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Cytokeratin 5 and cytokeratin 20 inversely correlate with tumour grading in Ta non-muscle-invasive bladder cancer.

Tim Muilwijk, Murat Akand, Frank Van der Aa, Vincent De Coninck, Marc Claessens, Robert Hente, Markus Eckstein, Yves Allory, Louis Libbrecht, Steven Joniau, Thomas Gevaert,

Cytokeratin 5 is a marker of basal molecular subtypes of muscle-invasive bladder cancer (MIBC), which correlates with worse overall survival compared to luminal subtypes. Our observations have not confirmed CK5 as a marker of high-grade (HG) disease in Ta non-muscle-invasive bladder cancer (NMIBC). Therefore, to understand the basal-luminal immunohistochemistry profile ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, :]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Recommendations to Balance Benefits and Risks Of Thromboprophylaxis and to Avoid Central Venous-access Devices During First-line Chemotherapy in Men with Metastatic Germ Cell Tumors: The European Association Of Urology Testicular Cancer Panel Position in 2021.

Christian Daniel Fankhauser, Jan Oldenburg, Peter Albers, Ferran Algaba, Carsten Bokemeyer, Joost L Boormans, Stefanie Fischer, Karim Fizazi, Hendrik Gremmels, Javier Mayor de Castro, Florian Janisch, Tim Muilwijk, Ricardo Leão, David Nicol, Nicola Nicolai, Torgrim Tandstad, M Pilar Laguna,

Men with metastatic germ cell tumors undergoing chemotherapy are at high risk of venous thromboembolic events and low risk of bleeding. A central venous-access device should be avoided whenever possible. Thromboprophylaxis may be prescribed after balancing the risks and benefits for each individual patient. ... Read more >>

Eur Urol (European urology)
[2021, 80(1):4-6]

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Head-to-Head Comparison of Two Nomograms Predicting Probability of Lymph Node Invasion in Prostate Cancer and the Therapeutic Impact of Higher Nomogram Threshold.

Zilvinas Venclovas, Tim Muilwijk, Aivaras J Matjosaitis, Mindaugas Jievaltas, Steven Joniau, Daimantas Milonas,

<i>Introduction</i>: The aim of the study was to compare the performance of the 2012 Briganti and Memorial Sloan Kettering Cancer Center (MSKCC) nomograms as a predictor for pelvic lymph node invasion (LNI) in men who underwent radical prostatectomy (RP) with pelvic lymph node dissection (PLND), to examine their performance and ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(5):]

Cited: 1 time

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Benefits and harms of the new prostate cancer grade grouping on the prediction of long-term oncological outcomes in patients after radical prostatectomy.

Daimantas Milonas, Tim Muilwijk, Zilvinas Venclovas, Gaëtan Devos, Steven Joniau,

<h4>Objective</h4>To investigate whether the new prostate cancer grade groups model provides significant predictive value and better patient stratification on tumor progression after radical prostatectomy compared with the former Gleason grading models.<h4>Methods</h4>Men treated at a tertiary center by radical prostatectomy between 2005 and 2017 were analyzed. The outcomes of interest were ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, 28(4):390-395]

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Assessment of the oncological outcomes of three different bacillus Calmette-Guérin strains in patients with high-grade T1 non-muscle-invasive bladder cancer.

Łukasz Nowak, Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Sławomir Poletajew, Andrzej Tukiendorf, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Rossella Orlando, Ettore Di Trapani, Mario Alvarez-Maestro, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy, ,

<h4>Objective</h4>: To determine whether there are significant differences in oncological outcomes between three different bacillus Calmette-Guérin (BCG) strains used for adjuvant intravesical immunotherapy in patients with high-grade T1 (T1HG) non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>: Data of 590 patients with a diagnosis of primary T1HG NMIBC were retrospectively reviewed. The ... Read more >>

Arab J Urol (Arab journal of urology)
[2021, 19(1):78-85]

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The potential of tumour microenvironment markers to stratify the risk of recurrence in prostate cancer patients.

Thomas Gevaert, Yves-Rémi Van Eycke, Thomas Vanden Broeck, Hein Van Poppel, Isabelle Salmon, Sandrine Rorive, Tim Muilwijk, Frank Claessens, Dirk De Ridder, Steven Joniau, Christine Decaestecker,

The tumour micro-environment (TME) plays a crucial role in the onset and progression of prostate cancer (PCa). Here we studied the potential of a selected panel of TME-markers to predict clinical recurrence (CLR) in PCa. Patient cohorts were matched for the presence or absence of CLR 5 years post-prostatectomy. Tissue ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0244663]

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Comparison of postoperative complications of ileal conduits versus orthotopic neobladders.

