Full Text Journal Articles by
Author Tian Xia

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A novel nanostructure to achieve ultrahigh strength and good tensile ductility of a CoCrFeNiMn high entropy alloy.

Yuehuang Xie, Tian Xia, Dengshan Zhou, Yifei Luo, Wei Zeng, Zhen Zhang, Jun Wang, Jiamiao Liang, Deliang Zhang,

A CoCrFeNiMn high entropy alloy with a novel nanostructure consisting of ultrafine grains, TiO(C) nanoparticles and nanotwins has been fabricated. It achieves an ultrahigh tensile yield strength of 1507 MPa by coupling multiple strengthening mechanisms, including grain boundary strengthening, twin boundary strengthening, nanoparticle strengthening and dislocation strengthening. The work hardening ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(9):5347-5352]

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LLGL1 regulates gemcitabine resistance by modulating ERK-SP1-OSMR pathway in pancreatic ductal adenocarcinoma.

Yin-Xin Zhu, Chi Han Li, Guolin Li, Huiyi Feng, Tian Xia, Chi Hin Wong, Frederic K C Fung, Joanna Hung-Man Tong, Ka-Fai To, Rufu Chen, Yangchao Chen,

BACKGROUND & AIMS:Gemcitabine resistance is rapidly acquired by pancreatic ductal adenocarcinoma (PDAC) patients. Novel approaches that predict gemcitabine response of patients and enhance gemcitabine chemosensitivity are important to improve patients' survival. We aimed to identify genes as novel biomarkers to predict gemcitabine response and the therapeutic targets to attenuate chemoresistance ... Read more >>

Cell Mol Gastroenterol Hepatol (Cellular and molecular gastroenterology and hepatology)
[2020, :]

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Incidence and risk factors for post-ERCP pancreatitis in pancreas divisum patients without chronic pancreatitis.

Qian-Qian Meng, Sheng-Bing Zhao, Zhi-Jie Wang, Zhen Shen, Tian Xia, Shu-Ling Wang, Lun Gu, Peng Pan, Zhao-Shen Li, Jun Yao, Yi-Hai Shi, Yu Bai,

Aims: The studies on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in pancreas divisum (PD) patients without chronic pancreatitis (CP) are rare. In this study, we aimed to evaluate the incidence of PEP in PD patients without CP and the risk and protective factors for PEP.Methods: Consecutive patients with symptomatic PD ... Read more >>

Scand. J. Gastroenterol. (Scandinavian journal of gastroenterology)
[2020, :1-5]

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Icariin accelerate fracture healing via activation of WNT1/β-catenin osteogenic signaling pathway.

Xiao-Yun Zhang, Yue-Ping Chen, Chi Zhang, Xuan Zhang, Tian Xia, Jie Han, Nan Yang, Shi-Lei Song, Can-Hong Xu,

BACKGROUND:Icariin has been shown to enhance bone formation. OBJECTIVE:The present study aimed to investigate whether icariin also promotes bone fracture healing and its mechanisms. METHODS:First, we isolated and cultured rat bone marrow stromal cells (rBMSCs) with icariin-containing serum at various concentrations (0%, 2.5%, 5% and 10%) and then measured alkaline ... Read more >>

Curr Pharm Biotechnol (Current pharmaceutical biotechnology)
[2020, :]

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Clinical, pathological, imaging, and genetic characterization in a Taiwanese cohort with limb-girdle muscular dystrophy.

Wen-Chen Liang, Yuh-Jyh Jong, Chien-Hua Wang, Chen-Hua Wang, Xia Tian, Wan-Zi Chen, Tzu-Min Kan, Narihiro Minami, Ichizo Nishino, Lee-Jun C Wong,

BACKGROUND:Limb-girdle muscular dystrophy (LGMD) is a genetically heterogeneous, hereditary disease characterized by limb-girdle weakness and histologically dystrophic changes. The prevalence of each subtype of LGMD varies among different ethnic populations. This study for the first time analyzed the phenotypes and genotypes in Taiwanese patients with LGMD in a referral center ... Read more >>

Orphanet J Rare Dis (Orphanet Journal of Rare Diseases)
[2020, 15(1):160]

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Pseudo-healthy synthesis with pathology disentanglement and adversarial learning.

Tian Xia, Agisilaos Chartsias, Sotirios A Tsaftaris,

Pseudo-healthy synthesis is the task of creating a subject-specific 'healthy' image from a pathological one. Such images can be helpful in tasks such as anomaly detection and understanding changes induced by pathology and disease. In this paper, we present a model that is encouraged to disentangle the information of pathology ... Read more >>

Med Image Anal (Medical image analysis)
[2020, 64:101719]

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Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.

