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Author Thomas S Price


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A Pilot Characterization of the Human Chronobiome.

Carsten Skarke, Nicholas F Lahens, Seth D Rhoades, Amy Campbell, Kyle Bittinger, Aubrey Bailey, Christian Hoffmann, Randal S Olson, Lihong Chen, Guangrui Yang, Thomas S Price, Jason H Moore, Frederic D Bushman, Casey S Greene, Gregory R Grant, Aalim M Weljie, Garret A FitzGerald,

Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data from remote sensors, physiological and multi-omics analyses to assess the feasibility of detecting time ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):17141]

Cited: 13 times

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Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

Janine F Felix, Jonathan P Bradfield, Claire Monnereau, Ralf J P van der Valk, Evie Stergiakouli, Alessandra Chesi, Romy Gaillard, Bjarke Feenstra, Elisabeth Thiering, Eskil Kreiner-Møller, Anubha Mahajan, Niina Pitkänen, Raimo Joro, Alana Cavadino, Ville Huikari, Steve Franks, Maria M Groen-Blokhuis, Diana L Cousminer, Julie A Marsh, Terho Lehtimäki, John A Curtin, Jesus Vioque, Tarunveer S Ahluwalia, Ronny Myhre, Thomas S Price, Natalia Vilor-Tejedor, Loïc Yengo, Niels Grarup, Ioanna Ntalla, Wei Ang, Mustafa Atalay, Hans Bisgaard, Alexandra I Blakemore, Amelie Bonnefond, Lisbeth Carstensen, , , Johan Eriksson, Claudia Flexeder, Lude Franke, Frank Geller, Mandy Geserick, Anna-Liisa Hartikainen, Claire M A Haworth, Joel N Hirschhorn, Albert Hofman, Jens-Christian Holm, Momoko Horikoshi, Jouke Jan Hottenga, Jinyan Huang, Haja N Kadarmideen, Mika Kähönen, Wieland Kiess, Hanna-Maaria Lakka, Timo A Lakka, Alexandra M Lewin, Liming Liang, Leo-Pekka Lyytikäinen, Baoshan Ma, Per Magnus, Shana E McCormack, George McMahon, Frank D Mentch, Christel M Middeldorp, Clare S Murray, Katja Pahkala, Tune H Pers, Roland Pfäffle, Dirkje S Postma, Christine Power, Angela Simpson, Verena Sengpiel, Carla M T Tiesler, Maties Torrent, André G Uitterlinden, Joyce B van Meurs, Rebecca Vinding, Johannes Waage, Jane Wardle, Eleftheria Zeggini, Babette S Zemel, George V Dedoussis, Oluf Pedersen, Philippe Froguel, Jordi Sunyer, Robert Plomin, Bo Jacobsson, Torben Hansen, Juan R Gonzalez, Adnan Custovic, Olli T Raitakari, Craig E Pennell, Elisabeth Widén, Dorret I Boomsma, Gerard H Koppelman, Sylvain Sebert, Marjo-Riitta Järvelin, Elina Hyppönen, Mark I McCarthy, Virpi Lindi, Niinikoski Harri, Antje Körner, Klaus Bønnelykke, Joachim Heinrich, Mads Melbye, Fernando Rivadeneira, Hakon Hakonarson, Susan M Ring, George Davey Smith, Thorkild I A Sørensen, Nicholas J Timpson, Struan F A Grant, Vincent W V Jaddoe, , ,

A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2016, 25(2):389-403]

Cited: 85 times

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The separation of ADHD inattention and hyperactivity-impulsivity symptoms: pathways from genetic effects to cognitive impairments and symptoms.

Jonna Kuntsi, Rebecca Pinto, Thomas S Price, Jaap J van der Meere, Alexis C Frazier-Wood, Philip Asherson,

Both shared and unique genetic risk factors underlie the two symptom domains of attention deficit hyperactivity disorder (ADHD): inattention and hyperactivity-impulsivity. The developmental course and relationship to co-occurring disorders differs across the two symptom domains, highlighting the importance of their partially distinct etiologies. Familial cognitive impairment factors have been identified ... Read more >>

J Abnorm Child Psychol (Journal of abnormal child psychology)
[2014, 42(1):127-136]

Cited: 29 times

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The correlation between reading and mathematics ability at age twelve has a substantial genetic component.