Liesbeth Demaegd, Maarten Albersen, Tim Muilwijk, Uros Milenkovic, Lisa Moris, Wouter Everaerts, Hendrik Van Poppel, Frank Van der Aa, Steven Joniau, Murat Akand,

<h4>Background</h4>Radical cystectomy (RC) and urinary diversion (UD), with either an ileal conduit (IC) or an orthotopic neobladder (NB), is a complex surgery, in which various complications can occur. In this study, we compared postoperative complication rates after a RC and UD performed for the treatment of muscle-invasive bladder cancer or ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(6):2541-2554]

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Delaying BCG immunotherapy onset after transurethral resection of non-muscle-invasive bladder cancer is associated with adverse survival outcomes.

Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Yuen-Chun Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Francesco Cianflone, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodríguez-Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Ekaterina Laukhtina, Karl Tully, Anna Kołodziej, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy, ,

<h4>Purpose</h4>This study was carried out to assess whether a prolonged time between primary transurethral resection of non-muscle-invasive bladder cancer (TURB) and implementation of bacillus Calmette-Guerin (BCG) immunotherapy (time to BCG; TTBCG) is associated with adverse oncological survival in patients with T1 high-grade (HG) non-muscle-invasive bladder cancer (NMIBC).<h4>Materials and methods</h4>Data on 429 ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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Pre-therapy serum albumin-to-globulin ratio in patients treated with neoadjuvant chemotherapy and radical nephroureterectomy for upper tract urothelial carcinoma.

Benjamin Pradere, David D'Andrea, Victor M Schuettfort, Beat Foerster, Fahad Quhal, Keiichiro Mori, Mohammad Abufaraj, Vitaly Margulis, Marine Deuker, Alberto Briganti, Tim Muilwijk, Kees Hendricksen, Yair Lotan, Pierre Karakiewic, Shahrokh F Shariat, ,

<h4>Purpose</h4>The accurate selection of patients who are most likely to benefit from neoadjuvant chemotherapy is an important challenge in oncology. Serum AGR has been found to be associated with oncological outcomes in various malignancies. We assessed the association of pre-therapy serum albumin-to-globulin ratio (AGR) with pathologic response and oncological outcomes ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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Restaging Transurethral Resection of Bladder Tumours after BCG Immunotherapy Induction in Patients with T1 Non-Muscle-Invasive Bladder Cancer Might not Be Associated with Oncologic Benefit.

Wojciech Krajewski, Marco Moschini, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Alessandra Gozzo, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodriguez Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Paweł Rajwa, Ekaterina Laukhtina, Aleksandra Zdrojowy-Wełna, Anna Kołodziej, Andrzej Paradysz, Karl Tully, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy,

<h4>Background and purpose</h4>The European Association of Urology guidelines recommend restaging transurethral resection of bladder tumours (reTURB) 2-6 weeks after primary TURB. However, in clinical practice some patients undergo a second TURB procedure after Bacillus Calmette-Guérin immunotherapy (BCG)induction. To date, there are no studies comparing post-BCG reTURB with the classic pre-BCG ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(10):]

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Patient-reported outcomes after buccal mucosal graft urethroplasty for bulbar urethral strictures: results of a prospective single-centre cohort study.

Pieter D'hulst, Tim Muilwijk, Kathy Vander Eeckt, Frank Van der Aa, Steven Joniau,

<h4>Objectives</h4>To describe patient-reported outcome measures (PROMs) after buccal mucosa graft (BMG) urethroplasty.<h4>Materials and methods</h4>We prospectively collected PROMs in patients who underwent BMG urethroplasty for bulbar urethral strictures between October 2009 and February 2017. Preoperatively and at the first, second and third postoperative follow-up visits, patients completed five PROM questionnaires: the ... Read more >>

BJU Int (BJU international)
[2020, 126(6):684-693]

Cited: 1 time

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The Cancer of the Bladder Risk Assessment (COBRA) score for estimating cancer-specific survival after radical cystectomy: external validation in a large bi-institutional cohort.

