Full Text Journal Articles by
Author Timo Rath

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Missed lesions and artificial intelligence during colonoscopy: the tireless working expert in the room.

Timo Rath,

Endoscopy (Endoscopy)
[2021, :]

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The outcome of patients with inflammatory bowel disease-associated colorectal cancer is not worse than that of patients with sporadic colorectal cancer-a matched-pair analysis of survival.

Francesco Vitali, Axel Wein, Timo Rath, Markus Eckstein, Clemens Neufert, Jürgen Siebler, Raja Atreya, Arndt Hartmann, Werner Hohenberger, Klaus Weber, Markus Friedrich Neurath, Robert Grützmann, Susanne Merkel,

<h4>Purpose</h4>Patients with inflammatory bowel disease (IBD) have an increased risk for colorectal cancer (CRC). In IBD patients, cancer is often diagnosed in advanced stages and conflicting data on survival compared to sporadic CRC have been reported. The aim of this study was to directly compare clinical characteristics and prognosis of ... Read more >>

Int J Colorectal Dis (International journal of colorectal disease)
[2021, :]

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The Ominous Ouzo Party - A Case Series of Four Patients with Accidental Alkali Ingestion.

Marcel Vetter, Timo Rath, Jürgen Siebler, Maximilian Waldner, Markus F Neurath, Lukas Pfeifer,

<h4>Background</h4>Ingestion of alkaline fluids is a common problem, which can lead to perforations, strictures and malignancy. We present a rare case series of several patients who accidentally ingested the same alkaline substance in different doses.<h4>Methods</h4>We investigated four patients with accidental ingestion of dishwashing liquid. All patients underwent gastroscopy within 24h ... Read more >>

Clin Exp Gastroenterol (Clinical and experimental gastroenterology)
[2021, 14:303-308]

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Targeting of the Tec Kinase ITK Drives Resolution of T Cell-Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis.

Kristina Lechner, Stefanie Mott, Ragheed Al-Saifi, Lisa Knipfer, Stefan Wirtz, Raja Atreya, Michael Vieth, Timo Rath, Tina Fraass, Zoltan Winter, Avery August, Jeremy Luban, Valérie S Zimmermann, Benno Weigmann, Markus F Neurath,

<h4>Background & aims</h4>The molecular checkpoints driving T cell activation and cytokine responses in ulcerative colitis (UC) are incompletely understood. Here, we studied the Tec kinase ITK in UC.<h4>Methods</h4>We analyzed patients with inflammatory bowel disease (n = 223) and evaluated ITK activity as well as the functional effects of cyclosporine-A (CsA). In ... Read more >>

Gastroenterology (Gastroenterology)
[2021, 161(4):1270-1287.e19]

Cited: 1 time

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Innovative Diagnostic Endoscopy in Inflammatory Bowel Diseases: From High-Definition to Molecular Endoscopy.

Christian Bojarski, Maximilian Waldner, Timo Rath, Sebastian Schürmann, Markus F Neurath, Raja Atreya, Britta Siegmund,

High-definition endoscopy is one essential step in the initial diagnosis of inflammatory bowel disease (IBD) characterizing the extent and severity of inflammation, as well as discriminating ulcerative colitis (UC) from Crohn's disease (CD). Following general recommendations and national guidelines, individual risk stratification should define the appropriate surveillance strategy, biopsy protocol ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:655404]

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Cross-sectional imaging of intestinal barrier dysfunction by confocal laser endomicroscopy can identify patients with food allergy in vivo with high sensitivity.

Timo Rath, Walburga Dieterich, Christiane Kätscher-Murad, Markus F Neurath, Yurdagül Zopf,

Food allergy (FA) affects approximately 3 to 4% of the adult population in westernized countries. Suspected FA is even more prevalent and requires extensive diagnostic work-up. Within this study, we evaluated whether assessment of the integrity of the epithelial barrier by confocal laser endomicroscopy (CLE) during colonoscopy can be used ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):12777]

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Computer-aided detection of colorectal polyps using a newly generated deep convolutional neural network: from development to first clinical experience.

Lukas Pfeifer, Clemens Neufert, Moritz Leppkes, Maximilian J Waldner, Michael Häfner, Albert Beyer, Arthur Hoffman, Peter D Siersema, Markus F Neurath, Timo Rath,

<h4>Aim</h4>The use of artificial intelligence represents an objective approach to increase endoscopist's adenoma detection rate (ADR) and limit interoperator variability. In this study, we evaluated a newly developed deep convolutional neural network (DCNN) for automated detection of colorectal polyps ex vivo as well as in a first in-human trial.<h4>Methods</h4>For training ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, :]

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Current Endoscopic Resection Techniques for Gastrointestinal Lesions: Endoscopic Mucosal Resection, Submucosal Dissection, and Full-Thickness Resection.

