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Author Thomas Tschernig

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Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis.

Ann-Kathrin Vlacil, Jutta Schuett, Volker Ruppert, Muhidien Soufi, Raghav Oberoi, Kinan Shahin, Christian Wächter, Thomas Tschernig, Yu Lei, Fan Liu, Uwe J F Tietge, Bernhard Schieffer, Harald Schuett, Karsten Grote,

Atherosclerosis is crucially fueled by inflammatory pathways including pattern recognition receptor (PRR)-related signaling of the innate immune system. Currently, the impact of the cytoplasmic PRRs nucleotide-binding oligomerization domain-containing protein (NOD) 1 and 2 is incompletely characterized. We, therefore, generated Nod1/Nod2 double knockout mice on a low-density lipoprotein receptor (Ldlr)-deficient background ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):47]

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Flexor tendon grafts for pulley reconstruction - Morphological aspects.

Tobias Fritz, Pascal Ducommun, Tim Pohlemann, Maurizio Calcagni, Thomas Tschernig, Michael D Menger, Wolfgang Metzger, Florian S Frueh,

BACKGROUND:Pulleys are crucial to convert flexor tendon excursion into angular motion at the metacarpophalangeal and interphalangeal joints. Loss of pulley function can lead to significant impairment of hand function and may require surgical reconstruction. This reconstruction can be achieved using different flexor tendons grafts, such as the intrasynovial flexor digitorum ... Read more >>

Ann. Anat. (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2020, 231:151550]

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Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

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ClpC affects the intracellular survival capacity of Staphylococcus aureus in non-professional phagocytic cells.

Gubesh Gunaratnam, Lorena Tuchscherr, Mohamed I Elhawy, Ralph Bertram, Janina Eisenbeis, Christian Spengler, Thomas Tschernig, Bettina Löffler, Greg A Somerville, Karin Jacobs, Mathias Herrmann, Markus Bischoff,

Invasion and persistence of bacteria within host cells requires that they adapt to life in an intracellular environment. This adaptation induces bacterial stress through events such as phagocytosis and enhanced nutrient-restriction. During stress, bacteria synthesize a family of proteins known as heat shock proteins (HSPs) to facilitate adaptation and survival. ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):16267]

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The Phagocytosis of Blood Leukocytes from Cystic Fibrosis Patients is not Impaired in General.

Laura Leuer, Angelika Krill, Heinrike Wilkens, Gudrun Wagenpfeil, Markus Bischoff, Carola Meier, Robert Bals, Thomas Tschernig,

Impaired phagocytosis of Pseudomonas aeruginosa was found in isolated monocytes of peripheral blood of cystic fibrosis patients, but not in their neutrophils, as reported some years ago. In the present study, we analysed the phagocytic capacity of peripheral blood neutrophils and monocytes of cystic fibrosis patients and of healthy controls. ... Read more >>

Lung (Lung)
[2020, 198(1):235-239]

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Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute Streptococcus pneumoniae Pneumonia.

Patrick Steck, Felix Ritzmann, Anja Honecker, Giovanna Vella, Christian Herr, Rosmarie Gaupp, Markus Bischoff, Timotheus Speer, Thomas Tschernig, Robert Bals, Christoph Beisswenger,

Neutrophils contribute to lung injury in acute pneumococcal pneumonia. The interleukin 17 receptor E (IL-17RE) is the functional receptor for the epithelial-derived cytokine IL-17C, which is known to mediate innate immune functions. The aim of this study was to investigate the contribution of IL-17RE/IL-17C to pulmonary inflammation in a mouse ... Read more >>

Infect. Immun. (Infection and immunity)
[2019, 87(11):]

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UV-C Irradiation Reduces the Experimentally Induced Bacterial Load on the Surface of a Human Cadaver: An Additional Option for the Preservation of Cadavers in Anatomy.

