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European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ).

Marko Babjuk, Maximilian Burger, Otakar Capoun, Daniel Cohen, Eva M Compérat, José L Dominguez Escrig, Paolo Gontero, Fredrik Liedberg, Alexandra Masson-Lecomte, A Hugh Mostafid, Joan Palou, Bas W G van Rhijn, Morgan Rouprêt, Shahrokh F Shariat, Thomas Seisen, Viktor Soukup, Richard J Sylvester,

<h4>Context</h4>The European Association of Urology (EAU) has released an updated version of the guidelines on non-muscle-invasive bladder cancer (NMIBC).<h4>Objective</h4>To present the 2021 EAU guidelines on NMIBC.<h4>Evidence acquisition</h4>A broad and comprehensive scoping exercise covering all areas of the NMIBC guidelines since the 2020 version was performed. Databases covered by the search ... Read more >>

Eur Urol (European urology)
[2021, :]

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Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study.

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We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave ... Read more >>

Anaesthesia (Anaesthesia)
[2021, :]

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Low-intensity extracorporeal shock wave therapy for Peyronie's disease: a single-center experience.

Maher Abdessater, William Akakpo, Anthony Kanbar, Jérome Parra, Thomas Seisen, Emmanuel Chartier-Kastler, Sarah J Drouin, Morgan Roupret,

The aim of this article is to assess the outcomes of a low-intensity extracorporeal shock wave therapy (LiESWT) protocol for the treatment of Peyronie's disease (PD). Patients treated for PD were prospectively recorded, and data were retrospectively reviewed. Age, characteristics of fibrous plaques, concomitant treatments, International Index of Erectile Function ... Read more >>

Asian J Androl (Asian journal of andrology)
[2021, :]

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Standardizing immunohistochemistry methodology for evaluation of PD-1 and PDL-1 expression in upper tract urothelial carcinoma.

Luca Campedel, Thomas Seisen, Justine Varinot, Géraldine Cancel-Tassin, Alain Ruffion, Emilien Seizilles De Mazancourt, Myriam Decaussin-Petrucci, Grégoire Robert, Nam-Son Vuong, Magali Philipp, Eva Compérat, Morgan Rouprêt, Olivier Cussenot,

<h4>Introduction</h4>Controversy regarding the prognostic and/or predictive role of PD-1 and PD-L1 expression for upper tract urothelial carcinoma (UTUC) could partly be explained by inconsistencies in the immunohistochemistry (IHC) methodology. Objective is to standardize the methodology for routine evaluation of PD-1 and PD-L1 expression in UTUC patients.<h4>Materials and methods</h4>Twenty-two cases treated ... Read more >>

Can J Urol (The Canadian journal of urology)
[2021, 28(3):10719-10724]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

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<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, :]

Cited: 15 times

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study.

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Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 ... Read more >>

Anaesthesia (Anaesthesia)
[2021, 76(6):748-758]

Cited: 34 times

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Long-term outcomes after penile prosthesis placement for the Management of Erectile Dysfunction: a single-Centre experience.

Valentine Frydman, Ugo Pinar, Maher Abdessater, William Akakpo, Pietro Grande, Marie Audouin, Pierre Mozer, Emmanuel Chartier-Kastler, Thomas Seisen, Morgan Roupret,

<h4>Background</h4>Penile prothesis (PP) is the gold-standard treatment of drug-refractory erectile dysfunction (ED). While postoperative outcomes have been widely described in the literature, there are few data about patient satisfaction and intraoperative events. We aimed to assess long-term patient satisfaction and perioperative outcomes after PP implantation in a single-centre cohort of ... Read more >>

Basic Clin Androl (Basic and clinical andrology)
[2021, 31(1):4]

Cited: 1 time

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A comparison of perioperative outcomes of laparoscopic versus open nephroureterectomy for upper tract urothelial carcinoma: a propensity score matching analysis.

