Full Text Journal Articles by
Author Tina Hinton

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Identifying the core concepts of pharmacology education.

Paul J White, Elizabeth A Davis, Marina Santiago, Tom Angelo, Alison Shield, Anna-Marie Babey, Barbara Kemp-Harper, Gregg Maynard, Hesham S Al-Sallami, Ian F Musgrave, Lynette B Fernandes, Suong N T Ngo, Tina Hinton,

Pharmacology education currently lacks an agreed knowledge curriculum. Evidence from physics and biology education indicates that core concepts are useful and effective structures around which such a curriculum can be designed to facilitate student learning. Building on previous work, we developed a novel, criterion-based method to identify the core concepts ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(4):e00836]

Cited: 0 times

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GABA-enriched teas as neuro-nutraceuticals.

Tina Hinton, Graham A R Johnston,

Teas enriched in GABA are consumed for their beneficial effects on blood pressure, stress and anxiety. These effects may involve actions of GABA on the central and peripheral nervous systems. The anaerobic procedures for the production of GABA-enriched teas increase GABA levels by 10-20 times. They also significantly alter the ... Read more >>

Neurochem Int (Neurochemistry international)
[2020, 141:104895]

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Effect of GABA-Fortified Oolong Tea on Reducing Stress in a University Student Cohort.

Tina Hinton, Herbert F Jelinek, Vincent Viengkhou, Graham A Johnston, Slade Matthews,

GABA-containing tea has gained popularity as an accessible intervention to reduce the impact of chronic stress-induced autonomic imbalance and increased risk for cardiovascular disease despite a lack of evidence concerning the γ-aminobutyric acid (GABA) content in a cup of the tea and its effects on physiological and psychological stress as ... Read more >>

Front Nutr (Frontiers in nutrition)
[2019, 6:27]

Cited: 1 time

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The α3 and α4 nicotinic acetylcholine receptor (nAChR) subunits in the brainstem medulla of sudden infant death syndrome (SIDS).

Atqiya Aishah, Tina Hinton, Karen A Waters, Rita Machaalani,

SIDS occurs in early infancy and predominantly during a sleep period. Abnormalities in nicotine receptor binding and in the expression of the nicotinic acetylcholine receptor (nAChR) subunits α7 and β2 have been reported in the brainstem of SIDS infants. This study focuses on the α3 and α4 nAChR subunits as ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2019, 125:23-30]

Cited: 1 time

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Long-lasting effects of early-life intervention in mice on adulthood behaviour, GABAA receptor subunit expression and synaptic clustering.

Kelly J Skilbeck, Graham A R Johnston, Tina Hinton,

Variations in the early postnatal environment of rodents produce long-term changes in responses to stress that may underlie neuropsychiatric diseases such as anxiety, depression and schizophrenia. GABA<sub>A</sub> receptors undergo marked changes in their subunit composition during this period, involving a regionally-dependent replacement of α<sub>2</sub> with α<sub>1</sub> subunits, the so-called α-subunit ... Read more >>

Pharmacol Res (Pharmacological research)
[2018, 128:179-189]

Cited: 6 times

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Effects of bilobalide, ginkgolide B and picrotoxinin on GABAA receptor modulation by structurally diverse positive modulators.

Chiu Chin Ng, Rujee K Duke, Tina Hinton, Graham A R Johnston,

Anxiolytics and anticonvulsants generally positively modulate the action of GABA, whereas many convulsants (including the chloride channel blocker picrotoxinin) negatively modulate the action of GABA on GABA<sub>A</sub> receptors. Like picrotoxinin, bilobalide and ginkgolide B, active constituents of Ginkgo biloba, have been shown to negatively modulate the action of GABA at ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2017, 806:83-90]

Cited: 5 times

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Cellular protein and mRNA expression of β1 nicotinic acetylcholine receptor (nAChR) subunit in brain, skeletal muscle and placenta.

Atqiya Aishah, Tina Hinton, Rita Machaalani,

The β1 nicotinic acetylcholine receptor (nAChR) subunit is a muscle type subunit of this family and as such, is found predominantly in muscle. Recent reports document its expression in other tissues and cell lines including adrenal glands, carcinomas, lung and brain. However, the majority of studies were of tissue lysates, ... Read more >>

Int J Dev Neurosci (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience)
[2017, 58:9-16]

Cited: 2 times

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Introduction to the Special issue Country in focus: Pharmacology in Australia.

Tina Hinton,

Pharmacol Res (Pharmacological research)
[2017, 116:1]

Cited: 0 times

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GABAA receptor cysteinyl mutants and the ginkgo terpenoid lactones bilobalide and ginkgolides.

Chiu Chin Ng, Rujee K Duke, Tina Hinton, Graham A R Johnston,

The terpenoid lactones from Ginkgo biloba, bilobalide and ginkgolides, have been shown to act as negative modulators at α1β2γ2L GABAA receptors. They have structural features similar to those of the chloride channel blocker picrotoxinin. Unlike picrotoxinin, however they are not known to produce convulsant effects. Using two-electrode voltage clamp electrophysiology, ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2016, 777:136-146]

Cited: 6 times

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Nicotinic acetylcholine receptors (nAChR) are increased in the pre-eclamptic placenta.

