Full Text Journal Articles by
Author Tina M Calderon

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Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19.

Vanessa Chilunda, Pablo Martinez-Aguado, Li C Xia, Laura Cheney, Aniella Murphy, Veronica Veksler, Vanessa Ruiz, Tina M Calderon, Joan W Berman,

The COVID-19 pandemic has caused more than three million deaths globally. The severity of the disease is characterized, in part, by a dysregulated immune response. CD16+ monocytes are innate immune cells involved in inflammatory responses to viral infections, and tissue repair, among other functions. We characterized the transcriptional changes in ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:665773]

Cited: 0 times

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The impact of substance abuse on HIV-mediated neuropathogenesis in the current ART era.

Vanessa Chilunda, Tina M Calderon, Pablo Martinez-Aguado, Joan W Berman,

Approximately 37 million people worldwide are infected with human immunodeficiency virus (HIV). One highly significant complication of HIV infection is the development of HIV-associated neurocognitive disorders (HAND) in 15-55% of people living with HIV (PLWH), that persists even in the antiretroviral therapy (ART) era. The entry of HIV into the ... Read more >>

Brain Res (Brain research)
[2019, 1724:146426]

Cited: 9 times

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CCR2 on Peripheral Blood CD14+CD16+ Monocytes Correlates with Neuronal Damage, HIV-Associated Neurocognitive Disorders, and Peripheral HIV DNA: reseeding of CNS reservoirs?

Mike Veenstra, Desiree A Byrd, Matilde Inglese, Korhan Buyukturkoglu, Dionna W Williams, Lazar Fleysher, Ming Li, Lucio Gama, Rosiris León-Rivera, Tina M Calderon, Janice E Clements, Susan Morgello, Joan W Berman,

HIV-associated neurocognitive disorders (HAND) occur in ~50% of HIV infected individuals despite combined antiretroviral therapy. Transmigration into the CNS of CD14<sup>+</sup>CD16<sup>+</sup> monocytes, particularly those that are HIV infected and express increased surface chemokine receptor CCR2, contributes to neuroinflammation and HAND. To examine whether in HIV infected individuals CCR2 on CD14<sup>+</sup>CD16<sup>+</sup> ... Read more >>

J Neuroimmune Pharmacol (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology)
[2019, 14(1):120-133]

Cited: 13 times

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Frontline Science: CXCR7 mediates CD14+CD16+ monocyte transmigration across the blood brain barrier: a potential therapeutic target for NeuroAIDS.

Mike Veenstra, Dionna W Williams, Tina M Calderon, Kathryn Anastos, Susan Morgello, Joan W Berman,

CD14<sup>+</sup>CD16<sup>+</sup> monocytes transmigrate into the CNS of HIV-positive people in response to chemokines elevated in the brains of infected individuals, including CXCL12. Entry of these cells leads to viral reservoirs, neuroinflammation, and neuronal damage. These may eventually lead to HIV-associated neurocognitive disorders. Although antiretroviral therapy (ART) has significantly improved the ... Read more >>

J Leukoc Biol (Journal of leukocyte biology)
[2017, 102(5):1173-1185]

Cited: 11 times

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Dopamine Increases CD14+CD16+ Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis.

Tina M Calderon, Dionna W Williams, Lillie Lopez, Eliseo A Eugenin, Laura Cheney, Peter J Gaskill, Mike Veenstra, Kathryn Anastos, Susan Morgello, Joan W Berman,

In human immunodeficiency virus-1 (HIV) infected individuals, substance abuse may accelerate the development and/or increase the severity of HIV associated neurocognitive disorders (HAND). It is proposed that CD14<sup>+</sup>CD16<sup>+</sup> monocytes mediate HIV entry into the central nervous system (CNS) and that uninfected and infected CD14<sup>+</sup>CD16<sup>+</sup> monocyte transmigration across the blood brain ... Read more >>

J Neuroimmune Pharmacol (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology)
[2017, 12(2):353-370]

Cited: 18 times

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Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes.