Luca Afferi, Mohammad Abufaraj, Francesco Soria, David D'Andrea, Evanguelos Xylinas, Thomas Seisen, Morgan Roupret, Chiara Lonati, Alexandre De la Taille, Benoit Peyronnet, Ekaterina Laukhtina, Benjamin Pradere, Andrea Mari, Wojciech Krajewski, Mario Alvarez-Maestro, Eiji Kikuchi, Keisuke Shigeta, Piotr Chlosta, Francesco Montorsi, Alberto Briganti, Giuseppe Simone, Paola I Ornaghi, Maria Angela Cerruto, Alessandro Antonelli, Kazumasa Matsumoto, Pierre I Karakiewicz, Livio Mordasini, Agostino Mattei, Shahrokh F Shariat, Marco Moschini,

<h4>Background</h4>Radical nephroureterectomy (RNU) with the concomitant excision of the distal ureter and bladder cuff is the current standard of care for the treatment of muscle invasive and/or high-risk upper tract urothelial carcinoma (UTUC). In small uncontrolled studies, laparoscopic RNU has been suggested to be associated with better perioperative outcomes compared ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2021, :]

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Functional outcomes after robot-assisted pyeloplasty for ureteropelvic junction obstruction: A bi-centre experience.

Marie-Bérénice Popelin, Ugo Pinar, Daniel Benamran, Alexandre Ingels, Jérome Parra, Christophe Vaessen, Thomas Seisen, Alexandre de La Taille, Morgan Roupret,

<h4>Background</h4>Robot-assisted pyeloplasty (RALP) for patients with clinically symptomatic ureteropelvic junction obstruction (UPJO) is increasing and needs assessment.<h4>Methods</h4>Patients who underwent RALP for UPJO in two academic centres were included. Demographic and perioperative data were collected retrospectively. UPJO was evaluated by imaging pre- and post-surgery. Patients had follow-up consultations 3,6 and 12 ... Read more >>

Int J Med Robot (The international journal of medical robotics + computer assisted surgery : MRCAS)
[2021, 17(2):e2201]

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Prognostic Impact of pT3 Subclassification in a Multicentre Cohort of Patients with Urothelial Carcinoma of the Renal Pelvicalyceal System Undergoing Radical Nephroureterectomy: A Propensity Score-weighted Analysis After Central Pathology Review.

Thomas Seisen, Andrea Mari, Riccardo Campi, Benoit Peyronnet, Karim Bensalah, Nathalie Rioux-Leclercq, Christian Pfister, Françoise Gobet, Alexandre De La Taille, Yves Allory, Evanguelos Xylinas, Yann Neuzillet, Camelia Radulescu, Jean-Luc Descotes, Géraldine Saada-Sebag, Jacques Irani, Céline Delpech-Debiais, Pierre Bigot, Caroline Eymerit, Sebastien Crouzet, Florence Mege-Lechevallier, Alain Ruffion, Myriam Decaussin-Petrucci, Stéphane Droupy, Pascal Roger, Xavier Durand, Philippe Camparo, Olivier Cussenot, Eva Compérat, Morgan Rouprêt,

<h4>Background</h4>The current pathological tumour-node-metastasis (pTNM) classification for upper tract urothelial carcinoma (UTUC) does not include any risk stratification of pT3 renal pelvicalyceal tumours.<h4>Objective</h4>To assess the prognostic impact of pT3 subclassification in a multicentre cohort of patients with UTUC of the renal pelvicalyceal system undergoing radical nephroureterectomy (RNU).<h4>Design, setting, and participants</h4>Data ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

Cited: 0 times

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The Performance of Tumor Size as Risk Stratification Parameter in Upper Tract Urothelial Carcinoma (UTUC).

