Full Text Journal Articles by
Author Timothy M Bahr

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Does heterozygosity for UGT1A1 *28 convey increased risk for severe neonatal jaundice?

Timothy M Bahr, Archana M Agarwal, Robert D Christensen,

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, :]

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Warming blood products for transfusion to neonates: In vitro assessments.

Whitley Hulse, Timothy M Bahr, Lauren Fredrickson, Christy M Canfield, Kim Friddle, Theodore J Pysher, Sarah J Ilstrup, Robin K Ohls, Robert D Christensen,

BACKGROUND:Blood products may be transfused into neonates at temperatures at or below room temperature. The benefits and risks of warming blood to 37°C are not defined in this population or with the equipment used in neonates. Physiologic warming might enhance product effectiveness or decrease transfusion-associated hypothermia. STUDY DESIGN AND METHODS:We ... Read more >>

Transfusion (Transfusion)
[2020, :]

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Improving thermoregulation in transported preterm infants.

Timothy M Bahr, Becky B Kerry, Mariana C Baserga, Robert D Christensen,

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, :]

Cited: 0 times

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Decision Accuracy and Safety of Transcutaneous Bilirubin Screening at Intermountain Healthcare.

Olive S Konana, Timothy M Bahr, Holly R Strike, Jennifer Coleman, Gregory L Snow, Robert D Christensen,

OBJECTIVE:To quantify the risk that transcutaneous bilirubin (TcB) screening would fail to recommend phototherapy for a neonate who would have qualified for it if total serum bilirubin (TSB) screening were used. STUDY DESIGN:We conducted a quality improvement project where simultaneous TcB and TSB were obtained on neonates ≥35 weeks of gestation ... Read more >>

J Pediatr (The Journal of pediatrics)
[2020, :]

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Urinary ferritin; a potential noninvasive way to screen NICU patients for iron deficiency.

Erick Gerday, Jennifer B Brereton, Timothy M Bahr, Jennifer O Elmont, Susan Fullmer, Bruce A Middleton, Diane M Ward, Robin K Ohls, Robert D Christensen,

OBJECTIVE:Building on our previous study, showing a correlation between ferritin in serum and urine, we conducted a feasibility evaluation, measuring urinary ferritin as a potential noninvasive screening test for iron deficiency among NICU patients. STUDY DESIGN:This was a prospective analysis of paired serum/urine ferritin levels. We defined iron-limited erythropoiesis by ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, :]

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Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content.

Timothy M Bahr, Vickie L Baer, Robin K Ohls, Thomas R Christensen, Diane M Ward, Sterling T Bennett, Robert D Christensen,

OBJECTIVE:To determine why serum ferritin and reticulocyte hemoglobin (RET-He), drawn to assess neonatal iron sufficiency, sometimes have markedly discordant results. STUDY DESIGN:Retrospective records review of five NICUs over 28 months, identifying all patients with a ferritin and RET-He within 48 h. We examined records of all who had marked discordance (one ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, :]

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A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity.

Timothy M Bahr, Michell Lozano-Chinga, Archana M Agarwal, Jessica A Meznarich, Christian C Yost, Peng Li, N Scott Reading, Josef T Prchal, Robert D Christensen,

We report a novel glucose-6-phosphate dehydrogenase (G6PD) variant (c.1375C>G) discovered in a 3-day-old Hispanic male child from Salt Lake City, UT, USA. This newborn presented with severe hyperbilirubinemia (29.8 mg/dL or 510 μmol/L) and marked hemolysis evidenced by elevated end-tidal carbon monoxide concentration (5.9 ppm, normal <1.7 ppm). Despite a ... Read more >>

Neonatology (Neonatology)
[2020, :1-4]

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Exchange transfusion for hemolytic hyperbilirubinemia: could some be averted by emergent administration of an inhibitor of bilirubin production?