Oliver S P Davis, Gavin Band, Matti Pirinen, Claire M A Haworth, Emma L Meaburn, Yulia Kovas, Nicole Harlaar, Sophia J Docherty, Ken B Hanscombe, Maciej Trzaskowski, Charles J C Curtis, Amy Strange, Colin Freeman, Céline Bellenguez, Zhan Su, Richard Pearson, Damjan Vukcevic, Cordelia Langford, Panos Deloukas, Sarah Hunt, Emma Gray, Serge Dronov, Simon C Potter, Avazeh Tashakkori-Ghanbaria, Sarah Edkins, Suzannah J Bumpstead, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Audrey Duncanson, Janusz A Z Jankowski, Hugh S Markus, Christopher G Mathew, Colin N A Palmer, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Ines Barroso, Leena Peltonen, Philip S Dale, Stephen A Petrill, Leonard S Schalkwyk, Ian W Craig, Cathryn M Lewis, Thomas S Price, , Peter Donnelly, Robert Plomin, Chris C A Spencer,

Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to children's ability in reading and mathematics, and estimate that around one half of the observed correlation in these ... Read more >>

Nat Commun (Nature communications)
[2014, 5:4204]

Cited: 17 times

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Common variation near ROBO2 is associated with expressive vocabulary in infancy.

Beate St Pourcain, Rolieke A M Cents, Andrew J O Whitehouse, Claire M A Haworth, Oliver S P Davis, Paul F O'Reilly, Susan Roulstone, Yvonne Wren, Qi W Ang, Fleur P Velders, David M Evans, John P Kemp, Nicole M Warrington, Laura Miller, Nicholas J Timpson, Susan M Ring, Frank C Verhulst, Albert Hofman, Fernando Rivadeneira, Emma L Meaburn, Thomas S Price, Philip S Dale, Demetris Pillas, Anneli Yliherva, Alina Rodriguez, Jean Golding, Vincent W V Jaddoe, Marjo-Riitta Jarvelin, Robert Plomin, Craig E Pennell, Henning Tiemeier, George Davey Smith,

Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the EArly Genetics and Lifecourse ... Read more >>

Nat Commun (Nature communications)
[2014, 5:4831]

Cited: 22 times

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Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.

Diana L Cousminer, Evangelia Stergiakouli, Diane J Berry, Wei Ang, Maria M Groen-Blokhuis, Antje Körner, Niina Siitonen, Ioanna Ntalla, Marcella Marinelli, John R B Perry, Johannes Kettunen, Rick Jansen, Ida Surakka, Nicholas J Timpson, Susan Ring, George Mcmahon, Chris Power, Carol Wang, Mika Kähönen, Jorma Viikari, Terho Lehtimäki, Christel M Middeldorp, Hilleke E Hulshoff Pol, Madlen Neef, Sebastian Weise, Katja Pahkala, Harri Niinikoski, Eleftheria Zeggini, Kalliope Panoutsopoulou, Mariona Bustamante, Brenda W J H Penninx, , Joanne Murabito, Maties Torrent, George V Dedoussis, Wieland Kiess, Dorret I Boomsma, Craig E Pennell, Olli T Raitakari, Elina Hyppönen, George Davey Smith, Samuli Ripatti, Mark I McCarthy, Elisabeth Widén, ,

Little is known about genes regulating male puberty. Further, while many identified pubertal timing variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2014, 23(16):4452-4464]

Cited: 31 times

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Genome-wide association study of receptive language ability of 12-year-olds.

Nicole Harlaar, Emma L Meaburn, Marianna E Hayiou-Thomas, , Oliver S P Davis, Sophia Docherty, Ken B Hanscombe, Claire M A Haworth, Thomas S Price, Maciej Trzaskowski, Philip S Dale, Robert Plomin,

PURPOSE:Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach. METHOD:The authors administered 4 Internet-based ... Read more >>

J. Speech Lang. Hear. Res. (Journal of speech, language, and hearing research : JSLHR)
[2014, 57(1):96-105]

Cited: 7 times

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Behavior genetics: past, present, future.

