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Defining Resistance to Immune Checkpoint Inhibitors in Urothelial Carcinoma: Insights from PURE-01.

Timothy N Clinton,

Eur Urol (European urology)
[2021, :]

Cited: 0 times

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

Cited: 0 times

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Metastasis-directed radiation therapy after radical cystectomy for bladder cancer.

Andre F Miranda, Jeffrey M Howard, Mark McLaughlin, Xiaosong Meng, Timothy Clinton, Öner Şanli, Aurelie Garant, Aditya Bagrodia, Vitaly Margulis, Yair Lotan, Raquibul Hannan, Neil Desai, Solomon L Woldu,

<h4>Purpose</h4>Metastasis-directed radiation therapy (MDRT) may improve oncologic and quality of life outcomes in patients with metastatic cancer, but data on its use in metastatic bladder cancer is severely limited. We sought to review our institutional experience with MDRT in patients with metastatic bladder cancer following radical cystectomy.<h4>Materials and methods</h4>We reviewed ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

Cited: 0 times

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Is there an oncological benefit to extended lymphadenectomy for muscle-invasive bladder cancer?

Timothy N Clinton, Chun Huang, Alvin C Goh,

The full optimal extent of a pelvic lymph node dissection (PLND) at time of radical cystectomy (RC) has not yet been determined. The diagnostic role of LND is clear and is extremely important for identifying those who may benefit from adjuvant therapy. While retrospective analyses have demonstrated improved survival when ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(6):2956-2964]

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Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts.

Kwanghee Kim, Wenhuo Hu, François Audenet, Nima Almassi, Aphrothiti J Hanrahan, Katie Murray, Aditya Bagrodia, Nathan Wong, Timothy N Clinton, Shawn Dason, Vishnu Mohan, Sylvia Jebiwott, Karan Nagar, Jianjiong Gao, Alex Penson, Chris Hughes, Benjamin Gordon, Ziyu Chen, Yiyu Dong, Philip A Watson, Ricardo Alvim, Arijh Elzein, Sizhi P Gao, Emiliano Cocco, Alessandro D Santin, Irina Ostrovnaya, James J Hsieh, Irit Sagi, Eugene J Pietzak, A Ari Hakimi, Jonathan E Rosenberg, Gopa Iyer, Herbert A Vargas, Maurizio Scaltriti, Hikmat Al-Ahmadie, David B Solit, Jonathan A Coleman,

Treatment paradigms for patients with upper tract urothelial carcinoma (UTUC) are typically extrapolated from studies of bladder cancer despite their distinct clinical and molecular characteristics. The advancement of UTUC research is hampered by the lack of disease-specific models. Here, we report the establishment of patient derived xenograft (PDX) and cell ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1975]

Cited: 2 times

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Pathologic stage as a surrogate for oncologic outcomes after receipt of neoadjuvant chemotherapy for high-grade upper tract urothelial carcinoma.

Nirmish Singla, Alana Christie, Yuval Freifeld, Rashed A Ghandour, Solomon L Woldu, Timothy N Clinton, Firas G Petros, Haley Robyak, Hsin-Chih Yeh, Dong Fang, Dmitry Enikeev, Aditya Bagrodia, Arthur I Sagalowsky, Yair Lotan, Jay D Raman, Surena F Matin, Vitaly Margulis,

<h4>Objective</h4>Whether pathologic stage at radical nephroureterectomy (RNU) can serve as an appropriate surrogate for oncologic outcomes in patients with high-grade (HG) upper tract urothelial carcinoma (UTUC) treated with neoadjuvant chemotherapy (NAC) is not defined. We sought to determine whether patients who achieve pathologically non-muscle-invasive (ypT0, ypTa, ypT1, ypTis) HG UTUC ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(12):933.e7-933.e12]

Cited: 0 times

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Efficacy of Preoperative Chemotherapy for High Risk Upper Tract Urothelial Carcinoma.

Beat Foerster, Mohammad Abufaraj, Firas Petros, Mounsif Azizi, Mohit Gupta, Donald Schweitzer, Vitaly Margulis, Takehiro Iwata, Shoji Kimura, Ahmad Shabsigh, Alberto Briganti, Ja H Ku, Tim Muilwijk, Wassim Kassouf, Surena F Matin, Philippe E Spiess, Phillip M Pierorazio, Kees Hendricksen, Shahrokh F Shariat, ,

PURPOSE:The impact of preoperative chemotherapy in patients with upper urinary tract urothelial carcinoma remains poorly investigated. We assessed the rates of pathological complete response (pT0N0/X) and downstaging (pT1N0/X or less) at radical nephroureterectomy after preoperative chemotherapy and evaluated their impact on survival. MATERIALS AND METHODS:This was an international observational study ... Read more >>

J Urol (The Journal of urology)
[2020, 203(6):1101-1108]

Cited: 2 times

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Urinary Diversion Disparity Following Radical Cystectomy for Bladder Cancer in the Hispanic Population.

