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Prognostic value of haemoglobin drop in patients with acute coronary syndromes.

Gjin Ndrepepa, Franz-Josef Neumann, Maurizio Menichelli, Stefan Holdenrieder, Gert Richardt, Katharina Mayer, Salvatore Cassese, Erion Xhepa, Sebastian Kufner, Jens Wiebe, Michael Joner, Thorsten Kessler, Karl Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati,

<h4>Background</h4>The prognostic value of in-hospital haemoglobin drop in patients with acute coronary syndrome (ACS) undergoing invasive therapy remains insufficiently investigated.<h4>Materials and methods</h4>This observational study included 3838 patients with ACS with admission and in-hospital nadir haemoglobin values available. Haemoglobin drop was defined as a positive difference between admission and nadir haemoglobin ... Read more >>

Eur J Clin Invest (European journal of clinical investigation)
[2021, :e13670]

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Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.

Julia Hinterdobler, Simin Schott, Hong Jin, Almut Meesmann, Anna-Lena Steinsiek, Anna-Sophia Zimmermann, Jana Wobst, Philipp Müller, Carina Mauersberger, Baiba Vilne, Alexandra Baecklund, Chien-Sin Chen, Aldo Moggio, Quinte Braster, Michael Molitor, Markus Krane, Wolfgang E Kempf, Karl-Heinz Ladwig, Michael Hristov, Maarten Hulsmans, Ingo Hilgendorf, Christian Weber, Philip Wenzel, Christoph Scheiermann, Lars Maegdefessel, Oliver Soehnlein, Peter Libby, Matthias Nahrendorf, Heribert Schunkert, Thorsten Kessler, Hendrik B Sager,

<h4>Aims </h4>Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim to investigate the underlying mechanisms of these contributions since they remain largely unclear.<h4>Methods and results </h4>Here, we show in humans and mice that leucocytes deplete rapidly from the blood after a single episode of ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(39):4077-4088]

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Impact of Acute and Chronic Psychosocial Stress on Vascular Inflammation.

Julia Hinterdobler, Heribert Schunkert, Thorsten Kessler, Hendrik B Sager,

<b><i>Significance:</i></b> Atherosclerosis and its complications, such as acute coronary syndromes, are the leading causes of death worldwide. A wide range of inflammatory processes substantially contribute to the initiation and progression of cardiovascular disease (CVD). In addition, epidemiological studies strongly associate both chronic stress and acute psychosocial stress with the occurrence ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, :]

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Deficiency of ZC3HC1 increases vascular smooth muscle cell migration, proliferation and neointima formation following injury

Redouane Aherrahrou, Tobias Reinberger, Julia Werner, Miriam Otto, Jaafar Al-Hasani, Maria Loreto Munoz-Venegas, Mete Civelek, Heribert Schunkert, Thorsten Kessler, Jeanette Erdmann, Zouhair Aherrahrou,

The ZC3HC1 gene is associated with various cardiovascular traits in that its common missense variant, rs11556924-T (p.Arg363His), lowers risk of coronary artery disease (CAD) and blood pressure, but increases carotid intima-media thickness (IMT). This study was designed to determine the mechanisms by which ZC3HC1 modulates IMT using in vitro and ... Read more >>

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Identification of a Functional PDE5A Variant at the Chromosome 4q27 Coronary Artery Disease Locus in an Extended Myocardial Infarction Family.

Tan An Dang, Thorsten Kessler, Jana Wobst, Michael Wierer, Ingrid Braenne, Tim M Strom, Stephanie Tennstedt, Hendrik B Sager, Thomas Meitinger, Jeanette Erdmann, Heribert Schunkert,

Circulation (Circulation)
[2021, 144(8):662-665]

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Transcriptome wide association study of coronary artery disease identifies novel susceptibility genes

Ling Li, Zhifen Chen, Moritz von Scheidt, Andrea Steiner, Ulrich Güldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, Aldons Lusis, Shichao Pang, Thorsten Kessler, Raili Ermel, Katyayani Sukhavasi, Arno Ruusalepp, Julien Gagneur, Jeanette Erdmann, Jason Kovacic, Johan L.M. Björkegren, Heribert Schunkert,

Transcriptome-wide association studies (TWAS) explore genetic variants affecting gene expression for association with a trait. Here we studied coronary artery disease (CAD) using this approach by first determining genotype-regulated expression levels in nine CAD relevant tissues by EpiXcan in two genetics-of-gene-expression panels, the Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task (STARNET) ... Read more >>

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Coronary Artery Disease Genetics Enlightened by Genome-Wide Association Studies.