Susan E Wiedmeier, Timothy M Bahr, Robin K Ohls, Thomas R Christensen, Vickie L Baer, Sarah J Ilstrup, Kelly Cail, Robert D Christensen,

OBJECTIVES:The objective of this study is to explore the hypothetical number of neonates where an exchange transfusion (ET) could be prevented by emergency administration of an inhibitor of bilirubin production. STUDY DESIGN:We identified all neonates who received an ET in our NICUs during the past 12 years. We reviewed the ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, :]

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Emergency-release blood transfusions after postpartum hemorrhage at the Intermountain Healthcare hospitals.

Whitley Hulse, Timothy M Bahr, David S Morris, Douglas S Richards, Sarah J Ilstrup, Robert D Christensen,

BACKGROUND:Most low-risk obstetric patients do not have crossmatched blood available to treat unexpected postpartum hemorrhage. An emergency-release blood transfusion (ERBT) program is critical for hospitals with obstetrical services. We performed a retrospective analysis of obstetrical ERBTs administered in our multihospital system. DESIGN AND METHODS:We collected data from the past 8 years ... Read more >>

Transfusion (Transfusion)
[2020, 60(7):1418-1423]

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Dizygotic twins with prolonged jaundice and microcytic, hypochromic, hemolytic anemia with pyropoikilocytosis.

Timothy M Bahr, Michell Lozano-Chinga, Archana M Agarwal, Jessica A Meznarich, Erick Gerday, Jennifer L Smoot, Ann Taylor, Robert D Christensen,

Dizygotic twin males, born at 34 weeks gestation, had prolonged jaundice, microcytic, hypochromic anemia, FABarts hemoglobin, elevated end-tidal CO, and blood films consistent with hereditary pyropoikilocytosis. DNA sequencing revealed both had a heterozygous alpha spectrin (SPTA1) mutation (c.460_462dup) inherited from their asymptomatic mother, plus a 3-base pair duplication in alpha globin ... Read more >>

Blood Cells Mol. Dis. (Blood cells, molecules & diseases)
[2020, 85:102462]

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Early Hyperbilirubinemia in Neonates with Down Syndrome.

Timothy M Bahr, Erick Henry, Whitley Hulse, Vickie L Baer, Josef T Prchal, Vinod K Bhutani, Robert D Christensen,

OBJECTIVE:To compare total serum bilirubin (TSB) levels, phototherapy usage, and hospital readmission for jaundice among neonates with Down syndrome vs controls. STUDY DESIGN:A retrospective cohort study using 15 years of multihospital data. We created control reference intervals (5th, median, and 95th percentiles) for initial TSB values hourly during the first days ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2020, 219:140-145]

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Improving the Bilirubin Management Program in the Newborn Nursery: Background, Aims, and Protocol.

Timothy M Bahr, Julie H Shakib, Carole H Stipelman, Kensaku Kawamoto, Kelly Cail, Sara Lauer, Robert D Christensen,

BACKGROUND:Practices to detect and manage hyperbilirubinemia in newborn nurseries are highly variable. American Academy of Pediatrics guidelines in 1999, 2004, and 2009 have generated, perhaps unintentionally, divergent practices that might not all be of equivalent value. Evidence-based progress is needed to define less invasive, less expensive, uniform, and safe methods ... Read more >>

Neonatology (Neonatology)
[2020, :1-7]

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Absence of severe neonatal ABO hemolytic disease at Intermountain Healthcare. Why?

Vickie L Baer, Whitley Hulse, Timothy M Bahr, Sarah J Ilstrup, Robert D Christensen,

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, 40(2):352-353]

Cited: 0 times

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The fragmented red cell count can support the diagnosis of a microangiopathic neonatal condition.

Timothy M Bahr, Allison J Judkins, Vickie L Baer, Erick Henry, Peter H Grubb, Whitley Hulse, Theodore J Pysher, Sterling T Bennett, Robert D Christensen,

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, 40(2):354-355]

Cited: 0 times

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First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage.

