Full Text Journal Articles by
Author Tina Histing

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Influence of axial limb rotation on radiographic lower limb alignment: a systematic review.

Marc-Daniel Ahrend, Heiko Baumgartner, Christoph Ihle, Tina Histing, Steffen Schröter, Felix Finger,

<h4>Introduction</h4>The influence of limb malrotation on long-leg radiographs (LLR) is frequently discussed in literature. This systematic review aimed to describe the influence of limb rotation on alignment measurements alone and in combination with knee flexion, and determine its clinical impact.<h4>Materials and methods</h4>A literature search was conducted in June 2021 using ... Read more >>

Arch Orthop Trauma Surg (Archives of orthopaedic and trauma surgery)
[2021, :]

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Establishment of a reliable model to study the failure of fracture healing in aged mice.

Maximilian M Menger, Matthias W Laschke, Claudia Scheuer, David Bauer, Michelle Bleimehl, Thomas Später, Mika F Rollmann, Benedikt J Braun, Steven C Herath, Ahsan Raza, Michael D Menger, Tina Histing,

The failure of fracture healing represents a substantial clinical problem. Moreover, aged patients demonstrate an elevated risk for failed bone healing. However, murine models to study the failure of fracture healing are established only in young adult animals. Therefore, the aim of this study was to develop a reliable model ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2021, :]

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A simple method for decellularizing a cell-derived matrix for bone cell cultivation and differentiation.

Weidong Weng, Filippo Zanetti, David Bovard, Bianca Braun, Sabrina Ehnert, Tatiana Uynuk-Ool, Tina Histing, Julia Hoeng, Andreas K Nussler, Romina H Aspera-Werz,

The extracellular matrix regulates cell survival, proliferation, and differentiation. In vitro two-dimensional cell experiments are typically performed on a plastic plate or a substrate of a single extracellular matrix constituent such as collagen or calcium phosphate. As these approaches do not include extracellular matrix proteins or growth factors, they fail ... Read more >>

J Mater Sci Mater Med (Journal of materials science. Materials in medicine)
[2021, 32(9):124]

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Altered Secretome of Diabetic Monocytes Could Negatively Influence Fracture Healing-An In Vitro Study.

Caren Linnemann, Lorena Savini, Mika F Rollmann, Tina Histing, Andreas K Nussler, Sabrina Ehnert,

Diabetes mellitus is a main risk factor for delayed fracture healing and fracture non-unions. Successful fracture healing requires stimuli from different immune cells, known to be affected in diabetics. Especially, application of mononuclear cells has been proposed to promote wound and fracture healing. Thus, aim was to investigate the effect ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

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Macrophage-activating lipoprotein (MALP)-2 impairs the healing of partial tendon injuries in mice.

Tobias Fritz, Julia Schäfer, Claudia Scheuer, Janine Stutz, Tina Histing, Tim Pohlemann, Michael D Menger, Matthias W Laschke, Moritz Klein, Marcel Orth,

Tendon injuries are accounted for up to 50% of musculoskeletal injuries and often result in poor outcomes. Inflammation is a major hallmark of tendon regeneration. Therefore, we analyzed in this study whether the topical application of the pro-inflammatory mediator macrophage-activating lipoprotein (MALP)-2 improves the healing of partial tendon injuries. C57BL/6 ... Read more >>

Ann Anat (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2021, 239:151818]

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Osteolectin+ stromal cells: Mechanical stimulation improves bone regeneration and supports bacterial clearance after fracture.

Sabrina Ehnert, Tina Histing, Andreas K Nüssler,

Signal Transduct Target Ther (Signal transduction and targeted therapy)
[2021, 6(1):257]

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Exposure to 16 Hz Pulsed Electromagnetic Fields Protect the Structural Integrity of Primary Cilia and Associated TGF-β Signaling in Osteoprogenitor Cells Harmed by Cigarette Smoke.