Lea Müller, Markus Bischoff, Thomas Tschernig,

Safety is a major issue in the embalming procedures of human cadavers. Reduced application of formaldehyde is often recommended. The aim of this study was to investigate the potency of ultraviolet light (UV-C irradiation) on the bacterial load on the surface of a conserved human cadaver. To test UV-C irradiation, ... Read more >>

Clin Anat (Clinical anatomy (New York, N.Y.))
[2020, 33(1):113-116]

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Intercellular communication between alveolar epithelial cells and macrophages.

Anja Beckmann, Alexander Grissmer, Carola Meier, Thomas Tschernig,

BACKGROUND:The alveolus in the lung tissue is an extremely vulnerable site. Alveolar macrophages control this micro-environment both in states of health and illnesssuch as acute lung injury and infection. It has been reported in mice in vivo that intercellular communication between alveolar macrophages and alveolar epithelial cells is mediated by ... Read more >>

Ann. Anat. (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2020, 227:151417]

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The vasa vasorum reach deep into the human thoracic aorta.

Jan Michael Federspiel, Thomas Tschernig, Matthias W Laschke, Stefan Wagenpfeil, Philipp Schnabel, Hans-Joachim Schäfers,

Only limited data are available on the extent of the vasa vasorum of the human thoracic aorta, although this could be important with regard to certain pathophysiological states, i.e. aortic aneurysm or atherosclerosis. A preliminary investigation shows that the vascularization of the human thoracic aorta reaches deeper layers than generally ... Read more >>

Ann. Anat. (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2019, 225:54-56]

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Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata.

Rebekka Christmann, Carla Thomas, Nadine Jager, Anne S Raber, Brigitta Loretz, Ulrich F Schaefer, Thomas Tschernig, Thomas Vogt, Claus-Michael Lehr,

J. Invest. Dermatol. (The Journal of investigative dermatology)
[2020, 140(1):243-246.e5]

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"Simple mechanical devices did not improve pelvis positioning in AP pelvis radiographs for reliable assessment of the acetabular orientation".

Matthias Brockmeyer, Sebastian Lott, Jonas Stroeder, Peter Fries, Stefan Wagenpfeil, Thomas Tschernig, Dieter Kohn,

BACKGROUND:The aim of this study was to develop two simple positioning devices for anteroposterior pelvis radiographs and to evaluate their effect on accuracy of the radiographs for assessment of the acetabular orientation compared with non-instrumented positioning. METHODS:The superior anterior iliac spines and the pubic symphysis were used as anatomical landmarks ... Read more >>

J Exp Orthop (Journal of experimental orthopaedics)
[2019, 6(1):20]

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Aorticorenal Ganglia Pacing: A Step Forward in Unblinding Renal Denervation Procedures?

Felix Mahfoud, Thomas Tschernig, Elazer R Edelman,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2019, 12(12):1121-1124]

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The anatomy of the anterolateral structures of the knee - A histologic and macroscopic approach.

Matthias Brockmeyer, Patrick Orth, Denis Höfer, Romain Seil, Friedrich Paulsen, Michael D Menger, Dieter Kohn, Thomas Tschernig,

BACKGROUND:The anatomy of the anterolateral structures of the knee is complex and still controversial. The aim of our study was to analyze this anatomy by histologic and macroscopic evaluation, with a particular emphasis on the anterolateral ligament (ALL). MATERIAL AND METHODS:Twenty-three cadaveric knee joints were dissected followed by a qualitative ... Read more >>

Knee (The Knee)
[2019, 26(3):636-646]

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Spatial and molecular changes of mouse brain metabolism in response to immunomodulatory treatment with teriflunomide as visualized by MALDI-MSI.

Ignacy Rzagalinski, Nadine Hainz, Carola Meier, Thomas Tschernig, Dietrich A Volmer,

Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of the central nervous system (CNS). One of the most promising recent medications for MS is teriflunomide. Its primary mechanism of action is linked to effects on the peripheral immune system by inhibiting dihydroorotate dehydrogenase (DHODH)-catalyzed de novo pyrimidine synthesis and reducing ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2019, 411(2):353-365]

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The transplantation of corneae from cadavers can prevent blindness.