Sara R Jaffee, Thomas S Price, Teresa M Reyes,

The disciplines of developmental psychopathology and behavior genetics are concerned with many of the same questions about the etiology and course of normal and abnormal behavior and about the factors that promote typical development despite the presence of risk. The goal of this paper is to summarize how research in ... Read more >>

Dev. Psychopathol. (Development and psychopathology)
[2013, 25(4 Pt 2):1225-1242]

Cited: 4 times

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Common DNA markers can account for more than half of the genetic influence on cognitive abilities.

Robert Plomin, Claire M A Haworth, Emma L Meaburn, Thomas S Price, , Oliver S P Davis,

For nearly a century, twin and adoption studies have yielded substantial estimates of heritability for cognitive abilities, although it has proved difficult for genomewide-association studies to identify the genetic variants that account for this heritability (i.e., the missing-heritability problem). However, a new approach, genomewide complex-trait analysis (GCTA), forgoes the identification ... Read more >>

Psychol Sci (Psychological science)
[2013, 24(4):562-568]

Cited: 49 times

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Genetics of callous-unemotional behavior in children.

Essi Viding, Thomas S Price, Sara R Jaffee, Maciej Trzaskowski, Oliver S P Davis, Emma L Meaburn, Claire M A Haworth, Robert Plomin,

Callous-unemotional behavior (CU) is currently under consideration as a subtyping index for conduct disorder diagnosis. Twin studies routinely estimate the heritability of CU as greater than 50%. It is now possible to estimate genetic influence using DNA alone from samples of unrelated individuals, not relying on the assumptions of the ... Read more >>

PLoS ONE (PloS one)
[2013, 8(7):e65789]

Cited: 13 times

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Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.

Diana L Cousminer, Diane J Berry, Nicholas J Timpson, Wei Ang, Elisabeth Thiering, Enda M Byrne, H Rob Taal, Ville Huikari, Jonathan P Bradfield, Marjan Kerkhof, Maria M Groen-Blokhuis, Eskil Kreiner-Møller, Marcella Marinelli, Claus Holst, Jaakko T Leinonen, John R B Perry, Ida Surakka, Olli Pietiläinen, Johannes Kettunen, Verneri Anttila, Marika Kaakinen, Ulla Sovio, Anneli Pouta, Shikta Das, Vasiliki Lagou, Chris Power, Inga Prokopenko, David M Evans, John P Kemp, Beate St Pourcain, Susan Ring, Aarno Palotie, Eero Kajantie, Clive Osmond, Terho Lehtimäki, Jorma S Viikari, Mika Kähönen, Nicole M Warrington, Stephen J Lye, Lyle J Palmer, Carla M T Tiesler, Claudia Flexeder, Grant W Montgomery, Sarah E Medland, Albert Hofman, Hakon Hakonarson, Mònica Guxens, Meike Bartels, Veikko Salomaa, , Joanne M Murabito, Jaakko Kaprio, Thorkild I A Sørensen, Ferran Ballester, Hans Bisgaard, Dorret I Boomsma, Gerard H Koppelman, Struan F A Grant, Vincent W V Jaddoe, Nicholas G Martin, Joachim Heinrich, Craig E Pennell, Olli T Raitakari, Johan G Eriksson, George Davey Smith, Elina Hyppönen, Marjo-Riitta Järvelin, Mark I McCarthy, Samuli Ripatti, Elisabeth Widén, ,

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2013, 22(13):2735-2747]

Cited: 72 times

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The implications of genotype-environment correlation for establishing causal processes in psychopathology.

Sara R Jaffee, Thomas S Price,

The significance of genotype-environment interplay is its focus on how causal factors, whether environmental or genetic, have their effects. It is difficult to establish causality in observational research because of the potential for reverse causation and confounding. Most environmental measures are heritable, which means that their effects on the risk ... Read more >>

Dev. Psychopathol. (Development and psychopathology)
[2012, 24(4):1253-1264]

Cited: 18 times

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Commentary: Replication, replication, replication: the continued need to substantiate GxE effects in child psychopathology--a response to Laucht et al. (2012).