Loreto Carvallo, Lillie Lopez, Fa-Yun Che, Jihyeon Lim, Eliseo A Eugenin, Dionna W Williams, Edward Nieves, Tina M Calderon, Carlos Madrid-Aliste, Andras Fiser, Louis Weiss, Ruth Hogue Angeletti, Joan W Berman,

Despite successful combined antiretroviral therapy, ∼ 60% of HIV-infected people exhibit HIV-associated neurocognitive disorders (HAND). CCL2 is elevated in the CNS of infected people with HAND and mediates monocyte influx into the CNS, which is critical in neuroAIDS. Many HIV-infected opiate abusers have increased neuroinflammation that may augment HAND. Buprenorphine ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2015, 194(7):3246-3258]

Cited: 17 times

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Dopamine increases CD14+CD16+ monocyte migration and adhesion in the context of substance abuse and HIV neuropathogenesis.

Jacqueline S Coley, Tina M Calderon, Peter J Gaskill, Eliseo A Eugenin, Joan W Berman,

Drug abuse is a major comorbidity of HIV infection and cognitive disorders are often more severe in the drug abusing HIV infected population. CD14+CD16+ monocytes, a mature subpopulation of peripheral blood monocytes, are key mediators of HIV neuropathogenesis. Infected CD14+CD16+ monocyte transmigration across the blood brain barrier mediates HIV entry ... Read more >>

PLoS One (PloS one)
[2015, 10(2):e0117450]

Cited: 28 times

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Monocytes mediate HIV neuropathogenesis: mechanisms that contribute to HIV associated neurocognitive disorders.

Dionna W Williams, Mike Veenstra, Peter J Gaskill, Susan Morgello, Tina M Calderon, Joan W Berman,

HIV infected people are living longer due to the success of combined antiretroviral therapy (cART). However, greater than 40-70% of HIV infected individuals develop HIV associated neurocognitive disorders (HAND) that continues to be a major public health issue. While cART reduces peripheral virus, it does not limit the low level, ... Read more >>

Curr HIV Res (Current HIV research)
[2014, 12(2):85-96]

Cited: 67 times

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Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis.

Dionna W Williams, Tina M Calderon, Lillie Lopez, Loreto Carvallo-Torres, Peter J Gaskill, Eliseo A Eugenin, Susan Morgello, Joan W Berman,

As HIV infected individuals live longer, the prevalence of HIV associated neurocognitive disorders is increasing, despite successful antiretroviral therapy. CD14(+)CD16(+) monocytes are critical to the neuropathogenesis of HIV as they promote viral seeding of the brain and establish neuroinflammation. The mechanisms by which HIV infected and uninfected monocytes cross the ... Read more >>

PLoS One (PloS one)
[2013, 8(7):e69270]

Cited: 77 times

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Drug induced increases in CNS dopamine alter monocyte, macrophage and T cell functions: implications for HAND.

Peter J Gaskill, Tina M Calderon, Jacqueline S Coley, Joan W Berman,

Central nervous system (CNS) complications resulting from HIV infection remain a major public health problem as individuals live longer due to the success of combined antiretroviral therapy (cART). As many as 70 % of HIV infected people have HIV associated neurocognitive disorders (HAND). Many HIV infected individuals abuse drugs, such as ... Read more >>

J Neuroimmune Pharmacol (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology)
[2013, 8(3):621-642]

Cited: 33 times

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Characterization of monocyte maturation/differentiation that facilitates their transmigration across the blood-brain barrier and infection by HIV: implications for NeuroAIDS.

Clarisa M Buckner, Tina M Calderon, Dionna W Willams, Thomas J Belbin, Joan W Berman,

The prevalence of human immunodeficiency virus 1 (HIV) associated neurocognitive disorders resulting from infection of the central nervous system (CNS) by HIV continues to increase despite the success of combination antiretroviral therapy. Although monocytes are known to transport HIV across the blood-brain barrier (BBB) into the CNS, there are few ... Read more >>

Cell Immunol (Cellular immunology)
[2011, 267(2):109-123]

Cited: 77 times

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HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.

Eliseo A Eugenin, Jessie E King, Avindra Nath, Tina M Calderon, R Suzanne Zukin, Michael V L Bennett, Joan W Berman,

HIV infection of the central nervous system can result in neurologic dysfunction with devastating consequences in AIDS patients. NeuroAIDS is characterized by neuronal injury and loss, yet there is no evidence that HIV can infect neurons. Here we show that the HIV-encoded protein tat triggers formation of a macromolecular complex ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2007, 104(9):3438-3443]

Cited: 128 times

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A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein.