Emily M Rios, Mitchell A Parma, Roman A Fernandez, Timothy N Clinton, Ryan M Reyes, Dharam Kaushik, Deepak Pruthi, Ahmed M Mansour, Neelam Mukherjee, Jon Gelfond, Karen M Wheeler, Robert S Svatek,

<h4>Objective</h4>To determine if disparities in quality of surgical care exist between Hispanics and non-Hispanics undergoing radical cystectomy for bladder cancer.<h4>Materials and methods</h4>An observational cohort study was conducted retrospectively on patients who underwent radical cystectomy for urothelial carcinoma of the bladder at our institution between January 2005 and July 2018. Data ... Read more >>

Urology (Urology)
[2020, 137:66-71]

Cited: 1 time

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Commentary: underutilization of curative-intent therapy for patients with muscle-invasive bladder cancer in Sweden mimics the United States.

Timothy N Clinton, Michal Wiseman, Aleksandra Walasek, Eugene Pietzak,

Transl Androl Urol (Translational andrology and urology)
[2019, 8(Suppl 5):S542-S545]

Cited: 1 time

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Preoperative predictive model and nomogram for disease recurrence following radical nephroureterectomy for high grade upper tract urothelial carcinoma.

Yuval Freifeld, Rashed Ghandour, Nirmish Singla, Solomon Woldu, Timothy Clinton, Rohan Kulangara, Aditya Bagrodia, Surena F Matin, Firas G Petros, Jay D Raman, Haley Robyak, Jingsheng Yan, Hong Zhu, Leonid Rapoport, Yair Lotan, Vitaly Margulis,

<h4>Purpose</h4>To identify preoperative risk factors for disease recurrence, following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), and to create a predictive nomogram.<h4>Materials and methods</h4>Based on a multicenter database, we identified patients who underwent RNU due to high grade UTUC. Urothelial carcinoma of the bladder or contralateral UTUC was ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(10):758-764]

Cited: 2 times

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Preoperative multiplex nomogram for prediction of high-risk nonorgan-confined upper-tract urothelial carcinoma.

Firas G Petros, Wei Qiao, Nirmish Singla, Timothy N Clinton, Haley Robyak, Jay D Raman, Vitaly Margulis, Surena F Matin,

<h4>Background</h4>Accurate risk stratification prior to radical nephroureterectomy remains a challenge with upper-tract urothelial carcinoma (UTUC). Herein, we generated an optimized preoperative tool predicting high-risk nonorgan-confined (NOC)-UTUC.<h4>Materials and methods</h4>Retrospective evaluation of 699 patients undergoing radical nephroureterectomy at 3 academic centers. Multiplex preoperative patient, imaging, endoscopic, and laboratory values were evaluated. Model ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(4):292.e1-292.e9]

Cited: 5 times

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Incidence and Outcomes of Delayed Targeted Therapy After Cytoreductive Nephrectomy for Metastatic Renal-Cell Carcinoma: A Nationwide Cancer Registry Study.

Solomon L Woldu, Justin T Matulay, Timothy N Clinton, Nirmish Singla, Yuval Freifeld, Oner Sanli, Laura-Maria Krabbe, Ryan C Hutchinson, Yair Lotan, Hans Hammers, Raquibul Hannan, James Brugarolas, Aditya Bagrodia, Vitaly Margulis,

<h4>Background</h4>The optimal timing of targeted therapy (TT) initiation for metastatic renal-cell carcinoma (mRCC) is not clear. We used a nationwide cancer registry to determine clinical and social factors associated with delayed TT and to evaluate the association of a delayed approach with overall survival (OS).<h4>Patients and methods</h4>We performed a retrospective ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2018, 16(6):e1221-e1235]

Cited: 2 times

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Impact of Hospital Case Volume on Outcomes Following Radical Nephrectomy and Inferior Vena Cava Thrombectomy.