Thorsten Kessler, Heribert Schunkert,

Many cardiovascular diseases are facilitated by strong inheritance. For example, large-scale genetic studies identified hundreds of genomic loci that affect the risk of coronary artery disease. At each of these loci, common variants are associated with disease risk with robust statistical evidence but individually small effect sizes. Only a minority ... Read more >>

JACC Basic Transl Sci (JACC. Basic to translational science)
[2021, 6(7):610-623]

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Transcriptome wide association study of coronary artery disease identifies novel susceptibility genes

Heribert Schunkert, Ling Li, Zhifen Chen, Moritz Scheidt, Andrea Steiner, Ulrich Güldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, Aldons Lusis, Shichao Pang, Thorsten Kessler, Raili Ermel, Katyayani Sukhavasi, Arno Ruusalepp, Julien Gagneur, Jeanette Erdmann, Jason Kovacic, Johan Bjorkegren,

Transcriptome-wide association studies (TWAS) explore genetic variants affecting gene expression for association with a trait. Here we studied coronary artery disease (CAD) using this approach by first determining genotype-regulated expression levels in nine CAD relevant tissues by EpiXcan in two genetics-of-gene-expression panels, the Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task (STARNET) ... Read more >>

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Ten-year clinical outcomes of polymer-free versus durable polymer new-generation drug-eluting stent in patients with coronary artery disease with and without diabetes mellitus : Results of the Intracoronary Stenting and Angiographic Results: Test Efficacy of Sirolimus- and Probucol- and Zotarolimus-Eluting Stents (ISAR-TEST 5) trial.

Tobias Koch, Tobias Lenz, Michael Joner, Erion Xhepa, Tobias Koppara, Jens Wiebe, J J Coughlan, Alp Aytekin, Tareq Ibrahim, Thorsten Kessler, Salvatore Cassese, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Sebastian Kufner, ,

<h4>Background</h4>Very long-term outcomes according to diabetic status of patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) with new-generation drug-eluting stents (DES) are scant. Both, the durable polymer zotarolimus-eluting stent (DP-ZES), the first DES to gain FDA-approval for specific use in patients with diabetes mellitus, and the polymer-free ... Read more >>

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2021, 110(10):1586-1598]

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Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Krishna Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke Wolford, Elle Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas Marston, Frederick Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn O Åsvold, Michael Brown, Ben Brumpton, Paul de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daniel Gudbjartsson, Ulrich Güldener, Syed Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas Nielsen, Markus Nöthen, Shichao Pang, Tobias Reinberger, Gudmar Thorleifsson, Moritz von Scheidt, Jacob Ulirsch, Biobank Japan, David Arnar, Deepak Atri, Noël P Burtt, Maria Costanzo, Jason Flannick, Rajat Gupta, Kaoru Ito, Dong-Keun Jang, Yoichiro Kamatani, Amit Khera, Issei Komuro, Iftikhar Kullo, Luca Lotta, Christopher Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas Webb, Aris Baras, Johan LM Björkegren, Eric Boerwinkle, George Dedoussis, Hilma Holm, Kristian Hveem, Olle Melander, Alanna Morrison, Marju Orho-Melander, Loukianos Rallidis, Arno Ruusalepp, Marc Sabatine, Kari Stefansson, Pierre Zalloua, Patrick Ellinor, Martin Farrall, John Danesh, Christian Ruff, Hilary Finucane, Jemma Hopewell, Robert Clarke, Jeanette Erdmann, Nilesh Samani, Heribert Schunkert, Hugh Watkins, Cristen Willer, Panos Deloukas, Sekar Kathiresan, Adam Butterworth, ,

<h4>ABSTRACT</h4> Rapid progress of the discovery of genetic loci associated with common, complex diseases has outpaced the elucidation of mechanisms pertinent to disease pathogenesis. To address relevant barriers for coronary artery disease (CAD), we combined genetic discovery analyses with downstream characterization of likely causal variants, genes, and biological pathways. Specifically, ... Read more >>

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A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy.