Philip Asherson, Thomas S Price,

J Child Psychol Psychiatry (Journal of child psychology and psychiatry, and allied disciplines)
[2012, 53(4):360-362]

Cited: 3 times

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A genome-wide association meta-analysis identifies new childhood obesity loci.

Jonathan P Bradfield, H Rob Taal, Nicholas J Timpson, André Scherag, Cecile Lecoeur, Nicole M Warrington, Elina Hypponen, Claus Holst, Beatriz Valcarcel, Elisabeth Thiering, Rany M Salem, Fredrick R Schumacher, Diana L Cousminer, Patrick M A Sleiman, Jianhua Zhao, Robert I Berkowitz, Karani S Vimaleswaran, Ivonne Jarick, Craig E Pennell, David M Evans, Beate St Pourcain, Diane J Berry, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Cornelia M van Duijn, Ralf J P van der Valk, Johan C de Jongste, Dirkje S Postma, Dorret I Boomsma, W James Gauderman, Mohamed T Hassanein, Cecilia M Lindgren, Reedik Mägi, Colin A G Boreham, Charlotte E Neville, Luis A Moreno, Paul Elliott, Anneli Pouta, Anna-Liisa Hartikainen, Mingyao Li, Olli Raitakari, Terho Lehtimäki, Johan G Eriksson, Aarno Palotie, Jean Dallongeville, Shikta Das, Panos Deloukas, George McMahon, Susan M Ring, John P Kemp, Jessica L Buxton, Alexandra I F Blakemore, Mariona Bustamante, Mònica Guxens, Joel N Hirschhorn, Matthew W Gillman, Eskil Kreiner-Møller, Hans Bisgaard, Frank D Gilliland, Joachim Heinrich, Eleanor Wheeler, Inês Barroso, Stephen O'Rahilly, Aline Meirhaeghe, Thorkild I A Sørensen, Chris Power, Lyle J Palmer, Anke Hinney, Elisabeth Widen, I Sadaf Farooqi, Mark I McCarthy, Philippe Froguel, David Meyre, Johannes Hebebrand, Marjo-Riitta Jarvelin, Vincent W V Jaddoe, George Davey Smith, Hakon Hakonarson, Struan F A Grant, ,

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile ... Read more >>

Nat. Genet. (Nature genetics)
[2012, 44(5):526-531]

Cited: 180 times

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Common variants at 6q22 and 17q21 are associated with intracranial volume.

M Arfan Ikram, Myriam Fornage, Albert V Smith, Sudha Seshadri, Reinhold Schmidt, Stéphanie Debette, Henri A Vrooman, Sigurdur Sigurdsson, Stefan Ropele, H Rob Taal, Dennis O Mook-Kanamori, Laura H Coker, W T Longstreth, Wiro J Niessen, Anita L DeStefano, Alexa Beiser, Alex P Zijdenbos, Maksim Struchalin, Clifford R Jack, Fernando Rivadeneira, Andre G Uitterlinden, David S Knopman, Anna-Liisa Hartikainen, Craig E Pennell, Elisabeth Thiering, Eric A P Steegers, Hakon Hakonarson, Joachim Heinrich, Lyle J Palmer, Marjo-Riitta Jarvelin, Mark I McCarthy, Struan F A Grant, Beate St Pourcain, Nicholas J Timpson, George Davey Smith, Ulla Sovio, , Mike A Nalls, Rhoda Au, Albert Hofman, Haukur Gudnason, Aad van der Lugt, Tamara B Harris, William M Meeks, Meike W Vernooij, Mark A van Buchem, Diane Catellier, Vincent W V Jaddoe, Vilmundur Gudnason, B Gwen Windham, Philip A Wolf, Cornelia M van Duijn, Thomas H Mosley, Helena Schmidt, Lenore J Launer, Monique M B Breteler, Charles DeCarli, ,

During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations ... Read more >>

Nat. Genet. (Nature genetics)
[2012, 44(5):539-544]

Cited: 71 times

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Common variants at 12q15 and 12q24 are associated with infant head circumference.

