Full Text Journal Articles by
Author Timothy R Sterling

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Effects of Pregnancy and Isoniazid Preventive Therapy on M. tuberculosis Interferon Gamma Response Assays in Women with HIV.

Adriana Weinberg, Lisa Aaron, Grace Montepiedra, Timothy R Sterling, Renee Browning, Blandina Mmbaga, Tichaona Vhembo, Shilpa Naik, Enid Kabugho, Gaerolwe Masheto, Savita Pahwa, Jyoti S Mathad, Sylvia M LaCourse, Katie McCarthy, Sarah Bradford, Gerhard Theron, Diane Costello, Bonnie Zimmer, Marie F Pierre, Kamunkhwala Gausi, Paolo Denti, David W Haas, Amita Gupta, ,

BACKGROUND:Pregnancy is accompanied by immune suppression. We hypothesized that M. tuberculosis-specific inflammatory responses used to identify latent tuberculosis infection (LTBI) lose positivity during pregnancy. We also hypothesized that isoniazid preventive therapy (IPT) may revert LTBI diagnoses because of its sterilizing activity. METHODS:944 women with HIV participating in a randomized, double-blind, ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Reply to Swindells et al.: Trials of Tuberculosis-Preventive Therapy in People with HIV Infection.

Jason E Stout, Nicholas A Turner, Robert W Belknap, C Robert Horsburgh, Timothy R Sterling, Patrick P J Phillips,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 202(2):305-306]

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Knowledge and stigma of latent tuberculosis infection in Brazil: implications for tuberculosis prevention strategies.

Peter F Rebeiro, Mollie J Cohen, Heather M Ewing, Marina Cruvinel Figueiredo, Lauren Saag Peetluk, Kleydson B Andrade, Marshall Eakin, Elizabeth J Zechmeister, Timothy R Sterling,

BACKGROUND:Tuberculosis (TB) elimination requires treatment of millions of persons with latent M. tuberculosis infection (LTBI). LTBI treatment acceptance depends on population-wide TB knowledge and low stigma, but limited data are available on the relationship between stigma and knowledge. We assessed knowledge of TB disease and LTBI throughout Brazil and examined ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):897]

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RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response.

Adam Penn-Nicholson, Stanley Kimbung Mbandi, Ethan Thompson, Simon C Mendelsohn, Sara Suliman, Novel N Chegou, Stephanus T Malherbe, Fatoumatta Darboe, Mzwandile Erasmus, Willem A Hanekom, Nicole Bilek, Michelle Fisher, Stefan H E Kaufmann, Jill Winter, Melissa Murphy, Robin Wood, Carl Morrow, Ildiko Van Rhijn, Branch Moody, Megan Murray, Bruno B Andrade, Timothy R Sterling, Jayne Sutherland, Kogieleum Naidoo, Nesri Padayatchi, Gerhard Walzl, Mark Hatherill, Daniel Zak, Thomas J Scriba, , , , , , , , ,

Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for multiple applications: identifying individuals at risk of incident disease, as a screening test for subclinical or clinical tuberculosis, and for monitoring tuberculosis treatment. RISK6 utility was ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8629]

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Increased Mortality After Tuberculosis Treatment Completion in Persons Living With Human Immunodeficiency Virus in Latin America.

Serena P Koenig, Ahra Kim, Bryan E Shepherd, Carina Cesar, Valdilea Veloso, Claudia P Cortes, Denis Padgett, Brenda Crabtree-Ramírez, Eduardo Gotuzzo, Catherine C McGowan, Timothy R Sterling, Jean W Pape,

We assessed the association between cured tuberculosis (TB) and mortality among persons living with human immunodeficiency virus (HIV) in Latin America. We compared survival among persons with and without TB at enrollment in HIV care, starting 9 months after clinic enrollment. In multivariable analysis, TB was associated with higher long-term ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(1):215-217]

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Identification of Mycobacterium tuberculosis Peptides in Serum Extracellular Vesicles from Persons with Latent Tuberculosis Infection.