Beat Foerster, Mohammad Abufaraj, Andrea Mari, Thomas Seisen, Marco Bandini, Donald Schweitzer, Anna K Czech, Marco Moschini, David D'Andrea, Marco Bianchi, Kees Hendricksen, Morgan Rouprêt, Alberto Briganti, Bas W G van Rhijn, Piotr Chłosta, Pierre Colin, Hubert John, Shahrokh F Shariat,

<h4>Introduction</h4>The objective of this study was to evaluate the performance of different tumor diameters for identifying ≥ pT2 upper tract urothelial carcinoma (UTUC) at radical nephroureterectomy.<h4>Patients and methods</h4>This was a multi-institutional retrospective study that included 932 patients who underwent radical nephroureterectomy for nonmetastatic UTUC between 2000 and 2016. Tumor sizes were ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, 19(3):272.e1-272.e7]

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Author Correction: Introducing PIONEER: a project to harness big data in prostate cancer research.

Muhammad Imran Omar, Monique J Roobol, Maria J Ribal, Thomas Abbott, Paul-Michael Agapow, Sonia Araujo, Alex Asiimwe, Charles Auffray, Irina Balaur, Katharina Beyer, Chiara Bernini, Anders Bjartell, Alberto Briganti, John-Edward Butler-Ransohoff, Riccardo Campi, Marinel Cavelaars, Bertrand De Meulder, Zsuzsanna Devecseri, Marc Dietrich Voss, Konstantinos Dimitropoulos, Susan Evans-Axelsson, Billy Franks, Louise Fullwood, Denis Horgan, Emma Jane Smith, Amit Kiran, Kati Kivinummi, Mark Lambrecht, Doron Lancet, Peter Lindgren, Sara MacLennan, Steven MacLennan, Maria Manuela Nogueira, Fredrik Moen, Maxim Moinat, Kishore Papineni, Christian Reich, Kristin Reiche, Stijn Rogiers, Claudio Sartini, Kees van Bochove, Femke van Diggelen, Mieke Van Hemelrijck, Hein Van Poppel, Jihong Zong, James N'Dow, ,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2020, 17(8):482]

Cited: 1 time

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Risk stratification for upper tract urinary carcinoma.

Daniel Benamran, Thomas Seisen, Elias Naoum, Christophe Vaessen, Jérome Parra, Pierre Mozer, Shahrokh F Shariat, Morgan Rouprêt,

Upper tract urinary carcinoma (UTUC) is a heterogeneous group of rare tumors. The aim of this article is to critically review current therapeutic strategies and to propose a change in the risk-stratification of the disease. A non-systematic review of the literature was performed using the Medline database with the search ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1799-1808]

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Introducing PIONEER: a project to harness big data in prostate cancer research.

Muhammad Imran Omar, Monique J Roobol, Maria J Ribal, Thomas Abbott, Paul-Michael Agapow, Sonia Araujo, Alex Asiimwe, Charles Auffray, Irina Balaur, Katharina Beyer, Chiara Bernini, Anders Bjartell, Alberto Briganti, John-Edward Butler-Ransohoff, Riccardo Campi, Marinel Cavelaars, Bertrand De Meulder, Zsuzsanna Devecseri, Marc Dietrich Voss, Konstantinos Dimitropoulos, Susan Evans-Axelsson, Billy Franks, Louise Fullwood, Denis Horgan, Emma Jane Smith, Amit Kiran, Kati Kivinummi, Mark Lambrecht, Doron Lancet, Peter Lindgren, Sara MacLennan, Steven MacLennan, Maria Manuela Nogueira, Fredrik Moen, Maxim Moinat, Kishore Papineni, Christian Reich, Kristin Reiche, Stijn Rogiers, Claudio Sartini, Kees van Bochove, Femke van Diggelen, Mieke Van Hemelrijck, Hein Van Poppel, Jihong Zong, James N'Dow, ,

Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. Launched by the Innovative Medicines Initiative 2 and part of the ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2020, 17(6):351-362]

Cited: 2 times

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The association of cigarette smoking and pathological response to neoadjuvant platinum-based chemotherapy in patients undergoing treatment for urinary bladder cancer - A prospective European multicenter observational study of the EAU Young Academic Urologists (YAU) urothelial carcinoma working group.