Kevin McCloskey, Eric A Sigel, Steven Kearnes, Ling Xue, Xia Tian, Dennis Moccia, Diana Gikunju, Sana Bazzaz, Betty Chan, Matthew A Clark, John W Cuozzo, Marie-Aude Guié, John P Guilinger, Christelle Huguet, Christopher D Hupp, Anthony D Keefe, Christopher J Mulhern, Ying Zhang, Patrick Riley,

DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value. We demonstrate a new approach applying machine learning to DEL selection data by identifying active molecules from large libraries of commercial and easily synthesizable compounds. We train models using only DEL ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2020, :]

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Stuck-moving Needle acupuncture the Myofascial Triggers Point to treat Idiopathic Frozen Shoulders: study protocol for a randomized controlled trial

YANG BAI, Ying Wang, Bo Chen, Qianqian Lei, Hailong Zhao, Jingbao Lu, Qian Fan, Yali Wang, HongBo Song, Maomao Cheng, Wei Wang, Shengen Hu, YuanHao Du, Tian Xia,

Abstract Background There are evidences for the efficacy of acupuncture treatment for chronic shoulder pain, however it remains unclear the best acupuncture modes for effective treatment. We compared the effect of myofascial trigger point (MTrp) Stuck-moving Needle acupuncture with that of common acupuncture treatments. Further, we evaluated the efficacy ... Read more >>

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Use of artificial intelligence for detection of gastric lesions by magnetically controlled capsule endoscopy.

Ji Xia, Tian Xia, Jun Pan, Fei Gao, Shuang Wang, Yang-Yang Qian, Heng Wang, Jie Zhao, Xi Jiang, Wen-Bin Zou, Yuan-Chen Wang, Wei Zhou, Zhao-Shen Li, Zhuan Liao,

BACKGROUND AND AIMS:Magnetically controlled capsule endoscopy (MCE) has become an efficient diagnostic modality for gastric diseases. We developed a novel automatic gastric lesion detection system to assist in diagnosis and reduce inter-physician variations. This study aimed to evaluate the diagnostic capability of the computer-aided detection system for MCE images. METHODS:We ... Read more >>

Gastrointest. Endosc. (Gastrointestinal endoscopy)
[2020, :]

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Noscapine Induces Apoptosis in Human Colon Cancer Cells by Regulating Mitochondrial Damage and Warburg Effect via PTEN/PI3K/mTOR Signaling Pathway.

Xia Tian, Meng Liu, Xiaodong Huang, Qingxi Zhu, Weijie Liu, Wei Chen, Yanli Zou, Yishan Cai, Shasha Huang, Aifang Chen, Ting Zhan, Min Huang, Xiaoli Chen, Zheng Han, Jie Tan,

Background:Noscapine is an opium alkaloid that has recently been shown to potentiate anti-cancer therapeutic effects by inducing apoptosis in various malignant cells without any detectable toxicity. However, the mechanism by which noscapine induces apoptosis in colon cancer cells remains unclear. Materials and Methods:In this study, we explored the anti-cancer activity ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2020, 13:5419-5428]

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Incidence of pulmonary tuberculosis in Chinese adults with type 2 diabetes: a retrospective cohort study in Shanghai.

Yanyun Li, Juntao Guo, Tian Xia, Fei Wu, Jingyan Tian, Minna Cheng, Wanghong Xu, Qinping Yang, Jing Chen, Zheyuan Wu, Qinghua Yan, Yan Shi, Fan Wu,

To estimate the incidence of pulmonary tuberculosis (PTB) in Chinese diabetes patients and to evaluate the effect of blood glucose on PTB risk, a retrospective cohort study was built based on the diabetes management system in Shanghai and included 240,692 adults aged 35 or above. Incidences of PTB in all ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8578]

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miR‑29b promotes the osteogenic differentiation of mesenchymal stem cells derived from human adipose tissue via the PTEN/AKT/β‑catenin signaling pathway.

Tian Xia, Shuanghai Dong, Jiwei Tian,

Accumulating evidence has documented that microRNAs (miRNAs or miRs) function as important post‑transcriptional regulators of the differentiation of mesenchymal stem cells (MSCs), including human adipose‑derived mesenchymal stem cells (hADSCs); however, their roles in hADSC osteogenic differentiation require further investigation. The present study aimed to investigate the role of miRNAs in ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2020, 46(2):709-717]

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Black Phosphorus Based Multicolor Light-Modulated Transparent Memristor with Enhanced Resistive Switching Performance.

