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The impact of lymph node dissection on survival in patients with clinical early-stage ovarian cancer.

Ting Deng, Qidan Huang, Ting Wan, Xiaoling Luo, Yanling Feng, He Huang, Jihong Liu,

<h4>Objective</h4>To estimate the impact of lymph node dissection on survival in patients with apparent early-stage epithelial ovarian cancer (EOC).<h4>Methods</h4>We conducted a retrospective review of patients with clinical stage I-II EOC. All patients underwent primary surgery at Sun Yat-sen University Cancer Center between January 2003 and December 2015. Demographic features and ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e40]

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ITGB2 as a Novel Biomarker Correlating With Prognosis and Immune Infiltrates in Ovarian Cancer

chanyuan li, Ting Wan, Ting Deng, Junya Cao, He Huang, Jihong Liu,

<h4>Background: </h4> Epithelial ovarian cancer is nowadays one of the malignancies in women, this study aimed to identify novel biomarkers to predict prognosis and immunotherapy efficacy. <h4>Methods:</h4> The differentially expressed genes (DEGs) obtained from online database Gene Expression Omnibus (GEO)were screened via GEO2R and Venn diagram software, gene enrichment was ... Read more >>

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Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.

He Huang, Yan-Ling Feng, Ting Wan, Yan-Na Zhang, Xin-Ping Cao, Yong-Wen Huang, Ying Xiong, Xin Huang, Min Zheng, Yan-Fang Li, Jun-Dong Li, Guan-Di Chen, Hu Li, Yi-Le Chen, Li-Guo Ma, Hong-Ying Yang, Li Li, Shu-Zhong Yao, Wei-Jun Ye, Hua Tu, Qi-Dan Huang, Li-Zhi Liang, Fu-Yuan Liu, Qing Liu, Ji-Hong Liu,

<h4>Importance</h4>There is no current consensus on the role of chemotherapy in addition to radiation for postoperative adjuvant treatment of patients with early-stage cervical cancer with adverse pathological factors.<h4>Objective</h4>To evaluate the clinical benefits of sequential chemoradiation (SCRT) and concurrent chemoradiation (CCRT) compared with radiation alone (RT) as a postoperative adjuvant treatment ... Read more >>

JAMA Oncol (JAMA oncology)
[2021, 7(3):361-369]

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Silencing of miR-483-5p alleviates postmenopausal osteoporosis by targeting SATB2 and PI3K/AKT pathway.

Fujiang Zhao, Yier Xu, Yulong Ouyang, Zhexu Wen, Guihao Zheng, Ting Wan, Guicai Sun,

Postmenopausal osteoporosis (PMOP) poses a significant threat to women's health worldwide. However, detailed molecular mechanism and therapeutic strategy for PMOP remain insufficient. Accumulating evidence suggests that miR-48-5p is implicated in the pathogenesis of osteoporosis. The present study aimed to determine the role and mechanism of miR-483-5p in PMOP. Results from ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(5):6945-6956]

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Serum Albumin Levels and Clinical Outcomes Among Ischemic Stroke Patients Treated with Endovascular Thrombectomy.

Jie Gao, Ying Zhao, Mingyang Du, Hongquan Guo, Ting Wan, Min Wu, Ling Liu, Huaiming Wang, Qin Yin, Xinfeng Liu,

<h4>Background and aims</h4>Albumin levels have been reported to be associated with all-cause and cardiovascular mortality. The aim of this study was to investigate the association between serum albumin and prognosis of ischemic stroke patients after endovascular thrombectomy (EVT) treatment.<h4>Methods</h4>Patients with EVT due to large artery occlusion in anterior circulation were ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric disease and treatment)
[2021, 17:401-411]

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Autologous fat transplantation for the treatment of abdominal wall scar adhesions after cesarean section.

