Full Text Journal Articles by
Author Timothy G Buchman

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Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines-Selecting Compounds for Clinical Evaluation in Coronavirus Disease 2019 Clinical Trials.

Timothy G Buchman, Ruxandra Draghia-Akli, Stacey J Adam, Neil R Aggarwal, Joshua P Fessel, Elizabeth S Higgs, Joseph P Menetski, Sarah W Read, Eric A Hughes, ,

Given the urgent need for coronavirus disease 2019 therapeutics, early in the pandemic the Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership rapidly designed a unique therapeutic agent intake and assessment process for candidate treatments of coronavirus disease 2019. These treatments included antivirals, immune modulators, severe acute ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1963-1973]

Cited: 0 times

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Sepsis Among Medicare Beneficiaries: 4. Precoronavirus Disease 2019 Update January 2012-February 2020.

Charles E Frank, Timothy G Buchman, Steven Q Simpson, Kimberly L Sciarretta, George E Plopper, Kristen P Finne, Nicole Sowers, Michael Collier, Saurabh Chavan, Cheng Lin, Ibijoke Oke, Kiersten E Rhodes, Aathira Santhosh, Steve Chu, Thomas E MaCurdy, Sandeep A Patel, Gary L Disbrow, Jeffrey A Kelman,

<h4>Objectives</h4>To provide updated information on the burdens of sepsis during acute inpatient admissions for Medicare beneficiaries.<h4>Design</h4>Analysis of paid Medicare claims via the Centers for Medicare and Medicaid Services DataLink Project.<h4>Setting</h4>All U.S. acute-care hospitals, excluding federally operated hospitals (Veterans Administration and Defense Health Agency).<h4>Patients</h4>All Medicare beneficiaries, January 2012-February 2020, with an ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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The Coronavirus Disease 2019 Pandemic Impacts Burnout Syndrome Differently Among Multiprofessional Critical Care Clinicians-A Longitudinal Survey Study.

Vanessa Moll, Heather Meissen, Sharon Pappas, Kejun Xu, Ramzy Rimawi, Timothy G Buchman, Lisa Fisher, Vishal Bakshi, Mary Zellinger, Craig M Coopersmith,

<h4>Objectives</h4>To determine the impact of coronavirus disease 2019 on burnout syndrome in the multiprofessional ICU team and to identify factors associated with burnout syndrome.<h4>Design</h4>Longitudinal, cross-sectional survey.<h4>Setting</h4>All adult ICUs within an academic health system.<h4>Subjects</h4>Critical care nurses, advanced practice providers, physicians, respiratory therapists, pharmacists, social workers, and spiritual health workers were surveyed ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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Disparities in Sepsis Outcomes May Be Attributable to Access to Care.

George E Plopper, Kimberly L Sciarretta, Timothy G Buchman,

Crit Care Med (Critical care medicine)
[2021, 49(8):1358-1360]

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Viral Micro-RNAs Are Detected in the Early Systemic Response to Injury and Are Associated With Outcomes in Polytrauma Patients.

Diego Vicente, Seth A Schobel, Simone Anfossi, Hannah Hensman, Felipe Lisboa, Henry Robertson, Vivek Khatri, Matthew J Bradley, Masayoshi Shimizu, Timothy G Buchman, Thomas A Davis, Christopher J Dente, Allan D Kirk, George A Calin, Eric A Elster,

<h4>Objectives</h4>To evaluate early activation of latent viruses in polytrauma patients and consider prognostic value of viral micro-RNAs in these patients.<h4>Design</h4>This was a subset analysis from a prospectively collected multicenter trauma database. Blood samples were obtained upon admission to the trauma bay (T0), and trauma metrics and recovery data were collected.<h4>Setting</h4>Two ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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A Locally Optimized Data-Driven Tool to Predict Sepsis-Associated Vasopressor Use in the ICU.

Andre L Holder, Supreeth P Shashikumar, Gabriel Wardi, Timothy G Buchman, Shamim Nemati,

<h4>Objectives</h4>To train a model to predict vasopressor use in ICU patients with sepsis and optimize external performance across hospital systems using domain adaptation, a transfer learning approach.<h4>Design</h4>Observational cohort study.<h4>Setting</h4>Two academic medical centers from January 2014 to June 2017.<h4>Patients</h4>Data were analyzed from 14,512 patients (9,423 at the development site and 5,089 ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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An integrative model using flow cytometry identifies nosocomial infection after trauma.