Carolina Mehaffy, Nicole A Kruh-Garcia, Barbara Graham, Leah G Jarlsberg, Charis E Willyerd, Andrey Borisov, Timothy R Sterling, Payam Nahid, Karen M Dobos,

Identification of biomarkers for latent Mycobacterium tuberculosis infection and risk of progression to tuberculosis (TB) disease are needed to better identify individuals to target for preventive therapy, predict disease risk, and potentially predict preventive therapy efficacy. Our group developed multiple reaction monitoring mass spectrometry (MRM-MS) assays that detected M. tuberculosis ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2020, 58(6):]

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Resistance-conferring mutations on whole-genome sequencing of fluoroquinolone-resistant and -susceptible M. tuberculosis isolates: a proposed threshold for identifying resistance.

Fernanda Maruri, Yan Guo, Amondrea Blackman, Yuri F van der Heijden, Peter F Rebeiro, Timothy R Sterling,

BACKGROUND:Fluoroquinolone resistance in Mycobacterium tuberculosis is conferred by DNA gyrase mutations, but not all fluoroquinolone-resistant M. tuberculosis isolates have mutations detected. The optimal allele frequency threshold to identify resistance-conferring mutations by whole-genome sequencing is unknown. METHODS:Phenotypically ofloxacin-resistant and lineage-matched ofloxacin-susceptible M. tuberculosis isolates underwent whole-genome sequencing at an average coverage ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Mood Disorders and Increased Risk of Noncommunicable Disease in Adults With HIV.

Jessica L Castilho, Peter F Rebeiro, Bryan E Shepherd, Robertson Nash, Rodney S Adams, Megan Turner, Sally S Furukawa, Todd Hulgan, John R Koethe, Timothy R Sterling,

BACKGROUND:People living with HIV (PLWH) experience high rates of mood disorders (major depression and bipolar affective disorder) which in the general population have been associated with noncommunicable disease (NCD) risk. We examined whether prevalent mood disorders are associated with incident NCDs and multimorbidity (accumulation of ≥2 NCDs) in PLWH. SETTING:Adult ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2020, 83(4):397-404]

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Lack of Weight Gain During the First 2 Months of Treatment and Human Immunodeficiency Virus Independently Predict Unsuccessful Treatment Outcomes in Tuberculosis.

Lauren S Peetluk, Peter F Rebeiro, Marcelo Cordeiro-Santos, Afranio Kritski, Bruno B Andrade, Betina Durovni, Solange Calvacante, María B Arriaga, Megan M Turner, Marina C Figueiredo, Valeria C Rolla, Timothy R Sterling,

BACKGROUND:Weight change may inform tuberculosis treatment response, but its predictive power may be confounded by human immunodeficiency virus (HIV). METHODS:We prospectively followed up adults with culture-confirmed, drug-susceptible, pulmonary tuberculosis receiving standard 4-drug therapy (isoniazid, rifampin, pyrazinamide, and ethambutol) in Brazil. We examined median weight change 2 months after treatment initiation ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, 221(9):1416-1424]

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Risk Factors for Tuberculosis and Effect of Preventive Therapy Among Close Contacts of Persons With Infectious Tuberculosis.

Mary R Reichler, Awal Khan, Timothy R Sterling, Hui Zhao, Bin Chen, Yan Yuan, Joyce Moran, James McAuley, Bonita Mangura, ,

BACKGROUND:Close contacts of persons with pulmonary tuberculosis (TB) have high rates of TB disease. METHODS:We prospectively enrolled TB patients and their close contacts at 9 US/Canadian sites. TB patients and contacts were interviewed to identify index patient, contact, and exposure risk factors for TB. Contacts were evaluated for latent TB ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(8):1562-1572]

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Weight gain among treatment-naïve persons with HIV starting integrase inhibitors compared to non-nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada.