Yuval Freifeld, Solomon L Woldu, Nirmish Singla, Timothy Clinton, Aditya Bagrodia, Ryan Hutchinson, Yair Lotan, Vitaly Margulis,

<h4>Background</h4>Radical nephrectomy with inferior vena cava thrombectomy (RN-IVCT) is a complicated procedure for which the impact of hospital case volume on overall survival (OS) is unknown.<h4>Objective</h4>To assess the degree to which renal cell carcinoma (RCC) with inferior vena cava tumor thrombus (IVC-TT) care is centralized and to evaluate the impact ... Read more >>

Eur Urol Oncol (European urology oncology)
[2019, 2(6):691-698]

Cited: 0 times

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Validating the predictors of outcomes after radical cystectomy for bladder cancer.

Solomon L Woldu, Oner Sanli, Timothy N Clinton, Yair Lotan,

<h4>Background</h4>An assessment of surgical risk is essential for patient counseling and decision making, and it can provide rationale adjustment for patient populations as health care moves from a fee-for-service to a value-based reimbursement model. The modified Frailty Index (mFI) has been proposed as a risk-stratification tool for radical cystectomy (RC), ... Read more >>

Cancer (Cancer)
[2019, 125(2):223-231]

Cited: 8 times

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Therapeutic strategies for upper tract urothelial carcinoma.

Yuval Freifeld, Laura-Maria Krabbe, Timothy N Clinton, Solomon L Woldu, Vitaly Margulis,

INTRODUCTION:Many controversies exist regarding the appropriate management of patients with upper tract urothelial carcinoma (UTUC), including staging, surgical management, use of systemic therapy, and prevention of bladder recurrence. Due to the rarity of this condition, high-level evidence is often lacking and in many cases guidelines are extrapolated from existing evidence ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2018, 18(8):765-774]

Cited: 0 times

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The use of blue light flexible cystoscopy with hexaminolevulinate & the diagnosis of bladder cancer.

Timothy N Clinton, Yair Lotan,

Blue light cystoscopy improves the detection of bladder cancer at time of transurethral resection of bladder tumor for nonmuscle-invasive bladder cancer. This has translated to decreased tumor recurrence. Given this improvement in rigid cystoscopy, the question remains whether the use of blue light flexible cystoscopy (BLFC) in the surveillance setting ... Read more >>

Future Oncol (Future oncology (London, England))
[2018, 14(27):2805-2810]

Cited: 1 time

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Discordance between Ureteroscopic Biopsy and Final Pathology for Upper Tract Urothelial Carcinoma.

Ezra J Margolin, Justin T Matulay, Gen Li, Xiaosong Meng, Brian Chao, Varun Vijay, Hayley Silver, Timothy N Clinton, Laura-Maria Krabbe, Solomon L Woldu, Nirmish Singla, Aditya Bagrodia, Vitaly Margulis, William C Huang, Marc A Bjurlin, Ojas Shah, Christopher B Anderson,

PURPOSE:We evaluated the discordance between ureteroscopic biopsy and surgical pathology findings for grading and staging upper tract urothelial carcinoma. We also sought to establish preoperative predictors of aggressive tumors. MATERIALS AND METHODS:We retrospectively reviewed the records of 314 patients who underwent ureteroscopic biopsy followed by surgical management of upper tract ... Read more >>

J Urol (The Journal of urology)
[2018, 199(6):1440-1445]

Cited: 10 times

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Practice Patterns and Impact of Postchemotherapy Retroperitoneal Lymph Node Dissection on Testicular Cancer Outcomes.

Solomon L Woldu, Joseph A Moore, Bo Ci, Yuval Freifeld, Timothy N Clinton, Ahmet M Aydin, Nirmish Singla, Krabbe Laura-Maria, Ryan C Hutchinson, James F Amatruda, Arthur Sagalowsky, Yair Lotan, Yull Arriaga, Vitaly Margulis, Yang Xie, Aditya Bagrodia,

<h4>Background</h4>Owing to surgical complexity and controversy regarding indications, there are wide practice variations in the use of postchemotherapy retroperitoneal lymph node dissection (PC-RPLND).<h4>Objective</h4>To evaluate patterns of PC-RPLND use in the USA and evaluate the association between PC-RPLND and survival in advanced nonseminomatous germ cell tumors (NSGCTs).<h4>Design setting and participants</h4>A retrospective, ... Read more >>

Eur Urol Oncol (European urology oncology)
[2018, 1(3):242-251]

Cited: 1 time

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Usage and survival implications of surgical staging of inguinal lymph nodes in intermediate- to high-risk, clinical localized penile cancer: A propensity-score matched analysis.

