Li, Hao Wang, Lu Wang, Ting Wei, Minggang Wu, Tingting Li, Jifen Liao, Bo Tan, Man Lu,

<h4>Background</h4>The aim of this study was to investigate the concordance in lesion detection, between conventional Handhold Ultrasound (HHUS) and The Anatomical Intelligence for Breast ultrasound scan method.<h4>Result</h4>The AI-breast showed the absolute agreement between the resident and an experienced breast radiologist. The ICC for the scan time, number, clockface location, distance ... Read more >>

BMC Med Imaging (BMC medical imaging)
[2021, 21(1):102]

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Study On The Performance Of Carbonate-Mineralized Bacteria Combined With Eggshell For Immobilizing Pb and Cd in Water And Soil

Ting Wei, Noman Yashir, Fengqiu An, Syed Asad Imtiaz, Xian Li, Hong Li,

Microbially induced carbonate precipitation (MICP) is an advanced bioremediation approach to remediate heavy metals (HMs) contaminated water and soil. In this study, metal tolerant urease-producing bacterial isolates, namely UR1, UR16, UR20 and UR21, were selected based on their urease activity. The efficiency of these isolates in water for Pb and ... Read more >>

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Presence of estrogen and progesterone receptors in proliferating and involuting infantile hemangiomas.

Adam Johnson, Haihong Zhang, Santiago R Gonzalez, Madison Lee, Ting Wei, Gresham Richter,

<h4>Background</h4>Studies in the literature have demonstrated the presence of sex hormone receptors in infantile hemangiomas (IHs), but further investigation is needed to determine the role of these receptors in their proliferation and involution. To date, there are no studies in the literature that aimed to quantitatively examine the expression of ... Read more >>

J Plast Reconstr Aesthet Surg (Journal of plastic, reconstructive & aesthetic surgery : JPRAS)
[2021, :]

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Effect of exogenous silicon and methyl jasmonate on the alleviation of cadmium-induced phytotoxicity in tomato plants.

Ting Wei, Xian Li, Noman Yashir, Hong Li, Yanni Sun, Li Hua, Xinhao Ren, Junkang Guo,

In the present study, a hydroponic experiment was performed to evaluate the effect of exogenous silicon (Si) and methyl jasmonate (MeJA) on the mitigation of Cd toxicity in tomato seedlings. The results revealed that Cd-stressed plants exhibited growth inhibition, increased lipid peroxidation, and impaired photosynthetic pigment accumulation. However, Si and ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, 28(37):51854-51864]

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