Rita Machaalani, Emma Ghazavi, Rona Victoria David, Tina Hinton, Angela Makris, Annemarie Hennessy,

The role of the nicotinic acetylcholine receptors (nAChR) in pre-eclampsia is unknown. Given that ACh levels are affected in pre-eclampsia, it has been suggested that compensatory changes in nAChR expression may ensue. This study aimed to determine the effects of pre-eclampsia on the mRNA and protein expression of 12 mammalian ... Read more >>

Hypertens Pregnancy (Hypertension in pregnancy)
[2015, 34(2):227-240]

Cited: 7 times

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PP007. Nicotinic acetylcholine receptor subunits in the pre-eclamptic and cigarette smoke exposed human placenta.

Emma Ghazavi, Rona David, Tina Hinton, Angela Makris, Annemarie Hennessy, Rita Machaalani,

<h4>Introduction</h4>Cigarette smoking during pregnancy is associated with low birth weight, prematurity and neonatal morbidity and mortality. Nicotine, a major constituent of cigarette smoke, binds to nicotinic acetylcholine receptors (nAChRs). To date, 16 mammalian nAChR subunits have been identified. The effect of smoking on these subunits in human placenta has not ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2013, 3(2):70]

Cited: 0 times

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An evaluation of pharmacology curricula in Australian science and health-related degree programs.

Hilary Lloyd, Tina Hinton, Shane Bullock, Anna-Marie Babey, Elizabeth Davis, Lynette Fernandes, Joanne Hart, Ian Musgrave, James Ziogas,

<h4>Background</h4>Pharmacology is a biomedical discipline taught in basic science and professional degree programs. In order to provide information that would facilitate pharmacology curricula to be refined and developed, and approaches to teaching to be updated, a national survey was undertaken in Australia that investigated pharmacology course content, teaching and summative ... Read more >>

BMC Med Educ (BMC medical education)
[2013, 13:153]

Cited: 3 times

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Stress and GABA receptors.

Kelly J Skilbeck, Graham A R Johnston, Tina Hinton,

GABA(A) receptors are sensitive to subtle changes in the environment in both early-life and adulthood. These neurochemical responses to stress in adulthood are sex-dependent. Acute stress induces rapid changes in GABA(A) receptors in experimental animals, with the direction of the changes varying according to the sex of the animals and ... Read more >>

J Neurochem (Journal of neurochemistry)
[2010, 112(5):1115-1130]

Cited: 38 times

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Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory.

Mary Chebib, Tina Hinton, Katrina L Schmid, Darren Brinkworth, Haohua Qian, Susana Matos, Hye-Lim Kim, Heba Abdel-Halim, Rohan J Kumar, Graham A R Johnston, Jane R Hanrahan,

This study reports pharmacological and physiological effects of cis- and trans-(3-aminocyclopentanyl)butylphosphinic acid (cis- and trans-3-ACPBPA). These compounds are conformationally restricted analogs of the orally active GABA(B/C) receptor antagonist (3-aminopropyl)-n-butylphosphinic acid (CGP36742 or SGS742). cis-[IC(50)(rho1) = 5.06 microM and IC(50)(rho2) = 11.08 microM; n = 4] and trans-3-ACPMPA [IC(50)(rho1) = 72.58 ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2009, 328(2):448-457]

Cited: 42 times

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Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites.

Kelly J Skilbeck, Jennifer N O'Reilly, Graham A R Johnston, Tina Hinton,

Post-mortem studies of the human brain indicate that certain GABA(A) receptor subtypes may be differentially altered in schizophrenia. Increased binding to the total population of GABA(A) receptors using [3H]muscimol is observed in the post-mortem schizophrenic brain, yet a proportion of these receptors which bind benzodiazepines and are labelled with [3H]flunitrazepam, ... Read more >>

Prog Neuropsychopharmacol Biol Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2008, 32(2):492-498]

Cited: 6 times

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Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors.

Tina Hinton, Mary Chebib, Graham A R Johnston,

The R- and S-enantiomers of 4-amino-3-hydroxybutanoic acid (GABOB) were full agonists at human recombinant rho1 GABA(C) receptors. Their enantioselectivity (R>S) matched that reported for their agonist actions at GABA(B) receptors, but was the opposite to that reported at GABA(A) receptors (S>R). The corresponding methylphosphinic acid analogues proved to be rho1 ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2008, 18(1):402-404]

Cited: 8 times

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The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined.

Kelly J Skilbeck, Jennifer N O'Reilly, Graham A R Johnston, Tina Hinton,

Changes in GABA(A) receptors are observed in schizophrenia, with benzodiazepine-sensitive GABA(A) receptor subtypes being affected differently to other subtypes. However, long-term antipsychotic drug use in schizophrenia may underlie these changes. To test this, we examined the effects of administering a typical (haloperidol) and an atypical (olanzapine) antipsychotic drug on the ... Read more >>

Schizophr Res (Schizophrenia research)
[2007, 90(1-3):76-80]

Cited: 19 times

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GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex in schizophrenia.

Sonja B Schleimer, Tina Hinton, Gavin Dixon, Graham A R Johnston,

This study aimed to investigate the binding affinity of [3H]GABA and [3H]beta-alanine to GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex (Brodmanns' area 9) in schizophrenia. Using post mortem tissue from individuals diagnosed with schizophrenia (n=6) and control subjects (n=6), the density of GAT-1 was established by ... Read more >>

Neuropsychobiology (Neuropsychobiology)
[2004, 50(3):226-230]

Cited: 18 times

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