Kassem Bourgi, Cathy A Jenkins, Peter F Rebeiro, Frank Palella, Richard D Moore, Keri N Altoff, John Gill, Charles S Rabkin, Stephen J Gange, Michael A Horberg, Joseph Margolick, Jun Li, Cherise Wong, Amanda Willig, Viviane D Lima, Heidi Crane, Jennifer Thorne, Michael Silverberg, Gregory Kirk, William C Mathews, Timothy R Sterling, Jordan Lake, John R Koethe, ,

INTRODUCTION:Weight gain following antiretroviral therapy (ART) initiation is common, potentially predisposing some persons with HIV (PWH) to cardio-metabolic disease. We assessed relationships between ART drug class and weight change among treatment-naïve PWH initiating ART in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). METHODS:Adult, treatment-naïve PWH in ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2020, 23(4):e25484]

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Self-reported Cannabis Use and Changes in Body Mass Index, CD4 T-Cell Counts, and HIV-1 RNA Suppression in Treated Persons with HIV.

James T Lee, Lauren A Saag, Aaron M Kipp, James Logan, Bryan E Shepherd, John R Koethe, Megan Turner, Sally Bebawy, Timothy R Sterling, Todd Hulgan,

Cannabis use is prevalent among HIV-positive persons, but evidence regarding the impact of cannabis in HIV-positive persons is limited. We conducted a retrospective cohort study of HIV-positive adults initiating their first antiretroviral therapy (ART) regimen. A dedicated intake form assessed self-reported cannabis use in the preceding 7 days at each visit. ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, 24(4):1275-1280]

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Greater Weight Gain in Treatment-naive Persons Starting Dolutegravir-based Antiretroviral Therapy.

Kassem Bourgi, Peter F Rebeiro, Megan Turner, Jessica L Castilho, Todd Hulgan, Stephen P Raffanti, John R Koethe, Timothy R Sterling,

BACKGROUND:Recent studies have reported weight gain in virologically suppressed persons living with human immunodeficiency virus (PLWH) switched from older antiretroviral therapy (ART) to newer integrase strand transfer inhibitor (INSTI)-based regimens. In this study, we investigated whether weight gain differs among treatment-naive PLWH starting INSTI-based regimens compared to other ART regimens. ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(7):1267-1274]

Cited: 7 times

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Optimizing the Design of Latent Tuberculosis Treatment Trials: Insights from Mathematical Modeling.

Jason E Stout, Nicholas A Turner, Robert W Belknap, C Robert Horsburgh, Timothy R Sterling, Patrick P J Phillips,

Rationale: Noninferiority trials of treatment for latent tuberculosis infection (LTBI) are challenging because of imperfect LTBI diagnostic tests.Objectives: To assess the effect on study outcomes of different enrollment strategies for a noninferiority trial of LTBI treatment.Methods: We mathematically simulated a two-arm randomized clinical trial of LTBI in which the experimental ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(5):598-605]

Cited: 3 times

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Association of Immunosuppression and Human Immunodeficiency Virus (HIV) Viremia With Anal Cancer Risk in Persons Living With HIV in the United States and Canada.

Raúl U Hernández-Ramírez, Li Qin, Haiqun Lin, Wendy Leyden, Romain S Neugebauer, Keri N Althoff, Nancy A Hessol, Chad J Achenbach, John T Brooks, M John Gill, Surbhi Grover, Michael A Horberg, Jun Li, W Christopher Mathews, Angel M Mayor, Pragna Patel, Charles S Rabkin, Anita Rachlis, Amy C Justice, Richard D Moore, Eric A Engels, Michael J Silverberg, Robert Dubrow, ,

BACKGROUND:People living with human immunodeficiency virus (HIV; PLWH) have a markedly elevated anal cancer risk, largely due to loss of immunoregulatory control of oncogenic human papillomavirus infection. To better understand anal cancer development and prevention, we determined whether recent, past, cumulative, or nadir/peak CD4+ T-cell count (CD4) and/or HIV-1 RNA ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(6):1176-1185]

Cited: 1 time

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Duration of Exposure Among Close Contacts of Patients With Infectious Tuberculosis and Risk of Latent Tuberculosis Infection.