Michael Wierer, Julia Werner, Jana Wobst, Adnan Kastrati, Ganildo Cepele, Redouane Aherrahrou, Hendrik B Sager, Jeanette Erdmann, Martin Dichgans, Veit Flockerzi, Mete Civelek, Alexander Dietrich, Matthias Mann, Heribert Schunkert, Thorsten Kessler,

<h4>Aims</h4>In-stent restenosis is a complication after coronary stenting associated with morbidity and mortality. Here, we sought to investigate the molecular processes underlying neointima formation and to identify new treatment and prevention targets.<h4>Methods and results</h4>Neointima formation was induced by wire injury in mouse femoral arteries. High-accuracy proteomic measurement of single femoral ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(18):1773-1785]

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Cis-epistasis at the LPA locus and risk of cardiovascular diseases.

Lingyao Zeng, Sylvain Moser, Nazanin Mirza-Schreiber, Claudia Lamina, Stefan Coassin, Christopher P Nelson, Tarmo Annilo, Oscar Franzén, Marcus E Kleber, Salome Mack, Till F M Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, Adnan Kastrati, Karl-Ludwig Laugwitz, Jeanette Erdmann, Susanne Moebus, Markus M NöThen, Annette Peters, Konstantin Strauch, Martina MüLler-Nurasyid, Christian Gieger, Thomas Meitinger, Elisabeth Steinhagen-Thiessen, Winfried MäRz, Andres Metspalu, Johan L M BjöRkegren, Nilesh J Samani, Florian Kronenberg, Bertram MüLler-Myhsok, Heribert Schunkert,

<h4>Aims</h4>Coronary artery disease (CAD) has a strong genetic predisposition. However, despite substantial discoveries made by genome-wide association studies (GWAS), a large proportion of heritability awaits identification. Non-additive genetic-effects might be responsible for part of the unaccounted genetic variance. Here we attempted a proof-of-concept study to identify non-additive genetic effects, namely ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, :]

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Letter by Kessler et al Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52 816 Patients From 12 Randomized Trials".

Thorsten Kessler, Salvatore Cassese, Adnan Kastrati,

Circulation (Circulation)
[2021, 143(6):e230-e231]

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SARS-CoV-2 Infection in Asymptomatic Patients Hospitalized for Cardiac Emergencies: Implications for Patient Management.

Thorsten Kessler, Jens Wiebe, Tobias Graf, Heribert Schunkert, Adnan Kastrati, Hendrik B Sager,

<b>Background:</b> The coronavirus disease (COVID-19) pandemic imposed diverse challenges on the health care system. Morbidity and mortality of non-COVID-19 emergencies might also have changed because hospitals may not be able to provide optimal care due to restructured resources and uncertainties how to deal with potentially infected patients. It has been ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2020, 7:599299]

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Functional investigation of the coronary artery disease gene SVEP1.

Michael J Winkler, Philipp Müller, Amin M Sharifi, Jana Wobst, Hanna Winter, Michal Mokry, Lijiang Ma, Sander W van der Laan, Shichao Pang, Benedikt Miritsch, Julia Hinterdobler, Julia Werner, Barbara Stiller, Ulrich Güldener, Tom R Webb, Folkert W Asselbergs, Johan L M Björkegren, Lars Maegdefessel, Heribert Schunkert, Hendrik B Sager, Thorsten Kessler,

A missense variant of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing protein 1 (SVEP1) is genome-wide significantly associated with coronary artery disease. The mechanisms how SVEP1 impacts atherosclerosis are not known. We found endothelial cells (EC) and vascular smooth muscle cells to represent the major ... Read more >>

Basic Res Cardiol (Basic research in cardiology)
[2020, 115(6):67]

Cited: 4 times

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Antihypertensive drugs in COVID-19 infection.