Sheng-Hong Li, Yin-Di Wu, Yan-Yun Wu, Xuan Liao, Pik-Nga Cheung, Ting Wan, Li-Ling Xiao, Jian-Xing Song, Hai-Ling Huang, Hong-Wei Liu,

Cesarean section results in scarring, which usually leads to adhesion between the subcutaneous fat and the abdominal wall muscle. The present study aimed to evaluate the therapeutic effect of autologous fat grafting on scar adhesion to the abdominal wall after cesarean section. Thirty-six patients with scar adhesion to the abdominal ... Read more >>

J Plast Surg Hand Surg (Journal of plastic surgery and hand surgery)
[2021, :1-6]

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The effects of teriparatide and bisphosphonates on new fractures in postmenopausal women with osteoporosis: A protocol for systematic review and meta-analysis.

YuLong Ouyang, ShuiLin Chen, Ting Wan, GuiHao Zheng, GuiCai Sun,

<h4>Background</h4>To systematically evaluate the efficacy of teriparatide and bisphosphonates in preventing fractures in postmenopausal women with osteoporosis.<h4>Materials and methods</h4>We performed a systematic search of PubMed, Embase, and the Cochrane Library for randomized controlled trials (RCTs) that compared teriparatide and bisphosphonates for osteoporosis treatment. Searches were performed without language restrictions and ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(7):e24839]

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Stability, Elastic Properties, and the Li Transport Mechanism of the Protonated and Fluorinated Antiperovskite Lithium Conductors.

Mohammed B Effat, Jiapeng Liu, Ziheng Lu, Ting Hei Wan, Antonino Curcio, Francesco Ciucci,

Lithium-rich antiperovskites (APs) have attracted significant research attention due to their ionic conductivity above 1 mS cm<sup>-1</sup> at room temperature. However, recent experimental reports suggest that proton-free lithium-rich APs, such as Li<sub>3</sub>OCl, may not be synthesized using conventional methods. While Li<sub>2</sub>OHCl has a lower conductivity of about 0.1 mS cm<sup>-1</sup> ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(49):55011-55022]

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Minimally invasive surgery vs laparotomy for early stage cervical cancer: A propensity score-matched cohort study.

Danian Dai, He Huang, Yanling Feng, Ting Wan, Zhimin Liu, Chongjie Tong, Jihong Liu,

<h4>Objective</h4>To compare the long-term oncologic outcomes of minimally invasive surgery (MIS) vs laparotomy for patients with stage IB (2018 FIGO) cervical cancer.<h4>Methods</h4>A matched retrospective study of cervical cancer patients who underwent MIS or laparotomy at Sun Yat-sen University Cancer Center from January 2012 to December 2015 was carried out. Patients ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(24):9236-9245]

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Systems pharmacology approach uncovers Ligustilide attenuates experimental colitis in mice by inhibiting PPARγ-mediated inflammation pathways.

Yujie Huang, Yifan Zhang, Ting Wan, Yu Mei, Zihao Wang, Jincheng Xue, Yi Luo, Min Li, Shuhuan Fang, Huafeng Pan, Qi Wang, Jiansong Fang,

Inflammatory bowel disease (IBD) is a chronic idiopathic disorder causing inflammation in the gastro-intestinal tract, which is lack of effective drug targets and medications. To identify novel therapeutic agents against consistent targets, we exploited a systems pharmacology-driven framework that incorporates drug-target networks of natural product and IBD disease genes. Our ... Read more >>

Cell Biol Toxicol (Cell biology and toxicology)
[2021, 37(1):113-128]

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SEC23A Regulated by Splicing Factor EIF3A may be Involved in the Development of Cervical Squamous Cell Cancer via Adherens Junction Pathway

Chen Li, Fang Yan, Ting Wan, Haifeng Gu, Gang Chen, Qiang Li, Hua Xian, Jingdun Xie,

<h4>Background: </h4> Cervical squamous cell cancer is a common malignancy in women globally. Increasing studies have indicated that there was an indivisible association between alternative splicing and cancer. However, comprehensive analysis of alternative splicing is scarce in cervical squamous cell cancer. <h4>Methods: </h4> Alternative mRNA splicing events data and clinical ... Read more >>

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Time trend of axial length and associated factors in 4- and 5-year-old children in Shanghai from 2013 to 2019.