H Rob Taal, Beate St Pourcain, Elisabeth Thiering, Shikta Das, Dennis O Mook-Kanamori, Nicole M Warrington, Marika Kaakinen, Eskil Kreiner-Møller, Jonathan P Bradfield, Rachel M Freathy, Frank Geller, Mònica Guxens, Diana L Cousminer, Marjan Kerkhof, Nicholas J Timpson, M Arfan Ikram, Lawrence J Beilin, Klaus Bønnelykke, Jessica L Buxton, Pimphen Charoen, Bo Lund Krogsgaard Chawes, Johan Eriksson, David M Evans, Albert Hofman, John P Kemp, Cecilia E Kim, Norman Klopp, Jari Lahti, Stephen J Lye, George McMahon, Frank D Mentch, Martina Müller, Paul F O'Reilly, Inga Prokopenko, Fernando Rivadeneira, Eric A P Steegers, Jordi Sunyer, Carla Tiesler, Hanieh Yaghootkar, , Monique M B Breteler, Stephanie Debette, Myriam Fornage, Vilmundur Gudnason, Lenore J Launer, Aad van der Lugt, Thomas H Mosley, Sudha Seshadri, Albert V Smith, Meike W Vernooij, , Alexandra If Blakemore, Rosetta M Chiavacci, Bjarke Feenstra, Julio Fernandez-Benet, Struan F A Grant, Anna-Liisa Hartikainen, Albert J van der Heijden, Carmen Iñiguez, Mark Lathrop, Wendy L McArdle, Anne Mølgaard, John P Newnham, Lyle J Palmer, Aarno Palotie, Annneli Pouta, Susan M Ring, Ulla Sovio, Marie Standl, Andre G Uitterlinden, H-Erich Wichmann, Nadja Hawwa Vissing, Charles DeCarli, Cornelia M van Duijn, Mark I McCarthy, Gerard H Koppelman, Xavier Estivill, Andrew T Hattersley, Mads Melbye, Hans Bisgaard, Craig E Pennell, Elisabeth Widen, Hakon Hakonarson, George Davey Smith, Joachim Heinrich, Marjo-Riitta Jarvelin, , Vincent W V Jaddoe,

To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome ... Read more >>

Nat. Genet. (Nature genetics)
[2012, 44(5):532-538]

Cited: 65 times

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Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.