Mary R Reichler, Awal Khan, Yan Yuan, Bin Chen, James McAuley, Bonita Mangura, Timothy R Sterling, ,

BACKGROUND:Predictors of latent tuberculosis infection (LTBI) among close contacts of persons with infectious tuberculosis (TB) are incompletely understood, particularly the number of exposure hours. METHODS:We prospectively enrolled adult patients with culture-confirmed pulmonary TB and their close contacts at 9 health departments in the United States and Canada. Patients with TB ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020.

Timothy R Sterling, Gibril Njie, Dominik Zenner, David L Cohn, Randall Reves, Amina Ahmed, Dick Menzies, C Robert Horsburgh, Charles M Crane, Marcos Burgos, Philip LoBue, Carla A Winston, Robert Belknap,

Comprehensive guidelines for treatment of latent tuberculosis infection (LTBI) among persons living in the United States were last published in 2000 (American Thoracic Society. CDC targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 2000;161:S221-47). Since then, several new regimens have been evaluated in ... Read more >>

MMWR Recomm Rep (MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports)
[2020, 69(1):1-11]

Cited: 1 time

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Mortality Among People With HIV Treated for Tuberculosis Based on Positive, Negative, or No Bacteriologic Test Results for Tuberculosis: The IeDEA Consortium.

John M Humphrey, Philani Mpofu, April C Pettit, Beverly Musick, E Jane Carter, Eugène Messou, Olivier Marcy, Brenda Crabtree-Ramirez, Marcel Yotebieng, Kathryn Anastos, Timothy R Sterling, Constantin Yiannoutsos, Lameck Diero, Kara Wools-Kaloustian,

Background:In resource-constrained settings, many people with HIV (PWH) are treated for tuberculosis (TB) without bacteriologic testing. Their mortality compared with those with bacteriologic testing is uncertain. Methods:We conducted an observational cohort study among PWH ≥15 years of age initiating TB treatment at sites affiliated with 4 International epidemiology Databases to Evaluate ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(1):ofaa006]

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Hepatitis C Coinfection and Mortality in People Living with HIV in Middle Tennessee.

Toni Hall, Cathy A Jenkins, Todd Hulgan, Sally Furukawa, Megan Turner, Siddharth Pratap, Timothy R Sterling, Mohammad Tabatabai, Vladimir Berthaud,

HIV and hepatitis C virus (HCV) coinfection is associated with poor health outcomes. This study was designed to assess risk factors for and mortality with coinfection before direct-acting antiviral treatment availability in a state with an evolving opioid epidemic. HCV infection was determined from review of the medical record at ... Read more >>

AIDS Res. Hum. Retroviruses (AIDS research and human retroviruses)
[2020, 36(3):193-199]

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Polymorphisms in interferon pathway genes and risk of Mycobacterium tuberculosis infection in contacts of tuberculosis cases in Brazil.

Juan Manuel Cubillos-Angulo, María B Arriaga, Mayla G M Melo, Elisangela C Silva, Lucia Elena Alvarado-Arnez, Alexandre S de Almeida, Milton O Moraes, Adriana S R Moreira, Jose R Lapa E Silva, Kiyoshi F Fukutani, Timothy R Sterling, Thomas R Hawn, Afrânio L Kritski, Martha M Oliveira, Bruno B Andrade,

BACKGROUND:Host genetic polymorphisms may be important in determining susceptibility to Mycobacterium tuberculosis (Mtb) infection, but their role is not fully understood. Detection of microbial DNA and activation of type I interferon (IFN) pathways regulate macrophage responses to Mtb infection. METHODS:We examined whether seven candidate gene SNPs were associated with tuberculin ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 92:21-28]

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Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low- and middle-income countries.

April C Pettit, Cathy A Jenkins, Meridith Blevins Peratikos, Marcel Yotebieng, Lameck Diero, Cuong D Do, Jeremy Ross, Valdilea G Veloso, Denise Hawerlander, Olivier Marcy, Bryan E Shepherd, Lukas Fenner, Timothy R Sterling, ,

INTRODUCTION:Identification of persons living with human immunodeficiency virus (HIV)-associated tuberculosis (TB) at increased risk for unfavourable TB outcomes would inform efforts to improve such outcomes. We sought to identify factors associated with a decreased risk of unfavourable TB treatment outcomes among people living with HIV-infection (PLHIV) in low- and middle-income ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2019, 22(12):e25423]

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Treatment of Latent Tuberculosis Infection-An Update.

