Full Text Journal Articles by
Author Tina Schmidt

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Brief Report: Changes in PrEP Use, Sexual Practice, and Use of Face Mask During Sex Among MSM During the Second Wave of COVID-19 in Melbourne, Australia.

Eric P F Chow, Jane S Hocking, Jason J Ong, Tiffany R Phillips, Tina Schmidt, Andrew Buchanan, Elena Rodriguez, Kate Maddaford, Christopher K Fairley,

<h4>Background</h4>A second wave of COVID-19 began in late June in Victoria, Australia. Stage 3 then Stage 4 restrictions were introduced in July-August. This study aimed to compare the use of pre-exposure prophylaxis (PrEP) and sexual practices among men who have sex with men taking PrEP between May-June (post-first lockdown) and ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):153-156]

Cited: 0 times

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Prolonged Course of COVID-19-Associated Pneumonia in a B-Cell Depleted Patient After Rituximab.

Igor Kos, Benedikt Balensiefer, Sophie Roth, Manfred Ahlgrimm, Martina Sester, Tina Schmidt, Lorenz Thurner, Moritz Bewarder, Robert Bals, Frank Lammert, Stephan Stilgenbauer, Dominic Kaddu-Mulindwa,

Patients with pre-existing comorbidities and immunosuppression are at greater risk for SARS-CoV-2 infection and severe manifestations of COVID-19. This also includes cancer patients, who are shown to have a poor prognosis after infection. Here, we describe the case of a 72-year old male patient with B-cell depletion after maintenance treatment ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1578]

Cited: 1 time

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High levels of SARS-CoV-2 specific T-cells with restricted functionality in patients with severe course of COVID-19

David Schub, Verena Klemis, Sophie Schneitler, Janine Mihm, Philipp Lepper, Heinrike Wilkens, Robert Bals, Hermann Eichler, Barbara Gärtner, Sören Becker, Urban Sester, Martina Sester, Tina Schmidt,

Patients infected with SARS-CoV-2 differ in the severity of disease. In this study, SARS-CoV-2 specific T-cells and antibodies were characterized in patients with different COVID-19 related disease severity. Despite severe lymphopenia affecting all major lymphocyte subpopulations, patients with severe disease mounted significantly higher levels of SARS-CoV-2 specific T-cells as compared ... Read more >>

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Changing the Use of HIV Pre-exposure Prophylaxis Among Men Who Have Sex With Men During the COVID-19 Pandemic in Melbourne, Australia.

Eric P F Chow, Jane S Hocking, Jason J Ong, Tina Schmidt, Andrew Buchanan, Elena Rodriguez, Kate Maddaford, Prital Patel, Christopher K Fairley,

We surveyed 204 men who have sex with men (MSM) who were pre-exposure prophylaxis (PrEP) users. One in 4 daily PrEP users stopped taking PrEP during the COVID-19 pandemic, and 5% switched to on-demand PrEP. Most men reduced PrEP use because they stopped having casual sex and reduced the number ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(7):ofaa275]

Cited: 3 times

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Timing of Vaccination after Training: Immune Response and Side Effects in Athletes.

Tanja Stenger, Alexandra Ledo, Clemens Ziller, David Schub, Tina Schmidt, Martin Enders, Barbara C GÄrtner, Martina Sester, Tim Meyer,

OBJECTIVES:Influenza vaccination was used to assess whether induction of immunity or side effects are influenced by the timing of the last training session before vaccination. METHODS:Forty-five healthy athletes (36 male, 23 ± 8 yr, ≥5 training sessions per week, predominantly national competition level) were vaccinated with the tetravalent influenza vaccine; ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2020, 52(7):1603-1609]

Cited: 1 time

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Elite athletes on regular training show more pronounced induction of vaccine-specific T-cells and antibodies after tetravalent influenza vaccination than controls.

Alexandra Ledo, David Schub, Clemens Ziller, Martin Enders, Tanja Stenger, Barbara C Gärtner, Tina Schmidt, Tim Meyer, Martina Sester,

Compliance of elite athletes with vaccination recommendations is low mainly based on concerns about side-effects and perceived poor vaccine efficacy due to continued physical training. We therefore employed seasonal influenza vaccination to investigate the effect of regular physical training on vaccine-induced cellular and humoral immunity in elite athletes and controls. ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2020, 83:135-145]

Cited: 3 times

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Rapid reconstitution of CMV-specific T-cells after stem-cell transplantation.