Arthur Hoffman, Raja Atreya, Timo Rath, Markus Ferdinand Neurath,

<h4>Background</h4>Endoscopic resection of dysplastic lesions in early stages of cancer reduces mortality rates and is recommended by many national guidelines throughout the world. Snare polypectomy and endoscopic mucosal resection (EMR) are established techniques of polyp removal. The advantages of these methods are their relatively short procedure times and acceptable complication ... Read more >>

Visc Med (Visceral medicine)
[2021, 37(5):358-371]

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An International Multicenter Real-Life Prospective Study of Electronic Chromoendoscopy Score PICaSSO in Ulcerative Colitis.

Marietta Iacucci, Samuel C L Smith, Alina Bazarova, Uday N Shivaji, Pradeep Bhandari, Rosanna Cannatelli, Marco Daperno, Jose Ferraz, Martin Goetz, Xianyong Gui, Bu Hayee, Gert De Hertogh, Mark Lazarev, Jim Li, Olga M Nardone, Adolfo Parra-Blanco, Luca Pastorelli, Remo Panaccione, Vincenzo Occhipinti, Timo Rath, Gian Eugenio Tontini, Michael Vieth, Vincenzo Villanacci, Davide Zardo, Raf Bisschops, Ralf Kiesslich, Subrata Ghosh,

<h4>Background & aims</h4>Endoscopic and histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre (PICaSSO) and other established endoscopic scores against multiple histological indices and prospectively assessed outcomes.<h4>Methods</h4>In this prospective multicenter international study, inflammatory activity ... Read more >>

Gastroenterology (Gastroenterology)
[2021, 160(5):1558-1569.e8]

Cited: 3 times

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Multicenter cohort study of patients with buried bumper syndrome treated endoscopically with a novel, dedicated device.

Deborah Costa, Edward J Despott, Nikolaos Lazaridis, Jeremy Woodward, Pavel Kohout, Timo Rath, Louise Scovell, Ian Gee, Pieter Hindryckx, Ewan Forrest, Coral Hollywood, Stephen Hearing, Imtiyaz Mohammed, Claudia Coppo, Nikolaos Koukias, Rachel Cooney, Hemant Sharma, Zeino Zeino, Ian Gooding, Alberto Murino,

<h4>Background and aims</h4>Buried bumper syndrome (BBS) is a rare adverse event of percutaneous endoscopic gastrostomy (PEG) placement in which the internal bumper migrates through the stomal tract to become embedded within the gastric wall. Excessive tension between the internal and external bumpers, causing ischemic necrosis of the gastric wall, is ... Read more >>

Gastrointest Endosc (Gastrointestinal endoscopy)
[2021, 93(6):1325-1332]

Cited: 1 time

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Long-term effectiveness, safety and immunogenicity of the biosimilar SB2 in inflammatory bowel disease patients after switching from originator infliximab.

Sarah Fischer, Sarah Cohnen, Entcho Klenske, Heike Schmitt, Francesco Vitali, Simon Hirschmann, Andreas Ramming, Sebastian Zundler, Timo Rath, Sabine Krebs, Frank Dörje, Wolfgang Uter, Daniel Nagore, Sebastian Meyer, Markus F Neurath, Raja Atreya,

<h4>Background</h4>Long-term data on inflammatory bowel disease (IBD) patients switched from originator to biosimilar infliximab SB2 are lacking. The aim of the conducted study was to investigate the effectiveness, immunogenicity and safety of a large prospectively followed-up IBD patient cohort that was entirely switched from originator infliximab to biosimilar SB2 treatment.<h4>Methods</h4>This ... Read more >>

Therap Adv Gastroenterol (Therapeutic advances in gastroenterology)
[2021, 14:1756284820982802]

Cited: 2 times

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Endoscopic recanalization of complete esophageal obstruction.

Francesco Vitali, Andreas Nägel, Lukas Pfeifer, Martin Goetz, Jürgen Siebler, Markus F Neurath, Timo Rath,

<h4>Background and aims</h4>Complete esophageal obstruction (CEO) is a rare complication after radiochemotherapy that dramatically impairs quality of life. Within this study, we assessed the outcome of two different endoscopic techniques for lumen restoration in patients with CEO.<h4>Methods</h4>17 patients were included. Esophageal recanalization was performed in an antegrade approach (Group A) ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, 35(6):3184-3188]

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Is histological healing a feasible endpoint in ulcerative colitis?