Tao Li, Ting Wan, Xiaoqian Yao, Huihong Qi, Xuefeng Chen, Man She, Qianqian Hu, Xiaodong Zhou,

<h4>Purpose</h4>To evaluate the time trend of axial length (AL) and associated factors in 4- and 5-year-old children in Shanghai from 2013 to 2019.<h4>Methods</h4>This was a 7-year observational study of 985 four-year-old and 1059 five-year-old children in Shanghai. AL, horizontal and vertical corneal curvature, spherical equivalent (SE), and body height and ... Read more >>

Int Ophthalmol (International ophthalmology)
[2021, 41(3):835-843]

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LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway.

Hu Li, Zheng Zeng, Xiang Yang, Ye Chen, Lei He, Ting Wan,

Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA ... Read more >>

Eur J Histochem (European journal of histochemistry : EJH)
[2020, 64(4):]

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Acetylsalicylic Acid Promotes Corneal Epithelium Migration by Regulating Neutrophil Extracellular Traps in Alkali Burn.

Ting Wan, Yue Zhang, Kelan Yuan, Jinjin Min, Yujie Mou, Xiuming Jin,

Neutrophils are the first cells to migrate into the cornea in response to alkali burns, and excessive neutrophil infiltration is associated with inflammatory injury and a poorer prognosis. In an effort to understand the mechanisms underlying the inflammation mediated by neutrophils after alkali burns, we examined the role of alkali-activated ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:551057]

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Prognostic nomogram for patients with invasive endocervical adenocarcinoma incorporating HPV E6/E7 mRNA in situ hybridization and clinical characteristics

Li-Li Liu, Shu-Lin Chen, Shu-Mei Yan, Yue Li, Xia Yang, Shi-Wen Zhang, Hai-Xia Yang, Ting Wan, Rong-Zhen Luo,

<h4>Background: </h4> Human papillomavirus (HPV) E6/E7 mRNA in situ hybridization (HPV E6/E7 RNAscope) appears to be a sensitive and specific method. We aimed to examine the diagnostic and prognostic utility of this technique in endocervical adenocarcinoma (ECA) and build a useful prognostic nomogram model using this approach. <h4>Methods: </h4> The ... Read more >>

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Elevated TWIST1 expression in myelodysplastic syndromes/acute myeloid leukemia reduces efficacy of hypomethylating therapy with decitabine.

Hongjiao Li, Yi Wang, Xingchen Pang, Chenglian Xie, Joachim H Deeg, Hui Wang, Ting Wan, Jinpeng Wu, Feng Guan, Xiang Li,

Haematologica (Haematologica)
[2020, 105(10):e502]

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Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway.

Yujia Zhou, Sufan Wang, Ting Wan, Yuanling Huang, Nengzhi Pang, Xuye Jiang, Yingying Gu, Zhenfeng Zhang, Jing Luo, Lili Yang,

Alcoholic liver disease (ALD) is a major cause of liver disease worldwide. In patients with ALD, an increased level of hepatic inflammasome components was observed, together with an increased circulating pro-inflammatory cytokines. Cyanidin-3-O-β-glucoside (Cy-3-G) is a bioactive compound belonging to the anthocyanin group, which widely exists in deep-colored fruits and ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2020, 160:334-341]

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Rh(III)-Catalyzed [4 + 2] Annulation of 3-Aryl-5-isoxazolone with Maleimides or Maleic Ester.

Ting Wan, Chao Pi, Yangjie Wu, Xiuling Cui,

The Rh(III)-catalyzed [4 + 2] annulation of 3-aryl-5-isoxazolones with maleimides or maleic ester has been developed, which gives synthetically important 3,4-dihydroisoquinoline derivatives in good to excellent yields. This facile protocol can tolerate a variety of functional groups, and CO2 was produced as the predominant byproduct. Notably, a C-C bond and ... Read more >>

Org Lett (Organic letters)
[2020, 22(16):6484-6488]

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Photothermal-Responsive Microporous Nanosheets Confined Ionic Liquid for Efficient CO2 Separation.