Solomon L Woldu, Bo Ci, Ryan C Hutchinson, Laura-Maria Krabbe, Nirmish Singla, Niccolo M Passoni, Timothy N Clinton, Ganesh V Raj, David S Miller, Arthur I Sagalowsky, Yair Lotan, Yang Xie, Vitaly Margulis, Aditya Bagrodia,

OBJECTIVES:To evaluate the usage of surgical staging of inguinal lymph nodes (SSILNs) in the United States for intermediate to high-risk, clinically localized penile squamous cell cancer (SCC), to explore patient and hospital factors associated with omission of this staging, and to evaluate the effect on survival. PATIENTS AND METHODS:Retrospective, observational ... Read more >>

Urol Oncol (Urologic oncology)
[2018, 36(4):159.e7-159.e17]

Cited: 4 times

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Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses.

Solomon L Woldu, Ahmet M Aydin, Ashwin V Rao, Ryan C Hutchinson, Nirmish Singla, Timothy N Clinton, Laura-Maria Krabbe, Niccolo M Passoni, Ganesh V Raj, David S Miller, James F Amatruda, Arthur I Sagalowsky, Yair Lotan, Yull Arriaga, Vitaly Margulis, Aditya Bagrodia,

<h4>Objective</h4>To describe epidemiologic patterns, stage at presentation, histology, and treatment differences associated with Hispanic men diagnosed with testicular germ cell tumor (TGCT). Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising most rapidly in this demographic, yet little is ... Read more >>

Urology (Urology)
[2018, 112:103-111]

Cited: 5 times

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Impact of hospital case volume on testicular cancer outcomes and practice patterns.

Solomon L Woldu, Justin T Matulay, Timothy N Clinton, Nirmish Singla, Laura-Maria Krabbe, Ryan C Hutchinson, Arthur Sagalowsky, Yair Lotan, Vitaly Margulis, Aditya Bagrodia,

<h4>Background</h4>Given the rarity of testicular germ cell tumors (TGCTs) and the complex aspects of management, we evaluate the effect of hospital TGCT case volume on overall survival outcomes and practice patterns.<h4>Materials and methods</h4>The National Cancer Database was queried for patients diagnosed with seminoma or nonseminomatous germ cell tumor (NSGCT). Hospitals ... Read more >>

Urol Oncol (Urologic oncology)
[2018, 36(1):14.e7-14.e15]

Cited: 14 times

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Tissue-based biomarkers in prostate cancer.

Timothy N Clinton, Aditya Bagrodia, Yair Lotan, Vitaly Margulis, Ganesh V Raj, Solomon L Woldu,

<h4>Introduction</h4>Prostate cancer is a heterogeneous disease. Existing risk stratification tools based on standard clinlicopathologic variables (prostate specific antigen [PSA], Gleason score, and tumor stage) provide a modest degree of predictive ability. Advances in high-throughput sequencing has led to the development of several novel tissue-based biomarkers that can improve prognostication in ... Read more >>

Expert Rev Precis Med Drug Dev (Expert review of precision medicine and drug development)
[2017, 2(5):249-260]

Cited: 6 times

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Review of the Clinical Approaches to the Use of Urine-based Tumor Markers in Bladder Cancer.

Timothy Clinton, Yair Lotan,

Bladder cancer is a common disease with a stable incidence for the past few decades despite advancements in molecular and genetic determinants of cancer development and progression. Cystoscopy remains the standard for detection and surveillance of bladder cancer, but it is an invasive and potentially costly procedure. With the knowledge ... Read more >>

Rambam Maimonides Med J (Rambam Maimonides medical journal)
[2017, 8(4):]

Cited: 6 times

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Degarelix versus luteinizing hormone-releasing hormone agonists for the treatment of prostate cancer.

Timothy N Clinton, Solomon L Woldu, Ganesh V Raj,

<h4>Introduction</h4>Androgen deprivation therapy (ADT) is the mainstay for advanced, hormone-sensitive prostate cancer, and options include surgical castration, luteinizing hormone-releasing hormone (LHRH) agonist, and more recently, gonadotropin releasing hormone (GnRH) antagonist therapy. Our understanding of the mechanisms and adverse effects of ADT has increased substantially, including the class-specific adverse effects of ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2017, 18(8):825-832]

Cited: 7 times

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