Tim Muilwijk, Murat Akand, Francesco Soria, Andrea Giordano, Uros Milenkovic, Lisa Moris, Thomas Gevaert, Hendrik Van Poppel, Maarten Albersen, Paolo Gontero, Steven Joniau,

<h4>Objective</h4>To perform an external validation of the Cancer of the Bladder Risk Assessment (COBRA) score for estimating cancer-specific survival (CSS) after radical cystectomy (RC) in a large bi-institutional cohort of patients.<h4>Patients and methods</h4>Patients treated with RC and lymph node dissection (LND) between May 1996 and July 2017 were retrieved from ... Read more >>

BJU Int (BJU international)
[2020, 126(6):704-714]

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Impact of Sex on Response to Neoadjuvant Chemotherapy in Patients with Upper-tract Urothelial Cancer.

David D'Andrea, Beat Foerster, Surena F Matin, Ja H Ku, Tim Muilwijk, Leonardo L Monteiro, Ross Liao, Firas G Petros, Philippe E Spiess, Trinity J Bivalacqua, Kees Hendricksen, Bas W G van Rhijn, Ahmad Shabsigh, Alberto Briganti, Steven Joniau, Wassim Kassouf, Phillip M Pierorazio, Vitaly Margulis, Andrea Necchi, Shahrokh F Shariat, ,

Eur Urol Open Sci (European urology open science)
[2020, 19:16-19]

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Time to change the management of upper urinary tract urothelial carcinoma.

Murat Akand, Tim Muilwijk, Frank Van Der Aa, Steven Joniau,

Cent European J Urol (Central European journal of urology)
[2020, 73(3):381-382]

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Metastasectomy of oligometastatic urothelial cancer: a single-center experience.

Tim Muilwijk, Murat Akand, Frank Van der Aa, Herlinde Dumez, Gert De Meerleer, Dirk Van Raemdonck, Paul De Leyn, Hendrik Van Poppel, Maarten Albersen, Steven Joniau,

<h4>Background</h4>Survival in patients with urothelial cancer (UC) recurrence after initial treatment with curative intent is limited and treatment options are sparse. Metastasectomy could be considered a treatment option in selected cases. Identifying prognostic factors for survival can be used to counsel patients and aid multidisciplinary teams in making treatment decisions.<h4>Methods</h4>We ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(3):1296-1305]

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Treatment of High-grade Non-muscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG Instillations Versus Reduced Number and Standard Dose of BCG Instillations: Results of the European Association of Urology Research Foundation Randomised Phase III Clinical Trial "NIMBUS".

Marc-Oliver Grimm, Antoine G van der Heijden, Marc Colombel, Tim Muilwijk, Luis Martínez-Piñeiro, Marko M Babjuk, Levent N Türkeri, Joan Palou, Anup Patel, Anders S Bjartell, Christien Caris, Raymond G Schipper, Wim P J Witjes, ,

<h4>Background</h4>Intravesical instillation of bacillus Calmette-Guérin (BCG) is an accepted strategy to prevent recurrence of non-muscle-invasive bladder cancer (NMIBC) but associated with significant toxicity.<h4>Objective</h4>NIMBUS assessed whether a reduced number of standard-dose BCG instillations are noninferior to the standard number and dose in patients with high-grade NMIBC.<h4>Design, setting, and participants</h4>A total of ... Read more >>

Eur Urol (European urology)
[2020, 78(5):690-698]

Cited: 3 times

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Prognostic score predicts overall survival following complete urinary tract extirpation.

Murat Akand, Tim Muilwijk, Frank Van Der Aa, Thomas Gevaert, Uros Milenkovic, Lisa Moris, Wim Blyweert, Hendrik Van Poppel, Maarten Albersen, Steven Joniau,

<b>Purpose:</b> To evaluate the oncological outcome and complications of patients treated with complete urinary tract extirpation (CUTE) in our department, and to identify prognostic factors for survival.<b>Methods:</b> Clinico-pathological data of patients treated with one-step or stepwise CUTE between 1999 and 2017 were collected retrospectively. Complications were classified according to the ... Read more >>

Scand J Urol (Scandinavian journal of urology)
[2020, 54(1):70-79]

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External validation of Memorial Sloan Kettering Cancer Center nomogram and prediction of optimal candidate for lymph node dissection in clinically localized prostate cancer.

Daimantas Milonas, Zilvinas Venclovas, Tim Muilwijk, Mindaugas Jievaltas, Steven Joniau,

Introduction:The aim of our study was to evaluate the external validity of the online Memorial Sloan Kettering Cancer Center (MSKCC) nomogram as a predictor for pelvic lymph node invasion (LNI) in men who underwent radical prostatectomy (RP) with pelvic lymph node dissection (PLND). Material and methods:The study cohort consisted of ... Read more >>

Cent European J Urol (Central European journal of urology)
[2020, 73(1):19-25]

Cited: 2 times

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Development of a Prospective Data Registry System for Non-muscle-Invasive Bladder Cancer Patients Incorporated in the Electronic Patient File System.