Sara-Joan Pinto-Sietsma, Michael Flossdorf, Veit R Buchholz, Joost Offerhaus, Hidde Bleijendaal, Martijn Beudel, Paul G A Volders, Rachel M A Ter Bekke, Tom Dormans, Peter-Paul Zwetsloot, Peter de Jager, Steffen Massberg, Patrick Rämer, Clemens Wendtner, Ellen Hoffmann, Kathrin Rothe, Susanne Feihl, Thorsten Kessler, Yigal M Pinto, Heribert Schunkert,

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2020, 6(6):415-416]

Cited: 5 times

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Hospital admissions with acute coronary syndromes during the COVID-19 pandemic in German cardiac care units.

Thorsten Kessler, Tobias Graf, Ingo Hilgendorf, Konstantinos Rizas, Eimo Martens, Constantin von Zur Mühlen, Peter Kraemer, Roza Meyer-Saraei, Franz-Josef Neumann, Christoph Bode, Karl-Ludwig Laugwitz, Steffen Massberg, Heribert Schunkert, Joachim Weil, Adnan Kastrati, Hendrik B Sager,

Cardiovasc Res (Cardiovascular research)
[2020, 116(11):1800-1801]

Cited: 5 times

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Should We Use Genetic Scores in the Determination of Treatment Strategies to Control Dyslipidemias?

Katharina Lechner, Thorsten Kessler, Heribert Schunkert,

<h4>Purpose of review</h4>Conventional risk stratification algorithms that rely on age, clustered phenotypic traits, and biomarkers under-recognize the sizeable subgroup of individuals at high polygenic risk for atherosclerotic cardiovascular disease (ASCVD). This review provides perspective on the promising role of genetic testing in cardiovascular prevention through the lens of lipid metabolism.<h4>Recent ... Read more >>

Curr Cardiol Rep (Current cardiology reports)
[2020, 22(11):146]

Cited: 1 time

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Angiographic performance of everolimus-eluting stents for the treatment of coronary in-stent restenosis in daily practice.

Jens Wiebe, Himanshu Rai, Constantin Kuna, Salvatore Cassese, Thorsten Kessler, Tobias Rheude, Roisin Colleran, Heribert Schunkert, Tobias Koch, Sebastian Kufner, Michael Joner, Adnan Kastrati, Robert A Byrne,

<h4>Objectives</h4>The present study aims to analyze the angiographic anti-restenotic performance of durable polymer everolimus-eluting stents (EES) for the treatment of in-stent restenosis (ISR) in daily practice.<h4>Background</h4>Randomized data is available supporting the use of drug-coated balloons and drug-eluting stents for the treatment of ISR; however, additional real-world data including angiographic follow-up ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2020, :]

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Novel Approaches to Fine-Tune Therapeutic Targeting of Platelets in Atherosclerosis: A Critical Appraisal.

Thorsten Kessler, Heribert Schunkert, Philipp von Hundelshausen,

The pathogenesis of atherosclerotic vascular disease is driven by a multitude of risk factors intertwining metabolic and inflammatory pathways. Increasing knowledge about platelet biology sheds light on how platelets take part in these processes from early to later stages of plaque development. Recent insights from experimental studies and mouse models ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2020, 120(11):1492-1504]

Cited: 2 times

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cGMP Signaling in Cardiovascular Diseases: Linking Genotype and Phenotype.

Tan An Dang, Heribert Schunkert, Thorsten Kessler,

Cyclic guanosine 3',5'-monophosphate (cGMP) is the key second messenger molecule in nitric oxide signaling. Its rapid generation and fate, but also its role in mediating acute cellular functions has been extensively studied. In the past years, genetic studies suggested an important role for cGMP in affecting the risk of chronic ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2020, 75(6):516-525]

Cited: 1 time

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Genomic Strategies Toward Identification of Novel Therapeutic Targets.

Thorsten Kessler, Heribert Schunkert,

Coronary artery disease, myocardial infarction, and secondary damages of the myocardium in the form of ischemic heart disease remain major causes of death in Western countries. Beyond traditional risk factors such as smoking, hypertension, dyslipidemia, or diabetes, a positive family history is known to increase risk. The genetic factors underlying ... Read more >>

Handb Exp Pharmacol (Handbook of experimental pharmacology)
[2020, :]

Cited: 2 times

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Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood.