Thomas Widmann, Urban Sester, Tina Schmidt, Barbara C Gärtner, Jörg Schubert, Michael Pfreundschuh, Martina Sester,

OBJECTIVE:As reconstitution of virus-specific T-cells is critical to control cytomegalovirus (CMV)-viremia following stem-cell transplantation (SCT), we characterized the dynamics in CMV-specific T-cell reconstitution after SCT. METHODS:Cytomegalovirus-specific T-cells from 51 SCT-recipients were prospectively quantified and phenotypically characterised by intracellular cytokine-staining after specific stimulation and HLA class-I-specific pentamers using flow cytometry. RESULTS:Cytomegalovirus-specific ... Read more >>

Eur J Haematol (European journal of haematology)
[2018, 101(1):38-47]

Cited: 0 times

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Robust method for isolation of tumor infiltrating lymphocytes with a high vital cell yield from small samples of renal cell carcinomas by a new collagenase-free mechanical procedure.

Fiona Crossey, Stefanie Marx, Sebastian Hölters, Kai Schmitt, Rainer M Bohle, Tina Schmidt, Michael Stöckle, Urban Sester, Martina Sester, Martin W W Janssen,

<h4>Background</h4>Tumor-infiltrating lymphocytes (TIL) play an important role in the pathogenesis of renal cell carcinoma. Characterization of TIL requires efficient isolation procedures, especially in early stage disease when the tumor is of small in size. Conventional methods for isolating TIL are based on enzymatic tissue digestion, most frequently with collagenase. Collagenase ... Read more >>

Urol Oncol (Urologic oncology)
[2018, 36(9):402.e1-402.e10]

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Assay for improved detection of antigen-specific immune cells from extrasanguinous fluids.

David Schub, Mathias Fousse, Julia Elsäßer, Klaus Faßbender, Urban Sester, Tina Schmidt, Martina Sester,

In this approach, pre-stained cells from extrasanguinous fluids (ESFs) are stimulated in the presence of blood from the same individual. Thus, blood-derived antigen-presenting cells enable stimulation of both ESF- and blood T cells. Pre-staining allows distinction of T cells from ESF and blood, and simultaneous analysis of antigen-specific T cells in both compartments. ... Read more >>

Eur J Immunol (European journal of immunology)
[2018, 48(8):1412-1414]

Cited: 0 times

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The effect of antiretroviral intensification with dolutegravir on residual virus replication in HIV-infected individuals: a randomised, placebo-controlled, double-blind trial.

Thomas A Rasmussen, James H McMahon, J Judy Chang, Jennifer Audsley, Ajantha Rhodes, Surekha Tennakoon, Ashanti Dantanarayana, Tim Spelman, Tina Schmidt, Stephen J Kent, Vincent Morcilla, Sarah Palmer, Julian H Elliott, Sharon R Lewin,

<h4>Background</h4>Whether ongoing virus replication occurs in HIV-infected individuals on antiretroviral therapy (ART) is unclear; therefore, whether residual virus replication is a barrier to achieving a cure for HIV is also unknown. We aimed to establish whether ART intensification with dolutegravir would reveal or affect residual virus replication in HIV-infected individuals ... Read more >>

Lancet HIV (The lancet. HIV)
[2018, 5(5):e221-e230]

Cited: 6 times

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CTLA-4-expression on VZV-specific T cells in CSF and blood is specifically increased in patients with VZV related central nervous system infections.

David Schub, Mathias Fousse, Klaus Faßbender, Barbara C Gärtner, Urban Sester, Martina Sester, Tina Schmidt,

VZV-reactivation may lead to symptomatic central nervous system (CNS) diseases, but identification of VZV as causative pathogen of CNS-diseases is challenging. This study was performed to characterize VZV-specific T cells from cerebrospinal fluid (CSF) and blood of patients with active CNS-disease and to determine whether this may improve differential diagnosis. ... Read more >>

Eur J Immunol (European journal of immunology)
[2018, 48(1):151-160]

Cited: 3 times

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Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor.