Thomas Tschernig, Berthold Seitz,

This Viewpoint describes the process by which corneae are obtained from body donors to anatomical institutes for subsequent clinical transplantation. Corneae from body donors are extremely valuable in clinical medicine. Clin. Anat., 2018. © 2018 Wiley Periodicals, Inc. ... Read more >>

Clin Anat (Clinical anatomy (New York, N.Y.))
[2019, 32(1):58-59]

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A snapshot of anatomy teaching: Peer-led anatomy boot camps - Priming for success?

Jana-Janina Scherer, Sandra Reichrath, Thomas Tschernig, Stephan Maxeiner,

INTRODUCTION:Pending changes regarding the medical curricula in Germany prompted us, members of the Department of Anatomy at the Medical Faculty of Saarland University, to critically evaluate anatomy teaching with special attention to macroscopic anatomy and the dissection class. Aiming at a thorough assessment we were particularly interested to which extend ... Read more >>

Ann. Anat. (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2019, 221:141-147]

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Toward Higher Sensitivity in Quantitative MALDI Imaging Mass Spectrometry of CNS Drugs Using a Nonpolar Matrix.

Ignacy Rzagalinski, Borislav Kovačević, Nadine Hainz, Carola Meier, Thomas Tschernig, Dietrich A Volmer,

Tissue-specific ion suppression is an unavoidable matrix effect in MALDI mass spectrometry imaging (MALDI-MSI), the negative impact of which on precision and accuracy in quantitative MALDI-MSI can be reduced to some extent by applying isotope internal standards for normalization and matrix-matched calibration routines. The detection sensitivity still suffers, however, often ... Read more >>

Anal. Chem. (Analytical chemistry)
[2018, 90(21):12592-12600]

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Trial integration of combined ultrasound and laparoscopy tuition in an undergraduate anatomy class with volunteer participation - A pilot study.

Amr Hamza, Julia Radosa, Gabriele Meyberg-Solomayer, Erich-Franz Solomayer, Zoltan Takacs, Ingolf Juhasz-Boess, Gabriela Krasteva-Christ, Thomas Tschernig, Stephan Maxeiner,

Anatomy is a cornerstone of medical undergraduate curricula. Due to increasing changes in various medical fields, a lot of new subjects were introduced in undergraduate curricula, while the teaching areas of basic sciences, i.e. anatomy, were reduced. The introduction of advanced diagnostic and therapeutic devices, i.e. ultrasound and laparoscopy, with ... Read more >>

Ann. Anat. (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2019, 221:101-107]

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Recommendations of the working group of the Anatomische Gesellschaft on reduction of formaldehyde exposure in anatomical curricula and institutes.

Jens Waschke, Martin Bergmann, Lars Bräuer, Erich Brenner, Andreas Buchhorn, Arlette Deutsch, Martin Dokter, Desalegn Tadesse Egu, Süleyman Ergün, Ulrich Fassnacht, Daniela Fietz, Stefanie Gundlach, Stephan Heermann, Bernhard Hirt, Daniela Kugelmann, Magdalena Müller-Gerbl, Wolfram Neiss, Ute Nimtschke, Johanna Plendl, Michael Pretterklieber, Christoph Redies, Martin Scaal, Mirko H H Schmidt, Andreas Schmiedl, Hans-Joachim Schnittler, Christof Schomerus, Tamás Sebestény, Björn Spittau, Birte Steiniger, Thomas Tschernig, Axel Unverzagt, Christoph Viebahn, Ernst Voigt, Janet Weigner, Imke Weyers, Andreas Winkelmann, Merle Winkler, Friedrich Paulsen,

The practice of human and veterinary medicine is based on the science of anatomy and dissection courses are still irreplaceable in the teaching of anatomy. Embalming is required to preserve body donors, for which process formaldehyde (FA) is the most frequently used and well characterized biocidal substance. Since January 2016, ... Read more >>

Ann. Anat. (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2019, 221:179-185]

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Isolated aggregates of lymphoid cells in the inner bronchial wall in asthma patients.