Yi Zhou, Danni Liu, Jiahong Wang, Ziqiang Cheng, Lei Liu, Na Yang, Yanxin Liu, Tian Xia, Xinyi Liu, Xin Zhang, Cong Ye, Zhong Xu, Wen Xiong, Paul K Chu, Xue-Feng Yu,

Light-modulated transparent memristors combining photoresponse and data storage are promising as multifunctional devices. Herein, a multicolor light-modulated transparent memristor based on black phosphorous (BP) is designed, fabricated, and investigated. BP is a class of emerging two-dimensional (2D) materials with a natural direct band gap and a broad light absorption. Herein, ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(22):25108-25114]

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miR-16 exhibits protective function in LPS-treated cardiomyocytes by targeting DOCK2 to repress cell apoptosis and exert anti-inflammatory effect.

Lei Wang, Yangyang Zhang, Guangfu Zhu, Yuncong Ma, Huan Zuo, Xia Tian,

This study aims to investigate the effects of microRNA (miR)-16/dedicator of cytokinesis 2 (DOCK2) on myocarditis. The differences in the expression of genes in acute myocarditis were filtered out across Gene Expression Omnibus (GEO) database. Myocarditis cell model was established by lipopolysaccharide (LPS) stimulation in cardiomyocytes. The association between miR-16 ... Read more >>

Cell Biol. Int. (Cell biology international)
[2020, :]

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Acupuncture techniques for COPD: a systematic review.

Carles Fernández-Jané, Jordi Vilaró, Yutong Fei, Congcong Wang, Jianping Liu, Na Huang, Ruyu Xia, Xia Tian, Ruixue Hu, Lingzi Wen, Mingkun Yu, Natàlia Gómara-Toldrà, Mireia Solà-Madurell, Mercè Sitjà-Rabert,

BACKGROUND:This is the second part of a large spectrum systematic review which aims to identify and assess the evidence for the efficacy of non-pharmacological acupuncture techniques in the treatment of chronic obstructive pulmonary disease (COPD). The results of all techniques except for filiform needle are described in this publication. METHODS:Eleven ... Read more >>

BMC Complement Med Ther (BMC complementary medicine and therapies)
[2020, 20(1):138]

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Mechanistic Differences in Cell Death Responses to Metal-Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes.

Xiang Wang, Chong Hyun Chang, Jinhong Jiang, Xiangsheng Liu, Jiulong Li, Qi Liu, Yu-Pei Liao, Linjiang Li, André E Nel, Tian Xia,

The mononuclear phagocyte system in the liver is a frequent target for nanoparticles (NPs). A toxicological profiling of metal-based NPs is performed in Kupffer cell (KC) and hepatocyte cell lines. Sixteen NPs are provided by the Nanomaterial Health Implications Research Consortium of the National Institute of Environmental Health Sciences to ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(21):e2000528]

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A collaborative online AI engine for CT-based COVID-19 diagnosis

Yongchao Xu, Liya Ma, Yang Fan, Yanyan Chen, Ke Ma, Jiehua Yang, Xian Yang, Yaobing Chen, Chang Shu, Ziwei Fan, Jiefeng Gan, Xinyu Zou, Renhao Huang, Changzheng Zhang, Xiaowu Liu, Dandan Tu, Chuou Xu, Wenqing Zhang, Dehua Yang, Ming-Wei Wang, Xi Wang, Xiaoliang Xie, Hongxiang Leng, Nagaraj Holalkere, Neil Halin, Ihab Roushdy Kamel, Jia Wu, Xuehua Peng, Xiang Wang, Jianbo Shao, Pattanasak Mongkolwat, Jianjun Zhang, Daniel Rubin, Guoping Wang, Chuangsheng Zheng, Zhen Li, Xiang Bai, Tian Xia,

Artificial intelligence can potentially provide a substantial role in streamlining chest computed tomography (CT) diagnosis of COVID-19 patients. However, several critical hurdles have impeded the development of robust AI model, which include deficiency, isolation, and heterogeneity of CT data generated from diverse institutions. These bring about lack of generalization of ... Read more >>

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Risk of Noninfectious Uveitis with Female Hormonal Therapy in a Large Healthcare Claims Database.