Rondi B Gelbard, Hannah Hensman, Seth Schobel, Linda L Stempora, Dimitrios Moris, Christopher J Dente, Timothy G Buchman, Allan D Kirk, Eric Elster,

<h4>Background</h4>Flow cytometry (FCM) is a rapid diagnostic tool for monitoring immune cell function. We sought to determine if assessment of cell phenotypes using standardized FCM could be used to identify nosocomial infection after trauma.<h4>Methods</h4>Prospective study of trauma patients at a Level I center from 2014 to 2018. Clinical and FCM ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 91(1):47-53]

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Predicting the need for massive transfusion: Prospective validation of a smartphone-based clinical decision support tool.

Christopher J Dente, Michael J Mina, Bryan C Morse, Hannah Hensman, Seth Schobel, Rondi B Gelbard, Arnaud Belard, Timothy G Buchman, Allan D Kirk, Eric A Elster,

<h4>Background</h4>Improper or delayed activation of a massive transfusion protocol may have consequences to individuals and institutions. We designed a complex predictive algorithm that was packaged within a smartphone application. We hypothesized it would accurately assess the need for massive transfusion protocol activation and assist clinicians in that decision.<h4>Methods</h4>We prospectively enrolled ... Read more >>

Surgery (Surgery)
[2021, :]

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Prediction of Acute Respiratory Failure Requiring Advanced Respiratory Support in Advance of Interventions and Treatment: A Multivariable Prediction Model From Electronic Medical Record Data.

An-Kwok I Wong, Rishikesan Kamaleswaran, Azade Tabaie, Matthew A Reyna, Christopher Josef, Chad Robichaux, Anne A H de Hond, Ewout W Steyerberg, Andre L Holder, Shamim Nemati, Timothy G Buchman, James M Blum,

<h4>Background</h4>Acute respiratory failure occurs frequently in hospitalized patients and often begins outside the ICU, associated with increased length of stay, cost, and mortality. Delays in decompensation recognition are associated with worse outcomes.<h4>Objectives</h4>The objective of this study is to predict acute respiratory failure requiring any advanced respiratory support (including noninvasive ventilation). ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(5):e0402]

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Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.

Jonathan E Sevransky, Richard E Rothman, David N Hager, Gordon R Bernard, Samuel M Brown, Timothy G Buchman, Laurence W Busse, Craig M Coopersmith, Christine DeWilde, E Wesley Ely, Lindsay M Eyzaguirre, Alpha A Fowler, David F Gaieski, Michelle N Gong, Alex Hall, Jeremiah S Hinson, Michael H Hooper, Gabor D Kelen, Akram Khan, Mark A Levine, Roger J Lewis, Chris J Lindsell, Jessica S Marlin, Anna McGlothlin, Brooks L Moore, Katherine L Nugent, Samuel Nwosu, Carmen C Polito, Todd W Rice, Erin P Ricketts, Caroline C Rudolph, Fred Sanfilippo, Kert Viele, Greg S Martin, David W Wright, ,

<h4>Importance</h4>Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.<h4>Objective</h4>To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo ... Read more >>

JAMA (JAMA)
[2021, 325(8):742-750]

Cited: 9 times

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A Celebration of the Society of Critical Care Medicine at the Half-Century Mark.

Timothy G Buchman,

Crit Care Med (Critical care medicine)
[2021, 49(2):167-168]

Cited: 0 times

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Pandemic-Related Submissions: The Challenge of Discerning Signal Amidst Noise.

Thomas P Bleck, Timothy G Buchman, R Phillip Dellinger, Clifford S Deutschman, John C Marshall, David M Maslove, Henry Masur, Margaret M Parker, Donald S Prough, Aarti Sarwal, Jonathan E Sevransky, Jean-Louis Vincent, Jerry J Zimmerman,

Crit Care Med (Critical care medicine)
[2020, 48(8):1099-1102]

Cited: 3 times

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Critical care journals during the COVID-19 pandemic: challenges and responsibilities.