Timo Rath, Raja Atreya, Markus F Neurath,

<h4>Introduction</h4>Currently, treatment goals in ulcerative colitis aim to achieve clinical remission and endoscopic mucosal healing. Emerging evidence suggests that histologic assessment of inflammation is a sensitive marker that can outcompete mucosal healing in predicting the clinical course of disease in patients with ulcerative colitis. Based on this, histologic healing is ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2021, 15(6):665-674]

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Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn's disease.

Corinna Lang-Schwarz, Abbas Agaimy, Raja Atreya, Christoph Becker, Silvio Danese, Jean-François Fléjou, Nikolaus Gaßler, Heike I Grabsch, Arndt Hartmann, Kateřina Kamarádová, Anja A Kühl, Gregory Y Lauwers, Alessandro Lugli, Iris Nagtegaal, Markus F Neurath, Georg Oberhuber, Laurent Peyrin-Biroulet, Timo Rath, Robert Riddell, Carlos A Rubio, Kieran Sheahan, Herbert Tilg, Vincenzo Villanacci, Maria Westerhoff, Michael Vieth,

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, 478(3):581-594]

Cited: 2 times

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IL-13 as Target to Reduce Cholestasis and Dysbiosis in Abcb4 Knockout Mice.

Luisa Hahn, Nora Helmrich, Diran Herebian, Ertan Mayatepek, Uta Drebber, Eugen Domann, Stefan Olejniczak, Markus Weigel, Torsten Hain, Timo Rath, Stefan Wirtz, Hans-Joachim Mollenkopf, Nadine Schmidt, Christa Ewers, Anne Baier, Yuri Churin, Anita Windhorst, Ralf Weiskirchen, Ulrich Steinhoff, Elke Roeb, Martin Roderfeld,

The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in an <i>Abcb4-</i>knockout mouse model (<i>Abcb4</i><sup>-/-</sup>). Lack of IL-13 ... Read more >>

Cells (Cells)
[2020, 9(9):]

Cited: 1 time

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Successful cyclosporin and ustekinumab combination therapy in a patient with severe steroid-refractory ulcerative colitis.

Ingo Ganzleben, Carol Geppert, Lourdes Osaba, Simon Hirschmann, Andreas Nägel, Christian Glück, Arthur Hoffman, Timo Rath, Daniel Nagore, Markus F Neurath, Raja Atreya,

The therapeutic management of patients with severe steroid-refractory ulcerative colitis still represents a critical clinical challenge. In this setting, cyclosporin is an effective and rapidly acting induction treatment that is applied in combination with maintenance therapeutic agents like thiopurines or vedolizumab. Here, we present the case of a 33-year-old ulcerative ... Read more >>

Therap Adv Gastroenterol (Therapeutic advances in gastroenterology)
[2020, 13:1756284820954112]

Cited: 0 times

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Perforations after routine biopsy in IBD patients, their management and potential risk reductions by microscopic imaging with endocytoscopy.

Entcho Klenske, Arndt Hartmann, Raja Atreya, Markus Neurath, Timo Rath,

J Gastrointestin Liver Dis (Journal of gastrointestinal and liver diseases : JGLD)
[2020, 29(3):465-466]

Cited: 0 times

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FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity.

Jonathan J Hubbard, Michal Pyzik, Timo Rath, Lisa K Kozicky, Kine M K Sand, Amit K Gandhi, Algirdas Grevys, Stian Foss, Susan C Menzies, Jonathan N Glickman, Edda Fiebiger, Derry C Roopenian, Inger Sandlie, Jan Terje Andersen, Laura M Sly, Kristi Baker, Richard S Blumberg,

IgG immune complexes (ICs) promote autoimmunity through binding fragment crystallizable (Fc) γ-receptors (FcγRs). Of these, the highly prevalent FcγRIIa (CD32a) histidine (H)-131 variant (CD32aH) is strongly linked to human autoimmune diseases through unclear mechanisms. We show that, relative to the CD32a arginine (R)-131 (CD32aR) variant, CD32aH more avidly bound human ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2020, 217(10):]

Cited: 3 times

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The JAK1/3 inhibitor tofacitinib suppresses T cell homing and activation in chronic intestinal inflammation.

