Full Text Journal Articles by
Author Ting Han

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Discovering Nature's super glue.

Zhi Zeng, Ting Han,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1155-1156]

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One-Step Multicomponent Polymerizations for the Synthesis of Multifunctional AIE Polymers.

Xiang Su, Qingqing Gao, Dong Wang, Ting Han, Ben Zhong Tang,

As a new class of functional luminescent materials, polymers with aggregation-induced emission (AIE) feature attract much attention because of their advantages of efficient solid-state fluorescence, excellent processability, structural diversity, and multifunctionalities. Among all polymerization methods toward AIE polymers, multicomponent polymerizations (MCPs) exhibit the merits of simple operation, good atom economy, ... Read more >>

Macromol Rapid Commun (Macromolecular rapid communications)
[2020, :e2000471]

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Ultramicroporous metal-organic frameworks for capillary gas chromatographic separation.

Sha-Sha Meng, Ze-Rong Tao, Wen-Qi Tang, Ting Han, Yan Du, Zhi-Yuan Gu,

Fine-tuning of the SiF62--containing metal-organic frameworks (SIFSIX) through the substitution of metal centers and ligands changed the apertures from 8.3 Å to 3.8 Å, resulting in ultramicropores and notably improving the separation performance of alkane isomers. Herein, we reported SIFSIX-1-Zn, SIFSIX-1-Cu and SIFSIX-3-Zn as representative stationary phases for capillary gas ... Read more >>

J Chromatogr A (Journal of chromatography. A)
[2020, 1632:461604]

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Hollow [email protected]/SnS nanocomposites: High efficient oxygen evolution reaction catalysts.

Meiwen Jiang, Ting Han, Xiaojun Zhang,

Using structural phase transitions to enhance electrochemical properties without has received wide attention due to its large active area and excellent electron transport capacity. In this work, hollow [email protected]/SnS nanocomposites were successfully synthesized from hollow [email protected] by controlling the temperature and time of the phase transitions. It is found that ... Read more >>

J Colloid Interface Sci (Journal of colloid and interface science)
[2020, 583:149-156]

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Aggregation behavior of zinc oxide nanoparticles and their biotoxicity to Daphnia magna: Influence of humic acid and sodium alginate.

Hongliang Dai, Tongshuai Sun, Ting Han, Zechong Guo, Xingang Wang, Yong Chen,

The widespread applications of zinc oxide nanoparticles (ZnO NPs) have raised increasing concerns due to their adverse environmental effects. The ubiquitous natural organic matter in natural aqueous environments can interact with ZnO NPs, thereby affecting their aggregation, sedimentation and biotoxicity. Here, we systematically investigated the effects of humic acid (HA) ... Read more >>

Environ Res (Environmental research)
[2020, 191:110086]

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Functional Heterochain Polymers Constructed by Alkyne Multicomponent Polymerizations.

Xiaolin Liu, Ting Han, Jacky W Y Lam, Ben Zhong Tang,

Heterochain polymers such as DNA and proteins are abundant in nature, but they are not ubiquitous in man-made polymers due to the synthetic difficulties. Traditional polymerization methodologies including chain polymerization, step-growth polymerization, and coordination polymerization all show obvious drawbacks in synthesizing heterochain polymers. The alkyne multicomponent polymerizations (MCPs) developed in ... Read more >>

Macromol Rapid Commun (Macromolecular rapid communications)
[2020, :e2000386]

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Ultra-stable fluorescent film sensor based on quantum dots for the real-time detection of Cu2.

Ting Han, Hong Kang, Sixia Ye, Ye Yuan, Yang Zhang, Lijie Dong,

Fluorescent films have recently gained attention as chemo-sensors for real-time detection in view of their high sensitivity and rapid response. However, these sensors are usually sensitive to UV irradiation, high temperature, etc., which seriously affects sensing accuracy and limits practical use. Here, an ultra-stable fluorescent film sensor based on CdSe/CdxZn1-xS ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 746:141412]

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Designing Effective Warnings about Addiction on the Patient Information Leaflet of Over-the-Counter Codeine Sold in England to University Students.