Timothy M Bahr, Tara L DuPont, David S Morris, Spencer E Pierson, Michael Sean Esplin, Samuel M Brown, Elizabeth A O'Brien, Sarah J Ilstrup, Robert D Christensen,

BACKGROUND:In cases of massive hemorrhage in the US military, improved outcomes have been reported with the use of warm, fresh whole blood transfusions. Cold-stored low-titer type O whole blood (LTOWB) has become the preferred product for resuscitation of severe bleeding in deployed surgical units. Reports of LTOWB use in civilian ... Read more >>

Transfusion (Transfusion)
[2019, 59(10):3089-3092]

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Evaluating emergency-release blood transfusion of newborn infants at the Intermountain Healthcare hospitals.

Timothy M Bahr, Tara L DuPont, Thomas R Christensen, Terry Rees, Elizabeth A O'Brien, Sarah J Ilstrup, Robert D Christensen,

BACKGROUND:An emergency-release blood transfusion (ERBT) protocol (uncrossmatched type O-negative red blood cells, AB plasma, AB platelets) is critical for neonatology practice. However, few reports of emergency transfusions are available. We conducted an ERBT quality improvement project as a basis for progress. STUDY DESIGN AND METHODS:For each ERBT in the past ... Read more >>

Transfusion (Transfusion)
[2019, 59(10):3113-3119]

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Neonates with suspected microangiopathic disorders: performance of standard manual schistocyte enumeration vs. the automated fragmented red cell count.

Timothy M Bahr, Allison J Judkins, Robert D Christensen, Vickie L Baer, Erick Henry, Stephen D Minton, Erick Gerday, Sterling T Bennett,

OBJECTIVES:To enhance the diagnosis of schistocyte-producing conditions, we compared routine manual schistocyte enumeration with automated fragmented red cell counts (FRCs). STUDY DESIGN:In neonates "suspected" of having sepsis, NEC, or DIC we compared manual schistocyte estimates vs. automated FRC counts. When the two disagreed, we used a "gold standard" from a  ≥ 1000 ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2019, 39(11):1555-1561]

Cited: 0 times

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The Association of Hydrocortisone Dosage on Mortality in Infants Born Extremely Premature.

Veeral N Tolia, Timothy M Bahr, Monica M Bennett, Gregory Martin, Rachel G Greenberg, Matthew M Laughon, Reese H Clark,

OBJECTIVE:To characterize common dosing strategies and to investigate the association between hydrocortisone dosage and in-hospital mortality in infants born extremely premature. STUDY DESIGN:We performed a retrospective review of a cohort of infants born ≤30 weeks' gestational age from 2010 to 2016 from the Pediatrix Clinical Data Warehouse who received hydrocortisone ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2019, 207:143-147.e3]

Cited: 0 times

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The Neonatal Acute Bilirubin Encephalopathy Registry (NABER): Background, Aims, and Protocol.

Timothy M Bahr, Robert D Christensen, Archana M Agarwal, Tracy I George, Vinod K Bhutani,

BACKGROUND:Acute bilirubin encephalopathy (ABE) is a potentially devastating condition that can lead to death or life-long neurodevelopmental handicaps. ABE is particularly tragic because it is, in theory, completely preventable. Progress toward its prevention has been hampered by the perception that the extreme hyperbilirubinemia giving rise to ABE typically has no ... Read more >>

Neonatology (Neonatology)
[2019, 115(3):242-246]

Cited: 3 times

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Polymorphisms in CYP2C9 are associated with response to indomethacin among neonates with patent ductus arteriosus.

Caitlin J Smith, Kelli K Ryckman, Timothy M Bahr, John M Dagle,

BackgroundPatent ductus arteriosus (PDA) is a common complication seen in preterm infants. Indomethacin is routinely used to treat PDA. Evidence suggests that the response of indomethacin is highly heritable. This study investigated the association between single-nucleotide polymorphisms (SNPs) in CYP2C9 and the closure of PDA in response to indomethacin.MethodsSix SNPs ... Read more >>

Pediatr Res (Pediatric research)
[2017, 82(5):776-780]

Cited: 4 times

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Integrative omics approach identifies interleukin-16 as a biomarker of emphysema.