Yangmengfan Chen, Romina H Aspera-Werz, Maximilian M Menger, Karsten Falldorf, Michael Ronniger, Christina Stacke, Tina Histing, Andreas K Nussler, Sabrina Ehnert,

Cigarette smoking (CS) is one of the main factors related to avoidable diseases and death across the world. Cigarette smoke consists of numerous toxic compounds that contribute to the development of osteoporosis and fracture nonunion. Exposure to pulsed electromagnetic fields (PEMF) was proven to be a safe and effective therapy ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(13):]

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[Case-based learning can improve the teaching quality in trauma surgery education : A survey analysis among medical students].

Friedemann Strobel, Tina Histing, Tim Pohlemann, Antonius Pizanis, Benedikt Johannes Braun, Marcel Orth, Tobias Fritz,

<h4>Background</h4>Medical education has always been challenging for students and teachers. Of growing importance is the promotion of knowledge of correlations and knowledge transfer from theoretical aspects into clinical practice. In order to achieve this aim, student-centered teaching concepts are increasingly being employed in the literature.<h4>Objective</h4>Can a trauma surgery practical seminar be ... Read more >>

Unfallchirurg (Der Unfallchirurg)
[2021, :]

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Awareness of predatory journals and open access publishing among orthopaedic and trauma surgeons - results from an online survey in Germany.

Elke Maurer, Nike Walter, Tina Histing, Lydia Anastasopoulou, Thaqif El Khassawna, Lisa Wenzel, Volker Alt, Markus Rupp,

<h4>Background</h4>Along with emerging open access journals (OAJ) predatory journals increasingly appear. As they harm accurate and good scientific research, we aimed to examine the awareness of predatory journals and open access publishing among orthopaedic and trauma surgeons.<h4>Methods</h4>In an online survey between August and December 2019 the knowledge on predatory journals ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2021, 22(1):365]

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3D Environment Is Required In Vitro to Demonstrate Altered Bone Metabolism Characteristic for Type 2 Diabetics.

Victor Häussling, Romina H Aspera-Werz, Helen Rinderknecht, Fabian Springer, Christian Arnscheidt, Maximilian M Menger, Tina Histing, Andreas K Nussler, Sabrina Ehnert,

A large British study, with almost 3000 patients, identified diabetes as main risk factor for delayed and nonunion fracture healing, the treatment of which causes large costs for the health system. In the past years, much progress has been made to treat common complications in diabetics. However, there is still ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

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Maqui berry extract prevents cigarette smoke induced oxidative stress in human osteoblasts in vitro.

Sheng Zhu, Romina H Aspera-Werz, Tao Chen, Weidong Weng, Bianca Braun, Tina Histing, Andreas K Nüssler,

Oxidative stress which can be induced by cigarette smoke (CS) is associated with an altered osteoblast differentiation, and an inhibition of the mineralization process. Therefore, treatments focusing on reducing oxidative stress in osteoblasts could be a potential therapy supporting bone formation. Maqui berry extract (MBE) is the richest natural source ... Read more >>

EXCLI J (EXCLI journal)
[2021, 20:281-296]

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Bisphosphonates Reduce Smoking-Induced Osteoporotic-Like Alterations by Regulating RANKL/OPG in an Osteoblast and Osteoclast Co-Culture Model.

Sheng Zhu, Victor Häussling, Romina H Aspera-Werz, Tao Chen, Bianca Braun, Weidong Weng, Tina Histing, Andreas K Nussler,

Co-culture models have become mandatory for obtaining better insights into bone homeostasis, which relies on the balance between osteoblasts and osteoclasts. Cigarette smoking (CS) has been proven to increase the risk of osteoporosis; however, there is currently no proven treatment for osteoporosis in smokers excluding cessation. Bisphosphonates (BPs) are classical ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 22(1):]

Cited: 2 times

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Pantoprazole impairs fracture healing in aged mice.

Maximilian M Menger, Philipp Bremer, Claudia Scheuer, Mika F Rollmann, Benedikt J Braun, Steven C Herath, Marcel Orth, Thomas Später, Tim Pohlemann, Michael D Menger, Tina Histing,

Proton pump inhibitors (PPIs) belong to the most common medication in geriatric medicine. They are known to reduce osteoclast activity and to delay fracture healing in young adult mice. Because differentiation and proliferation in fracture healing as well as pharmacologic actions of drugs markedly differ in the elderly compared to ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):22376]

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Development of a dynamic fall risk profile in elderly nursing home residents: A free field gait analysis based study.