Giuseppe Citerio, Jan Bakker, Laurent Brochard, Timothy G Buchman, Samir Jaber, Peter J Mazzone, Jean-Louis Teboul, Jean-Louis Vincent, Elie Azoulay,

Intensive Care Med (Intensive care medicine)
[2020, 46(8):1521-1523]

Cited: 3 times

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Correction to: Advanced Modeling to Predict Pneumonia in Combat Trauma Patients.

Matthew Bradley, Christopher Dente, Vivek Khatri, Seth Schobel, Felipe Lisboa, Audrey Shi, Hannah Hensman, Allan Kirk, Timothy G Buchman, Eric Elster,

In the original article, the units indicated on the y-axes of Fig. 3 are incorrectly labelled. The correct label is pg/mL. Following is the corrected Fig. 3. ... Read more >>

World J Surg (World journal of surgery)
[2020, 44(7):2263]

Cited: 0 times

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Advanced Modeling to Predict Pneumonia in Combat Trauma Patients.

Matthew Bradley, Christopher Dente, Vivek Khatri, Seth Schobel, Felipe Lisboa, Audrey Shi, Hannah Hensman, Allan Kirk, Timothy G Buchman, Eric Elster,

<h4>Background</h4>Tools to assist clinicians in predicting pneumonia could lead to a significant decline in morbidity. Therefore, we sought to develop a model in combat trauma patients for identifying those at highest risk of pneumonia.<h4>Methods</h4>This was a retrospective study of 73 primarily blast-injured casualties with combat extremity wounds. Binary classification models ... Read more >>

World J Surg (World journal of surgery)
[2020, 44(7):2255-2262]

Cited: 1 time

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Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018.

Timothy G Buchman, Steven Q Simpson, Kimberly L Sciarretta, Kristen P Finne, Nicole Sowers, Michael Collier, Saurabh Chavan, Ibijoke Oke, Meghan E Pennini, Aathira Santhosh, Marie Wax, Robyn Woodbury, Steve Chu, Tyler G Merkeley, Gary L Disbrow, Rick A Bright, Thomas E MaCurdy, Jeffrey A Kelman,

OBJECTIVE:To evaluate the impact of sepsis, age, and comorbidities on death following an acute inpatient admission and to model and forecast inpatient and skilled nursing facility costs for Medicare beneficiaries during and subsequent to an acute inpatient sepsis admission. DESIGN:Analysis of paid Medicare claims via the Centers for Medicare & ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(3):302-318]

Cited: 5 times

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Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018.

Timothy G Buchman, Steven Q Simpson, Kimberly L Sciarretta, Kristen P Finne, Nicole Sowers, Michael Collier, Saurabh Chavan, Ibijoke Oke, Meghan E Pennini, Aathira Santhosh, Marie Wax, Robyn Woodbury, Steve Chu, Tyler G Merkeley, Gary L Disbrow, Rick A Bright, Thomas E MaCurdy, Jeffrey A Kelman,

OBJECTIVES:To provide contemporary estimates of the burdens (costs and mortality) associated with acute inpatient Medicare beneficiary admissions for sepsis. DESIGN:Analysis of paid Medicare claims via the Centers for Medicare & Medicaid Services DataLink Project. SETTING:All U.S. acute care hospitals, excluding federally operated hospitals (Veterans Administration and Defense Health Agency). PATIENTS:All ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(3):276-288]

Cited: 21 times

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Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012-2018.

Timothy G Buchman, Steven Q Simpson, Kimberly L Sciarretta, Kristen P Finne, Nicole Sowers, Michael Collier, Saurabh Chavan, Ibijoke Oke, Meghan E Pennini, Aathira Santhosh, Marie Wax, Robyn Woodbury, Steve Chu, Tyler G Merkeley, Gary L Disbrow, Rick A Bright, Thomas E MaCurdy, Jeffrey A Kelman,

OBJECTIVES:To distinguish characteristics of Medicare beneficiaries who will have an acute inpatient admission for sepsis from those who have an inpatient admission without sepsis, and to describe their further trajectories during and subsequent to those inpatient admissions. DESIGN:Analysis of paid Medicare claims via the Centers for Medicare and Medicaid Services ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(3):289-301]

Cited: 5 times

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Exploring the Epigenetics of Severe Sepsis: First Step in a Long Journey.