Russell P Bowler, Timothy M Bahr, Grant Hughes, Sharon Lutz, Yu-Il Kim, Christopher D Coldren, Nichole Reisdorph, Katerina J Kechris,

Interleukin-16 (IL-16) is a multifunctional cytokine that has been associated with autoimmune and allergic diseases. To investigate comprehensively whether IL-16 is also associated with chronic obstructive pulmonary disease (COPD) and emphysema, we performed an integrated analysis of multiple "omics" data. Over 500 subjects participating in the COPDGene® study donated blood ... Read more >>

OMICS (Omics : a journal of integrative biology)
[2013, 17(12):619-626]

Cited: 19 times

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Angiotensin II-induced cardiovascular load regulates cardiac remodeling and related gene expression in late-gestation fetal sheep.

Andrew W Norris, Timothy M Bahr, Thomas D Scholz, Emily S Peterson, Ken A Volk, Jeffrey L Segar,

Angiotensin II (ANG II) stimulates fetal heart growth, although little is known regarding changes in cardiomyocyte endowment or the molecular pathways mediating the response. We measured cardiomyocyte proliferation and morphology in ANG II-treated fetal sheep and assessed transcriptional pathway responses in ANG II and losartan (an ANG II type 1 ... Read more >>

Pediatr Res (Pediatric research)
[2014, 75(6):689-696]

Cited: 7 times

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Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease.

Timothy M Bahr, Grant J Hughes, Michael Armstrong, Rick Reisdorph, Christopher D Coldren, Michael G Edwards, Christina Schnell, Ross Kedl, Daniel J LaFlamme, Nichole Reisdorph, Katerina J Kechris, Russell P Bowler,

Although most cases of chronic obstructive pulmonary disease (COPD) occur in smokers, only a fraction of smokers develop the disease. We hypothesized distinct molecular signatures for COPD and emphysema in the peripheral blood mononuclear cells (PBMCs) of current and former smokers. To test this hypothesis, we identified and validated PBMC ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2013, 49(2):316-323]

Cited: 51 times

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Selective protection against extremes in childhood body size, abdominal fat deposition, and fat patterning in breastfed children.

Tessa L Crume, Timothy M Bahr, Elizabeth J Mayer-Davis, Richard F Hamman, Ann L Scherzinger, Elizabeth Stamm, Dana Dabelea,

OBJECTIVE:To determine whether the effect of breastfeeding on childhood measures of adiposity differs across percentiles of childhood body mass index (BMI), subcutaneous (SAT) and visceral (VAT) adipose tissue deposition, ratio of subcutaneous to triceps skinfold (STR), and intramyocellular lipid accumulation (IMCL). DESIGN:Retrospective cohort. SETTING:Denver, Colorado. PARTICIPANTS:Four hundred forty-two children and ... Read more >>

Arch Pediatr Adolesc Med (Archives of pediatrics & adolescent medicine)
[2012, 166(5):437-443]

Cited: 6 times

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DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.

Kunal Rai, Sharmistha Sarkar, Talmage J Broadbent, Matthew Voas, Kenneth F Grossmann, Lincoln D Nadauld, Somaye Dehghanizadeh, Fanuel T Hagos, Yumei Li, Rachel K Toth, Stephanie Chidester, Timothy M Bahr, W Evan Johnson, Brad Sklow, Randall Burt, Bradley R Cairns, David A Jones,

Although genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system and the concomitant hypomethylation of key intestinal cell fating genes. Notably, this hypomethylation maintained zebrafish intestinal cells ... Read more >>

Cell (Cell)
[2010, 142(6):930-942]

Cited: 49 times

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