Full Text Journal Articles by
Author Tianliangwen Zhou

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Assessing the variations in breast/ovarian cancer risk for Chinese BRCA1/2 carriers

Ang Li, Yi Zi, Jiaqi Luo, Xiaobin You, Zhaoji Lan, Tianliangwen Zhou, Yangming Wu, Qihuan Zhi, Huijun Su, Mei Zhu, Siwen Xu, Yun Gao, Zaixuan Zhong, Ling Xie, Yuanqin Wang, Qiuping Lin, Xiaoting Li, Jiamin Zhan, Hui Weng, Dan Li, Shulan Xu, Gang Sun, Yujian Shi,

<h4>Background</h4> Cancer risks vary in different BRCA1/2 mutations. Previous studies based on Caucasian population have identified regions associated with elevated/reduced risks of breast/ovarian cancers. Since ethnic differences are known to affect BRCA1/2 mutation spectra, we are interested in defining Chinese-specific ovarian/breast cancer cluster regions (OCCR/BCCR) and comparing with previously reported ... Read more >>

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T-CNV: a robust tool for detecting and visualizing copy number variants in targeted sequencing data.

liu ye, wu yangming, zheng zexin, zhou tianliangwen,

<h4>Background: </h4> Copy number variants (CNVs) are widespread among human genes, causing Mendelian or sporadic traits, or associating with complex diseases. Several tools have been developed for CNV assessment based on next generation sequencing (NGS) data using Read-depth (RD) strategy. However, maintaining high level of sensitivity and specificity is always ... Read more >>

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Retrospective reinterpretation and reclassification of BRCA1/2 variants from Chinese population.

Dan Li, Yujian Shi, Ang Li, Dandan Cao, Huijun Su, Haiqi Yang, Qihuan Zhi, Yuchen Yang, Zhaoji Lan, Tianliangwen Zhou, Xiaobin You, Guifang Hu,

<h4>Background</h4>The accurate interpretation of BRCA1/2 variants becomes increasingly important in breast cancer and other related cancers including ovarian cancer, prostate cancer, pancreatic cancer and so forth. In the past decades, especially before year 2015, limitations of techniques and lack of databases and guidelines have led to possible misinterpretation of the ... Read more >>

Breast Cancer (Breast cancer (Tokyo, Japan))
[2020, 27(6):1158-1167]

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Assessing concordance among human, in silico predictions and functional assays on genetic variant classification.

Jiaqi Luo, Tianliangwen Zhou, Xiaobin You, Yi Zi, Xiaoting Li, Yangming Wu, Zhaoji Lan, Qihuan Zhi, Dandan Yi, Lei Xu, Ang Li, Zaixuan Zhong, Mei Zhu, Gang Sun, Tao Zhu, Jianmei Rao, Luhua Lin, Jianfeng Sang, Yujian Shi,

<h4>Motivation</h4>A variety of in silico tools have been developed and frequently used to aid high-throughput rapid variant classification, but their performances vary, and their ability to classify variants of uncertain significance were not systemically assessed previously due to lack of validation data. This has been changed recently by advances of ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2019, 35(24):5163-5170]

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Rapid diagnosis of Propionibacterium acnes infection in patient with hyperpyrexia after hematopoietic stem cell transplantation by next-generation sequencing: a case report.

Mingzhi Ye, Wei Wei, Zhikai Yang, Yingzhen Li, Shaomin Cheng, Kang Wang, Tianliangwen Zhou, Jingmeng Sun, Sha Liu, Na Ni, Hui Jiang, Hua Jiang,

<h4>Background</h4>The rapid determination of pathogenic agent is very important to clinician for guiding their clinical medication. However, current diagnostic methods are of limitation in many aspects, such as detecting range, time-consuming, specificity and sensitivity. In this report, we apply our new-developing pathogen detection method to clarify that Propionibacterium acnes is ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2016, 16:5]

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