Michelle B Hookham, Imran H A Ali, Christina L O'Neill, Emer Hackett, Melanie H Lambe, Tina Schmidt, Reinhold J Medina, Sara Chamney, Bharathi Rao, Eibhlin McLoone, David Sweet, Alan W Stitt, Derek P Brazil,

<h4>Background</h4>Endothelial colony-forming cells (ECFCs), also termed late outgrowth endothelial cells, are a well-defined circulating endothelial progenitor cell type with an established role in vascular repair. ECFCs have clear potential for cell therapy to treat ischaemic disease, although the precise mechanism(s) underlying their response to hypoxia remains ill-defined.<h4>Methods</h4>In this study, we ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2016, 7(1):173]

Cited: 2 times

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Quantitative, Phenotypical, and Functional Characterization of Cellular Immunity in Children and Adolescents With Down Syndrome.

Justine Schoch, Tilman R Rohrer, Michael Kaestner, Hashim Abdul-Khaliq, Ludwig Gortner, Urban Sester, Martina Sester, Tina Schmidt,

<h4>Background</h4>Infections and autoimmune disorders are more frequent in Down syndrome, suggesting abnormality of adaptive immunity. Although the role of B cells and antibodies is well characterized, knowledge regarding T cells is limited.<h4>Methods</h4>Lymphocyte subpopulations of 40 children and adolescents with Down syndrome and 51 controls were quantified, and phenotype and functionality ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2017, 215(10):1619-1628]

Cited: 9 times

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Altered phenotype and functionality of varicella zoster virus-specific cellular immunity in individuals with active infection.

David Schub, Eva Janssen, Sarah Leyking, Urban Sester, Gunter Assmann, Pia Hennes, Sigrun Smola, Thomas Vogt, Tilman Rohrer, Martina Sester, Tina Schmidt,

<h4>Background</h4>Varicella zoster virus (VZV) establishes lifelong persistence and may reactivate in individuals with impaired immune function. To investigate immunologic correlates of protection and VZV reactivation, we characterized specific immunity in 207 nonsymptomatic immunocompetent and 132 immunocompromised individuals in comparison with patients with acute herpes zoster.<h4>Methods</h4>VZV-specific CD4 T cells were quantified ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2015, 211(4):600-612]

Cited: 25 times

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Serial influenza-vaccination reveals impaired maintenance of specific T-cell memory in patients with end-stage renal failure.

Urban Sester, Tina Schmidt, Martin K Kuhlmann, Barbara C Gärtner, Heike Uhlmann-Schiffler, Martina Sester,

To investigate correlates for the well-known impaired response of haemodialysis-patients to a variety of recommended vaccinations, the induction of antigen-specific cellular and humoral immunity was characterised after influenza-vaccination in two following seasons where the identical vaccine-composition was used. Influenza-specific T-cells were flow-cytometrically characterised from whole blood of 24 healthy controls ... Read more >>

Vaccine (Vaccine)
[2013, 31(38):4111-4120]

Cited: 7 times

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Evaluation of Electronic Medical Record (EMR) at large urban primary care sexual health centre.

Christopher K Fairley, Lenka A Vodstrcil, Sarah Huffam, Rosey Cummings, Marcus Y Chen, Jun K Sze, Glenda Fehler, Catriona S Bradshaw, Tina Schmidt, Karen Berzins, Jane S Hocking,

<h4>Objective</h4>Despite substantial investment in Electronic Medical Record (EMR) systems there has been little research to evaluate them. Our aim was to evaluate changes in efficiency and quality of services after the introduction of a purpose built EMR system, and to assess its acceptability by the doctors, nurses and patients using ... Read more >>

PLoS One (PloS one)
[2013, 8(4):e60636]

Cited: 8 times

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Cytomegalovirus-specific T cells are detectable in early childhood and allow assignment of the infection status in children with passive maternal antibodies.

Marion Ritter, Tina Schmidt, Jan Dirks, Pia Hennes, Ingolf Juhasz-Böss, Erich F Solomayer, Ludwig Gortner, Barbarac Gärtner, Tilman Rohrer, Urban Sester, Martina Sester,

Serological identification of the cytomegalovirus (CMV) status in children less than 18 months of age is complicated by the variable persistence of maternal antibodies. As T cells are not passively transferred, we attempted to assess whether CMV-specific cellular immunity may be superior to determine the actual CMV status; we also ... Read more >>

Eur J Immunol (European journal of immunology)
[2013, 43(4):1099-1108]

Cited: 14 times

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Detection of antigen-specific T cells based on intracellular cytokine staining using flow-cytometry.

