Full Text Journal Articles by
Author Thomas M Scalea

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An Estrogen (17α-ethinyl estradiol-3-sulfate) Reduces Mortality in a Swine Model of Poly Trauma and Hemorrhagic Shock.

Hossam Abdou, Jonathan J Morrison, Joseph Edwards, Neerav Patel, Eric Lang, Michael J Richmond, Noha Elansary, Mathangi Gopalakrishnan, Jonathan Berman, William J Hubbard, Thomas M Scalea, Irshad H Chaudry,

Although 17α-ethinyl estradiol-3-sulfate (EES) reduces mortality in animal models of controlled hemorrhage, its role in a clinically relevant injury model is unknown. We assessed the impact of EES in a swine model of poly trauma and hemorrhage. The study was performed under Good Laboratory Practice, with 30 male uncastrated swine ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, :]

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The Algorithm Examining the Risk of Massive Transfusion (ALERT) Score Accurately Predicts Massive Transfusion at the Scene of Injury and on Arrival to the Trauma Bay: A Retrospective Analysis.

Jonathan H Chow, Justin E Richards, Samuel M Galvagno, Patrick J Coleman, Allison S Lankford, Cheralyn Hendrix, Jackson Dunitz, Ikeoluwapo Ibrahim, Mira Ghneim, Kenichi A Tanaka, Thomas M Scalea, Michael A Mazzeffi, Peter Hu,

<h4>Background</h4>Massive transfusion (MT) is required to resuscitate traumatically injured patients with complex derangements. Scoring systems for MT typically require laboratory values and radiological imaging that may delay the prediction of MT.<h4>Study design</h4>The Trauma ALgorithm Examining the Risk of massive Transfusion (Trauma ALERT) study was an observational cohort study. Prehospital and ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(4):529-536]

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Predicting success of resuscitative endovascular occlusion of the aorta: Timing supersedes variable techniques in predicting patient survival.

Alexis L Cralley, Ernest E Moore, Thomas M Scalea, Kenji Inaba, Eileen M Bulger, David E Meyer, Charles J Fox, Angela Sauaia,

<h4>Background</h4>Resuscitative endovascular occlusion of the aorta (REBOA) is used for temporary aortic occlusion of trauma patients in the management of noncompressible hemorrhage. Previous studies have focused on how to properly perform REBOA in the trauma environment to improve survival rates, but high-grade evidence defining the ideal patient population does not ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 91(3):473-479]

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Factors Associated with Increased Mortality in Severe Abdominopelvic Injury.

Neerav Patel, Melike Harfouche, David P Stonko, Noha Elansary, Thomas M Scalea, Jonathan J Morrison,

<h4>Background</h4>Associated injuries are thought to increase mortality in patients with severe abdominopelvic trauma. This study aimed to identify clinical factors contributing to increased mortality in patients with severe abdominopelvic trauma, with the hypothesis that a greater number of concomitant injuries would result in increased mortality.<h4>Methods</h4>This was a retrospective review of ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, :]

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Repair of the Iliac Arterial Injury in Trauma: An Endovascular Operation?

Hossam Abdou, Rishi Kundi, Joseph J DuBose, Thomas M Scalea, Jonathan J Morrison, Marcus Ottochian,

<h4>Background</h4>Endovascular therapy is effective for non-traumatic iliac arterial diseases. The role of endovascular surgery in traumatic iliac lesions is unclear. The aim of this study is to compare outcomes for open versus endovascular management of traumatic iliac injuries.<h4>Materials and methods</h4>The National Trauma Data Bank was searched for patients from 2002to ... Read more >>

J Surg Res (The Journal of surgical research)
[2021, 268:347-353]

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Contemporary Management and Outcomes of Injuries to the Inferior Vena Cava: A Prospective Multicenter Trial From PROspective Observational Vascular Injury Treatment.

David P Stonko, Faris K Azar, Richard D Betzold, Jonathan J Morrison, Ryan B Fransman, John Holcomb, Tiffany Bee, Timothy C Fabian, David J Skarupa, Deborah M Stein, Rosemary A Kozar, James V O'Connor, Thomas M Scalea, Joseph J DuBose, David V Feliciano,

<h4>Introduction</h4>Injuries to the inferior vena cava (IVC), while uncommon, have a high mortality despite modern advances. The goal of this study is to describe the diagnosis and management in the largest available prospective data set of vascular injuries across anatomic levels of IVC injury.<h4>Methods</h4>The American Association for the Surgery of ... Read more >>

Am Surg (The American surgeon)
[2021, :31348211038556]

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A descriptive evaluation of causes of death in venovenous extracorporeal membrane oxygenation.