Eduard Witiko Unger, Tina Histing, Mika Frieda Rollmann, Marcel Orth, Esther Herath, Maximilian Menger, Steven Christian Herath, Bernd Grimm, Tim Pohlemann, Benedikt Johannes Braun,

Falls in nursing home residents are associated with a significant individual and socioeconomic burden of disease. To trigger and tailor individual intervention programs, solid early detection measures of residents at risk are needed. Aim of this study was thus to test the capability of a free field gait analysis insole ... Read more >>

Arch Gerontol Geriatr (Archives of gerontology and geriatrics)
[2021, 93:104294]

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Anterior approaches to the acetabulum: which one to choose?

Tim Pohlemann, Steven C Herath, Benedikt J Braun, Mika F Rollmann, Tina Histing, Antonius Pizanis,

Surgical treatment of acetabular fractures remains challenging even for experienced surgeons.Whilst the ilioinguinal and the Kocher-Langenbeck approach remain the standard procedures to expose the anterior or posterior aspects of the acetabulum, some modified anterior approaches for the stabilization of the acetabulum have been introduced.This article will provide an overview of ... Read more >>

EFORT Open Rev (EFORT open reviews)
[2020, 5(10):707-712]

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A novel press-fit minimally-invasive symphysiodesis technique.

Sascha J Hopp, Antonius Pizanis, Jeremy Briem, Jill Hahner, Laura Mettelsiefen, Steven C Herath, Tina Histing, Tim Pohlemann, Tobias Fritz,

<h4>Objective</h4>Instability of the pubic symphysis often results in a poor outcome and reduced mobility of the patient. In some cases, an arthrodesis of the pubic symphysis is required. Until today, there is no data published how many of these procedures are performed annually and there is also no data about ... Read more >>

J Exp Orthop (Journal of experimental orthopaedics)
[2020, 7(1):67]

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Vascularization Strategies in the Prevention of Nonunion Formation.

Maximilian M Menger, Matthias W Laschke, Marcel Orth, Tim Pohlemann, Michael D Menger, Tina Histing,

Delayed healing and nonunion formation are major challenges in orthopedic surgery, which require the development of novel treatment strategies. Vascularization is considered one of the major prerequisites for successful bone healing, providing an adequate nutrient supply and allowing the infiltration of progenitor cells to the fracture site. Hence, during the ... Read more >>

Tissue Eng Part B Rev (Tissue engineering. Part B, Reviews)
[2021, 27(2):107-132]

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Azetabulumfrakturen – Zugänge und Implantate im Wandel.

Tina Histing, Steven C Herath, Antonius Pizanis, Tim Pohlemann,

Z Orthop Unfall (Zeitschrift fur Orthopadie und Unfallchirurgie)
[2020, 158(3):353-363]

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Long-term results of reconstructing the joints' articular surface in the knee and ankle with the surgical diamond instrumentation (SDI).

Mika Frieda Rollmann, Steven Christian Herath, Tina Histing, Benedikt Johannes Braun, Julia Schmalenbach, Yvette Draenert, Klaus Draenert, Tim Pohlemann,

<h4>Purpose</h4>The surgical diamond instrumentation (SDI), a precise wet-grinding technology, promised contact healing of press-fit inserted bone and even hyaline cartilage, lacks medium- and long-term results. This retrospective study was conducted to identify risk factors associated with the failure of the technique and the subjective patient outcome.<h4>Methods</h4>All patients treated for cartilage ... Read more >>

Eur J Trauma Emerg Surg (European journal of trauma and emergency surgery : official publication of the European Trauma Society)
[2021, 47(5):1627-1634]

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A novel internal fixation method for open book injuries of the pubic symphysis- A biomechanical analysis.