Katharina Gerlach, Kristina Lechner, Vanessa Popp, Laura Offensperger, Sebastian Zundler, Maximilian Wiendl, Emily Becker, Raja Atreya, Timo Rath, Markus F Neurath, Benno Weigmann,

<h4>Background & aims</h4>The molecular mechanism of action of the Janus kinase (JAK) inhibitor tofacitinib is poorly understood.<h4>Methods</h4>Here, we analysed the inhibitory effect of tofacitinib on mucosal and blood T cells from patients with ulcerative colitis (UC). Furthermore tofacitinib treatment was analysed in experimental colitis models and wound healing. Additionally, tofacitinib ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2020, :]

Cited: 6 times

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Technical success, resection status, and procedural complication rate of colonoscopic full-wall resection: a pooled analysis from 7 hospitals of different care levels.

Irmengard Krutzenbichler, Markus Dollhopf, Helmut Diepolder, Andreas Eigler, Martin Fuchs, Simon Herrmann, Gerhard Kleber, Björn Lewerenz, Christoph Kaiser, Tilman Lilje, Timo Rath, Ayman Agha, Francesco Vitali, Claus Schäfer, Wolfgang Schepp, Felix Gundling,

<h4>Introduction</h4>Endoscopic full-thickness resection (eFTR) using the full-thickness resection device (FTRD®) is a novel minimally invasive procedure that allows the resection of various lesions in the gastrointestinal tract including the colorectum. Real-world data outside of published studies are limited. The aim of this study was a detailed analysis of the outcomes ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, 35(7):3339-3353]

Cited: 0 times

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Endoscopic management of buried bumper syndrome using a novel grasping-type scissor forceps.

Timo Rath, Francesco Vitali, Andreas Nägel, Markus F Neurath,

Endoscopy (Endoscopy)
[2021, 53(1):E21-E22]

Cited: 1 time

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The TLR9 Agonist Cobitolimod Induces IL10-Producing Wound Healing Macrophages and Regulatory T Cells in Ulcerative Colitis.

Heike Schmitt, Julia Ulmschneider, Ulrike Billmeier, Michael Vieth, Patrizio Scarozza, Sophia Sonnewald, Stephen Reid, Imke Atreya, Timo Rath, Sebastian Zundler, Melanie Langheinrich, Jürgen Schüttler, Arndt Hartmann, Thomas Winkler, Charlotte Admyre, Thomas Knittel, Christine Dieterich Johansson, Arezou Zargari, Markus F Neurath, Raja Atreya,

<h4>Background and aims</h4>The topically applied Toll-like receptor 9 [TLR9] agonist cobitolimod is a first-in-class DNA-based oligonucleotide with demonstrated therapeutic efficacy in clinical trials with ulcerative colitis [UC] patients. We here characterized its anti-inflammatory mechanism in UC.<h4>Methods</h4>Luminal cobitolimod administration was evaluated in an experimental dextran sodium sulfate [DSS]-induced colitis model. Cultured ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2020, 14(4):508-524]

Cited: 6 times

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Label-Free In Vivo Histopathology of Experimental Colitis via 3-Channel Multiphoton Endomicroscopy.

Lucas Kreiß, Oana-Maria Thoma, Ashwathama Dilipkumar, Birgitta Carlé, Pascal Longequeue, Timo Kunert, Timo Rath, Kai Hildner, Clemens Neufert, Michael Vieth, Markus F Neurath, Oliver Friedrich, Sebastian Schürmann, Maximilian J Waldner,

Gastroenterology (Gastroenterology)
[2020, 159(3):832-834]

Cited: 1 time

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Retrograde inspection vs standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial.

Timo Rath, Lukas Pfeifer, Clemens Neufert, Andreas Kremer, Moritz Leppkes, Arthur Hoffman, Markus F Neurath, Steffen Zopf,

<h4>Background</h4>The adenoma detection rate (ADR) is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during screening colonoscopy. However, adenoma miss rates reach up to 26% and studies have shown that a second inspection of the right colon in retroflected view (RFV) can ... Read more >>

World J Gastroenterol (World journal of gastroenterology)
[2020, 26(16):1962-1970]

Cited: 0 times

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Functional Molecular Network Analysis Enables Prediction of Response to Vedolizumab Therapy in Anti-TNF Refractory IBD Patients.

Matthias Breidert, Pierre Eftekhari, François Louis, Claudia Rotoiu, Timo Rath, Markus F Neurath, Raja Atreya,

Background:We applied for the first time 2 label-free technologies, physiological intermolecular modulation spectroscopy (PIMS) and nematic protein organization technic (NPOT) in anti-tumor necrosis factor (TNF) refractory inflammatory bowel disease (IBD) patients to identify clinical responders to vedolizumab therapy and elucidate their underlying functional molecular network. Methods:PIMS analysis was performed in ... Read more >>

Crohns Colitis 360 (Crohn's & colitis 360)
[2020, 2(2):otaa037]

Cited: 0 times

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