Philipp Gild, Malte W Vetterlein, Roland Seiler, Andrea Necchi, Kees Hendricksen, Laura S Mertens, Florian Roghmann, Nicolas V Landenberg, Paolo Gontero, Marcus Cumberbatch, Jakub Dobruch, Thomas Seisen, Pietro Grande, David D'Andrea, Julien Anract, Evi Comploj, Armin Pycha, Karim Saba, Cedric Poyet, Bas W van Rhijn, Aidan P Noon, Morgan Roupret, Shahrokh F Shariat, Margit Fisch, Evanguelos Xylinas, Michael Rink,

<h4>Objective</h4>To prospectively study the impact of smoking on pathological response to neoadjuvant chemotherapy (NAC) in patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB).<h4>Materials & methods</h4>We collected standard clinicopathological variables, including smoking status (never, former, current) in patients undergoing NAC and RC for UCB at 12 European ... Read more >>

Surg Oncol (Surgical oncology)
[2020, 34:312-317]

Cited: 1 time

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European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.

Morgan Rouprêt, Marko Babjuk, Maximilian Burger, Otakar Capoun, Daniel Cohen, Eva M Compérat, Nigel C Cowan, Jose L Dominguez-Escrig, Paolo Gontero, A Hugh Mostafid, Joan Palou, Benoit Peyronnet, Thomas Seisen, Viktor Soukup, Richard J Sylvester, Bas W G van Rhijn, Richard Zigeuner, Shahrokh F Shariat,

<h4>Context</h4>The European Association of Urology (EAU) Guidelines Panel on Upper Urinary Tract Urothelial Carcinoma (UTUC) has prepared updated guidelines to aid clinicians in the current evidence-based management of UTUC and to incorporate recommendations into clinical practice.<h4>Objective</h4>To provide an overview of the EAU guidelines on UTUC as an aid to clinicians.<h4>Evidence ... Read more >>

Eur Urol (European urology)
[2021, 79(1):62-79]

Cited: 34 times

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Current status and future directions of the use of novel immunotherapeutic agents in bladder cancer.

Louis Lenfant, Alireza Aminsharifi, Thomas Seisen, Morgan Rouprêt,

<h4>Purpose of review</h4>To report the available information on the current status and future direction of the use of checkpoint inhibitors as novel immunotherapeutic agents in bladder cancer.<h4>Recent findings</h4>In the past 3 years, five immunotherapies targeting programmed cell death 1 (Pembrolizumab and Durvalumab) or programmed cell death-ligand 1 (PD-L1) (Atezolizumab, nivolumab ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2020, 30(3):428-440]

Cited: 3 times

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Adjustments in the Use of Intravesical Instillations of Bacillus Calmette-Guérin for High-risk Non-muscle-invasive Bladder Cancer During the COVID-19 Pandemic.

Louis Lenfant, Thomas Seisen, Yohann Loriot, Morgan Rouprêt,

Non-muscle-invasive bladder cancer patients with COVID-19 are more likely to develop acute respiratory distress syndrome. Thus, several adjustments to the use of intravesical instillations of bacillus Calmette-Guérin should be made during the current pandemic to limit the risk of contamination. ... Read more >>

Eur Urol (European urology)
[2020, 78(1):1-3]

Cited: 10 times

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Functional outcomes obtained with intracorporeal neobladder after robotic radical cystectomy for cancer: a narrative review.

Daniel Benamran, Véronique Phé, Sarah J Drouin, Ophélie Perrot, Adrien Grégoris, Jérôme Parra, Christophe Vaessen, Thomas Seisen, Morgan Rouprêt,

Robot-assisted radical cystectomy with intracorporeal urinary diversion is one of the most challenging procedures in urological surgery. Over the past 15 years, this procedure has gained in popularity and the number of procedures performed has increased significantly. While ileal conduit remains the most common diversion, orthotopic neobladders are also formed in ... Read more >>

J Robot Surg (Journal of robotic surgery)
[2020, 14(6):813-820]

Cited: 2 times

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Regression Discontinuity Analysis of Salvage Radiotherapy in Prostate Cancer.