Jianan Zhao, Yun Chen, Ting Han, Stephen Westland,

(1) Background: The harm of misusing over-the-counter (OTC) codeine-containing medicines among university students in England is being increasingly recognized. Based on English university students, this paper aims to study the importance of information design on information communication, explore methods for effective warning design, and investigate university students' perception of OTC ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(15):]

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Progress in Understanding the Functional Roles of Extracellular Vesicles in Reproduction.

Ting Ting Han, Wei Li, Guo Ping Li,

Biomed. Environ. Sci. (Biomedical and environmental sciences : BES)
[2020, 33(7):518-527]

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Mechanochromic Fluorescent Polymers Enabled by AIE Processes.

Ting Han, Lijie Liu, Dong Wang, Jinglei Yang, Ben Zhong Tang,

Polymeric materials are susceptible to the chain re-conformation, reorientation, slippage, and bond cleavage upon mechanical stimuli, which are likely to further grow into macro-damages and eventually lead to the compromise or loss of materials performance. Therefore, it is of great academic importance and practical significance to sensitively detect the local ... Read more >>

Macromol Rapid Commun (Macromolecular rapid communications)
[2020, :e2000311]

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Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors.

Qifei Li, Jieming Li, Yan Cai, Yuxing Zou, Bin Chen, Feng Zou, Jiaxian Mo, Ting Han, Weiwei Guo, Wenlong Huang, Qianqian Qiu, Hai Qian,

Bromodomain-containing protein 4 (BRD4) is a key epigenetic regulator in cancer, and inhibitors targeting BRD4 exhibit great anticancer activity. By replacing the methyltriazole ring of the BRD4 inhibitor I-BET-762 with an N-methylthiazolidone heterocyclic ring, fifteen novel BRD4 inhibitors were designed and synthesized. Compound 13f had a hydrophobic acetylcyclopentanyl side chain, ... Read more >>

Bioorg. Med. Chem. (Bioorganic & medicinal chemistry)
[2020, 28(15):115601]

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Screening of non-invasive miRNA biomarker candidates for metastasis of gastric cancer by small RNA sequencing of plasma exosomes.

Yingyi Zhang, Ting Han, Dan Feng, Jie Li, Meihong Wu, Xiaobo Peng, Bin Wang, Xianbao Zhan, Peng Fu,

Gastric cancer remains one of the most lethal and prevalent malignancies, particularly in China. The majority of patients are diagnosed with gastric cancer at the late stages of the disease. Besides, the high relapse rate also contributes to the high mortality. Therefore, there exists an imperative need for the development ... Read more >>

Carcinogenesis (Carcinogenesis)
[2020, 41(5):582-590]

Cited: 3 times

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Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities.

Xiaolei Sun, Wenhua Chen, Wei Dai, Hailiang Xin, Khalid Rahmand, Yan Wang, Jiabao Zhang, Shiyao Zhang, Lingchuan Xu, Ting Han,

ETHNOPHARMACOLOGICAL RELEVANCE:Piper sarmentosum Roxb. (Piperaceae) is a traditional medicinal plant widely distributed in India, Malaysia, Thailand, and the southeastern coastal areas of China including Fujian, Guangdong, and Guizhou. It has been used for centuries for the treatment of wind-cold cough, fever, rheumatism arthralgia, diarrhea dysentery, postpartum foot swelling, stomachache, toothache, ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 263:112897]

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A poly(thymine)-templated fluorescent copper nanoparticle hydrogel-based visual and portable strategy for an organophosphorus pesticide assay.