Richa Saxena, Clara C Elbers, Yiran Guo, Inga Peter, Tom R Gaunt, Jessica L Mega, Matthew B Lanktree, Archana Tare, Berta Almoguera Castillo, Yun R Li, Toby Johnson, Marcel Bruinenberg, Diane Gilbert-Diamond, Ramakrishnan Rajagopalan, Benjamin F Voight, Ashok Balasubramanyam, John Barnard, Florianne Bauer, Jens Baumert, Tushar Bhangale, Bernhard O Böhm, Peter S Braund, Paul R Burton, Hareesh R Chandrupatla, Robert Clarke, Rhonda M Cooper-DeHoff, Errol D Crook, George Davey-Smith, Ian N Day, Anthonius de Boer, Mark C H de Groot, Fotios Drenos, Jane Ferguson, Caroline S Fox, Clement E Furlong, Quince Gibson, Christian Gieger, Lisa A Gilhuijs-Pederson, Joseph T Glessner, Anuj Goel, Yan Gong, Struan F A Grant, Diederick E Grobbee, Claire Hastie, Steve E Humphries, Cecilia E Kim, Mika Kivimaki, Marcus Kleber, Christa Meisinger, Meena Kumari, Taimour Y Langaee, Debbie A Lawlor, Mingyao Li, Maximilian T Lobmeyer, Anke-Hilse Maitland-van der Zee, Matthijs F L Meijs, Cliona M Molony, David A Morrow, Gurunathan Murugesan, Solomon K Musani, Christopher P Nelson, Stephen J Newhouse, Jeffery R O'Connell, Sandosh Padmanabhan, Jutta Palmen, Sanjey R Patel, Carl J Pepine, Mary Pettinger, Thomas S Price, Suzanne Rafelt, Jane Ranchalis, Asif Rasheed, Elisabeth Rosenthal, Ingo Ruczinski, Sonia Shah, Haiqing Shen, Günther Silbernagel, Erin N Smith, Annemieke W M Spijkerman, Alice Stanton, Michael W Steffes, Barbara Thorand, Mieke Trip, Pim van der Harst, Daphne L van der A, Erik P A van Iperen, Jessica van Setten, Jana V van Vliet-Ostaptchouk, Niek Verweij, Bruce H R Wolffenbuttel, Taylor Young, M Hadi Zafarmand, Joseph M Zmuda, , , Michael Boehnke, David Altshuler, Mark McCarthy, W H Linda Kao, James S Pankow, Thomas P Cappola, Peter Sever, Neil Poulter, Mark Caulfield, Anna Dominiczak, Denis C Shields, Deepak L Bhatt, Li Zhang, Sean P Curtis, John Danesh, Juan P Casas, Yvonne T van der Schouw, N Charlotte Onland-Moret, Pieter A Doevendans, Gerald W Dorn, Martin Farrall, Garret A FitzGerald, Anders Hamsten, Robert Hegele, Aroon D Hingorani, Marten H Hofker, Gordon S Huggins, Thomas Illig, Gail P Jarvik, Julie A Johnson, Olaf H Klungel, William C Knowler, Wolfgang Koenig, Winfried März, James B Meigs, Olle Melander, Patricia B Munroe, Braxton D Mitchell, Susan J Bielinski, Daniel J Rader, Muredach P Reilly, Stephen S Rich, Jerome I Rotter, Danish Saleheen, Nilesh J Samani, Eric E Schadt, Alan R Shuldiner, Roy Silverstein, Kandice Kottke-Marchant, Philippa J Talmud, Hugh Watkins, Folkert W Asselbergs, Paul I W de Bakker, Jeanne McCaffery, Cisca Wijmenga, Marc S Sabatine, James G Wilson, Alex Reiner, Donald W Bowden, Hakon Hakonarson, David S Siscovick, Brendan J Keating,

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with ∼2000 candidate genes in 39 multiethnic population-based studies, case-control studies, and clinical trials totaling 17,418 cases and 70,298 controls. First, meta-analysis of 25 studies ... Read more >>

Am. J. Hum. Genet. (American journal of human genetics)
[2012, 90(3):410-425]

Cited: 156 times

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Low-dose naproxen interferes with the antiplatelet effects of aspirin in healthy subjects: recommendations to minimize the functional consequences.

Paola Anzellotti, Marta L Capone, Anita Jeyam, Stefania Tacconelli, Annalisa Bruno, Paola Tontodonati, Luigia Di Francesco, Linda Grossi, Giulia Renda, Gabriele Merciaro, Patrizia Di Gregorio, Thomas S Price, Luis A Garcia Rodriguez, Paola Patrignani,

OBJECTIVE: To investigate whether low-dose naproxen sodium (220 mg twice a day) interferes with aspirin's antiplatelet effect in healthy subjects. METHODS: We performed a crossover, open-label study in 9 healthy volunteers. They received for 6 days 3 different treatments separated by 14 days of washout: 1) naproxen 2 hours before ... Read more >>

Arthritis Rheum. (Arthritis and rheumatism)
[2011, 63(3):850-859]

Cited: 33 times

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Fetal genotype for the xenobiotic metabolizing enzyme NQO1 influences intrauterine growth among infants whose mothers smoked during pregnancy.

Thomas S Price, Tilo Grosser, Robert Plomin, Sara R Jaffee,

Maternal smoking during pregnancy retards fetal growth and depresses infant birth weight. The magnitude of these effects may be moderated by fetal genotype. The current study investigated maternal smoking, fetal genotype, and fetal growth in a large population sample of dizygotic twins. Maternal smoking retarded fetal growth in a dose-dependent ... Read more >>

Child Dev (Child development)
[2010, 81(1):101-114]

Cited: 7 times

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Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.