Yan Zheng, Tao Huang, Tiange Wang, Zhendong Mei, Zhonghan Sun, Tao Zhang, Christina Ellervik, Jin-Fang Chai, Xueling Sim, Rob M van Dam, E-Shyong Tai, Woon-Puay Koh, Rajkumar Dorajoo, Seang-Mei Saw, Charumathi Sabanayagam, Tien Yin Wong, Preeti Gupta, Peter Rossing, Tarunveer S Ahluwalia, Rebecca K Vinding, Hans Bisgaard, Klaus Bønnelykke, Yujie Wang, Mariaelisa Graff, Trudy Voortman, Frank J A van Rooij, Albert Hofman, Diana van Heemst, Raymond Noordam, Angela C Estampador, Tibor V Varga, Cornelia Enzenbach, Markus Scholz, Joachim Thiery, Ralph Burkhardt, Marju Orho-Melander, Christina-Alexandra Schulz, Ulrika Ericson, Emily Sonestedt, Michiaki Kubo, Masato Akiyama, Ang Zhou, Tuomas O Kilpeläinen, Torben Hansen, Marcus E Kleber, Graciela Delgado, Mark McCarthy, Rozenn N Lemaitre, Janine F Felix, Vincent W V Jaddoe, Ying Wu, Karen L Mohlke, Terho Lehtimäki, Carol A Wang, Craig E Pennell, Heribert Schunkert, Thorsten Kessler, Lingyao Zeng, Christina Willenborg, Annette Peters, Wolfgang Lieb, Veit Grote, Peter Rzehak, Berthold Koletzko, Jeanette Erdmann, Matthias Munz, Tangchun Wu, Meian He, Caizheng Yu, Cécile Lecoeur, Philippe Froguel, Dolores Corella, Luis A Moreno, Chao-Qiang Lai, Niina Pitkänen, Colin A Boreham, Paul M Ridker, Frits R Rosendaal, Renée de Mutsert, Chris Power, Lavinia Paternoster, Thorkild I A Sørensen, Anne Tjønneland, Kim Overvad, Luc Djousse, Fernando Rivadeneira, Nanette R Lee, Olli T Raitakari, Mika Kähönen, Jorma Viikari, Jean-Paul Langhendries, Joaquin Escribano, Elvira Verduci, George Dedoussis, Inke König, Beverley Balkau, Oscar Coltell, Jean Dallongeville, Aline Meirhaeghe, Philippe Amouyel, Frédéric Gottrand, Katja Pahkala, Harri Niinikoski, Elina Hyppönen, Winfried März, David A Mackey, Dariusz Gruszfeld, Katherine L Tucker, Frédéric Fumeron, Ramon Estruch, Jose M Ordovas, Donna K Arnett, Dennis O Mook-Kanamori, Dariush Mozaffarian, Bruce M Psaty, Kari E North, Daniel I Chasman, Lu Qi,

Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data ... Read more >>

Eur J Epidemiol (European journal of epidemiology)
[2020, 35(7):685-697]

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Inhibitors of the renin-angiotensin system and SARS-CoV-2 infection.

Thorsten Kessler, Heribert Schunkert,

Herz (Herz)
[2020, 45(4):323-324]

Cited: 3 times

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Functional association of a CD40 gene single-nucleotide polymorphism with the pathogenesis of coronary heart disease.

Cheryl S Sultan, Michael Weitnauer, Martin Turinsky, Thorsten Kessler, Maik Brune, Christian A Gleissner, Florian Leuschner, Andreas H Wagner, Markus Hecker,

<h4>Aims</h4>Endothelial dysfunction is a major contributor to the pathogenesis of atherosclerosis. CD40-CD40 ligand interactions confer a pro-inflammatory phenotype to endothelial cells (ECs). Recently, a thymine to cytosine transition (-1T>C) in the Kozak sequence of the CD40 gene (rs1883832) has been associated with coronary heart disease (CHD) in an Asian population. ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2020, 116(6):1214-1225]

Cited: 4 times

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