Tina Schmidt, Martina Sester,

CMV-specific T cells may be detected and quantified after antigen-specific stimulation based on the induction of cytokines as a readout system. Secreted cytokines may be detected from the supernatant of stimulated cells using ELISA. Alternatively, antigen-specific cytokine-secreting cells may be enumerated using an ELISPOT assay. These assays generally rely on ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2013, 1064:267-274]

Cited: 8 times

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CD4+ T-cell immunity after pandemic influenza vaccination cross-reacts with seasonal antigens and functionally differs from active influenza infection.

Tina Schmidt, Jan Dirks, Martin Enders, Barbara C Gärtner, Heike Uhlmann-Schiffler, Urban Sester, Martina Sester,

Antigen-specific antibodies are well characterized after vaccination with pandemic H1N1 or seasonal influenza vaccines. However, knowledge on cellular immunity toward pandemic H1N1 after vaccination and infection and cross-reactivities toward seasonal antigens is limited. Nineteen individuals were vaccinated with the pandemic H1N1 vaccine. Among those, ten had been prevaccinated against seasonal ... Read more >>

Eur J Immunol (European journal of immunology)
[2012, 42(7):1755-1766]

Cited: 16 times

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Cytomegalovirus-specific T-cell immunity to assign the infection status in individuals with passive immunity: a proof of principle.

Tina Schmidt, Marion Ritter, Jan Dirks, Barbara C Gärtner, Urban Sester, Martina Sester,

<h4>Background</h4>Serological analysis of the infection status with the human cytomegalovirus (CMV) may be inaccurate after transfusion of blood products due to the variable content of CMV-specific antibodies.<h4>Objectives</h4>In this situation, analysis of cellular immunity may represent a more accurate parameter to assign the individual CMV-infection status. This hypothesis was assessed in ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2012, 54(3):272-275]

Cited: 9 times

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Facing depression with botulinum toxin: a randomized controlled trial.

M Axel Wollmer, Claas de Boer, Nadeem Kalak, Johannes Beck, Thomas Götz, Tina Schmidt, Muris Hodzic, Ursula Bayer, Thilo Kollmann, Katja Kollewe, Daniela Sönmez, Katja Duntsch, Martin D Haug, Manfred Schedlowski, Martin Hatzinger, Dirk Dressler, Serge Brand, Edith Holsboer-Trachsler, Tillmann H C Kruger,

Positive effects on mood have been observed in subjects who underwent treatment of glabellar frown lines with botulinum toxin and, in an open case series, depression remitted or improved after such treatment. Using a randomized double-blind placebo-controlled trial design we assessed botulinum toxin injection to the glabellar region as an ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2012, 46(5):574-581]

Cited: 53 times

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Sexually transmissible infections - Old enemies and a new friend.

Siobhan Bourke, Tina Schmidt,

History is repeating itself. Syphilis largely disappeared from the radar of general practitioners following a precipitous fall with the onset of the human immunodeficiency virus (HIV) epidemic in the early 1980s; however, infection rates are once again rising dramatically, both in Australia and in other parts of the developed world. ... Read more >>

Aust Fam Physician (Australian family physician)
[2009, 38(6):373]

Cited: 0 times

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Effect of rosiglitazone on peroxisome proliferator-activated receptor gamma gene expression in human adipose tissue is limited by antiretroviral drug-induced mitochondrial dysfunction.

Patrick W G Mallon, Rebecca Sedwell, Gary Rogers, David Nolan, Patrick Unemori, Jennifer Hoy, Katherine Samaras, Anthony Kelleher, Sean Emery, David A Cooper, Andrew Carr, ,

<h4>Background</h4>Treatment of human immunodeficiency virus (HIV)-1 with thymidine-analogue nucleoside reverse-transcriptase inhibitors (tNRTIs) causes lipoatrophy, mitochondrial toxicity, and lower adipose tissue expression of peroxisome proliferator-activated receptor gamma (PPARgamma [PPARG gene]). Rosiglitazone (RSG), a PPARgamma agonist, improves congenital lipoatrophy but not HIV lipoatrophy.<h4>Methods</h4>Serial fat biopsies were taken from HIV-infected, lipoatrophic men randomized ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2008, 198(12):1794-1803]

Cited: 19 times

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