Lucia Sobrin, Yinxi Yu, Gayatri Susarla, Weilin Chan, Tian Xia, John H Kempen, Rebecca A Hubbard, Brian L VanderBeek,

PURPOSE:To determine if female hormonal therapy (FHT) increases the incidence of noninfectious uveitis. DESIGN:Retrospective cohort study. PARTICIPANTS:Women exposed to FHT and matched women unexposed to FHT enrolled in a national insurance plan. METHODS:Estimation of noninfectious uveitis incidence used multivariable Cox proportional hazards regression. To account for differences between the exposed ... Read more >>

Ophthalmology (Ophthalmology)
[2020, :]

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Coronavirus disease 2019 and transplantation: The combination of lopinavir/ritonavir and hydroxychloroquine is responsible for excessive tacrolimus trough level and unfavorable outcome.

Tian Xia, Yanfeng Wang,

Am. J. Transplant. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, :]

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Multiple acid-base and electrolyte disturbances upregulate NBCn1, NBCn2, IRBIT and L-IRBIT in the mTAL.

Jin-Lin Wang, Xiao-Yu Wang, Deng-Ke Wang, Mark D Parker, Raif Musa-Aziz, Jacob Popple, Yi-Min Guo, Tian-Xin Min, Tian Xia, Min Tan, Ying Liu, Walter F Boron, Li-Ming Chen,

KEY POINTS:The roles of the Na+ /HCO3 - cotransporters NBCn1 and NBCn2 as well as their activators IRBIT and L-IRBIT in the regulation of the mTAL transport of NH4 + , HCO3 - , and NaCl are investigated. Dietary challenges of NH4 Cl, NaHCO3 or NaCl all increase the abundance ... Read more >>

J. Physiol. (Lond.) (The Journal of physiology)
[2020, :]

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Recommendations for control and prevention of infections for pediatric orthopedics during the epidemic period of COVID-19.

Chunxing Wu, Zhiqiang Zhang, Yueqiang Mo, Dahui Wang, Bo Ning, Ping Xu, Jun Song, Xinhong Pei, Xiaoyan Ni, Yiming Zheng, Tian Xia, Yanhui Jing, Wanlin Sun, Junrong Meng, Chuang Qian,

The outbreak of Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged and spread rapidly throughout the world. As of February 29, 2020, 79 389 cases of COVID-19 have been reported, and the outbreak is linked to 2838 deaths. The population is generally susceptible to the ... Read more >>

(World Journal of Pediatric Surgery)
[2020, 3(1):]

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Continued Efforts on Nanomaterial-Environmental Health and Safety Is Critical to Maintain Sustainable Growth of Nanoindustry.

Sijin Liu, Tian Xia,

Nanotechnology is enjoying an impressive growth and the global nanotechnology industry is expected to exceed US$ 125 billion by 2024. Based on these successes, there are notions that enough is known and efforts on engineered nanomaterial environmental health and safety (nano-EHS) research should be put on the back burner. However, ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(21):e2000603]

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Glucose and lipid metabolism screening models of hepatocyte spheroids after culture with injectable fiber fragments.

Jiaojun Wei, Tian Xia, Weijia Chen, Pan Ran, Maohua Chen, Xiaohong Li,

With the rise of obesity, diabetes, and other metabolic diseases, in vitro hepatic cell and tissue models play an essential role in the identification of active pharmaceutical ingredients. Up to now, three-dimensional (3D) culture models have rarely focused on hepatic glucose and lipid metabolism. In addition, primary human liver cells ... Read more >>

J Tissue Eng Regen Med (Journal of tissue engineering and regenerative medicine)
[2020, 14(6):774-788]

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Liraglutide attenuates renal tubular ectopic lipid deposition in rats with diabetic nephropathy by inhibiting lipid synthesis and promoting lipolysis.

Ke Su, Bo Yi, Bi-Qing Yao, Tian Xia, Yi-Fei Yang, Zhi-Hao Zhang, Cheng Chen,

Liraglutide is a new hypoglycemic drug. The previous studies have shown that liraglutide can improve the renal outcomes of patients with type 2 diabetes. Recently, it was approved by the U.S. FDA for used as a weight-loss drugs. However, the mechanism of its improvements of renal function in diabetic nephropathy ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 156:104778]

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Control of Plant Branching by the CUC2/CUC3-DA1-UBP15 Regulatory Module.

Yu Li, Tian Xia, Fan Gao, Yunhai Li,

Lateral branches are important for plant architecture and production, but how plants determine their lateral branches remains to be further understood. Here, we report that the CUP-SHAPED COTYLEDON2 (CUC2)/CUC3-DA1-UBIQUITIN-SPECIFIC PROTEASE15 (UBP15) regulatory module controls the initiation of axillary meristems, thereby determining the number of lateral branches in Arabidopsis (Arabidopsis thaliana). ... Read more >>

Plant Cell (The Plant cell)
[2020, 32(6):1919-1932]

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