Moises A Huaman, Timothy R Sterling,

Treatment of latent tuberculosis infection (LTBI) is an important component of TB control and elimination. LTBI treatment regimens include once-weekly isoniazid plus rifapentine for 3 months, daily rifampin for 4 months, daily isoniazid plus rifampin for 3-4 months, and daily isoniazid for 6-9 months. Isoniazid monotherapy is efficacious in preventing ... Read more >>

Clin. Chest Med. (Clinics in chest medicine)
[2019, 40(4):839-848]

Cited: 2 times

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Life-Expectancy Disparities Among Adults With HIV in the United States and Canada: The Impact of a Reduction in Drug- and Alcohol-Related Deaths Using the Lives Saved Simulation Model.

Keri N Althoff, Aruna Chandran, Jinbing Zhang, Wendy Miranda Arevalo, Stephen J Gange, Timothy R Sterling, M John Gill, Amy C Justice, Frank J Palella, Peter F Rebeiro, Michael J Silverberg, Angel M Mayor, Michael A Horberg, Jennifer E Thorne, Charles S Rabkin, W Christopher Mathews, Marina B Klein, Elizabeth Humes, Jennifer Lee, Robert Hogg, Richard D Moore, ,

Improvements in life expectancy among people living with human immunodeficiency virus (PLWH) receiving antiretroviral treatment in the United States and Canada might differ among key populations. Given the difference in substance use among key populations and the current opioid epidemic, drug- and alcohol-related deaths might be contributing to the disparities ... Read more >>

Am. J. Epidemiol. (American journal of epidemiology)
[2019, 188(12):2097-2109]

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Differential expression of activation markers by Mycobacterium tuberculosis-specific CD4+ T-cell distinguishes extrapulmonary from pulmonary tuberculosis and latent infection.

Paulo S Silveira-Mattos, Beatriz Barreto-Duarte, Beatriz Vasconcelos, Kiyoshi F Fukutani, Caian L Vinhaes, Deivide Oliveira-de-Souza, Chris C Ibegbu, Marina C Figueiredo, Timothy R Sterling, Jyothi Rengarajan, Bruno B Andrade,

BACKGROUND:Diagnosis of active tuberculosis (ATB) currently relies on detection of M. tuberculosis (Mtb). Identifying patients with extrapulmonary TB (EPTB) remains challenging because microbiological confirmation is often not possible. Highly accurate blood-based tests could improve diagnosis of both EPTB and pulmonary TB (PTB), and timely initiation of anti-TB therapy. METHODS:A case-control ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, :]

Cited: 1 time

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Isoniazid Preventive Therapy in HIV-Infected Pregnant and Postpartum Women.

Amita Gupta, Grace Montepiedra, Lisa Aaron, Gerhard Theron, Katie McCarthy, Sarah Bradford, Tsungai Chipato, Tichaona Vhembo, Lynda Stranix-Chibanda, Carolyne Onyango-Makumbi, Gaerolwe R Masheto, Avy Violari, Blandina T Mmbaga, Linda Aurpibul, Ramesh Bhosale, Vidya Mave, Vanessa Rouzier, Anneke Hesseling, Katherine Shin, Bonnie Zimmer, Diane Costello, Timothy R Sterling, Nahida Chakhtoura, Patrick Jean-Philippe, Adriana Weinberg, ,

BACKGROUND:The safety, efficacy, and appropriate timing of isoniazid therapy to prevent tuberculosis in pregnant women with human immunodeficiency virus (HIV) infection who are receiving antiretroviral therapy are unknown. METHODS:In this multicenter, double-blind, placebo-controlled, noninferiority trial, we randomly assigned pregnant women with HIV infection to receive isoniazid preventive therapy for 28 ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(14):1333-1346]

Cited: 2 times

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