Sagar B Dave, Kristopher B Deatrick, Samuel M Galvagno, Michael A Mazzeffi, David J Kaczorowski, Ronson J Madathil, Raymond Rector, Ali Tabatabai, Daniel J Haase, Daniel Herr, Thomas M Scalea, Jay Menaker,

Veno-venous extracorporeal membrane oxygenation (VV ECMO) has become an important support modality for patients with acute respiratory failure refractory to optimal medical therapy, such as low tidal volume mechanical ventilator support, early paralytic infusion, and early prone positioning. The objective of this cohort study was to investigate the causes and ... Read more >>

Perfusion (Perfusion)
[2021, :2676591211035938]

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The Bitter and the Sweet: Relationship of Lactate, Glucose, and Mortality After Severe Blunt Trauma.

Justin E Richards, Michael A Mazzeffi, Michael S Massey, Peter Rock, Samuel M Galvagno, Thomas M Scalea,

<h4>Background</h4>Hyperglycemia is associated with mortality after trauma; however, few studies have simultaneously investigated the association of depth of shock and acute hyperglycemia. We evaluated lactate, as a surrogate measure for depth of shock, and glucose levels on mortality following severe blunt trauma. We hypothesize that measurements of both lactate and ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(2):455-461]

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LASER Fenestration of Thoracic Endoluminal Stent Grafts for Preservation of the Left Subclavian Artery.

Meaghan P Keville, Ara Ko, Joseph J Dubose, Rishi Kundi, Thomas M Scalea, Jonathan J Morrison,

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 91(1):e13-e17]

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Integrating Endovascular and Operative Intervention in Trauma.

Melike Harfouche, Hossam Abdou, Sakib M Adnan, Anna N Romagnoli, James R Martinson, Marta J Madurska, Joseph J Dubose, Thomas M Scalea, Jonathan J Morrison,

<h4>Background</h4>Patterns of utilization of the hybrid operating room (hybrid-OR) in trauma have not been described. The aim of this study was to describe the sequencing and integration of endovascular and operative interventions in trauma using a hybrid-OR.<h4>Materials and methods</h4>This is a single-center, retrospective cohort study of trauma patients who underwent ... Read more >>

J Surg Res (The Journal of surgical research)
[2021, 267:82-90]

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Blunt cerebrovascular injuries: Outcomes from the American Association for the Surgery of Trauma PROspective Observational Vascular Injury Treatment (PROOVIT) multicenter registry.

Rachel M Russo, Anders J Davidson, Hasan B Alam, Joseph J DuBose, Joseph M Galante, Timothy C Fabian, Stephanie Savage, John B Holcomb, Thomas M Scalea, Todd E Rasmussen, ,

<h4>Background</h4>Administering antithrombotics (AT) to the multiply injured patient with blunt cerebrovascular injury (BCVI) requires a thoughtful assessment of the risk of stroke and death associated with nontreatment. Large, multicenter analysis of outcomes stratified by injury grade and vessel injured is needed to inform future recommendations.<h4>Methods</h4>Nine hundred and seventy-one BCVIs were ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 90(6):987-995]

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Extracorporeal Life Support (ECLS): A Review and Focus on Considerations for COVID-19.

Ali Tabatabai, Samuel M Galvagno, James V O'Connor, Thomas M Scalea, Kristopher B Deatrick,

<h4>Abstract</h4>Extracorporeal life support (ECLS) is a support modality for patients with severe acute respiratory distress syndrome (ARDS) who have failed conventional treatments including low tidal volume ventilation, prone positioning, and neuromuscular blockade. In addition, ECLS can be used for hemodynamic support for patients with cardiogenic shock or following cardiac arrest. ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 55(6):742-751]

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A technique for open chest selective aortic arch perfusion.

Hossam Abdou, Marta J Madurska, Joseph Edwards, Neerav Patel, Michael J Richmond, Samuel Galvagno, Rishi Kundi, Joseph J DuBose, Thomas M Scalea, Jonathan J Morrison,

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 90(6):e158-e162]

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Complete Title: Selective Prehospital Advanced Resuscitative Care - Developing A Strategy to Prevent Prehospital Deaths From Noncompressible Torso Hemorrhage.