Zheng Deng, Ting Wan, Danke Chen, Wen Ying, Yu-Jia Zeng, Youguo Yan, Xinsheng Peng,

2D materials hold promising potential for novel gas separation. However, a lack of in-plane pores and the randomly stacked interplane channels of these membranes still hinder their separation performance. In this work, ferrocene based-MOFs (Zr-Fc MOF) nanosheets, which contain abundant of in-plane micropores, are synthesized as porous supports to fabricate ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(34):e2002699]

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A randomized clinical study of the treatment of white lesions of the vulva with a fractional ultrapulsed CO2 laser.

Lina Zhang, Yiqing Lai, Ting Wan, Beibei Zhou, Xian Qiang, Sumei Ge, Keliang Zhang, Zhilei Mao,

<h4>Background</h4>White lesions of the vulva are a common vulvar disease of unclear etiology. Although a variety of treatments have been used to treat the disease in clinical practice, there is currently a lack of effective radical therapies. This study aimed to compare the feasibility and effectiveness of fractional ultrapulsed CO2 ... Read more >>

Ann Palliat Med (Annals of palliative medicine)
[2020, 9(4):2229-2236]

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Rapid assembly of cyclopentene spiroisoindolinones via a rhodium-catalysed redox-neutral cascade reaction.

Tingting Yuan, Chao Pi, Chang You, Xiuling Cui, Sidong Du, Ting Wan, Yangjie Wu,

An unprecedented strategy of a rhodium-catalysed redox-neutral cascade reaction starting from benzamides and cyclopropenones via addition of a C-H bond into a polar carbonyl group for the rapid assembly of cyclopentene spiroisoindolinones has been developed. Water was produced as the sole by-product. Metal migration and abstraction of a H-atom from ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2018, 55(2):163-166]

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Potential risks in sentinel lymph node biopsy for cervical cancer: a single-institution pilot study.

Hua Tu, Ting Wan, Xinke Zhang, Haifeng Gu, Yanling Feng, He Huang, Jihong Liu,

<h4>Background</h4>Sentinel lymph node (SLN) biopsy is an attractive technique that is widely performed in many oncological surgeries. However, the potential risks in SLN biopsy for cervical cancer remains largely unclear.<h4>Methods</h4>Seventy-five patients with histologically confirmed cervical cancer were enrolled between May 2014 and June 2016. SLN biopsies were performed followed by ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2020, 18(1):133]

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Potential risks in sentinel lymph node biopsy for cervical cancer: a single-institution pilot study

Hua Tu, Ting Wan, Xinke Zhang, Haifeng Gu, Yanling Feng, He Huang, Jihong Liu,

<h4>Background: </h4> : Sentinel lymph node (SLN) biopsy is an attractive technique that widely performed in many oncological surgeries. However, the potential risks in SLN biopsy for cervical cancer remains largely unclear. <h4>Methods: </h4> : Seventy-five patients with histologically confirmed cervical cancer were enrolled between May 2014 and June 2016. ... Read more >>

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Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow.

Alexander V Nyuchev, Ting Wan, Borja Cendón, Carlo Sambiagio, Job J C Struijs, Michelle Ho, Moisés Gulías, Ying Wang, Timothy Noël,

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was ... Read more >>

Beilstein J Org Chem (Beilstein journal of organic chemistry)
[2020, 16:1305-1312]

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Vector analysis of small incision lenticule extraction and toric implantable collamer lens implantation for astigmatism correction.

Ting Wan, Houfa Yin, Zhiyi Wu, Yabo Yang,

OBJECTIVES:To compare the efficacy of small incision lenticule extraction (SMILE) and toric implantable collamer lens (TICL) implantation for myopic astigmatism correction using vector analysis. METHODS:In this retrospective study, 171 eyes of 171 patients with cylinder ⩾1.0 diopters (D) were recruited, with 97 eyes underwent SMILE and 74 eyes underwent TICL ... Read more >>

Eur J Ophthalmol (European journal of ophthalmology)
[2020, :1120672120930607]

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