Jihua Chen, Ting Han, Xiuyun Feng, Baojuan Wang, Guangfeng Wang,

Since fluorescence assays with high sensitivity for organophosphorus pesticides (OPs) are urgently required to protect the ecosystem and prevent disease, an environmentally friendly and label-free fluorescent probe is desirable. Herein, a poly-thymine30 DNA-templated copper nanoparticle (poly T30-Cu NPs) hydrogel fluorescent probe was explored for the construction of an OPs sensing ... Read more >>

Analyst (The Analyst)
[2019, 144(7):2423-2429]

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Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger Cyclin K degradation

Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yue Cui, Qingcui Wu, Jiaojiao Li, Jian-Hua Wang, Meng-Qiu Dong, Xiangbing Qi, Ting Han,

Abstract Molecular glues are small molecules that exert their biologic or therapeutic activities by inducing gain-of-function interactions between pairs of proteins. In particular, molecular-glue degraders, which mediate interactions between target proteins and components of the ubiquitin proteasome system to cause targeted protein degradation, hold great promise as a unique modality ... Read more >>

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Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents.

Zhiwen Ye, Chunxia Liu, Feng Zou, Yan Cai, Bin Chen, Yuxing Zou, Jiaxian Mo, Ting Han, Wenlong Huang, Qianqian Qiu, Hai Qian,

Free fatty acid receptor 1 (FFA1 or GPR40) has been studied for many years as a target for the treatment of type 2 diabetes mellitus. In order to increase potency and reduce hepatotoxicity, a series of novel compounds containing imidazo[1,2-a]pyridine scaffold as GPR40 agonist were synthesized. Compound I-14 was identified ... Read more >>

Bioorg. Med. Chem. (Bioorganic & medicinal chemistry)
[2020, 28(13):115574]

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Target triggered ultrasensitive electrochemical polychlorinated biphenyl aptasensor based on DNA microcapsules and nonlinear hybridization chain reaction.

Ting Han, Shaozhen Wang, Feifan Sheng, Sicheng Wang, Tianyue Dai, Xiaojun Zhang, Guangfeng Wang,

In this work, we demonstrated an ultrasensitive detection platform for polychlorinated biphenyls (PCBs) based on DNA microcapsules and a nonlinear hybridization chain reaction (NHCR). In the process, first, electrochemical signal molecules (Methylene Blue, MB) were sealed in the prepared DNA microcapsules. In the presence of PCB-72, DNA microcapsules could be ... Read more >>

Analyst (The Analyst)
[2020, 145(10):3598-3604]

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Roles of pH, cation valence, and ionic strength in the stability and aggregation behavior of zinc oxide nanoparticles.

Xingang Wang, Tongshuai Sun, Hui Zhu, Ting Han, Jie Wang, Hongliang Dai,

The effects of pH, cation valence, and ionic strength (IS) on the stability and aggregation behavior of zinc oxide nanoparticles (ZnO NPs) were investigated in this study. Results showed that ZnO NPs were most prone to aggregation at the isoelectric point (pH = 8.7), with an aggregation rate (ΔD/Δt) of 30.1. ZnO ... Read more >>

J. Environ. Manage. (Journal of environmental management)
[2020, 267:110656]

Cited: 1 time

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Plant NLR immune receptor Tm-22 activation requires NB-ARC domain-mediated self-association of CC domain.

Junzhu Wang, Tianyuan Chen, Meng Han, Lichao Qian, Jinlin Li, Ming Wu, Ting Han, Jidong Cao, Ugrappa Nagalakshmi, John P Rathjen, Yiguo Hong, Yule Liu,

The nucleotide-binding, leucine-rich repeat-containing (NLR) class of immune receptors of plants and animals recognize pathogen-encoded proteins and trigger host defenses. Although animal NLRs form oligomers upon pathogen recognition to activate downstream signaling, the mechanisms of plant NLR activation remain largely elusive. Tm-22 is a plasma membrane (PM)-localized coiled coil (CC)-type ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2020, 16(4):e1008475]

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A natural compound (LCA) isolated from Litsea cubeba inhibits RANKL-induced osteoclast differentiation by suppressing Akt and MAPK pathways in mouse bone marrow macrophages.