Murat Akand, Tim Muilwijk, Jan Cornelissen, Siska Van Bruwaene, Kathy Vander Eeckt, Frederic Baekelandt, Pieter Mattelaer, Raf Van Reusel, Ben Van Cleynenbreugel, Steven Joniau, Frank Van Der Aa,

Purpose: To develop a prospective non-muscle-invasive bladder cancer (NMIBC) data registry by generating NMIBC-specific electronic case report forms (eCRFs) in our institution's electronic patient file system, and to report on the development and implementation of a prospective multicentric registry. Methods: Templates for data collection, including clinical outcome parameters and quality ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:1402]

Cited: 1 time

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Efficacy of Preoperative Chemotherapy for High Risk Upper Tract Urothelial Carcinoma.

Beat Foerster, Mohammad Abufaraj, Firas Petros, Mounsif Azizi, Mohit Gupta, Donald Schweitzer, Vitaly Margulis, Takehiro Iwata, Shoji Kimura, Ahmad Shabsigh, Alberto Briganti, Ja H Ku, Tim Muilwijk, Wassim Kassouf, Surena F Matin, Philippe E Spiess, Phillip M Pierorazio, Kees Hendricksen, Shahrokh F Shariat, ,

PURPOSE:The impact of preoperative chemotherapy in patients with upper urinary tract urothelial carcinoma remains poorly investigated. We assessed the rates of pathological complete response (pT0N0/X) and downstaging (pT1N0/X or less) at radical nephroureterectomy after preoperative chemotherapy and evaluated their impact on survival. MATERIALS AND METHODS:This was an international observational study ... Read more >>

J Urol (The Journal of urology)
[2020, 203(6):1101-1108]

Cited: 2 times

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Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography with Computed Tomography for Lymph Node Staging in Patients with Upper Tract Urothelial Carcinoma.

Charlotte S Voskuilen, Donald Schweitzer, Jørgen Bjerggaard Jensen, Anna M Nielsen, Steven Joniau, Tim Muilwijk, Andrea Necchi, Mounsif Azizi, Philippe E Spiess, Alberto Briganti, Marco Bandini, Karolien Goffin, Kirsten Bouchelouche, Erik van Werkhoven, Shahrokh F Shariat, Evanguelos Xylinas, Nessn H Azawi, Ja Hyeon Ku, Beat Foerster, Bas W G van Rhijn, Erik Vegt, Kees Hendricksen,

<h4>Background</h4>Presence of lymph node metastases (LNM) is an important prognostic factor for cancer-specific survival (CSS) in patients with upper tract urothelial carcinoma (UTUC). In various neoplasms, <sup>18</sup>F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) is an established modality for preoperative lymph node (LN) staging. In UTUC, the diagnostic value of ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(1):73-79]

Cited: 3 times

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Comparison of Peri-operative and Early Oncological Outcomes of Robot-Assisted vs. Open Salvage Lymph Node Dissection in Recurrent Prostate Cancer.

Gaëtan Devos, Tim Muilwijk, Yannic Raskin, Victor Calderon, Lisa Moris, Thomas Van den Broeck, Charlien Berghen, Gert De Meerleer, Maarten Albersen, Hendrik Van Poppel, Wouter Everaerts, Steven Joniau,

Introduction: Salvage lymph node dissection (sLND) has been proposed as a treatment option for prostate cancer patients with lymph node (LN) recurrence following radical prostatectomy to delay or avoid palliative androgen deprivation therapy (ADT). Historically sLND has been performed using an open approach, with its associated morbidity. A limited number ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:781]

Cited: 1 time

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Quality Control Indicators for Transurethral Resection of Non-Muscle-Invasive Bladder Cancer.

Murat Akand, Tim Muilwijk, Yannic Raskin, Maxime De Vrieze, Steven Joniau, Frank Van Der Aa,

Complete transurethral resection of bladder tumor (TURBT) is the initial procedure of choice for non-muscle-invasive bladder cancer, but its quality is far from optimal in clinical practice. We evaluated the existing body of evidence substantiating current quality control indicators (QCIs) for TURBT. A literature search was performed using PubMed and ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2019, 17(4):e784-e792]

Cited: 4 times

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