Guilherme Polanczyk, Avshalom Caspi, Benjamin Williams, Thomas S Price, Andrea Danese, Karen Sugden, Rudolf Uher, Richie Poulton, Terrie E Moffitt,

A previous study reported a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]).To replicate the interaction between childhood maltreatment ... Read more >>

Arch. Gen. Psychiatry (Archives of general psychiatry)
[2009, 66(9):978-985]

Cited: 156 times

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Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

Brendan J Keating, Sam Tischfield, Sarah S Murray, Tushar Bhangale, Thomas S Price, Joseph T Glessner, Luana Galver, Jeffrey C Barrett, Struan F A Grant, Deborah N Farlow, Hareesh R Chandrupatla, Mark Hansen, Saad Ajmal, George J Papanicolaou, Yiran Guo, Mingyao Li, Stephanie Derohannessian, Paul I W de Bakker, Swneke D Bailey, Alexandre Montpetit, Andrew C Edmondson, Kent Taylor, Xiaowu Gai, Susanna S Wang, Myriam Fornage, Tamim Shaikh, Leif Groop, Michael Boehnke, Alistair S Hall, Andrew T Hattersley, Edward Frackelton, Nick Patterson, Charleston W K Chiang, Cecelia E Kim, Richard R Fabsitz, Willem Ouwehand, Alkes L Price, Patricia Munroe, Mark Caulfield, Thomas Drake, Eric Boerwinkle, David Reich, A Stephen Whitehead, Thomas P Cappola, Nilesh J Samani, A Jake Lusis, Eric Schadt, James G Wilson, Wolfgang Koenig, Mark I McCarthy, Sekar Kathiresan, Stacey B Gabriel, Hakon Hakonarson, Sonia S Anand, Muredach Reilly, James C Engert, Deborah A Nickerson, Daniel J Rader, Joel N Hirschhorn, Garret A Fitzgerald,

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so their delineation currently requires integration of diverse ... Read more >>

PLoS ONE (PloS one)
[2008, 3(10):e3583]

Cited: 290 times

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Genotype-environment correlations: implications for determining the relationship between environmental exposures and psychiatric illness.

Sara R Jaffee, Thomas S Price,

Psychosocial risk factors for psychiatric illness are moderately heritable. This has two implications: first, that individuals actively shape their environments through heritable behaviour; second, that the relationship between environmental exposure and psychopathology may be confounded by genotype. We define three types of genotype-environment correlation (passive, evocative, and active), describe the ... Read more >>

Psychiatry (Psychiatry)
[2008, 7(12):496-499]

Cited: 10 times

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Effects of the family environment: gene-environment interaction and passive gene-environment correlation.

Thomas S Price, Sara R Jaffee,

The classical twin study provides a useful resource for testing hypotheses about how the family environment influences children's development, including how genes can influence sensitivity to environmental effects. However, existing statistical models do not account for the possibility that children can inherit exposure to family environments (i.e., passive gene-environment correlation). ... Read more >>

Dev Psychol (Developmental psychology)
[2008, 44(2):305-315]

Cited: 22 times

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Phenotypic and genetic overlap between autistic traits at the extremes of the general population.

Angelica Ronald, Francesca Happé, Thomas S Price, Simon Baron-Cohen, Robert Plomin,

OBJECTIVE:To investigate children selected from a community sample for showing extreme autistic-like traits and to assess the degree to which these individual traits--social impairments (SIs), communication impairments (CIs), and restricted repetitive behaviors and interests (RRBIs)--are caused by genes and environments, whether all of them are caused by the same genes ... Read more >>

J Am Acad Child Adolesc Psychiatry (Journal of the American Academy of Child and Adolescent Psychiatry)
[2006, 45(10):1206-1214]

Cited: 98 times

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EBP, a program for protein identification using multiple tandem mass spectrometry datasets.

Thomas S Price, Margaret B Lucitt, Weichen Wu, David J Austin, Angel Pizarro, Anastasia K Yocum, Ian A Blair, Garret A FitzGerald, Tilo Grosser,

MS/MS combined with database search methods can identify the proteins present in complex mixtures. High throughput methods that infer probable peptide sequences from enzymatically digested protein samples create a challenge in how best to aggregate the evidence for candidate proteins. Typically the results of multiple technical and/or biological replicate experiments ... Read more >>

Mol. Cell Proteomics (Molecular & cellular proteomics : MCP)
[2007, 6(3):527-536]

Cited: 33 times

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