Luyao Yu, Dan Jia, Kunmiao Feng, Xiaolei Sun, Wumu Xu, Luying Ding, Hailiang Xin, Luping Qin, Ting Han,

ETHNOPHARMACOLOGICAL RELEVANCE:Litsea cubeba (Lour.) Pers. has been traditionally used as a folk prescription for treating rheumatic diseases in China. AIM OF THE STUDY:This study aimed to investigate the effects and underlying mechanism of LCA, a new type of dibenzyl butane lignin compound extracted from L. cubeba, on macrophage colony stimulating ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 257:112873]

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Lycium barbarum polysaccharides ameliorate intestinal barrier dysfunction and inflammation through the MLCK-MLC signaling pathway in Caco-2 cells.

Wei Li, Mingbo Gao, Ting Han,

Impairment of the intestinal barrier often occurs in inflammatory bowel diseases, and pro-inflammatory factors play a vital role in the pathogenesis of intestinal diseases. In our study, the potential protective effects of Lycium barbarum polysaccharides (LBP) against intestinal barrier dysfunction evoked by pro-inflammatory factors and its anti-inflammatory effects were investigated. ... Read more >>

Food Funct (Food & function)
[2020, 11(4):3741-3748]

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Integrative analysis of proteomic and metabonomics data for identification of pathways related to Rhizoma Paridis-induced hepatotoxicity.

Chongjun Zhao, Mingshuang Wang, Jianmei Huang, Zhe Jia, Xia Zhao, Erwen Li, Ziying Wei, Ying Dong, Wenxue Liu, Ting Han, Ying Liu, Farong Li, Ruichao Lin,

Clinical reports on hepatotoxicity that arise from Rhizoma Paridis have recently received widespread attention. Because the hepatotoxicity mechanism is little understood, this research strived to investigate the hepatotoxicity mechanism of Rhizoma Paridis extracts based on iTRAQ quantitative proteomics and metabonomics. The extraction solutions were administrated to rats for 7 days ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6540]

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Efficacy of health education on treatment of children with atopic dermatitis: a meta-analysis of randomized controlled trials.

Yunling Li, Ting Han, Wei Li, Yin Li, Xiaoxuan Guo, Lei Zheng,

Atopic dermatitis (AD) seriously affects the quality of life of children and their families. This meta-analysis aimed to comprehensively analyze health education on the treatment of children with AD and the quality of life of the patient's family. A comprehensive search of reference lists in PubMed, Embase, Cochrane Library, Wanfang, ... Read more >>

Arch Dermatol Res (Archives of dermatological research)
[2020, 312(10):685-695]

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Encapsulation and solubilization of ultrastable quantum dots with multidentate bilayer ligands and rheological behaviour.

Xiao Liang, Ye Yuan, Ting Han, Yunyun Cheng, Chuanxi Xiong, Lijie Dong,

Quantum dots with unique optical and chemical properties show great potential applications in biology and chemical and medical science. Nevertheless, their practical applications in various fields are greatly limited due to the presence of hydrophobic organic surfaces. In this paper, we report a simple and effective method based on ligand ... Read more >>

Nanoscale (Nanoscale)
[2018, 10(44):20796-20803]

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Highly sensitive and ultrafast film sensor based on polyethyleneimine-capped quantum dots for trinitrophenol visual detection.

Ting Han, Hong Kang, Ye Yuan, Yang Zhang, Lijie Dong,

Real-time detection of nitroaromatic explosives is a pressing problem for public security and environmental monitoring. Although many efforts have been devoted, sensing of explosives still suffers limitations of complicated and time-consuming sensing procedure. In this work, we develop a fluorescent film for rapid and visual detection of 2,4,6-trinitrophenol (TNP) by ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2020, 234:118243]

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