Philipp Gild, Raisa S Pompe, Thomas Seisen, Jacob Keeley, Hoang J Tang, Alberto Bossi, Derya Tilki, Mani Menon, Firas Abdollah,

There is a lack of randomized evidence comparing early (eSRT) to late (lSRT) salvage radiotherapy (SRT) after radical prostatectomy (RP) for prostate cancer (PCa). Moreover, the existing evidence is often affected by lead-time bias. We sought to address this gap in a cohort of 1458 PCa patients undergoing SRT for ... Read more >>

Eur Urol Oncol (European urology oncology)
[2019, :]

Cited: 0 times

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European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ) - 2019 Update.

Marko Babjuk, Maximilian Burger, Eva M Compérat, Paolo Gontero, A Hugh Mostafid, Joan Palou, Bas W G van Rhijn, Morgan Rouprêt, Shahrokh F Shariat, Richard Sylvester, Richard Zigeuner, Otakar Capoun, Daniel Cohen, José Luis Dominguez Escrig, Virginia Hernández, Benoit Peyronnet, Thomas Seisen, Viktor Soukup,

<h4>Context</h4>This overview presents the updated European Association of Urology (EAU) guidelines for non-muscle-invasive bladder cancer (NMIBC), TaT1, and carcinoma in situ (CIS).<h4>Objective</h4>To provide practical recommendations on the clinical management of NMIBC with a focus on clinical presentation and recommendations.<h4>Evidence acquisition</h4>A broad and comprehensive scoping exercise covering all areas of the ... Read more >>

Eur Urol (European urology)
[2019, 76(5):639-657]

Cited: 152 times

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A preoperative nomogram to predict major complications after robot assisted partial nephrectomy (UroCCR-57 study).

Zine-Eddine Khene, Benoit Peyronnet, Jean-Christophe Bernhard, Neil J Kocher, Christophe Vaessen, Nicolas Doumerc, Benjamin Pradere, Thomas Seisen, Jean-Baptiste Beauval, Grégory Verhoest, Mathieu Roumiguié, Alexandre De la Taille, Franck Bruyere, Morgan Roupret, Arnaud Mejean, Romain Mathieu, Shahrokh Shariat, Jay D Raman, Karim Bensalah, ,

<h4>Objective</h4>To generate a nomogram based on preoperative parameters to predict the occurrence of a major complication within 30-days of robotic partial nephrectomy.<h4>Materials and methods</h4>The study included 1,342 patients with a clinically localized renal tumor who underwent robotic partial nephrectomy (RPN) between 2010 and 2017 at 7 academic centers. The primary ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(9):577.e1-577.e7]

Cited: 0 times

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Robotic radical nephroureterectomy and segmental ureterectomy for upper tract urothelial carcinoma: a multi-institutional experience.

Riccardo Campi, Juliette Cotte, Francesco Sessa, Thomas Seisen, Riccardo Tellini, Daniele Amparore, Nicola Mormile, Aurélien Gobert, Andrea Mari, Francesco Porpiglia, Sergio Serni, Andrea Minervini, Morgan Rouprêt,

<h4>Purpose</h4>To report a multi-institutional experience on robotic radical nephroureterectomy (RNU) and segmental ureterectomy (SU) for upper tract urothelial carcinoma (UTUC).<h4>Methods</h4>Data were prospectively collected from patients with non-metastatic UTUC undergoing robotic SU or RNU at three referral centers between 2015 and 2018. Transperitoneal, single-docking robotic RNU followed established principles. Bladder cuff ... Read more >>

World J Urol (World journal of urology)
[2019, 37(11):2303-2311]

Cited: 6 times

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