Zaffer Qasim, Frank K Butler, John B Holcomb, Joseph G Kotora, Brian J Eastridge, Karim Brohi, Thomas M Scalea, C William Schwab, Brendon Drew, Jennifer Gurney, Jan O Jansen, Lewis J Kaplan, Matthew J Martin, Todd E Rasmussen, Stacy A Shackelford, Eric A Bank, Darren Braude, Megan Brenner, Francis X Guyette, Bellal Joseph, William R Hinckley, Jason L Sperry, Juan Duchesne,

<h4>Abstract</h4>Hemorrhage, and particularly noncompressible torso hemorrhage (NCTH) remains a leading cause of potentially preventable prehospital death from trauma in the United States and globally. A subset of severely-injured patients either die in the field or develop irreversible hemorrhagic shock before they can receive hospital definitive care, resulting in poor outcomes. ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, :]

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A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part II: Clinical Management.

Aakash Shah, Sagar Dave, Samuel Galvagno, Kristen George, Ashley R Menne, Daniel J Haase, Brian McCormick, Raymond Rector, Siamak Dahi, Ronson J Madathil, Kristopher B Deatrick, Mehrdad Ghoreishi, James S Gammie, David J Kaczorowski, Thomas M Scalea, Jay Menaker, Daniel Herr, Ali Tabatabai, Eric Krause,

(1) Background: COVID-19 acute respiratory distress syndrome (CARDS) has several distinctions from traditional acute respiratory distress syndrome (ARDS); however, patients with refractory respiratory failure may still benefit from veno-venous extracorporeal membrane oxygenation (VV-ECMO) support. We report our challenges caring for CARDS patients on VV-ECMO and alterations to traditional management strategies. ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(5):]

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Selective aortic arch perfusion versus open cardiac massage in exsanguination cardiac arrest: A comparison of coronary pressure dynamics in swine.

Joseph Edwards, Hossam Abdou, Marta J Madurska, Neerav Patel, Michael J Richmond, David Poliner, Joseph M White, Todd E Rasmussen, Thomas M Scalea, Jonathan J Morrison,

<h4>Aim</h4>To evaluate the mean aortic-right atrial pressure (AoP-RAP) gradients and mean coronary perfusion pressures (CPPs) observed during open cardiac massage (OCM) versus those obtained with selective aortic arch perfusion (SAAP) in post-mortem hypovolemic swine.<h4>Methods</h4>Post-mortum, male swine, utilized in prior studies of hemorrhage, were included in the study. Animals were bled ... Read more >>

Resuscitation (Resuscitation)
[2021, 163:1-5]

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A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part I: System Planning and Care Teams.

Sagar Dave, Aakash Shah, Samuel Galvagno, Kristen George, Ashley R Menne, Daniel J Haase, Brian McCormick, Raymond Rector, Siamak Dahi, Ronson J Madathil, Kristopher B Deatrick, Mehrdad Ghoreishi, James S Gammie, David J Kaczorowski, Thomas M Scalea, Jay Menaker, Daniel Herr, Eric Krause, Ali Tabatabai,

<h4>Background</h4>The most critically ill patients with coronavirus disease 2019 (COVID-19) may require advanced support modalities, such as veno-venous extracorporeal membrane oxygenation (VV-ECMO). A systematic, methodical approach to a respiratory pandemic on a state and institutional level is critical.<h4>Methods</h4>We conducted retrospective review of our institutional response to the COVID-19 pandemic, focusing ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(4):]

Cited: 1 time

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Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.

Jonathan H Chow, Ashish K Khanna, Shravan Kethireddy, David Yamane, Andrea Levine, Amanda M Jackson, Michael T McCurdy, Ali Tabatabai, Gagan Kumar, Paul Park, Ivy Benjenk, Jay Menaker, Nayab Ahmed, Evan Glidewell, Elizabeth Presutto, Shannon Cain, Naeha Haridasa, Wesley Field, Jacob G Fowler, Duy Trinh, Kathleen N Johnson, Aman Kaur, Amanda Lee, Kyle Sebastian, Allison Ulrich, Salvador Peña, Ross Carpenter, Shruti Sudhakar, Pushpinder Uppal, Benjamin T Fedeles, Aaron Sachs, Layth Dahbour, William Teeter, Kenichi Tanaka, Samuel M Galvagno, Daniel L Herr, Thomas M Scalea, Michael A Mazzeffi,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality.<h4>Methods</h4>A retrospective, observational cohort study of adult patients admitted with ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):930-941]

Cited: 66 times

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Development of a Computed Tomography Perfusion Protocol to Support Large Animal Resuscitation Research.