Timothy G Buchman, Barbara A Zehnbauer,

Crit Care Med (Critical care medicine)
[2020, 48(2):254-255]

Cited: 0 times

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Intensive Care Unit Telemedicine: Innovations and Limitations.

William Bender, Cheryl A Hiddleson, Timothy G Buchman,

Intensive care unit (ICU) telemedicine is an established entity that has the ability to not only improve the effectiveness, efficiency, and safety of critical care, but to also serve as a tool to combat staffing shortages and resource-limited environments. Several areas for future innovation exist within the field, including the ... Read more >>

Crit Care Clin (Critical care clinics)
[2019, 35(3):497-509]

Cited: 2 times

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Control of Confounding and Reporting of Results in Causal Inference Studies. Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals.

David J Lederer, Scott C Bell, Richard D Branson, James D Chalmers, Rachel Marshall, David M Maslove, David E Ost, Naresh M Punjabi, Michael Schatz, Alan R Smyth, Paul W Stewart, Samy Suissa, Alex A Adjei, Cezmi A Akdis, Élie Azoulay, Jan Bakker, Zuhair K Ballas, Philip G Bardin, Esther Barreiro, Rinaldo Bellomo, Jonathan A Bernstein, Vito Brusasco, Timothy G Buchman, Sudhansu Chokroverty, Nancy A Collop, James D Crapo, Dominic A Fitzgerald, Lauren Hale, Nicholas Hart, Felix J Herth, Theodore J Iwashyna, Gisli Jenkins, Martin Kolb, Guy B Marks, Peter Mazzone, J Randall Moorman, Thomas M Murphy, Terry L Noah, Paul Reynolds, Dieter Riemann, Richard E Russell, Aziz Sheikh, Giovanni Sotgiu, Erik R Swenson, Rhonda Szczesniak, Ronald Szymusiak, Jean-Louis Teboul, Jean-Louis Vincent,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2019, 16(1):22-28]

Cited: 116 times

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Exploring the Endless Frontier.

Timothy G Buchman,

Crit Care Explor (Critical care explorations)
[2019, 1(1):e0002]

Cited: 1 time

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Quantifying resilience of humans and other animals.

Marten Scheffer, J Elizabeth Bolhuis, Denny Borsboom, Timothy G Buchman, Sanne M W Gijzel, Dave Goulson, Jan E Kammenga, Bas Kemp, Ingrid A van de Leemput, Simon Levin, Carmel Mary Martin, René J F Melis, Egbert H van Nes, L Michael Romero, Marcel G M Olde Rikkert,

All life requires the capacity to recover from challenges that are as inevitable as they are unpredictable. Understanding this resilience is essential for managing the health of humans and their livestock. It has long been difficult to quantify resilience directly, forcing practitioners to rely on indirect static indicators of health. ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(47):11883-11890]

Cited: 34 times

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An Interpretable Machine Learning Model for Accurate Prediction of Sepsis in the ICU.

Shamim Nemati, Andre Holder, Fereshteh Razmi, Matthew D Stanley, Gari D Clifford, Timothy G Buchman,

OBJECTIVES:Sepsis is among the leading causes of morbidity, mortality, and cost overruns in critically ill patients. Early intervention with antibiotics improves survival in septic patients. However, no clinically validated system exists for real-time prediction of sepsis onset. We aimed to develop and validate an Artificial Intelligence Sepsis Expert algorithm for ... Read more >>

Crit Care Med (Critical care medicine)
[2018, 46(4):547-553]

Cited: 98 times

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Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis.

Djillali Annane, Jean-Paul Mira, Lorraine B Ware, Anthony C Gordon, Charles J Hinds, David C Christiani, Jonathan Sevransky, Kathleen Barnes, Timothy G Buchman, Patrick J Heagerty, Robert Balshaw, Nadia Lesnikova, Karen de Nobrega, Hugh F Wellman, Mauricio Neira, Alexandra D J Mancini, Keith R Walley, James A Russell,

PURPOSE:To explore potential design for pharmacogenomics trials in sepsis, we investigate the interaction between pharmacogenomic biomarkers and response to drotrecogin alfa (activated) (DrotAA). This trial was designed to validate whether previously identified improved response polymorphisms (IRPs A and B) were associated with an improved response to DrotAA in severe sepsis. ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2018, 8(1):16]

Cited: 0 times

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