Thomas Tschernig, Reinhard Pabst, Frauke Prenzler, Susanne Rittinghausen, Armin Braun, Jens M Hohlfeld,

Here, we report findings in volunteers with bronchial asthma. Biopsies were obtained from the inner bronchial wall before and a short time again after segmental allergen provocation. In most of the baseline biopsies and in all evaluable biopsies after segmental allergen provocation, the follicular lymphoid tissue was detected by immunohistochemistry ... Read more >>

Cell Tissue Res. (Cell and tissue research)
[2018, 374(2):423-425]

Cited: 1 time

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Vitamin A Supplementation by Endotracheal Application of a Nano-encapsulated Preparation Is Feasible in Ventilated Preterm Lambs.

Holger B Wahl, Matthias C Hütten, Dominik Monz, Erol Tutdibi, Daan Ophelders, Maria Nikiforou, Thomas Tschernig, Ludwig Gortner, Donatus Nohr, Hans K Biesalski, Boris W Kramer,

BACKGROUND:Vitamin A (VA) is crucial for lung growth and development. In premature infants, inadequate VA levels are associated with an increased risk of bronchopulmonary dysplasia (BPD). Intramuscular VA supplementation has been shown to decrease the incidence of BPD, but is not widely used in the clinical setting due to concerns ... Read more >>

J Aerosol Med Pulm Drug Deliv (Journal of aerosol medicine and pulmonary drug delivery)
[2018, 31(6):323-330]

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Reaching the sellar region endonasally - One or both nostrils? A pilot study in body donors.

Stefan Linsler, David Breuskin, Thomas Tschernig, Joachim Oertel,

<label>INTRODUCTION</label>The purpose of this study was to evaluate the effect of posterior septectomy size on surgical exposure and surgical freedom during the endoscopic transsphenoidal approach to the sellar and parasellar region.<label>METHODS</label>A mononostril and binostril approach to the sellar region was performed on 4 formalin-fixed cadaveric heads. Predefined anatomical structures were ... Read more >>

Ann. Anat. (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2018, 217:40-46]

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Human stem cells express pannexins.

Nadine Hainz, Anja Beckmann, Madline Schubert, Alexandra Haase, Ulrich Martin, Thomas Tschernig, Carola Meier,

Pannexins are channel proteins important for the release of calcium and adenosine triphosphate, which are among other functions involved in early development. Here, the expression of pannexins was investigated in induced pluripotent stem cells derived from human cord blood endothelial cells (hCBiPS2), in hematopoietic stem cell-derived induced pluripotent stem cells ... Read more >>

BMC Res Notes (BMC research notes)
[2018, 11(1):54]

Cited: 3 times

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Massa adiposa ligamenti falciformis or anterior abdominal fat pad - Its dimension and relation to body weight.

Friedemann Strobel, Eckart Schirg, Martin Schlaud, Thomas Tschernig,

The anterior abdominal fat pad is associated with the falciform ligament in the upper middle/right abdomen and is frequently seen there in diagnostic imaging. It varies greatly in size and has often been described as an incidental finding in adults and has hitherto rarely been regarded as being illness-relevant. The ... Read more >>

Ann. Anat. (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2018, 216:100-102]

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Probenecid arrests the progression of pronounced clinical symptoms in a mouse model of multiple sclerosis.

Nadine Hainz, Sandra Wolf, Artjom Beck, Stefan Wagenpfeil, Thomas Tschernig, Carola Meier,

While it has been established that Probenecid (PBN) prevents the onset of experimental autoimmune encephalomyelitis (EAE) in mice, it is not clear whether it has any effect on already manifest EAE. The aim of this study was therefore to analyze the therapeutic effect of PBN in pronounced EAE. Mice with ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):17214]

Cited: 4 times

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