Tobias Fritz, Laura Mettelsiefen, Friedemann Strobel, Benedikt J Braun, Steven C Herath, Sascha J Hopp, Tina Histing, Tim Pohlemann, Antonius Pizanis,

<h4>Background</h4>Pelvic fractures in adults are common injuries and account for up to 3.64% of all fractures. Usually, the treatment of open book injuries (Types B1.1 and B1.2 AO-Classification) is open reduction and plate stabilization using dynamic compression plates, with or without interlocking screws. These implants seem to enhance the outcome ... Read more >>

Clin Biomech (Bristol, Avon) (Clinical biomechanics (Bristol, Avon))
[2020, 77:105009]

Cited: 1 time

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Profiling microRNA expression in murine bone healing and non-union formation: Role of miR-140 during the early stage of bone healing.

Marcel Orth, Claudia Scheuer, Christina Backes, Andreas Keller, Mika F Rollmann, Benedikt J Braun, Nicole Ludwig, Eckart Meese, Tim Pohlemann, Matthias W Laschke, Michael D Menger, Tina Histing,

Although cellular and molecular mechanisms during the course of bone healing have been thoroughly investigated, the regulation of gene expression by microRNA during bone regeneration is still poorly understood. We hypothesized that nonunion formation is associated with different microRNA expression patterns and that target proteins of these microRNAs are differently ... Read more >>

PLoS One (PloS one)
[2019, 14(7):e0218395]

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Increased therapy demand and impending loss of previous residence status after proximal femur fractures can be determined by continuous gait analysis - A clinical feasibility study.

Benedikt J Braun, David Osche, Mika Rollmann, Marcel Orth, Philipp Mörsdorf, Tina Histing, Tim Pohlemann, Steven C Herath,

Proximal femur fractures account for increased healthcare costs whenever patients are unable to return to their previous state of residence. Studies suggest that patients benefit from early weight-bearing, yet compliance to weight-bearing regimes is poorly investigated. Aim of the study was thus to show the clinical feasibility of a new ... Read more >>

Injury (Injury)
[2019, 50(7):1329-1332]

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In-hospital mortality of pelvic ring fractures in older adults now and then: A pelvic registry study.

Mika F Rollmann, Steven C Herath, Benedikt J Braun, Joerg H Holstein, Tim Pohlemann, Michael D Menger, Tina Histing,

<h4>Aim</h4>With the predicted demographic change, the treatment of geriatric patients will become a major issue for health systems worldwide. The majority of pelvic ring fractures occur in older adults, and their treatment might be associated with a distinct mortality. Herein, we analyzed the data of 5665 patients with pelvic ring ... Read more >>

Geriatr Gerontol Int (Geriatrics & gerontology international)
[2019, 19(1):24-29]

Cited: 3 times

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VEGF-loaded mineral-coated microparticles improve bone repair and are associated with increased expression of epo and RUNX-2 in murine non-unions.

Marcel Orth, Amira K Shenar, Claudia Scheuer, Benedikt J Braun, Steven C Herath, Jörg H Holstein, Tina Histing, Xiaohua Yu, William L Murphy, Tim Pohlemann, Matthias W Laschke, Michael D Menger,

A poor vascular supply of the fracture gap is a key factor for the development of atrophic non-unions. Mineral-coated microparticles (MCM) represent a sophisticated carrier system for the delivery of vascular endothelial growth factor (VEGF). Hence, we investigated whether VEGF-loaded MCM improve bone repair in non-unions. For this purpose, we ... Read more >>

J Orthop Res (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2019, 37(4):821-831]

Cited: 2 times

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Marble-derived microcalcite improves bone healing in mice osteotomy.

Marcel Orth, Takhirjan Shadmanov, Claudia Scheuer, Benedikt J Braun, Tobias Fritz, Jörg H Holstein, Tina Histing, Matthias W Laschke, Tim Pohlemann, Michael D Menger,

Approximately 10% of all fractures result in delayed healing or non-unions. Bone healing can be improved by the application of osteoconductive and osteoinductive biomaterials. Microcalcite (MCA) as a naturally available calcium carbonate-based biomaterial derived from marble may have the potential to improve bone healing. Herein, we studied for the first ... Read more >>

Biomed Mater (Biomedical materials (Bristol, England))
[2018, 14(2):025001]

Cited: 1 time

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