Tina M Calderon, Eliseo A Eugenin, Lillie Lopez, Sridhar Sampath Kumar, Joseph Hesselgesser, Cedric S Raine, Joan W Berman,

The pathogenic mechanisms that contribute to multiple sclerosis (MS) include leukocyte chemotaxis into the central nervous system (CNS) and the production of inflammatory mediators, resulting in oligodendrocyte damage, demyelination, and neuronal injury. Thus, factors that regulate leukocyte entry may contribute to early events in MS, as well as to later ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2006, 177(1-2):27-39]

Cited: 89 times

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MCP-1/CCL2 protects cardiac myocytes from hypoxia-induced apoptosis by a G(alphai)-independent pathway.

Sima T Tarzami, Tina M Calderon, Arnel Deguzman, Lillie Lopez, Richard N Kitsis, Joan W Berman,

Chemokines, in addition to their chemotactic properties, act upon resident cells within a tissue and mediate other cellular functions. In a previous study, we demonstrated that CCL2 protects cultured mouse neonatal cardiac myocytes from hypoxia-induced cell death. Leukocyte chemotaxis has been shown to contribute to ischemic injury. While the chemoattractant ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2005, 335(4):1008-1016]

Cited: 43 times

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CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS.

Eliseo A Eugenin, Kristin Osiecki, Lillie Lopez, Harris Goldstein, Tina M Calderon, Joan W Berman,

Encephalitis and dementia associated with acquired immunodeficiency syndrome (AIDS) are characterized by leukocyte infiltration into the CNS, microglia activation, aberrant chemokine expression, blood-brain barrier (BBB) disruption, and eventual loss of neurons. Little is known about whether human immunodeficiency virus 1 (HIV-1) infection of leukocytes affects their ability to transmigrate in ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2006, 26(4):1098-1106]

Cited: 241 times

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HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS.

Eliseo A Eugenin, Gawain Dyer, Tina M Calderon, Joan W Berman,

Acquired immune deficiency syndrome (AIDS) encephalitis and dementia are characterized by neuronal loss, astrogliosis, and microglia activation and migration that contribute to the formation of multinucleated giant cells. Despite extensive evidence of pathological changes in the brain of infected individuals, the mechanisms of human immune deficiency virus type 1 (HIV-1) ... Read more >>

Glia (Glia)
[2005, 49(4):501-510]

Cited: 56 times

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Inhibitory effect of brachytherapy on intimal hyperplasia in arteriovenous fistula.

Shuching Sun, Jonathan J Beitler, Takao Ohki, Tina M Calderon, Richard Schechner, Ravindra Yaparpalvi, Joan W Berman, Vivian A Tellis, Stuart M Greenstein,

PURPOSE:To determine whether endovascular radiation can inhibit intimal hyperplasia in a swine model of hemodialysis access. MATERIALS AND METHODS:Polytetrafluoroethylene arteriovenous grafts (6 mm in diameter) were placed between the common carotid artery and the external jugular vein bilaterally in 8 pigs. Two days after the surgery, fistulography was performed. Gamma ... Read more >>

J Surg Res (The Journal of surgical research)
[2003, 115(2):200-208]

Cited: 20 times

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Mechanisms of hepatocyte growth factor-mediated vascular smooth muscle cell migration.

Harry Ma, Tina M Calderon, Tamar Kessel, Anthony W Ashton, Joan W Berman,

The migration of vascular smooth muscle cells (SMCs) from the media into the neointima and their subsequent proliferation is important in the pathogenesis of atherosclerosis. This process is regulated by multiple factors, including growth factors, and involves changes in the interaction of SMCs with the extracellular matrix and in intracellular ... Read more >>

Circ Res (Circulation research)
[2003, 93(11):1066-1073]

Cited: 27 times

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Hepatocyte growth factor is a survival factor for endothelial cells and is expressed in human atherosclerotic plaques.

Harry Ma, Tina M Calderon, John T Fallon, Joan W Berman,

Hepatocyte growth factor (HGF) has multiple effects on target cells upon activation of its receptor, c-Met. In endothelial cells, HGF induces migration, proliferation, and angiogenesis. HGF can also act as an anti-apoptotic factor for several cell types. The signal transduction pathways involved in mediating its anti-apoptotic effects have not been ... Read more >>

Atherosclerosis (Atherosclerosis)
[2002, 164(1):79-87]

Cited: 44 times

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