Hossam Abdou, Noha Elansary, David Poliner, Neerav Patel, Joseph Edwards, Michael Richmond, Todd Rasmussen, Thomas Ptak, Thomas M Scalea, Jonathan Morrison,

<h4>Background</h4>Adequate cerebral perfusion is crucial for a positive neurological outcome in trauma; however, it is difficult to characterize in the acute setting with non-invasive methods. Intra-arterial computed tomography perfusion (IA-CTP) may offer a solution. The aim of this study is to develop an IA-CTP protocol for resuscitation research.<h4>Methods</h4>The study examined ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, :]

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Do It to Them, Not to Me: Doctors' and Nurses' Personal Preferences Versus Recommendations for End-of-Life Care.

Lyudmyla Demyan, Sara Siskind, Laura Harmon, Christine L Ramirez, Matthew A Bank, Ronald A Dela Cruz, Matthew D Giangola, Vihas M Patel, Thomas M Scalea, Deborah M Stein, Isadora Botwinick,

<h4>Background</h4>The emotional toll and financial cost of end-of-life care can be high. Existing literature suggests that medical providers often choose to forego many aggressive interventions and life-prolonging therapies for themselves. To further investigate this phenomenon, we compared how providers make medical decisions for themselves versus for relatives and unrelated patients.<h4>Methods</h4>Between ... Read more >>

J Surg Res (The Journal of surgical research)
[2021, 264:76-80]

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PREHOSPITAL CONTINUOUS VITAL SIGNS PREDICT NEED FOR REBOA AND RESUSCITATIVE THORACOTOMY.

Ahmad Zeineddin, Peter Hu, Shiming Yang, Douglas Floccare, Chien-Yu Lin, Thomas M Scalea, Rosemary A Kozar,

<h4>Background</h4>Rapid triage and intervention to control hemorrhage are key to survival following traumatic injury. Patients presenting in hemorrhagic shock may undergo resuscitative thoracotomy (RT) or resuscitative endovascular balloon occlusion of the aorta (REBOA) as adjuncts to rapidly control bleeding. We hypothesized that machine learning along with automated calculation of continuously ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, :]

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Determination of optimal deployment strategy for REBOA in patients with non-compressible hemorrhage below the diaphragm.

Nicholas L Johnson, Charles E Wade, Erin E Fox, David E Meyer, Charles J Fox, Ernest E Moore, Jonathan Morrison, Thomas Scalea, Eileen M Bulger, Kenji Inaba, Bryan C Morse, Laura J Moore, ,

<h4>Background</h4>Non-compressible truncal hemorrhage (NCTH) is the leading cause of preventable death after trauma. Resuscitative endovascular balloon occlusion of the aorta (REBOA) achieves temporary hemorrhage control, supporting cardiac and cerebral perfusion prior to definitive hemostasis. Aortic zone selection algorithms vary among institutions. We evaluated the efficacy of an algorithm for REBOA ... Read more >>

Trauma Surg Acute Care Open (Trauma surgery & acute care open)
[2021, 6(1):e000660]

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Subclavian artery bullet embolism.

Patience Green, Jacyln Clark, Shailvi Gupta, Thomas M Scalea, Brandon R Bruns,

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 90(3):e65-e66]

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State-of-the-Art Review-Endovascular Resuscitation.

Marta J Madurska, James D Ross, Thomas M Scalea, Jonathan J Morrison,

<h4>Abstract</h4>The emerging concept of endovascular resuscitation applies catheter-based techniques in the management of patients in shock to manipulate physiology, optimize hemodynamics, and bridge to definitive care. These interventions hope to address an unmet need in the care of severely injured patients, or those with refractory non-traumatic cardiac arrest, who were ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 55(3):288-300]

Cited: 1 time

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Transplant Hepatectomy With Portacaval Shunt and MARS Therapy for Perioperative Catastrophe: A Series of Four Liver Transplant Cases.

Arielle Cimeno, Samuel Sultan, Josue Alvarez-Casas, Steven I Hanish, David A Bruno, William R Hutson, Deborah M Stein, Thomas M Scalea, Rolf N Barth, John C LaMattina,

Increased worldwide focus on maximal donor utilization and transplantation of patients once considered too ill to survive liver transplantation may increase the otherwise rare frequency of catastrophic graft failure. Although the deleterious effects of an acutely failing allograft have been established for decades, the optimal strategy in this patient population ... Read more >>

Transplant Direct (Transplantation direct)
[2021, 7(3):e674]

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